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The map label for this gene is lpxB [H]

Identifier: 187736531

GI number: 187736531

Start: 2498201

End: 2499331

Strand: Reverse

Name: lpxB [H]

Synonym: Amuc_2052

Alternate gene names: 187736531

Gene position: 2499331-2498201 (Counterclockwise)

Preceding gene: 187736534

Following gene: 187736526

Centisome position: 93.82

GC content: 56.23

Gene sequence:

>1131_bases
ATGCAGATAGTGATGAAGCTTTATATTATAGCAGGCGAAAAGAGCGGGGACATTCATGGCGCCCTGCTGTTGAAGAATCT
GCTGCGCCTGATGCCCGGCATGGAGGTCGCAGGGTTGGGCGGCCAGGGCATGCACGCGTTATGTCCCGGCGTGGAAGACT
GGGCGGATGAAGCCGCCGTTATCGGCGTGGTGGAGGTGCTCAAAAAATACGGATGGTTCAGAAGGCGTTTTCTCTCCATT
CTGGAAAGGATACGGCAGGACCAGCCGGATTGCCTTGTTTTGATTGATTATCCGGGGTTTAATCTGCGGCTGGCGGAGAG
GGTCCGCAAGTGCTGCCCCCGCACCAGAATCGTTTATTTTATCTCCCCGCAGGTGTGGGCATGGCATCGCGGGCGCATTC
CCAAGATGGTGCGCATGCTGGATTTGATGATGTGCATCTTCCCTTTTGAGGCTCCCTTGTTCCAGGAAGCCGGACTGAGA
ACGGAGTTTGTGGGGCATCCCCTGGTAGATGAAATTGCTTCCATCCGTAAGGAGGGCGTCCGGGATCCGTCACTGGTCGG
TCTTTTTCCCGGCAGCCGGAACCGTGAAATTGACAGGCATTTCCCGGTATTTATAGAGGTAGTGAACCGCCTTTCCCGGG
AACGTCCGGAACTGTCTTTTGAAACCGCCGCTTCCACGGAGGCTCTGGCGGAAAGAATGCGCGGCATGGTGCGGAAGGCC
GGCATGCCTCCGGAACTGTTCCACATTGCGGTGGGAAAATATCATGAGCTGATGGACCGCGCCGCCGTGGGAATTGTGGC
TTCCGGCACCGCCACGATGGAAGCCGCCTTGCACCGTCTGCCGTACATGCTGGTGTACAAGGTTCCCCTGCTGACGTACT
GGATGGCCCGCATGCTCATCAAAATACGCTTCATCGGCATGGTGAATATCCTGGCGCAGAAACCCGTGGTGAAGGAGCTG
GTTCAGTTTGATTTTACACCGGACAAGGTGATTGATGAAATAGAACGCCTGCTTGTTCCGGAAAACAGGGATGTCCTGCT
GGAGGAAATGAAACAGGCCTCCGACAAGTTGGGGCAGGGAGGGGCGGCGGAACATGCGGCTCAGGCCGTCTGCCGCCTGT
TAAATGAATAA

Upstream 100 bases:

>100_bases
ATAACGGCGCGTATCTTGCATTAAAATCCTTGAAAGGAAAGTCTTTTATTGCGTCCCGGGAACGGGGCTGGTAAGGTAGG
GAGGCGTCCGGCGTGCGCCG

Downstream 100 bases:

>100_bases
CAGTGCCTTTTAAAAATCGGAGCCGGGGAAGCGTTTTTCCGGTTCTTGATGCAGGAACATGAAGAAGGGGAAGAGAATGG
CCCTTCAAATTCCGGAGACA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MQIVMKLYIIAGEKSGDIHGALLLKNLLRLMPGMEVAGLGGQGMHALCPGVEDWADEAAVIGVVEVLKKYGWFRRRFLSI
LERIRQDQPDCLVLIDYPGFNLRLAERVRKCCPRTRIVYFISPQVWAWHRGRIPKMVRMLDLMMCIFPFEAPLFQEAGLR
TEFVGHPLVDEIASIRKEGVRDPSLVGLFPGSRNREIDRHFPVFIEVVNRLSRERPELSFETAASTEALAERMRGMVRKA
GMPPELFHIAVGKYHELMDRAAVGIVASGTATMEAALHRLPYMLVYKVPLLTYWMARMLIKIRFIGMVNILAQKPVVKEL
VQFDFTPDKVIDEIERLLVPENRDVLLEEMKQASDKLGQGGAAEHAAQAVCRLLNE

