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The map label for this gene is dxs [C]

Identifier: 187932893

GI number: 187932893

Start: 3538485

End: 3539429

Strand: Reverse

Name: dxs [C]

Synonym: CLL_A3355

Alternate gene names: 187932893

Gene position: 3539429-3538485 (Counterclockwise)

Preceding gene: 187933869

Following gene: 187935180

Centisome position: 93.13

GC content: 31.85

Gene sequence:

>945_bases
ATGGGTAATAAAATAGCAACTAGAGAAGCTTATGGTAAAGCATTAGTAAAACTTTCAAACATGAATAAAGATGTTGTAGT
ATTAGATGCAGATTTATCAAAGTCAACTAAAACAGCAGATTTTAAAGCAGCTGCACCAGAAAGATTTATTAATATGGGAA
TAGCAGAAGCTAATATGATGGGAGTTGCATCAGGTCTTTCAACTTGTGGAAAAATTCCATTTGTTAGTACATTTGCAATG
TTTGCAGCCGGTAGAGCATTTGAACAAATTAGAAATTCAATTTGTTATCCAAAACTTAATGTTAAAGTTTGTGCAACTCA
TGCAGGATTAACAGTAGGAGAAGATGGAGCATCTCATCAATCGGTTGAAGATATTTCATTAATGAGAAGTATTCCTAATA
TGACAGTAATAAATCCGGCAGATGCAATTGAAACTGAAGCAGCTATTTTAGCTGTAGCAGAATACAAAGGACCTTGTTAT
GTAAGACTTGGTAGATTAGCAGTTGAAAATGTAAATGATAATGCTAACTATAAGTTTGAAATAGGAAAAGGTGTAACATT
AGCAAATGGAAATGATGTTACTATAGTAGCAACAGGAATAATGGTTAAATTAGCATTAGAAGCTAAAGAAGAATTAGCTA
AAGACGGAATAGATGCAAGAGTTATTAATATTCATACTATAAAACCTATAGACTCAGATTTATTAATAAAAGCAGCTAAA
GAAACTGGAGCTATTGTTACAGCTGAAGAACATAGCATAATTGGTGGATTAGGTTCTGCTGTATCAGAAGTATTATGTGA
AGAAATGCCAGTTCCAGTATTAAAAGTTGGAATTGAAGATACATTTGGTGAAAGTGGAAAGCCAGAACAATTGTTAAAGG
CATATGGTTTAACAACTGAAAAAATAGTTGAAAGAGCTAAAAAGGCTATATCAATTAAAAAATAA

Upstream 100 bases:

>100_bases
AGGGTGTTTCATTCATGGAAAACCAAGCAGGATGGCATGGAGCAGCACCAAGCGTAGAACAACGTGATCAAGCATTAAGA
GAAATTGGAGGGGAAAACTA

Downstream 100 bases:

>100_bases
TTTAATAATTTATATAATATATAAATTATAAGATAGCAATATGTATTTATTGCTATCTTTTTTTTCATAAATTAAATATT
TATAAATTTATATAATTAGC

Product: transketolase, pyridine binding domain

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MGNKIATREAYGKALVKLSNMNKDVVVLDADLSKSTKTADFKAAAPERFINMGIAEANMMGVASGLSTCGKIPFVSTFAM
FAAGRAFEQIRNSICYPKLNVKVCATHAGLTVGEDGASHQSVEDISLMRSIPNMTVINPADAIETEAAILAVAEYKGPCY
VRLGRLAVENVNDNANYKFEIGKGVTLANGNDVTIVATGIMVKLALEAKEELAKDGIDARVINIHTIKPIDSDLLIKAAK
ETGAIVTAEEHSIIGGLGSAVSEVLCEEMPVPVLKVGIEDTFGESGKPEQLLKAYGLTTEKIVERAKKAISIKK

Sequences:

