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The map label for this gene is ribB [H]

Identifier: 187927758

GI number: 187927758

Start: 702989

End: 704128

Strand: Reverse

Name: ribB [H]

Synonym: Rpic_0662

Alternate gene names: 187927758

Gene position: 704128-702989 (Counterclockwise)

Preceding gene: 187927759

Following gene: 187927757

Centisome position: 17.86

GC content: 65.53

Gene sequence:

>1140_bases
ATGTCGATCGCCACAGTCGAAGAAATCATTGCCGAAATCCGCGCCGGCCGCATGGTCATCCTGGTCGACGAGGAAGACCG
TGAGAACGAAGGCGACCTGATCCTGGCGAGCGACTTTGTCACGCCGGAAGCCATCAACTTCATGGTCACGCACGCGCGTG
GCCTGGTGTGCCTGACGCTCACCGAAGAGCACTGCGACCAGCTCGACCTGCCGATGATGGCAAGCCGCAACGGTACGCAG
TTCGGCACCAATTTCACCGTATCGATCGAAGCGGCCGAAGGCGTGACCACTGGTATTTCCGCGGCCGACCGCGCACGCAC
CATTCAGGTGGCGGCCGCCAAGAACGCCAAACCGTCTGACCTGGTGAACCCGGGCCACATCTTCCCGCTGCGGGCCCAGA
AGGGCGGCGTGCTGATGCGCGCCGGCCACACCGAAGCCGGTTGCGACCTGACCGCCATGGCGGGCCTGACACCCGCCGCC
GTAATCTGCGAGATCCTGAAGGACGACGGCACCATGGCGCGCTTGCCGGACCTCGTGGAATTCGCCAAGAAACACGGCCT
GAAGATCGGCACGATTGCCGACATGATCCAATACCGCAGCCGCACCGAGAGCATCGTCGAGCGCGTCGGCGAGCGCACGA
TGGAGACGCAGTTCGGCACGTTCCACGCCGTCGCCTTCCGCGATCGGGCGGCCGGCCGCGCCCATCTGGCGCTGGTCAAG
GGCACGCCGACGCCGGACACCGAAACGCTGGTGCGCGTACATGAACCCCTCTCGGTGCTGGACCTGCTCGAGTGCCAGCG
CACGACGCACTCGTGGAGCGTGCCCGCTGCCCTGCGTGCCATCCAGGCTGCCCCGACCGGCGTGGTCGTGCTGCTCAATT
GCGGCGATTCGGCGGACCGGCTGTTCACGCAGTTCTCCGCGCTGGACGCGCCGCATGAGCGCCCGCGTACGAAACCCGAT
CCGCGCATCTACGGCATCGGCGCGCAAATCCTCAAGGACGTGGGTGTGGGCAAAATGCGTGTGCTGGCCTCGCCGCTCAA
ACTGCCGAGCATGGTCGGCTACGATCTGGAGGTGACGGCGTACCAGTCGATGGCAGATGCACCCGACGTCACTTCCTCTG
CATCCACCGCGACACACTGA

Upstream 100 bases:

>100_bases
CCTTGGCGTACAATAGCAGGCTTCCCATCTACGCAGTCGCACGGCCCCCGAAATCACCGATTGACGGGAGTTGACCGGCG
GCGCGCACCCCTGCTACGCC

Downstream 100 bases:

>100_bases
TTTTCCCGCGGCAGCCGAGACTGCCGCGCCGGCTTTCTTCTTCTGACGTTGCCCGACCGGCAACCTTAACTGGAATACAC
CATGGACCACGGCTTCTACC

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSIATVEEIIAEIRAGRMVILVDEEDRENEGDLILASDFVTPEAINFMVTHARGLVCLTLTEEHCDQLDLPMMASRNGTQ
FGTNFTVSIEAAEGVTTGISAADRARTIQVAAAKNAKPSDLVNPGHIFPLRAQKGGVLMRAGHTEAGCDLTAMAGLTPAA
VICEILKDDGTMARLPDLVEFAKKHGLKIGTIADMIQYRSRTESIVERVGERTMETQFGTFHAVAFRDRAAGRAHLALVK
GTPTPDTETLVRVHEPLSVLDLLECQRTTHSWSVPAALRAIQAAPTGVVVLLNCGDSADRLFTQFSALDAPHERPRTKPD
PRIYGIGAQILKDVGVGKMRVLASPLKLPSMVGYDLEVTAYQSMADAPDVTSSASTATH

Sequences:

>Translated_379_residues
MSIATVEEIIAEIRAGRMVILVDEEDRENEGDLILASDFVTPEAINFMVTHARGLVCLTLTEEHCDQLDLPMMASRNGTQ
FGTNFTVSIEAAEGVTTGISAADRARTIQVAAAKNAKPSDLVNPGHIFPLRAQKGGVLMRAGHTEAGCDLTAMAGLTPAA
VICEILKDDGTMARLPDLVEFAKKHGLKIGTIADMIQYRSRTESIVERVGERTMETQFGTFHAVAFRDRAAGRAHLALVK
GTPTPDTETLVRVHEPLSVLDLLECQRTTHSWSVPAALRAIQAAPTGVVVLLNCGDSADRLFTQFSALDAPHERPRTKPD
PRIYGIGAQILKDVGVGKMRVLASPLKLPSMVGYDLEVTAYQSMADAPDVTSSASTATH
>Mature_378_residues
SIATVEEIIAEIRAGRMVILVDEEDRENEGDLILASDFVTPEAINFMVTHARGLVCLTLTEEHCDQLDLPMMASRNGTQF
GTNFTVSIEAAEGVTTGISAADRARTIQVAAAKNAKPSDLVNPGHIFPLRAQKGGVLMRAGHTEAGCDLTAMAGLTPAAV
ICEILKDDGTMARLPDLVEFAKKHGLKIGTIADMIQYRSRTESIVERVGERTMETQFGTFHAVAFRDRAAGRAHLALVKG
TPTPDTETLVRVHEPLSVLDLLECQRTTHSWSVPAALRAIQAAPTGVVVLLNCGDSADRLFTQFSALDAPHERPRTKPDP
RIYGIGAQILKDVGVGKMRVLASPLKLPSMVGYDLEVTAYQSMADAPDVTSSASTATH

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=55.5555555555556, Blast_Score=233, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=43.6893203883495, Blast_Score=177, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 40736; Mature: 40605

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIATVEEIIAEIRAGRMVILVDEEDRENEGDLILASDFVTPEAINFMVTHARGLVCLTL
CCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHEEEEECCCEEEEEE
TEEHCDQLDLPMMASRNGTQFGTNFTVSIEAAEGVTTGISAADRARTIQVAAAKNAKPSD
CHHHCCCCCCCHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCC
LVNPGHIFPLRAQKGGVLMRAGHTEAGCDLTAMAGLTPAAVICEILKDDGTMARLPDLVE
CCCCCCEEEEEECCCCEEEEECCCCCCCCEEHHCCCCHHHHHHHHHHCCCCHHHHHHHHH
FAKKHGLKIGTIADMIQYRSRTESIVERVGERTMETQFGTFHAVAFRDRAAGRAHLALVK
HHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCCEEEEEEE
GTPTPDTETLVRVHEPLSVLDLLECQRTTHSWSVPAALRAIQAAPTGVVVLLNCGDSADR
CCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHH
LFTQFSALDAPHERPRTKPDPRIYGIGAQILKDVGVGKMRVLASPLKLPSMVGYDLEVTA
HHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHCCCCHHHHHHCCCCCCHHCCCCEEEEH
YQSMADAPDVTSSASTATH
HHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SIATVEEIIAEIRAGRMVILVDEEDRENEGDLILASDFVTPEAINFMVTHARGLVCLTL
CCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHEEEEECCCEEEEEE
TEEHCDQLDLPMMASRNGTQFGTNFTVSIEAAEGVTTGISAADRARTIQVAAAKNAKPSD
CHHHCCCCCCCHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCC
LVNPGHIFPLRAQKGGVLMRAGHTEAGCDLTAMAGLTPAAVICEILKDDGTMARLPDLVE
CCCCCCEEEEEECCCCEEEEECCCCCCCCEEHHCCCCHHHHHHHHHHCCCCHHHHHHHHH
FAKKHGLKIGTIADMIQYRSRTESIVERVGERTMETQFGTFHAVAFRDRAAGRAHLALVK
HHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCCEEEEEEE
GTPTPDTETLVRVHEPLSVLDLLECQRTTHSWSVPAALRAIQAAPTGVVVLLNCGDSADR
CCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHH
LFTQFSALDAPHERPRTKPDPRIYGIGAQILKDVGVGKMRVLASPLKLPSMVGYDLEVTA
HHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHCCCCHHHHHHCCCCCCHHCCCCEEEEH
YQSMADAPDVTSSASTATH
HHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]