Sequences:

>Translated_376_residues
MQIVMKLYIIAGEKSGDIHGALLLKNLLRLMPGMEVAGLGGQGMHALCPGVEDWADEAAVIGVVEVLKKYGWFRRRFLSI
LERIRQDQPDCLVLIDYPGFNLRLAERVRKCCPRTRIVYFISPQVWAWHRGRIPKMVRMLDLMMCIFPFEAPLFQEAGLR
TEFVGHPLVDEIASIRKEGVRDPSLVGLFPGSRNREIDRHFPVFIEVVNRLSRERPELSFETAASTEALAERMRGMVRKA
GMPPELFHIAVGKYHELMDRAAVGIVASGTATMEAALHRLPYMLVYKVPLLTYWMARMLIKIRFIGMVNILAQKPVVKEL
VQFDFTPDKVIDEIERLLVPENRDVLLEEMKQASDKLGQGGAAEHAAQAVCRLLNE
>Mature_376_residues
MQIVMKLYIIAGEKSGDIHGALLLKNLLRLMPGMEVAGLGGQGMHALCPGVEDWADEAAVIGVVEVLKKYGWFRRRFLSI
LERIRQDQPDCLVLIDYPGFNLRLAERVRKCCPRTRIVYFISPQVWAWHRGRIPKMVRMLDLMMCIFPFEAPLFQEAGLR
TEFVGHPLVDEIASIRKEGVRDPSLVGLFPGSRNREIDRHFPVFIEVVNRLSRERPELSFETAASTEALAERMRGMVRKA
GMPPELFHIAVGKYHELMDRAAVGIVASGTATMEAALHRLPYMLVYKVPLLTYWMARMLIKIRFIGMVNILAQKPVVKEL
VQFDFTPDKVIDEIERLLVPENRDVLLEEMKQASDKLGQGGAAEHAAQAVCRLLNE

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=384, Percent_Identity=30.46875, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42686; Mature: 42686

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIVMKLYIIAGEKSGDIHGALLLKNLLRLMPGMEVAGLGGQGMHALCPGVEDWADEAAV
CCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHCCCHHHHHHHHHH
IGVVEVLKKYGWFRRRFLSILERIRQDQPDCLVLIDYPGFNLRLAERVRKCCPRTRIVYF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEE
ISPQVWAWHRGRIPKMVRMLDLMMCIFPFEAPLFQEAGLRTEFVGHPLVDEIASIRKEGV
ECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHCCCCHHHHHHHHHHCCC
RDPSLVGLFPGSRNREIDRHFPVFIEVVNRLSRERPELSFETAASTEALAERMRGMVRKA
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
GMPPELFHIAVGKYHELMDRAAVGIVASGTATMEAALHRLPYMLVYKVPLLTYWMARMLI
CCCHHHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
KIRFIGMVNILAQKPVVKELVQFDFTPDKVIDEIERLLVPENRDVLLEEMKQASDKLGQG
HHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
GAAEHAAQAVCRLLNE
CCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQIVMKLYIIAGEKSGDIHGALLLKNLLRLMPGMEVAGLGGQGMHALCPGVEDWADEAAV
CCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHCCCHHHHHHHHHH
IGVVEVLKKYGWFRRRFLSILERIRQDQPDCLVLIDYPGFNLRLAERVRKCCPRTRIVYF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEE
ISPQVWAWHRGRIPKMVRMLDLMMCIFPFEAPLFQEAGLRTEFVGHPLVDEIASIRKEGV
ECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHCCCCHHHHHHHHHHCCC
RDPSLVGLFPGSRNREIDRHFPVFIEVVNRLSRERPELSFETAASTEALAERMRGMVRKA
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
GMPPELFHIAVGKYHELMDRAAVGIVASGTATMEAALHRLPYMLVYKVPLLTYWMARMLI
CCCHHHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
KIRFIGMVNILAQKPVVKELVQFDFTPDKVIDEIERLLVPENRDVLLEEMKQASDKLGQG
HHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
GAAEHAAQAVCRLLNE
CCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA