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The map label for this gene is kefBC [H]

Identifier: 187927376

GI number: 187927376

Start: 283343

End: 285322

Strand: Direct

Name: kefBC [H]

Synonym: Rpic_0269

Alternate gene names: 187927376

Gene position: 283343-285322 (Clockwise)

Preceding gene: 187927363

Following gene: 187927379

Centisome position: 7.19

GC content: 66.46

Gene sequence:

>1980_bases
ATGCATTCGCCGCTGGAACTCACCCTCGTGTTGCTGGCCGCCGCCGTGATCGGCGTGGTGCTGTTCCGCATGCTGCAATT
GCCGCCGATGCTGGCCTACCTGGTGGTGGGCGTGCTGATCGGGCCGAAGGCGACGGGGCTGGAGTCCGATTCGGCCCAGA
CGCGCTATCTGGCCGAGTTCGGGGTGGTGTTCCTGATGTTCTCGATCGGGCTGGAGTTCAACCTCTCCAAGCTGCGTTCG
ATGCGGCGGCTGGTGCTAGGGCTCGGGGCGTCGCAGGTGGGGCTGACCATCCTGCTCACGATTCCAGTTTCGATGGTGCT
GTCCCACTGGTACCCGCTGTCGTGGCAAGCAGGACTGGCGCTGGGTGGCGCGTTGGCCATGTCGTCCACGGCCATCGTCT
CAAAAATGCTGGCCGAGCGTCTGCAGCTGGAGACCGAGCACGGCCGCAACATCATCAGCGTGTTGCTGTTCCAGGATCTG
GCGGTCGTGCTGCTGCTGATCGTGGTGCCGTCATTGGGCAAGAACCCGACCGACCTCGTGCTCGCGCTGTCCATTGCCGC
GCTCAAGATCACCGTTGCGCTGGTGCTGATCCTGTTTCTGGGGCAGAAGCTGCTGTCGCGCTGGTTCCATCTGGTGGCGG
CGCGGCGCTCGCAGGAGCTGTTCATGCTGAACCTGCTGCTGGTTACGCTGGGCATGGCGGCGCTGACGGAGCGGCTGGGC
TTGTCGATGGCGCTGGGCGCCTTCTTGGCCGGCATGCTGGTGTCGGAAACGCCTTACAAGCTGCAGGTGGAAGAAGACAT
CAAGCCGTTTCGCGACGTGCTGCTGGGCCTGTTCTTCGTGACGGTCGGCATGCTGCTGGACCCGCGCGTGGTCTTCGAGC
ACTGGGCGCTCGTGCTGGGGCTGGTGATGGCGCCGGTGCTGTTCAAGTTTGTGCTGATTGCGCTGCTGGCGCGGGTCTTC
GGTTCCGGTGGCGGCGCGGCGATCCGTACGGCGCTGGGCCTGGCGCAGGCCGGTGAGTTCGGCTTTGTGCTGCTCAACCA
GATTGACGGCATGCGGCTGATCGACCCGCTGCTCGGCCAGGCAATCCTGGCGGCCATGCTGCTGTCGATGCTGCTGGCGC
CGTTCCTGATCCAGTACAGCGATGTGATCGCCATGCGCCTGTCGCGCACGGACTGGCTGATGCAATCGCTGGCAATGACC
AAGATCGCCGCGCAGAGCATTGCCACCGAGCGCCACGTCATCATCTGCGGCTACGGGCGCAGTGGCCAAAACCTGGCGCA
CATGGTGGAGCAGGAAGGCATCGGCTATGTCGCGCTGGATCTGGACCCCGACCGCGTGCGCGACGCCGCGGCCGCCGGCG
AGCATGTCGTCTATGGCGACGCGGCGCGGCGCGAGTCGCTGGTGGCGGCCGGCATCCATCGCGCAGCGGCGGTCGCCATT
ACCTATGCCGACACGGCGTCAGCGCTGAAGGTGCTACACCACGTGCAGGCGCTGGAGCCGACCCTGCCCGTGATCGTGCG
CACCATCGACGATGCCGACCTCGATCGCCTGCAGCAAGCCGGCGCCACCGAGGTCGTTCCCGAGATCATCGAAGGGAGCC
TGATGCTGGCCTCACACGCGCTGGTGCTGCTGGGCGTGCCCTTGCGCCGTGTGGTGCGCCGTGCGCAAGAGATGCGCGAC
GCACGCTACAGCCTGCTGCGCGGCTACTTCCACGGTCAGGACGACGAGGAAGACATGCTCGAGCGCGACGCCGTGCGCCT
GCATTCGGTGCCGCTGGCCAAGGGTTCGCCCGCCATTGGCCGCAAGCTGGGCACGATGGGGCTGGAGACGTTCAAGACGT
CGGTCACGGCGATCCGGCGCCAGGGCATTCGCGCGCTCGATCCCGATCCGGACACCGTGCTGGAGCTGGGCGATATCGTT
GTGCTGCGCGGCACGCCCGAGGGGCTGCAGATGGCGGAGGAGCGGCTCTCGCCGCGTTGA

