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The map label for this gene is rsbU [H]

Identifier: 187918387

GI number: 187918387

Start: 539919

End: 541502

Strand: Direct

Name: rsbU [H]

Synonym: BH0522A

Alternate gene names: 187918387

Gene position: 539919-541502 (Clockwise)

Preceding gene: 187918386

Following gene: 187918389

Centisome position: 58.54

GC content: 27.02

Gene sequence:

>1584_bases
ATGAATAGTAATAATGTTATTAGTATATTAAATGAGTTTAGTTTAAAATTAGAAGAGATTTTCTTGCTTATCAATACTGA
TTCTTCTGAACTTTACAAAGAGACTCCTAGATATTTTTATAATGATATTACAAATTATCTTGAATTAACTTTAGAGATCG
CTAATAAATTTCAGGGGGAATTCGAAGACCCACAAGACTTAAATTTAGGCAAATTTTTGATTAGAAGTATGAAATGCGAT
TTAATTTCTTATTTATATTTATCTTTGGAATTAATAGATAATGCTATGCGTTATAGTGAGATTAAAGATGCTGGTATTGC
CTTTTTTAAGGCCATTGCTTTTAAGATCTCATCGATAATATCTTATATAGAGATTGAGCTTGAGAATGTGGTTCTCTCTT
CTGCTATTGCAAGTAGACAAGCTTTAAATAAAGATGGACATAAGATATTAATTTTCTCTTGTGATAGTATGTATAGTAAA
AAGCTTAAAGACCATTTGATTTTAAAAGACTATGCTGTTTTATCTACAAATACTGTGGACTTATTTAATCAGTTACTCTG
TAATGATTTTTATGATTTAATTATTTTTGATTTAAGTTCGGATAAAGATATACAGTTGATTTTAAACTTGCTTAAGAATG
TTAAGAATAATAGTTTTTATGAAATGATTCCTGTTATTGTTATTTCTCAAATAAATAGGAAAGATATTATTCAGACTTTT
ATTGAAGAGCAAGTCGATGATTATTTTTTAAGAAATCTAGATTTCTTGGTATTAGATCTTAGGATAAGTAGTTTTCTTGA
AAAGAAAAAGGTTATAGAACAGGGACAAAAATATTTAGATCTTATACTTCATAATAGAGAATATTTCGAGAGTGAGCTAA
TTGAGGCTGGGAATTATATTGAAACTTTATTGCCCATGAAGATGCAAAATGAATTTTTTAGTTCTAATTGGATTTTTGTT
CCATCAAAACGAATTGGCGGTGATTTTTTTAATTATTATTTTGTTAATGATGATAATTTAATAATCTATTTGATAGATAT
TTCAGGTCATGGAGTAGGTTCTGCACTTTTATCCCTTAGCGTTTCAAGTGTTATTAATTCTTATATCATGAACAATAATG
ATATAAGTCCTTCTAAGGTATTAAGATATGTTAACAGTTATTTTGTTAAGTTTAAAAGTGATATGCTGATTACATTGTGG
TATGGTGTTTTAAATGTAAAAACAAGACATCTAAGGTTTGCATCAGCAGGAGCACCACCTGCTGTTGTTTTAAGTGCTGA
GGATAATATTTATCTTCAGACAAGAGGGGCGATTCTTGGGATTGAAGAGATGTATTCTTGTGAGGAAAATGAATATTCAT
TGAGTAAGTTTTCGCATCTCGTACTCTTTAGTGATGGTGTTTATGAGATTGAAAATAAGCAAGATATAATAATGTCTATT
GATGATTTTTATAAGATATTGAAAAAAAATTCATATGATTTAAATGATTTTATTTTAGTAAGTCTTTATGAAAAGATGTT
GAATTTATCAAAATATAATGCCTTTAGGGATGATTTTTCTATTTTGGAGTTTATTCTTAATTAG

Upstream 100 bases:

>100_bases
GAGTATAAAAGAAGGAAAGGCCCTATGATAGTTAAAGTTTCTAGAAAAGCTTTTGGTAATGACATTTTACTTCCTATTTC
AAGAGTTGCGTTAACTGAGG

Downstream 100 bases:

