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The map label for this gene is mtaD [H]

Identifier: 188586216

GI number: 188586216

Start: 1675337

End: 1676641

Strand: Reverse

Name: mtaD [H]

Synonym: Nther_1599

Alternate gene names: 188586216

Gene position: 1676641-1675337 (Counterclockwise)

Preceding gene: 188586217

Following gene: 188586215

Centisome position: 52.97

GC content: 34.41

Gene sequence:

>1305_bases
ATGACTAAAGTTACATTAATTGAAAATGCAGTTGTCATTACTATGGACAAGGAGGATATTTTAAACCCGGGATATATTCT
CATTGAAGGCGACAAAATAAAAAAAGTCAGTTCTGAACCCTTTGATGAAGAAACCAAGAAAACTGCTCACGAAATTATTG
ATGCCCAAGGAAACTTCGTTTTACCAGGACTAATAAACACCCACACACATGCAGGAATGAGTTTATTAAGAAGTTACGCG
GATGATATGTCATTGATGGATTGGCTAGAAAATAAAATTTGGCCTGCAGAAGGAAACTTAACAAGTGAAAGTATTTACTG
GGGTACATTACTATCTATAGTAGAAATGATTAAAAGTGGAACCACTACCTTTGCTGATATGTACTTTTTTATGGATGATG
TGGCTAGAGCCGTTCAAGAAAGTGGTATGAGAGCTTCACTATCCAGAGGGATGATTGGATTTAAAGGTGATGACAGCTTA
TATGAGGCTAAAGAATTTGTTAAGAAATGGCATAATGGCGCAGAAGGAAGAATAACTTGTATGCTAGGACCTCATGCTCC
GTATACATGTCCTCCTGAATTTTTGAACAAAACTTTGTCAATGGCTCATGAACTTGAAATGCCTATACATATCCACCTTT
CAGAAACGGAAGGTGAAGTTACAGATAACTATAAAGAATATAATAAATCACCAGTAGAGCATCTTAATGAGTTAGGAATA
TTTGATGTTCCAACTTTAGCTGCTCACTGCGTACATGTTAACGATGAAGATATCAGGATATTAGCGGATAATAACGTCTC
TGTCAGTCACAACATTGGCAGTAATTTAAAATTGGGATCTGGAATTGCACCAATTGATAAAATGTTATCAGAAAATGTAA
CAGTTTCTTTAGGGACCGATGGAGCTTCATCCAATAATAATCTCGACCTTTTAGAAGAAGTTAGACTAAGTTCTTTGGTA
CAAAAAGGATTTCATGAAAATCCAACTTTAATTAATGCTTACACTGCTTTAGAAATGGCAACAATAAAAGGAGGAGAAAC
TCTAAAATTACCAGAGGTAGGTAAGTTAGCTCCCGAATATAAGGCAGATATTATTGTAATTGATAAGAACTCAGCCGAGT
TATATCCAAGACACGATCCTATCGCTAATATTGTTTATTCATGTAATTCTAATAATGTTTCAACTGTAATAATTGATGGG
AAAATAGTAATGAAAGACGGAAATTTACAAACTATCGATGAAGAAAAAGTTTATCATGAAGCTGATAAACATGCAAAAAT
GATTACTGATCAAGATAAGAATTAA

Upstream 100 bases:

>100_bases
TGGTCAAAAAATCAATTGGAATTTATGACAAAAAAGGAATTTTATATTTAATAACGAAGTTATATAAACAGCTTGCATTT
AAAAAGGGGGAAGATAGTTA

Downstream 100 bases:

>100_bases
ATTGATTCAGACTTGGAACTGGAGGGAAGACTATGAAAGTTTTACTTACTAATGACGATGGAATTTATGCACCTGGTATA
TTTGCAATGGCTAAAGAAAT

Product: Atrazine chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTKVTLIENAVVITMDKEDILNPGYILIEGDKIKKVSSEPFDEETKKTAHEIIDAQGNFVLPGLINTHTHAGMSLLRSYA
DDMSLMDWLENKIWPAEGNLTSESIYWGTLLSIVEMIKSGTTTFADMYFFMDDVARAVQESGMRASLSRGMIGFKGDDSL
YEAKEFVKKWHNGAEGRITCMLGPHAPYTCPPEFLNKTLSMAHELEMPIHIHLSETEGEVTDNYKEYNKSPVEHLNELGI
FDVPTLAAHCVHVNDEDIRILADNNVSVSHNIGSNLKLGSGIAPIDKMLSENVTVSLGTDGASSNNNLDLLEEVRLSSLV
QKGFHENPTLINAYTALEMATIKGGETLKLPEVGKLAPEYKADIIVIDKNSAELYPRHDPIANIVYSCNSNNVSTVIIDG
KIVMKDGNLQTIDEEKVYHEADKHAKMITDQDKN

Sequences:

>Translated_434_residues
MTKVTLIENAVVITMDKEDILNPGYILIEGDKIKKVSSEPFDEETKKTAHEIIDAQGNFVLPGLINTHTHAGMSLLRSYA
DDMSLMDWLENKIWPAEGNLTSESIYWGTLLSIVEMIKSGTTTFADMYFFMDDVARAVQESGMRASLSRGMIGFKGDDSL
YEAKEFVKKWHNGAEGRITCMLGPHAPYTCPPEFLNKTLSMAHELEMPIHIHLSETEGEVTDNYKEYNKSPVEHLNELGI
FDVPTLAAHCVHVNDEDIRILADNNVSVSHNIGSNLKLGSGIAPIDKMLSENVTVSLGTDGASSNNNLDLLEEVRLSSLV
QKGFHENPTLINAYTALEMATIKGGETLKLPEVGKLAPEYKADIIVIDKNSAELYPRHDPIANIVYSCNSNNVSTVIIDG
KIVMKDGNLQTIDEEKVYHEADKHAKMITDQDKN
>Mature_433_residues
TKVTLIENAVVITMDKEDILNPGYILIEGDKIKKVSSEPFDEETKKTAHEIIDAQGNFVLPGLINTHTHAGMSLLRSYAD
DMSLMDWLENKIWPAEGNLTSESIYWGTLLSIVEMIKSGTTTFADMYFFMDDVARAVQESGMRASLSRGMIGFKGDDSLY
EAKEFVKKWHNGAEGRITCMLGPHAPYTCPPEFLNKTLSMAHELEMPIHIHLSETEGEVTDNYKEYNKSPVEHLNELGIF
DVPTLAAHCVHVNDEDIRILADNNVSVSHNIGSNLKLGSGIAPIDKMLSENVTVSLGTDGASSNNNLDLLEEVRLSSLVQ
KGFHENPTLINAYTALEMATIKGGETLKLPEVGKLAPEYKADIIVIDKNSAELYPRHDPIANIVYSCNSNNVSTVIIDGK
IVMKDGNLQTIDEEKVYHEADKHAKMITDQDKN

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=375, Percent_Identity=24, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1789249, Length=380, Percent_Identity=26.0526315789474, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082177, Length=452, Percent_Identity=23.0088495575221, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17540282, Length=420, Percent_Identity=25.7142857142857, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319963, Length=337, Percent_Identity=23.4421364985163, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24643849, Length=384, Percent_Identity=23.4375, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 48099; Mature: 47968

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVTLIENAVVITMDKEDILNPGYILIEGDKIKKVSSEPFDEETKKTAHEIIDAQGNFV
CCEEEEECCEEEEEECHHHCCCCCEEEEECCCEECCCCCCCCHHHHHHHHHHHCCCCCEE
LPGLINTHTHAGMSLLRSYADDMSLMDWLENKIWPAEGNLTSESIYWGTLLSIVEMIKSG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
TTTFADMYFFMDDVARAVQESGMRASLSRGMIGFKGDDSLYEAKEFVKKWHNGAEGRITC
CCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEE
MLGPHAPYTCPPEFLNKTLSMAHELEMPIHIHLSETEGEVTDNYKEYNKSPVEHLNELGI
EECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCHHHHHHHCCC
FDVPTLAAHCVHVNDEDIRILADNNVSVSHNIGSNLKLGSGIAPIDKMLSENVTVSLGTD
CCCCHHHEEEEECCCCCEEEEECCCEEEECCCCCCCCCCCCCCHHHHHHCCCCEEEECCC
GASSNNNLDLLEEVRLSSLVQKGFHENPTLINAYTALEMATIKGGETLKLPEVGKLAPEY
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHEEEEEECCCCEECCCCCCCCCCCC
KADIIVIDKNSAELYPRHDPIANIVYSCNSNNVSTVIIDGKIVMKDGNLQTIDEEKVYHE
CCCEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEEECEEEEECCCEEECCHHHHHHH
ADKHAKMITDQDKN
HHHHHHHCCCCCCC
>Mature Secondary Structure 
TKVTLIENAVVITMDKEDILNPGYILIEGDKIKKVSSEPFDEETKKTAHEIIDAQGNFV
CEEEEECCEEEEEECHHHCCCCCEEEEECCCEECCCCCCCCHHHHHHHHHHHCCCCCEE
LPGLINTHTHAGMSLLRSYADDMSLMDWLENKIWPAEGNLTSESIYWGTLLSIVEMIKSG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
TTTFADMYFFMDDVARAVQESGMRASLSRGMIGFKGDDSLYEAKEFVKKWHNGAEGRITC
CCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEE
MLGPHAPYTCPPEFLNKTLSMAHELEMPIHIHLSETEGEVTDNYKEYNKSPVEHLNELGI
EECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCHHHHHHHCCC
FDVPTLAAHCVHVNDEDIRILADNNVSVSHNIGSNLKLGSGIAPIDKMLSENVTVSLGTD
CCCCHHHEEEEECCCCCEEEEECCCEEEECCCCCCCCCCCCCCHHHHHHCCCCEEEECCC
GASSNNNLDLLEEVRLSSLVQKGFHENPTLINAYTALEMATIKGGETLKLPEVGKLAPEY
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHEEEEEECCCCEECCCCCCCCCCCC
KADIIVIDKNSAELYPRHDPIANIVYSCNSNNVSTVIIDGKIVMKDGNLQTIDEEKVYHE
CCCEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEEECEEEEECCCEEECCHHHHHHH
ADKHAKMITDQDKN
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA