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The map label for this gene is gppA [H]

Identifier: 188527084

GI number: 188527084

Start: 270244

End: 271698

Strand: Direct

Name: gppA [H]

Synonym: HPSH_01445

Alternate gene names: 188527084

Gene position: 270244-271698 (Clockwise)

Preceding gene: 188527083

Following gene: 188527085

Centisome position: 16.8

GC content: 41.58

Gene sequence:

>1455_bases
ATGGCTAAAATCACAACCGTGATTGATATAGGATCCAATTCGGTGCGTTTGGCTATCTTTAAAAAGACGAGCCAGTTTGG
GTTTTACTTGCTTTTTGAAACCAAATCTAGGGTTAGGATTTCAGAGGGCTGTTATGCGTTTGATGGGGTTTTGCAAGAAA
TCCCCATGCAAAGAGCCATTAAAGCTTTGAGCGAATTTAAAGAAATCGCCCTTAAATACAAAAGCAAAAAAATCTTATGC
GTAGCGACATCAGCGGTGCGCGATGCCCCTAATCGGCTGGAGTTTGTAGCGAGGGTGAAAAAGGCTTGCGGTTTGCAAAT
CAAAATCATTGACGGGCAAAAAGAAGCGCTCTATGGCGGGATTGCGTGCGCGAATTTGTTGCATAAAAATTCAGGGATCA
CGATAGATATTGGAGGGGGTAGCACGGAGTGCGCGTTGATTGAAAAAGGCAAGATTAAGGATCTCATCTCGCTTGATGTT
GGCACGATTCGCATTAAAGAAATGTTTTTAGACAAAGACTTAGATGTCAAAACCGCTAAAGCCTTTATCCAAAAAGAGGT
TTCTAAACTGCCCTTTAAGCATAAAAACGCCTTTGGGGTGGGGGGGACGATTAGGGCGTTGAGTAAGGTATTGATGAAAC
GCTTTGATTACCCTATTGATTCTTTGCATGGTTATGAAATAGATGCGCATAAAAATTTAGCGTTCATTGAAAAGATTGTT
ACGCTCAAAGAAGATCAATTACGGCTTTTAGGGGTGAATGAAGAGCGTTTGGATAGTATCAGGAGCGGGGCGTTGATTTT
ATTGGTCGTTTTGGAGCATTTAAAAACTTCTTTGATGATCACCAGCGGCGTAGGGGTGAGAGAAGGCGTGTTTTTAAGCG
ATTTATTGCGCCACCACTACCACAAATTCCCCCCCAATATCAACCCCTCTCTGATCTCTTTAAAAGATCGCTTTTTACCC
CATGAAAAGCACAGCCAAAAGGTCAAAAAAGAATGCGTGAAATTGTTTGAAGCCTTATCGCCTTTGCATAAAATAGATGA
AAAATACCTTTTCCATTTAAAGATTGCGGGGGAATTAGCGAGCATGGGTAAGATTTTAAGCGTCTATTTGGCCCACAAGC
ACAGCGCGTATTTTATTCTAAACGCTTTGAGTTATGGCTTTAGCCACCAAGATAGAGCGATCATTTGCTTATTGGCGCAA
TTCAGCCATAAAAAAATCCCTAAAGACAACGCTATCGCCCACATGAGTGCGATGATGCCAAGCCTTTTAACCTTACAATG
GCTGAGTTTTATCCTTTCTTTAGCCGAAAATCTGTGCCTGACAGACAGCCATCATCTAAAATACACGCTAGAAAAAAACA
AGCTTGTGATCCATTCTAATGATGCGCTTTACTTGGCTAAAGAGATGCTCCCTAAACTCGTTAAGCCTATTCCTTTGATG
ATAGAGTTTGCTTGA

Upstream 100 bases:

>100_bases
CCCTGTAGATGCGATTTTACCGGATCCTAACAATGCAGAGAGCAAAGAGGAATTGAAATACAAATACGAAAGCTTAAAAG
AGCAAGATTAAAGGCTAGCA

Downstream 100 bases:

>100_bases
AGATAGCAATTGTCAGGCTTTCAGCGCTCGGGGATATTATCGTGAGTGCGGTGTTTTTAGCGCTGATTAAAGAGCGTTTT
ACTAACGCTCAAATAGAATG

Product: guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MAKITTVIDIGSNSVRLAIFKKTSQFGFYLLFETKSRVRISEGCYAFDGVLQEIPMQRAIKALSEFKEIALKYKSKKILC
VATSAVRDAPNRLEFVARVKKACGLQIKIIDGQKEALYGGIACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDV
GTIRIKEMFLDKDLDVKTAKAFIQKEVSKLPFKHKNAFGVGGTIRALSKVLMKRFDYPIDSLHGYEIDAHKNLAFIEKIV
TLKEDQLRLLGVNEERLDSIRSGALILLVVLEHLKTSLMITSGVGVREGVFLSDLLRHHYHKFPPNINPSLISLKDRFLP
HEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELASMGKILSVYLAHKHSAYFILNALSYGFSHQDRAIICLLAQ
FSHKKIPKDNAIAHMSAMMPSLLTLQWLSFILSLAENLCLTDSHHLKYTLEKNKLVIHSNDALYLAKEMLPKLVKPIPLM
IEFA

