Click here to switch to the map view.

The map label for this gene is tktA [C]

Identifier: 187933869

GI number: 187933869

Start: 3539429

End: 3540253

Strand: Reverse

Name: tktA [C]

Synonym: CLL_A3356

Alternate gene names: 187933869

Gene position: 3540253-3539429 (Counterclockwise)

Preceding gene: 187935033

Following gene: 187932893

Centisome position: 93.16

GC content: 32.48

Gene sequence:

>825_bases
ATGAATAATAACAAAGAAAAGCTTCAAGAAATATCAAAGCTTATAAGAAAAGATATAGTAACTATGCTTACTGAATCAGC
ATCAGGACATCCGGGTGGATCTTTATCAATAGCAGATATAATGAGTGTATTATTTTTTAATGAGATGAATATTGATCCTA
AAAATTCAAAGAATCCTGATAGAGACAGATTTGTATTATCAAAAGGACATGCTGCACCAGCATTATACAGTGCATTAGCA
AGAAAAGGTTATTTTGATGTAGAAGAATTAAATACTTTAAGAAAGATAGGATCTAGATTACAAGGACATCCTAATATGAA
TGACTTACCAGGAATTGATATGTCAACAGGTTCATTAGGACAAGGAATTTCAGCAGCTGTTGGAATGGCATTAGCAGGTA
AATTAGATAATAAAAACTATAGAGTTTATACTATATTAGGTGATGGAGAGCTTGAAGAAGGTCAAGTTTGGGAAGCTTCA
ATGTCAGCTGCTCACTATAATTTAGATAATTTAACTGCATTTGTAGATTATAATGGATTACAAATAGATGGAAATATTTC
AGATGTAATGAATCCAGCTCCAATTGATAAAAAATTTGAAGCTTTTGGATGGAATACTTTAATAATAGATGGTCATGATT
ATGATCAAATTTTAGCTGCAATCGAAAAAGCTAAAAACACAAAAGGACAACCAACGGTTATAGTATGTAAAACAGTAAAA
GGTAAGGGTGTTTCATTCATGGAAAACCAAGCAGGATGGCATGGAGCAGCACCAAGCGTAGAACAACGTGATCAAGCATT
AAGAGAAATTGGAGGGGAAAACTAA

Upstream 100 bases:

>100_bases
TGTATATATACAAATGGCAATTATTATGATAGAATAAATTGAATATAAAATGAAAAAAATATGTTCTAGGTAAGGAATTT
AATCATAGGAGGATTATAGT

Downstream 100 bases:

>100_bases
TGGGTAATAAAATAGCAACTAGAGAAGCTTATGGTAAAGCATTAGTAAAACTTTCAAACATGAATAAAGATGTTGTAGTA
TTAGATGCAGATTTATCAAA

Product: transketolase, thiamine diphosphate binding domain

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MNNNKEKLQEISKLIRKDIVTMLTESASGHPGGSLSIADIMSVLFFNEMNIDPKNSKNPDRDRFVLSKGHAAPALYSALA
RKGYFDVEELNTLRKIGSRLQGHPNMNDLPGIDMSTGSLGQGISAAVGMALAGKLDNKNYRVYTILGDGELEEGQVWEAS
MSAAHYNLDNLTAFVDYNGLQIDGNISDVMNPAPIDKKFEAFGWNTLIIDGHDYDQILAAIEKAKNTKGQPTVIVCKTVK
GKGVSFMENQAGWHGAAPSVEQRDQALREIGGEN

Sequences:

>Translated_274_residues
MNNNKEKLQEISKLIRKDIVTMLTESASGHPGGSLSIADIMSVLFFNEMNIDPKNSKNPDRDRFVLSKGHAAPALYSALA
RKGYFDVEELNTLRKIGSRLQGHPNMNDLPGIDMSTGSLGQGISAAVGMALAGKLDNKNYRVYTILGDGELEEGQVWEAS
MSAAHYNLDNLTAFVDYNGLQIDGNISDVMNPAPIDKKFEAFGWNTLIIDGHDYDQILAAIEKAKNTKGQPTVIVCKTVK
GKGVSFMENQAGWHGAAPSVEQRDQALREIGGEN
>Mature_274_residues
MNNNKEKLQEISKLIRKDIVTMLTESASGHPGGSLSIADIMSVLFFNEMNIDPKNSKNPDRDRFVLSKGHAAPALYSALA
RKGYFDVEELNTLRKIGSRLQGHPNMNDLPGIDMSTGSLGQGISAAVGMALAGKLDNKNYRVYTILGDGELEEGQVWEAS
MSAAHYNLDNLTAFVDYNGLQIDGNISDVMNPAPIDKKFEAFGWNTLIIDGHDYDQILAAIEKAKNTKGQPTVIVCKTVK
GKGVSFMENQAGWHGAAPSVEQRDQALREIGGEN

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=274, Percent_Identity=44.1605839416058, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4507521, Length=274, Percent_Identity=44.1605839416058, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI133778974, Length=271, Percent_Identity=42.0664206642066, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI225637459, Length=261, Percent_Identity=34.4827586206897, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI225637461, Length=230, Percent_Identity=35.6521739130435, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI225637463, Length=231, Percent_Identity=34.6320346320346, Blast_Score=140, Evalue=9e-34,
Organism=Escherichia coli, GI48994911, Length=258, Percent_Identity=37.2093023255814, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788808, Length=275, Percent_Identity=34.9090909090909, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1786304, Length=263, Percent_Identity=26.9961977186312, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539652, Length=249, Percent_Identity=47.7911646586345, Blast_Score=230, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6325331, Length=268, Percent_Identity=40.6716417910448, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6319593, Length=282, Percent_Identity=36.8794326241135, Blast_Score=158, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24666278, Length=267, Percent_Identity=43.0711610486891, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI45551847, Length=251, Percent_Identity=43.4262948207171, Blast_Score=214, Evalue=4e-56,
Organism=Drosophila melanogaster, GI45550715, Length=251, Percent_Identity=43.4262948207171, Blast_Score=214, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24645119, Length=216, Percent_Identity=45.3703703703704, Blast_Score=193, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 29842; Mature: 29842

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNKEKLQEISKLIRKDIVTMLTESASGHPGGSLSIADIMSVLFFNEMNIDPKNSKNPD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCC
RDRFVLSKGHAAPALYSALARKGYFDVEELNTLRKIGSRLQGHPNMNDLPGIDMSTGSLG
HHHEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
QGISAAVGMALAGKLDNKNYRVYTILGDGELEEGQVWEASMSAAHYNLDNLTAFVDYNGL
CCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCE
QIDGNISDVMNPAPIDKKFEAFGWNTLIIDGHDYDQILAAIEKAKNTKGQPTVIVCKTVK
EECCCHHHHCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCC
GKGVSFMENQAGWHGAAPSVEQRDQALREIGGEN
CCCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNNNKEKLQEISKLIRKDIVTMLTESASGHPGGSLSIADIMSVLFFNEMNIDPKNSKNPD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCC
RDRFVLSKGHAAPALYSALARKGYFDVEELNTLRKIGSRLQGHPNMNDLPGIDMSTGSLG
HHHEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
QGISAAVGMALAGKLDNKNYRVYTILGDGELEEGQVWEASMSAAHYNLDNLTAFVDYNGL
CCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCE
QIDGNISDVMNPAPIDKKFEAFGWNTLIIDGHDYDQILAAIEKAKNTKGQPTVIVCKTVK
EECCCHHHHCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCC
GKGVSFMENQAGWHGAAPSVEQRDQALREIGGEN
CCCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]