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The map label for this gene is pth [H]

Identifier: 188584705

GI number: 188584705

Start: 77360

End: 77983

Strand: Direct

Name: pth [H]

Synonym: Nther_0063

Alternate gene names: 188584705

Gene position: 77360-77983 (Clockwise)

Preceding gene: 188584704

Following gene: 188584706

Centisome position: 2.44

GC content: 35.26

Gene sequence:

>624_bases
ATGCGCCCTTTTAAATTGGTATTAAATGAACTAGGAAACTATGGGAGGTATTATATGAAGTTAATAGCCGGCCTTGGAAA
TCCAGGCAAAAAATATCAGTACAACAAGCATAATATAGGTTTTATGGTAATTGACTACTTCGCAAAACAGCATGGTTTAT
CGGTTACCAAACTTAAACATCAGTCCATGTGGGATGAGCTCCGCCTAGAAGGTGAAAAAATCGTTTTAATAAAGCCTTTA
ACTTATATGAACAGAAGTGGGCATGCTATTAAACTTTGGAAAGACTACTTTAAGATTGAAAATCAAGATTTGTTGATTAT
TTATGACGACTTGGATTTGGAACTAGGGGATTTGAGAATGCGTCCTAAGGGTGGCACAGGTGGTCATAACGGATTAAAGT
CTATTGTGTCAACTTTAGGTGGTAAAGAATTTCCCAGAATTAGATTCGGAATTGGCCGTCCTGCTAGCCAAGAGTCAACA
TCTTCTTATGTATTAAAAGATTTTACTAAAAAAGAGTTTGAAACCATAAATAATAAATTCCCTGACTTGTCAAAAGGTAT
TGAACTGTTTTGCAAAGAAGGCATTAACGAAGCTATGAATTTCGTTAATAGCTTGCAAAACTAA

Upstream 100 bases:

>100_bases
ATACAGAAGAAGATGAAGAAGGCGAAGAAGACGTTGAAGAAGAAAGTGAAGAAGAGGAAGAAGAATCTGAAGAGTAATTG
GAACAAGAGGGCGCATGTAA

Downstream 100 bases:

>100_bases
GCTAAAGTTTTAAAGTTGCATACGGTTAAAGAGGCAAAGAAAATTAGTCCTTGACATTTAAACAACCCCCTGTTTTAATA
ATACTTGGGAGTAATTTTTT

Product: Aminoacyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MRPFKLVLNELGNYGRYYMKLIAGLGNPGKKYQYNKHNIGFMVIDYFAKQHGLSVTKLKHQSMWDELRLEGEKIVLIKPL
TYMNRSGHAIKLWKDYFKIENQDLLIIYDDLDLELGDLRMRPKGGTGGHNGLKSIVSTLGGKEFPRIRFGIGRPASQEST
SSYVLKDFTKKEFETINNKFPDLSKGIELFCKEGINEAMNFVNSLQN

Sequences:

>Translated_207_residues
MRPFKLVLNELGNYGRYYMKLIAGLGNPGKKYQYNKHNIGFMVIDYFAKQHGLSVTKLKHQSMWDELRLEGEKIVLIKPL
TYMNRSGHAIKLWKDYFKIENQDLLIIYDDLDLELGDLRMRPKGGTGGHNGLKSIVSTLGGKEFPRIRFGIGRPASQEST
SSYVLKDFTKKEFETINNKFPDLSKGIELFCKEGINEAMNFVNSLQN
>Mature_207_residues
MRPFKLVLNELGNYGRYYMKLIAGLGNPGKKYQYNKHNIGFMVIDYFAKQHGLSVTKLKHQSMWDELRLEGEKIVLIKPL
TYMNRSGHAIKLWKDYFKIENQDLLIIYDDLDLELGDLRMRPKGGTGGHNGLKSIVSTLGGKEFPRIRFGIGRPASQEST
SSYVLKDFTKKEFETINNKFPDLSKGIELFCKEGINEAMNFVNSLQN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=159, Percent_Identity=31.4465408805031, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=32.6315789473684, Blast_Score=94, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6321983, Length=176, Percent_Identity=31.25, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 23776; Mature: 23776

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPFKLVLNELGNYGRYYMKLIAGLGNPGKKYQYNKHNIGFMVIDYFAKQHGLSVTKLKH
CCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHH
QSMWDELRLEGEKIVLIKPLTYMNRSGHAIKLWKDYFKIENQDLLIIYDDLDLELGDLRM
HHHHHHHHCCCCEEEEECCHHHHCCCCCEEHEEHHHHHCCCCCEEEEEECCCCEECCEEE
RPKGGTGGHNGLKSIVSTLGGKEFPRIRFGIGRPASQESTSSYVLKDFTKKEFETINNKF
CCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
PDLSKGIELFCKEGINEAMNFVNSLQN
CCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRPFKLVLNELGNYGRYYMKLIAGLGNPGKKYQYNKHNIGFMVIDYFAKQHGLSVTKLKH
CCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHH
QSMWDELRLEGEKIVLIKPLTYMNRSGHAIKLWKDYFKIENQDLLIIYDDLDLELGDLRM
HHHHHHHHCCCCEEEEECCHHHHCCCCCEEHEEHHHHHCCCCCEEEEEECCCCEECCEEE
RPKGGTGGHNGLKSIVSTLGGKEFPRIRFGIGRPASQESTSSYVLKDFTKKEFETINNKF
CCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
PDLSKGIELFCKEGINEAMNFVNSLQN
CCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA