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The map label for this gene is comEC [H]

Identifier: 188586217

GI number: 188586217

Start: 1676714

End: 1677559

Strand: Reverse

Name: comEC [H]

Synonym: Nther_1600

Alternate gene names: 188586217

Gene position: 1677559-1676714 (Counterclockwise)

Preceding gene: 188586218

Following gene: 188586216

Centisome position: 52.99

GC content: 31.21

Gene sequence:

>846_bases
TTGTTTATAACCATGATAATATCGATGCTAATTATTTTTTCTTCACCGCTTAAAGCTAGTTGTGAAGACAATTTCATTGA
AAGATTCGAAAAACGAGAAGAAGTTATGGAAGTTCATTTCCCAGATGTAAAAAATGGAGAAGTTAGCATAATTAGATTAC
CTAAAAGTGATAAAGTTTTTGTAATCGATACTGGCTCACCAGAAGAAAATAAAACAATAGTAGACTATTTAGAGGAAATT
GATGTAAACACCATTGATGCGTTAATTATTACTAATCCCTATTCAAATTATATTGGGGGAGCACCTAAGATAATTGATAG
ATTTGATGTTAAAAAAACAATCGATAGCGGGACTGCTTTAAAAACAAATTATTTTAGAAAATATTTAACAGCTGCTACAA
AGGAGACGGACTTTCACATTGCCAGAAGGGGAGATGAATTATATCAATCTGAAATAGCCAAACTTGAAATTATATATCCA
GAAAAAATCTTATTTAATGATCCCAGAGAAAATTCTTTAGTTTTACATCTACAATATGGTCAAATAAATTTTCTTTTTAC
TGGTGGTTTAGGTTTAAAAGGAGAACAAAGACTAAATTTTGACCAGAACATTGATATTTTGAAAATAGCTCGTATGGGGG
ATACCAGTGGAACATCAGGAATGTTTTTAGAATCTATAGAGCCCGAAGTGGGAGTGATATTAGGAGGTTCAGACAATAAA
CGCAATCTTCCTAAACAGGAATTACTTGAGAAACTTGACGAAAAAAATATTCATATAGAGAGAACTGGCCAATCAGGCAC
GATAATTTTTAGAACTAATGGTCAAAAAATCAATTGGAATTTATGA

Upstream 100 bases:

>100_bases
GTTATTAAAGTCAAAGCACATTTCAAAAATATTATAGAACAAAGATATACAGGGGTGTGATAAGTTGTTATTAATAACGT
CAGGGATTAGGTACTTTTTC

Downstream 100 bases:

>100_bases
CAAAAAAGGAATTTTATATTTAATAACGAAGTTATATAAACAGCTTGCATTTAAAAAGGGGGAAGATAGTTAATGACTAA
AGTTACATTAATTGAAAATG

Product: hydrolase of metallo-beta-lactamase fold

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MFITMIISMLIIFSSPLKASCEDNFIERFEKREEVMEVHFPDVKNGEVSIIRLPKSDKVFVIDTGSPEENKTIVDYLEEI
DVNTIDALIITNPYSNYIGGAPKIIDRFDVKKTIDSGTALKTNYFRKYLTAATKETDFHIARRGDELYQSEIAKLEIIYP
EKILFNDPRENSLVLHLQYGQINFLFTGGLGLKGEQRLNFDQNIDILKIARMGDTSGTSGMFLESIEPEVGVILGGSDNK
RNLPKQELLEKLDEKNIHIERTGQSGTIIFRTNGQKINWNL

Sequences:

>Translated_281_residues
MFITMIISMLIIFSSPLKASCEDNFIERFEKREEVMEVHFPDVKNGEVSIIRLPKSDKVFVIDTGSPEENKTIVDYLEEI
DVNTIDALIITNPYSNYIGGAPKIIDRFDVKKTIDSGTALKTNYFRKYLTAATKETDFHIARRGDELYQSEIAKLEIIYP
EKILFNDPRENSLVLHLQYGQINFLFTGGLGLKGEQRLNFDQNIDILKIARMGDTSGTSGMFLESIEPEVGVILGGSDNK
RNLPKQELLEKLDEKNIHIERTGQSGTIIFRTNGQKINWNL
>Mature_281_residues
MFITMIISMLIIFSSPLKASCEDNFIERFEKREEVMEVHFPDVKNGEVSIIRLPKSDKVFVIDTGSPEENKTIVDYLEEI
DVNTIDALIITNPYSNYIGGAPKIIDRFDVKKTIDSGTALKTNYFRKYLTAATKETDFHIARRGDELYQSEIAKLEIIYP
EKILFNDPRENSLVLHLQYGQINFLFTGGLGLKGEQRLNFDQNIDILKIARMGDTSGTSGMFLESIEPEVGVILGGSDNK
RNLPKQELLEKLDEKNIHIERTGQSGTIIFRTNGQKINWNL

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 31987; Mature: 31987

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFITMIISMLIIFSSPLKASCEDNFIERFEKREEVMEVHFPDVKNGEVSIIRLPKSDKVF
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCEEEEEECCCCCEE
VIDTGSPEENKTIVDYLEEIDVNTIDALIITNPYSNYIGGAPKIIDRFDVKKTIDSGTAL
EEECCCCCCCCHHHHHHHHCCCCEEEEEEEECCCHHHCCCCCHHHHHHHHHHHHCCCCEE
KTNYFRKYLTAATKETDFHIARRGDELYQSEIAKLEIIYPEKILFNDPRENSLVLHLQYG
HHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCEEEEECCCCEEECCCCCCCEEEEEEEC
QINFLFTGGLGLKGEQRLNFDQNIDILKIARMGDTSGTSGMFLESIEPEVGVILGGSDNK
CEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCC
RNLPKQELLEKLDEKNIHIERTGQSGTIIFRTNGQKINWNL
CCCCHHHHHHHHCCCCEEEEECCCCCEEEEEECCCEEECCC
>Mature Secondary Structure
MFITMIISMLIIFSSPLKASCEDNFIERFEKREEVMEVHFPDVKNGEVSIIRLPKSDKVF
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCEEEEEECCCCCEE
VIDTGSPEENKTIVDYLEEIDVNTIDALIITNPYSNYIGGAPKIIDRFDVKKTIDSGTAL
EEECCCCCCCCHHHHHHHHCCCCEEEEEEEECCCHHHCCCCCHHHHHHHHHHHHCCCCEE
KTNYFRKYLTAATKETDFHIARRGDELYQSEIAKLEIIYPEKILFNDPRENSLVLHLQYG
HHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCEEEEECCCCEEECCCCCCCEEEEEEEC
QINFLFTGGLGLKGEQRLNFDQNIDILKIARMGDTSGTSGMFLESIEPEVGVILGGSDNK
CEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCC
RNLPKQELLEKLDEKNIHIERTGQSGTIIFRTNGQKINWNL
CCCCHHHHHHHHCCCCEEEEECCCCCEEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]