Upstream 100 bases:

>100_bases
GGTCTTGCAGCGCCTGCGTGCTCGTTTGCGCACGCACCGTCTTGATGCGTAGTTGCCGGCCCTCCTGTCCAACCCCTTTC
GATTGGTTTTTTCGCGTCGC

Downstream 100 bases:

>100_bases
TGCCGCCGCTTACTTCACGAGCGATTCGAGCAGTGGCCCGCGTGAGCGGCGCGGCGGCGGGGCATCCGCCATGTTGGGCG
GCAGGCCGTCGAGCACTGCT

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MHSPLELTLVLLAAAVIGVVLFRMLQLPPMLAYLVVGVLIGPKATGLESDSAQTRYLAEFGVVFLMFSIGLEFNLSKLRS
MRRLVLGLGASQVGLTILLTIPVSMVLSHWYPLSWQAGLALGGALAMSSTAIVSKMLAERLQLETEHGRNIISVLLFQDL
AVVLLLIVVPSLGKNPTDLVLALSIAALKITVALVLILFLGQKLLSRWFHLVAARRSQELFMLNLLLVTLGMAALTERLG
LSMALGAFLAGMLVSETPYKLQVEEDIKPFRDVLLGLFFVTVGMLLDPRVVFEHWALVLGLVMAPVLFKFVLIALLARVF
GSGGGAAIRTALGLAQAGEFGFVLLNQIDGMRLIDPLLGQAILAAMLLSMLLAPFLIQYSDVIAMRLSRTDWLMQSLAMT
KIAAQSIATERHVIICGYGRSGQNLAHMVEQEGIGYVALDLDPDRVRDAAAAGEHVVYGDAARRESLVAAGIHRAAAVAI
TYADTASALKVLHHVQALEPTLPVIVRTIDDADLDRLQQAGATEVVPEIIEGSLMLASHALVLLGVPLRRVVRRAQEMRD
ARYSLLRGYFHGQDDEEDMLERDAVRLHSVPLAKGSPAIGRKLGTMGLETFKTSVTAIRRQGIRALDPDPDTVLELGDIV
VLRGTPEGLQMAEERLSPR

Sequences:

>Translated_659_residues
MHSPLELTLVLLAAAVIGVVLFRMLQLPPMLAYLVVGVLIGPKATGLESDSAQTRYLAEFGVVFLMFSIGLEFNLSKLRS
MRRLVLGLGASQVGLTILLTIPVSMVLSHWYPLSWQAGLALGGALAMSSTAIVSKMLAERLQLETEHGRNIISVLLFQDL
AVVLLLIVVPSLGKNPTDLVLALSIAALKITVALVLILFLGQKLLSRWFHLVAARRSQELFMLNLLLVTLGMAALTERLG
LSMALGAFLAGMLVSETPYKLQVEEDIKPFRDVLLGLFFVTVGMLLDPRVVFEHWALVLGLVMAPVLFKFVLIALLARVF
GSGGGAAIRTALGLAQAGEFGFVLLNQIDGMRLIDPLLGQAILAAMLLSMLLAPFLIQYSDVIAMRLSRTDWLMQSLAMT
KIAAQSIATERHVIICGYGRSGQNLAHMVEQEGIGYVALDLDPDRVRDAAAAGEHVVYGDAARRESLVAAGIHRAAAVAI
TYADTASALKVLHHVQALEPTLPVIVRTIDDADLDRLQQAGATEVVPEIIEGSLMLASHALVLLGVPLRRVVRRAQEMRD
ARYSLLRGYFHGQDDEEDMLERDAVRLHSVPLAKGSPAIGRKLGTMGLETFKTSVTAIRRQGIRALDPDPDTVLELGDIV
VLRGTPEGLQMAEERLSPR
>Mature_659_residues
MHSPLELTLVLLAAAVIGVVLFRMLQLPPMLAYLVVGVLIGPKATGLESDSAQTRYLAEFGVVFLMFSIGLEFNLSKLRS
MRRLVLGLGASQVGLTILLTIPVSMVLSHWYPLSWQAGLALGGALAMSSTAIVSKMLAERLQLETEHGRNIISVLLFQDL
AVVLLLIVVPSLGKNPTDLVLALSIAALKITVALVLILFLGQKLLSRWFHLVAARRSQELFMLNLLLVTLGMAALTERLG
LSMALGAFLAGMLVSETPYKLQVEEDIKPFRDVLLGLFFVTVGMLLDPRVVFEHWALVLGLVMAPVLFKFVLIALLARVF
GSGGGAAIRTALGLAQAGEFGFVLLNQIDGMRLIDPLLGQAILAAMLLSMLLAPFLIQYSDVIAMRLSRTDWLMQSLAMT
KIAAQSIATERHVIICGYGRSGQNLAHMVEQEGIGYVALDLDPDRVRDAAAAGEHVVYGDAARRESLVAAGIHRAAAVAI
TYADTASALKVLHHVQALEPTLPVIVRTIDDADLDRLQQAGATEVVPEIIEGSLMLASHALVLLGVPLRRVVRRAQEMRD
ARYSLLRGYFHGQDDEEDMLERDAVRLHSVPLAKGSPAIGRKLGTMGLETFKTSVTAIRRQGIRALDPDPDTVLELGDIV
VLRGTPEGLQMAEERLSPR