>100_bases
TTGATAAGCTAGATTGGGATTTCAAGGGCTACGCATGTTTGTTAAATAATGTTGCTATTTTGGGAATTAAAGTTTAATTT
GATTTATATTGTGACTTGCA

Product: transcriptional regulatory protein

Products: NA

Alternate protein names: Sigma factor sigB regulation protein rsbU [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MNSNNVISILNEFSLKLEEIFLLINTDSSELYKETPRYFYNDITNYLELTLEIANKFQGEFEDPQDLNLGKFLIRSMKCD
LISYLYLSLELIDNAMRYSEIKDAGIAFFKAIAFKISSIISYIEIELENVVLSSAIASRQALNKDGHKILIFSCDSMYSK
KLKDHLILKDYAVLSTNTVDLFNQLLCNDFYDLIIFDLSSDKDIQLILNLLKNVKNNSFYEMIPVIVISQINRKDIIQTF
IEEQVDDYFLRNLDFLVLDLRISSFLEKKKVIEQGQKYLDLILHNREYFESELIEAGNYIETLLPMKMQNEFFSSNWIFV
PSKRIGGDFFNYYFVNDDNLIIYLIDISGHGVGSALLSLSVSSVINSYIMNNNDISPSKVLRYVNSYFVKFKSDMLITLW
YGVLNVKTRHLRFASAGAPPAVVLSAEDNIYLQTRGAILGIEEMYSCEENEYSLSKFSHLVLFSDGVYEIENKQDIIMSI
DDFYKILKKNSYDLNDFILVSLYEKMLNLSKYNAFRDDFSILEFILN

Sequences:

>Translated_527_residues
MNSNNVISILNEFSLKLEEIFLLINTDSSELYKETPRYFYNDITNYLELTLEIANKFQGEFEDPQDLNLGKFLIRSMKCD
LISYLYLSLELIDNAMRYSEIKDAGIAFFKAIAFKISSIISYIEIELENVVLSSAIASRQALNKDGHKILIFSCDSMYSK
KLKDHLILKDYAVLSTNTVDLFNQLLCNDFYDLIIFDLSSDKDIQLILNLLKNVKNNSFYEMIPVIVISQINRKDIIQTF
IEEQVDDYFLRNLDFLVLDLRISSFLEKKKVIEQGQKYLDLILHNREYFESELIEAGNYIETLLPMKMQNEFFSSNWIFV
PSKRIGGDFFNYYFVNDDNLIIYLIDISGHGVGSALLSLSVSSVINSYIMNNNDISPSKVLRYVNSYFVKFKSDMLITLW
YGVLNVKTRHLRFASAGAPPAVVLSAEDNIYLQTRGAILGIEEMYSCEENEYSLSKFSHLVLFSDGVYEIENKQDIIMSI
DDFYKILKKNSYDLNDFILVSLYEKMLNLSKYNAFRDDFSILEFILN
>Mature_527_residues
MNSNNVISILNEFSLKLEEIFLLINTDSSELYKETPRYFYNDITNYLELTLEIANKFQGEFEDPQDLNLGKFLIRSMKCD
LISYLYLSLELIDNAMRYSEIKDAGIAFFKAIAFKISSIISYIEIELENVVLSSAIASRQALNKDGHKILIFSCDSMYSK
KLKDHLILKDYAVLSTNTVDLFNQLLCNDFYDLIIFDLSSDKDIQLILNLLKNVKNNSFYEMIPVIVISQINRKDIIQTF
IEEQVDDYFLRNLDFLVLDLRISSFLEKKKVIEQGQKYLDLILHNREYFESELIEAGNYIETLLPMKMQNEFFSSNWIFV
PSKRIGGDFFNYYFVNDDNLIIYLIDISGHGVGSALLSLSVSSVINSYIMNNNDISPSKVLRYVNSYFVKFKSDMLITLW
YGVLNVKTRHLRFASAGAPPAVVLSAEDNIYLQTRGAILGIEEMYSCEENEYSLSKFSHLVLFSDGVYEIENKQDIIMSI
DDFYKILKKNSYDLNDFILVSLYEKMLNLSKYNAFRDDFSILEFILN

