Click here to switch to the map view.

The map label for this gene is apt [H]

Identifier: 187927379

GI number: 187927379

Start: 286464

End: 287072

Strand: Direct

Name: apt [H]

Synonym: Rpic_0272

Alternate gene names: 187927379

Gene position: 286464-287072 (Clockwise)

Preceding gene: 187927376

Following gene: 187927380

Centisome position: 7.27

GC content: 65.52

Gene sequence:

>609_bases
ATGAGCCAAGTCCCTCATCACCAGGCGGCGCTGCTGACGCCGTCGTCCGTTCCCGCGTCCACCGAACTGGGCGATGTGTC
GCGCTACCTGCGTGACCGTATCCGCACGGTGCCGGACTGGCCGCAGGCCGGGGTGATGTTTCGCGATATCACGCCGCTGC
TGCAGGACCCGAAGAGCCTGCGCGTGCTGGTGGACGTGTTCGTCCATCGCTACATGGGGCAGGGGCTGAACCTGGTGGCG
GGCATCGACGCGCGCGGATTCATCCTGGGCTCGATCGTGGCGTATGAGTTGAACCTTGGCTTCGTGCCGATCCGCAAGAA
AGGCAAGCTGCCGTTCAACACGGTGGCCGAGGAGTACATGCTCGAATACGGCAGCGCGACAGTGGAAATCCATGCCGATG
CCTGCAAGCCCGGCGACCGCGTCCTGTTGATCGACGACCTGATCGCCACTGGCGGCACCATGCTGGCCGACAAGCGTCTG
CTCGAACGGCTGGGGGCGACGGTGGTGGAGGGCGCGGCGATTGTCGACCTGCCCGAACTGGGCGGCTCGCAACTGCTGAT
CGAGGGCGGCCTGCCGCTCTTCACGGTCTGCCGCTTTGACGGACACTGA

Upstream 100 bases:

>100_bases
CTCCTGTATGGTTGCGGTTTGCCCATTGTGGTTCGGCGCCATTCGGCCCGGGTGGTAGCCCATTACCGCAGACCACATTT
CCTGCTTTCCTGTTTTTGCC

Downstream 100 bases:

>100_bases
GCGGCTGTCTGCTGCCTTCGCGTGATGCGCTAGCCGCATACGCTCATGTGACAAAAATATGACGACTTGCTGCTGCGCGC
AGTAGCATGACCCCTTCCAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MSQVPHHQAALLTPSSVPASTELGDVSRYLRDRIRTVPDWPQAGVMFRDITPLLQDPKSLRVLVDVFVHRYMGQGLNLVA
GIDARGFILGSIVAYELNLGFVPIRKKGKLPFNTVAEEYMLEYGSATVEIHADACKPGDRVLLIDDLIATGGTMLADKRL
LERLGATVVEGAAIVDLPELGGSQLLIEGGLPLFTVCRFDGH

Sequences:

>Translated_202_residues
MSQVPHHQAALLTPSSVPASTELGDVSRYLRDRIRTVPDWPQAGVMFRDITPLLQDPKSLRVLVDVFVHRYMGQGLNLVA
GIDARGFILGSIVAYELNLGFVPIRKKGKLPFNTVAEEYMLEYGSATVEIHADACKPGDRVLLIDDLIATGGTMLADKRL
LERLGATVVEGAAIVDLPELGGSQLLIEGGLPLFTVCRFDGH
>Mature_201_residues
SQVPHHQAALLTPSSVPASTELGDVSRYLRDRIRTVPDWPQAGVMFRDITPLLQDPKSLRVLVDVFVHRYMGQGLNLVAG
IDARGFILGSIVAYELNLGFVPIRKKGKLPFNTVAEEYMLEYGSATVEIHADACKPGDRVLLIDDLIATGGTMLADKRLL
ERLGATVVEGAAIVDLPELGGSQLLIEGGLPLFTVCRFDGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=176, Percent_Identity=44.3181818181818, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=48, Blast_Score=121, Evalue=4e-28,
Organism=Escherichia coli, GI1786675, Length=175, Percent_Identity=48, Blast_Score=181, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17509087, Length=160, Percent_Identity=44.375, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323619, Length=180, Percent_Identity=32.2222222222222, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320649, Length=174, Percent_Identity=29.3103448275862, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136334, Length=160, Percent_Identity=41.25, Blast_Score=127, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 21947; Mature: 21816

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVPHHQAALLTPSSVPASTELGDVSRYLRDRIRTVPDWPQAGVMFRDITPLLQDPKSL
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHCCHHHHCHHHH
RVLVDVFVHRYMGQGLNLVAGIDARGFILGSIVAYELNLGFVPIRKKGKLPFNTVAEEYM
HHHHHHHHHHHHCCCCEEEECCCCCHHHHHHEEEEEECCCEEEECCCCCCCHHHHHHHHH
LEYGSATVEIHADACKPGDRVLLIDDLIATGGTMLADKRLLERLGATVVEGAAIVDLPEL
HHCCCEEEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCHHHHCCEEEEECCCC
GGSQLLIEGGLPLFTVCRFDGH
CCCEEEEECCCCEEEEEEECCC
>Mature Secondary Structure 
SQVPHHQAALLTPSSVPASTELGDVSRYLRDRIRTVPDWPQAGVMFRDITPLLQDPKSL
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHCCHHHHCHHHH
RVLVDVFVHRYMGQGLNLVAGIDARGFILGSIVAYELNLGFVPIRKKGKLPFNTVAEEYM
HHHHHHHHHHHHCCCCEEEECCCCCHHHHHHEEEEEECCCEEEECCCCCCCHHHHHHHHH
LEYGSATVEIHADACKPGDRVLLIDDLIATGGTMLADKRLLERLGATVVEGAAIVDLPEL
HHCCCEEEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCHHHHCCEEEEECCCC
GGSQLLIEGGLPLFTVCRFDGH
CCCEEEEECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]