>Translated_314_residues
MGNKIATREAYGKALVKLSNMNKDVVVLDADLSKSTKTADFKAAAPERFINMGIAEANMMGVASGLSTCGKIPFVSTFAM
FAAGRAFEQIRNSICYPKLNVKVCATHAGLTVGEDGASHQSVEDISLMRSIPNMTVINPADAIETEAAILAVAEYKGPCY
VRLGRLAVENVNDNANYKFEIGKGVTLANGNDVTIVATGIMVKLALEAKEELAKDGIDARVINIHTIKPIDSDLLIKAAK
ETGAIVTAEEHSIIGGLGSAVSEVLCEEMPVPVLKVGIEDTFGESGKPEQLLKAYGLTTEKIVERAKKAISIKK
>Mature_313_residues
GNKIATREAYGKALVKLSNMNKDVVVLDADLSKSTKTADFKAAAPERFINMGIAEANMMGVASGLSTCGKIPFVSTFAMF
AAGRAFEQIRNSICYPKLNVKVCATHAGLTVGEDGASHQSVEDISLMRSIPNMTVINPADAIETEAAILAVAEYKGPCYV
RLGRLAVENVNDNANYKFEIGKGVTLANGNDVTIVATGIMVKLALEAKEELAKDGIDARVINIHTIKPIDSDLLIKAAKE
TGAIVTAEEHSIIGGLGSAVSEVLCEEMPVPVLKVGIEDTFGESGKPEQLLKAYGLTTEKIVERAKKAISIKK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=316, Percent_Identity=39.2405063291139, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI4507521, Length=316, Percent_Identity=39.2405063291139, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI225637461, Length=307, Percent_Identity=40.0651465798046, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI225637463, Length=307, Percent_Identity=40.0651465798046, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI225637459, Length=307, Percent_Identity=40.0651465798046, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI133778974, Length=306, Percent_Identity=37.9084967320261, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4557353, Length=254, Percent_Identity=26.3779527559055, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI34101272, Length=254, Percent_Identity=26.3779527559055, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786622, Length=289, Percent_Identity=30.4498269896194, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1788808, Length=324, Percent_Identity=26.5432098765432, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI48994911, Length=323, Percent_Identity=27.2445820433437, Blast_Score=100, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17539652, Length=310, Percent_Identity=38.0645161290323, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17506935, Length=207, Percent_Identity=26.0869565217391, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325331, Length=341, Percent_Identity=29.3255131964809, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319593, Length=348, Percent_Identity=25.5747126436782, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24645119, Length=308, Percent_Identity=38.3116883116883, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI45551847, Length=308, Percent_Identity=38.3116883116883, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI45550715, Length=308, Percent_Identity=38.3116883116883, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24666278, Length=309, Percent_Identity=37.8640776699029, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI160714828, Length=176, Percent_Identity=31.8181818181818, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI160714832, Length=176, Percent_Identity=31.8181818181818, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21358145, Length=252, Percent_Identity=25, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650940, Length=252, Percent_Identity=25, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 33342; Mature: 33211

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNKIATREAYGKALVKLSNMNKDVVVLDADLSKSTKTADFKAAAPERFINMGIAEANMM
CCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCCHHHHHH
GVASGLSTCGKIPFVSTFAMFAAGRAFEQIRNSICYPKLNVKVCATHAGLTVGEDGASHQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEECCCCCCCC
SVEDISLMRSIPNMTVINPADAIETEAAILAVAEYKGPCYVRLGRLAVENVNDNANYKFE
HHHHHHHHHHCCCCEEECCHHHHHCHHHEEEEEECCCCEEEEECEEEEECCCCCCCEEEE
IGKGVTLANGNDVTIVATGIMVKLALEAKEELAKDGIDARVINIHTIKPIDSDLLIKAAK
ECCCEEEECCCEEEEEEECEEEEHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHEEEHH
ETGAIVTAEEHSIIGGLGSAVSEVLCEEMPVPVLKVGIEDTFGESGKPEQLLKAYGLTTE
HCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHCCCCCCHHHHHHHHCCCHH
KIVERAKKAISIKK
HHHHHHHHHCCCCC
>Mature Secondary Structure 
GNKIATREAYGKALVKLSNMNKDVVVLDADLSKSTKTADFKAAAPERFINMGIAEANMM
CCCCCHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCCHHHHHH
GVASGLSTCGKIPFVSTFAMFAAGRAFEQIRNSICYPKLNVKVCATHAGLTVGEDGASHQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEECCCCCCCC
SVEDISLMRSIPNMTVINPADAIETEAAILAVAEYKGPCYVRLGRLAVENVNDNANYKFE
HHHHHHHHHHCCCCEEECCHHHHHCHHHEEEEEECCCCEEEEECEEEEECCCCCCCEEEE
IGKGVTLANGNDVTIVATGIMVKLALEAKEELAKDGIDARVINIHTIKPIDSDLLIKAAK
ECCCEEEECCCEEEEEEECEEEEHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHEEEHH
ETGAIVTAEEHSIIGGLGSAVSEVLCEEMPVPVLKVGIEDTFGESGKPEQLLKAYGLTTE
HCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHCCCCCCHHHHHHHHCCCHH
KIVERAKKAISIKK
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]