Sequences:

>Translated_484_residues
MAKITTVIDIGSNSVRLAIFKKTSQFGFYLLFETKSRVRISEGCYAFDGVLQEIPMQRAIKALSEFKEIALKYKSKKILC
VATSAVRDAPNRLEFVARVKKACGLQIKIIDGQKEALYGGIACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDV
GTIRIKEMFLDKDLDVKTAKAFIQKEVSKLPFKHKNAFGVGGTIRALSKVLMKRFDYPIDSLHGYEIDAHKNLAFIEKIV
TLKEDQLRLLGVNEERLDSIRSGALILLVVLEHLKTSLMITSGVGVREGVFLSDLLRHHYHKFPPNINPSLISLKDRFLP
HEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELASMGKILSVYLAHKHSAYFILNALSYGFSHQDRAIICLLAQ
FSHKKIPKDNAIAHMSAMMPSLLTLQWLSFILSLAENLCLTDSHHLKYTLEKNKLVIHSNDALYLAKEMLPKLVKPIPLM
IEFA
>Mature_483_residues
AKITTVIDIGSNSVRLAIFKKTSQFGFYLLFETKSRVRISEGCYAFDGVLQEIPMQRAIKALSEFKEIALKYKSKKILCV
ATSAVRDAPNRLEFVARVKKACGLQIKIIDGQKEALYGGIACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDVG
TIRIKEMFLDKDLDVKTAKAFIQKEVSKLPFKHKNAFGVGGTIRALSKVLMKRFDYPIDSLHGYEIDAHKNLAFIEKIVT
LKEDQLRLLGVNEERLDSIRSGALILLVVLEHLKTSLMITSGVGVREGVFLSDLLRHHYHKFPPNINPSLISLKDRFLPH
EKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELASMGKILSVYLAHKHSAYFILNALSYGFSHQDRAIICLLAQF
SHKKIPKDNAIAHMSAMMPSLLTLQWLSFILSLAENLCLTDSHHLKYTLEKNKLVIHSNDALYLAKEMLPKLVKPIPLMI
EFA

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=456, Percent_Identity=23.9035087719298, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788848, Length=432, Percent_Identity=24.537037037037, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 54373; Mature: 54242

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKITTVIDIGSNSVRLAIFKKTSQFGFYLLFETKSRVRISEGCYAFDGVLQEIPMQRAI
CCEEEEEEEECCCCEEEEEEEECCCCEEEEEEECCCCEEECCCCHHHHHHHHHCCHHHHH
KALSEFKEIALKYKSKKILCVATSAVRDAPNRLEFVARVKKACGLQIKIIDGQKEALYGG
HHHHHHHHHHHHHCCCEEEEEEEHHHHCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
IACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDVGTIRIKEMFLDKDLDVKTAK
HHHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHCCCCCEEEEHHHHCCCCCHHHHH
AFIQKEVSKLPFKHKNAFGVGGTIRALSKVLMKRFDYPIDSLHGYEIDAHKNLAFIEKIV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHH
TLKEDQLRLLGVNEERLDSIRSGALILLVVLEHLKTSLMITSGVGVREGVFLSDLLRHHY
HCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHH
HKFPPNINPSLISLKDRFLPHEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELA
HCCCCCCCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEHHHHH
SMGKILSVYLAHKHSAYFILNALSYGFSHQDRAIICLLAQFSHKKIPKDNAIAHMSAMMP
HHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHH
SLLTLQWLSFILSLAENLCLTDSHHLKYTLEKNKLVIHSNDALYLAKEMLPKLVKPIPLM
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHCCCCEE
IEFA
EEEC
>Mature Secondary Structure 
AKITTVIDIGSNSVRLAIFKKTSQFGFYLLFETKSRVRISEGCYAFDGVLQEIPMQRAI
CEEEEEEEECCCCEEEEEEEECCCCEEEEEEECCCCEEECCCCHHHHHHHHHCCHHHHH
KALSEFKEIALKYKSKKILCVATSAVRDAPNRLEFVARVKKACGLQIKIIDGQKEALYGG
HHHHHHHHHHHHHCCCEEEEEEEHHHHCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
IACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDVGTIRIKEMFLDKDLDVKTAK
HHHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHCCCCCEEEEHHHHCCCCCHHHHH
AFIQKEVSKLPFKHKNAFGVGGTIRALSKVLMKRFDYPIDSLHGYEIDAHKNLAFIEKIV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHH
TLKEDQLRLLGVNEERLDSIRSGALILLVVLEHLKTSLMITSGVGVREGVFLSDLLRHHY
HCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHH
HKFPPNINPSLISLKDRFLPHEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELA
HCCCCCCCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEHHHHH
SMGKILSVYLAHKHSAYFILNALSYGFSHQDRAIICLLAQFSHKKIPKDNAIAHMSAMMP
HHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHH
SLLTLQWLSFILSLAENLCLTDSHHLKYTLEKNKLVIHSNDALYLAKEMLPKLVKPIPLM
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHCCCCEE
IEFA
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA