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The map label for this gene is ribE [H]

Identifier: 187927759

GI number: 187927759

Start: 704256

End: 704909

Strand: Reverse

Name: ribE [H]

Synonym: Rpic_0663

Alternate gene names: 187927759

Gene position: 704909-704256 (Counterclockwise)

Preceding gene: 187927760

Following gene: 187927758

Centisome position: 17.88

GC content: 64.22

Gene sequence:

>654_bases
ATGTTCACCGGAATCGTCGCCGCAGTTGGCCGTATTGAAACCGTCTCGCCGCTTGGCGACAACGCCGATGCCGGCGTGCG
CTTGTCCATCGACGCCGGCGGCCTGCCGCTAGCCGACGTGGCCTTGGGCGATTCGATTGCCATCCAGGGCGCATGCATGA
CGGTCGTCGCCAAAACCGAGACCCGCTTCGACGTGGATGTATCGCGCGAATCGCTGTCCAAGACGGTCGGACTGGAACGC
CCCGGCGAGGTCAATCTGGAGAAGGCTCTGCGCTTGGCTGACCACATCGGCGGGCACCTCGTATCCGGCCATGTGGACGG
CCTGGGCACGGTCACATACTTCGCGCCGGTCAACGAATCGCACGAACTGCGCGTGCGGGCTCCGGTAGAGCTGGGCAAGT
ATCTGGCCTACAAGGGCTCCGTGGTGGTGAACGGCGTGTCGCTTACGGTCAATTCCGTCCGGGACGATGCCGACGGCTGC
GAGTTCTCGATCAATCTGATCCCGCACACCGTGGCAGTCACCACGCTCAAGCACCTGAAGGCCGGCAGCCAGGTCAACCT
GGAGATCGACCTGATCGCCCGCTACGTGGAGCGCATGCTCACCCACGCCGCTATTGGCCTGCCCGTGGGCACACAACCCC
TGGCAGCCGTTTGA

Upstream 100 bases:

>100_bases
GACGCTGGAAGGCGCGGCCGAATTCTTCTTTCACGATATCTCGCGCATCGGGGGCGATCTCCGCATCCTGGCGCGCCGCA
ACCCGACGGATTGATTGCTT

Downstream 100 bases:

>100_bases
ACCATTGGCCCCACTGGCTTGGGGCCGCCTTGGCGTACAATAGCAGGCTTCCCATCTACGCAGTCGCACGGCCCCCGAAA
TCACCGATTGACGGGAGTTG

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MFTGIVAAVGRIETVSPLGDNADAGVRLSIDAGGLPLADVALGDSIAIQGACMTVVAKTETRFDVDVSRESLSKTVGLER
PGEVNLEKALRLADHIGGHLVSGHVDGLGTVTYFAPVNESHELRVRAPVELGKYLAYKGSVVVNGVSLTVNSVRDDADGC
EFSINLIPHTVAVTTLKHLKAGSQVNLEIDLIARYVERMLTHAAIGLPVGTQPLAAV

Sequences:

>Translated_217_residues
MFTGIVAAVGRIETVSPLGDNADAGVRLSIDAGGLPLADVALGDSIAIQGACMTVVAKTETRFDVDVSRESLSKTVGLER
PGEVNLEKALRLADHIGGHLVSGHVDGLGTVTYFAPVNESHELRVRAPVELGKYLAYKGSVVVNGVSLTVNSVRDDADGC
EFSINLIPHTVAVTTLKHLKAGSQVNLEIDLIARYVERMLTHAAIGLPVGTQPLAAV
>Mature_217_residues
MFTGIVAAVGRIETVSPLGDNADAGVRLSIDAGGLPLADVALGDSIAIQGACMTVVAKTETRFDVDVSRESLSKTVGLER
PGEVNLEKALRLADHIGGHLVSGHVDGLGTVTYFAPVNESHELRVRAPVELGKYLAYKGSVVVNGVSLTVNSVRDDADGC
EFSINLIPHTVAVTTLKHLKAGSQVNLEIDLIARYVERMLTHAAIGLPVGTQPLAAV

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=210, Percent_Identity=32.3809523809524, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319733, Length=208, Percent_Identity=33.6538461538462, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 22713; Mature: 22713

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00693 LUM_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGIVAAVGRIETVSPLGDNADAGVRLSIDAGGLPLADVALGDSIAIQGACMTVVAKTE
CCCCHHHHHCCCEECCCCCCCCCCCEEEEEECCCCCEEHEECCCCEEECCEEEEEEEECC
TRFDVDVSRESLSKTVGLERPGEVNLEKALRLADHIGGHLVSGHVDGLGTVTYFAPVNES
CEEEEEECHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCEEEEEEEEECCCC
HELRVRAPVELGKYLAYKGSVVVNGVSLTVNSVRDDADGCEFSINLIPHTVAVTTLKHLK
CEEEEECCHHHHHHHEECCCEEEEEEEEEEECCCCCCCCCEEEEEECCHHHHHHHHHHHC
AGSQVNLEIDLIARYVERMLTHAAIGLPVGTQPLAAV
CCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MFTGIVAAVGRIETVSPLGDNADAGVRLSIDAGGLPLADVALGDSIAIQGACMTVVAKTE
CCCCHHHHHCCCEECCCCCCCCCCCEEEEEECCCCCEEHEECCCCEEECCEEEEEEEECC
TRFDVDVSRESLSKTVGLERPGEVNLEKALRLADHIGGHLVSGHVDGLGTVTYFAPVNES
CEEEEEECHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCEEEEEEEEECCCC
HELRVRAPVELGKYLAYKGSVVVNGVSLTVNSVRDDADGCEFSINLIPHTVAVTTLKHLK
CEEEEECCHHHHHHHEECCCEEEEEEEEEEECCCCCCCCCEEEEEECCHHHHHHHHHHHC
AGSQVNLEIDLIARYVERMLTHAAIGLPVGTQPLAAV
CCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144477 [H]