Specific function: Positive regulator of sigma-B activity. Dephosphorylates rsbV in response to environmental stress conveyed from the rsbXST module [H]

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017944
- InterPro:   IPR001932
- InterPro:   IPR014787
- InterPro:   IPR010822
- ProDom:   PD685490 [H]

Pfam domain/function: PF08673 RsbU_N; PF07228 SpoIIE [H]

EC number: =3.1.3.3 [H]

Molecular weight: Translated: 61176; Mature: 61176

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSNNVISILNEFSLKLEEIFLLINTDSSELYKETPRYFYNDITNYLELTLEIANKFQGE
CCCCHHHHHHHHHHHEEEEEEEEEECCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCC
FEDPQDLNLGKFLIRSMKCDLISYLYLSLELIDNAMRYSEIKDAGIAFFKAIAFKISSII
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYIEIELENVVLSSAIASRQALNKDGHKILIFSCDSMYSKKLKDHLILKDYAVLSTNTVD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHEECCCHHH
LFNQLLCNDFYDLIIFDLSSDKDIQLILNLLKNVKNNSFYEMIPVIVISQINRKDIIQTF
HHHHHHHCCHHEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHH
IEEQVDDYFLRNLDFLVLDLRISSFLEKKKVIEQGQKYLDLILHNREYFESELIEAGNYI
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHH
ETLLPMKMQNEFFSSNWIFVPSKRIGGDFFNYYFVNDDNLIIYLIDISGHGVGSALLSLS
HHHCCHHHHHHHHCCCCEEEECHHCCCCEEEEEEEECCCEEEEEEEECCCCHHHHHHHHH
VSSVINSYIMNNNDISPSKVLRYVNSYFVKFKSDMLITLWYGVLNVKTRHLRFASAGAPP
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHEEEEECCCCCC
AVVLSAEDNIYLQTRGAILGIEEMYSCEENEYSLSKFSHLVLFSDGVYEIENKQDIIMSI
EEEEECCCCEEEEECCCEEEHHHHHCCCCCCCCHHHHCEEEEEECCEEEECCCCCEEEEH
DDFYKILKKNSYDLNDFILVSLYEKMLNLSKYNAFRDDFSILEFILN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNSNNVISILNEFSLKLEEIFLLINTDSSELYKETPRYFYNDITNYLELTLEIANKFQGE
CCCCHHHHHHHHHHHEEEEEEEEEECCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCC
FEDPQDLNLGKFLIRSMKCDLISYLYLSLELIDNAMRYSEIKDAGIAFFKAIAFKISSII
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYIEIELENVVLSSAIASRQALNKDGHKILIFSCDSMYSKKLKDHLILKDYAVLSTNTVD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHEECCCHHH
LFNQLLCNDFYDLIIFDLSSDKDIQLILNLLKNVKNNSFYEMIPVIVISQINRKDIIQTF
HHHHHHHCCHHEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHH
IEEQVDDYFLRNLDFLVLDLRISSFLEKKKVIEQGQKYLDLILHNREYFESELIEAGNYI
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHH
ETLLPMKMQNEFFSSNWIFVPSKRIGGDFFNYYFVNDDNLIIYLIDISGHGVGSALLSLS
HHHCCHHHHHHHHCCCCEEEECHHCCCCEEEEEEEECCCEEEEEEEECCCCHHHHHHHHH
VSSVINSYIMNNNDISPSKVLRYVNSYFVKFKSDMLITLWYGVLNVKTRHLRFASAGAPP
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHEEEEECCCCCC
AVVLSAEDNIYLQTRGAILGIEEMYSCEENEYSLSKFSHLVLFSDGVYEIENKQDIIMSI
EEEEECCCCEEEEECCCEEEHHHHHCCCCCCCCHHHHCEEEEEECCEEEECCCCCEEEEH
DDFYKILKKNSYDLNDFILVSLYEKMLNLSKYNAFRDDFSILEFILN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 8002609; 9384377; 8824586; 9786195; 12499568 [H]