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=339, Percent_Identity=29.2035398230088, Blast_Score=110, Evalue=6e-24,
Organism=Escherichia coli, GI1786232, Length=560, Percent_Identity=33.5714285714286, Blast_Score=243, Evalue=4e-65,
Organism=Escherichia coli, GI1789749, Length=562, Percent_Identity=33.8078291814947, Blast_Score=236, Evalue=4e-63,
Organism=Escherichia coli, GI1786685, Length=540, Percent_Identity=30.1851851851852, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322367, Length=360, Percent_Identity=22.2222222222222, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 71421; Mature: 71421

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSPLELTLVLLAAAVIGVVLFRMLQLPPMLAYLVVGVLIGPKATGLESDSAQTRYLAEF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
GVVFLMFSIGLEFNLSKLRSMRRLVLGLGASQVGLTILLTIPVSMVLSHWYPLSWQAGLA
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LGGALAMSSTAIVSKMLAERLQLETEHGRNIISVLLFQDLAVVLLLIVVPSLGKNPTDLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LALSIAALKITVALVLILFLGQKLLSRWFHLVAARRSQELFMLNLLLVTLGMAALTERLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LSMALGAFLAGMLVSETPYKLQVEEDIKPFRDVLLGLFFVTVGMLLDPRVVFEHWALVLG
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LVMAPVLFKFVLIALLARVFGSGGGAAIRTALGLAQAGEFGFVLLNQIDGMRLIDPLLGQ
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHH
AILAAMLLSMLLAPFLIQYSDVIAMRLSRTDWLMQSLAMTKIAAQSIATERHVIICGYGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
SGQNLAHMVEQEGIGYVALDLDPDRVRDAAAAGEHVVYGDAARRESLVAAGIHRAAAVAI
CCCHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHEEE
TYADTASALKVLHHVQALEPTLPVIVRTIDDADLDRLQQAGATEVVPEIIEGSLMLASHA
EEHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHH
LVLLGVPLRRVVRRAQEMRDARYSLLRGYFHGQDDEEDMLERDAVRLHSVPLAKGSPAIG
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHH
RKLGTMGLETFKTSVTAIRRQGIRALDPDPDTVLELGDIVVLRGTPEGLQMAEERLSPR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCEEEECCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MHSPLELTLVLLAAAVIGVVLFRMLQLPPMLAYLVVGVLIGPKATGLESDSAQTRYLAEF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
GVVFLMFSIGLEFNLSKLRSMRRLVLGLGASQVGLTILLTIPVSMVLSHWYPLSWQAGLA
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LGGALAMSSTAIVSKMLAERLQLETEHGRNIISVLLFQDLAVVLLLIVVPSLGKNPTDLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LALSIAALKITVALVLILFLGQKLLSRWFHLVAARRSQELFMLNLLLVTLGMAALTERLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LSMALGAFLAGMLVSETPYKLQVEEDIKPFRDVLLGLFFVTVGMLLDPRVVFEHWALVLG
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LVMAPVLFKFVLIALLARVFGSGGGAAIRTALGLAQAGEFGFVLLNQIDGMRLIDPLLGQ
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHH
AILAAMLLSMLLAPFLIQYSDVIAMRLSRTDWLMQSLAMTKIAAQSIATERHVIICGYGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
SGQNLAHMVEQEGIGYVALDLDPDRVRDAAAAGEHVVYGDAARRESLVAAGIHRAAAVAI
CCCHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHEEE
TYADTASALKVLHHVQALEPTLPVIVRTIDDADLDRLQQAGATEVVPEIIEGSLMLASHA
EEHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHH
LVLLGVPLRRVVRRAQEMRDARYSLLRGYFHGQDDEEDMLERDAVRLHSVPLAKGSPAIG
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHH
RKLGTMGLETFKTSVTAIRRQGIRALDPDPDTVLELGDIVVLRGTPEGLQMAEERLSPR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCEEEECCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]