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The map label for this gene is mutA [H]

Identifier: 187736464

GI number: 187736464

Start: 2408273

End: 2410327

Strand: Reverse

Name: mutA [H]

Synonym: Amuc_1984

Alternate gene names: 187736464

Gene position: 2410327-2408273 (Counterclockwise)

Preceding gene: 187736470

Following gene: 187736463

Centisome position: 90.47

GC content: 60.68

Gene sequence:

>2055_bases
ATGCAACAGGGAAATAAAACAACGGCTCCGGAAATTGATTTCGGAGAATTCGCACCAGCCACATACGCCGAATGGCGCGA
GGCAGCAGTCGCTGCCCTGAAAGGGGCTGATTTTGACAAAAAGCTTTTTACCAAGCTTGTGGAGGGAATTACCCTGCATC
CCATCTATAACAAATGGGATGAACATTCCCCGGTAATGCCTGCCGGGCAATTTCCGTACCGCCGCGGAACGCGCGCCCTG
GGCTATATGGAAAAGCCCTGCGAAATCGCCCAGAGCATTCCCGCTTCCTCTCCGGAAGACTTCAACGCCAAGCTTCTGCA
TGACCTGGACCGCGGCCTGACCGCCGTAAACGTTCAGCTCAACTGCAAATGCGGCCTGAAGCTGCGCAAGCAGGCTGACT
GGGATGCGGCCCTCAGGGGCGTCCGGCTGGACGGGCTTCCCGTATATGTCACTCCCGGTTCCTGCGGCCTGGGAACCCTC
TCCATGTTCCTGAACACCTGCAAGGCCGCCGGCGTCAAGACGGCGGACCTCAAGGGCGGCGTTCTGTATGACCCGGTGGG
GAAAGCTGTGATGAAGGGCTCCCTTTGCGGGGGGAAGGGCATCTGCGCCTACTATGACCAGATGGCCGTGATGACCAAAT
GGGCTGTTGCCAACGCTCCCGGCTTCCAGACCATCGGCGTCAGCGGGCTGCCTTACGCGGACTCCGGAGCTTCCGCCTTT
GAGGAAGTGGGCGCCATGCTGTCCACTGCCGTGGCCTACCTGCGCGCCATGGAGGAACGCGGCCTCTCCGTGGATGAAAC
TGCGGCGCACATGCGCTTTACGGTTTCCATCGGCGCCAACCTGTTCCTGGAAATCGCCAAAATCCGCGCTCTGCGCGAAC
TTTGGGCCATCATCGTAAAAGAATGCGGCGGCAGCGAGGAAGCTGCCAAAATCAAGCTCCATGCCCGCACCTCCTTCTGG
ACCCTCTCCAAGGTGGATCCCTGGGTCAACCTGCTGCGCGGCTCCGCCCAGGCGTTCTCCGCCATCATGGGCGGCGTGGA
CAGTATTGACGTTCTTCCCTTTGACGCTGCCGTGCGCATGCCGGACGAATTCTCTCGCCGCATTGCCCGCAACTGCCCGC
TGATTCTGCTGGGCGAATGCAATCTGGACAAGGTCGTTGACCCCGCCGGCGGTTCCTGGTACCTGGAAAACCTGACGGAT
GAAGCCTCCCGGAAGATATGGGAATTCTTCCAGGGCATCGAAAAGGAAGGCGGCATCGTCAAGGCCCTCAAAGCCGGCAG
CATCCAGAAGAAGGTGAACGCCACCGCCGCCAGGCGTTACGAGCTGGCGGACCAGCGCCGGCAGTCCATCGTGGGCGTCA
ACCAGTATGTCAACCTGGCGGAGAAAAAGCTGGAAGTTCCGGAAGGCTCCTGCTGTTCCGCCCACAAGGGCCACGGCTGC
TGCAAGAATGCGGATATTCAGCTCCCGGTCGTGGAAATGAGCGTGGACTCCGCCTGCAAGGCCGCCGAAGAAGGCTTTTC
CACCTGCCTTATCAACAAGGCCCTGGTGGCCGGCGCTGACTGCAAGTGCGGCGAACCCCTGGAAATGGAAGCCCTGCCGA
AGCGCCGCCTGGCGGAACGTTTTGAATCCCTGCTCGCCAAGGCTGACGCCTGGGTGGCAGAAAAGGGTTCCCGCCCGATG
GTCTTCTTCGCCAACATGGGGCCGCTCCGCCAGCACAAGGCCCGCGCGGACTTCTCCCGCGACTTCCTGCGCGCCGGCGG
TCTGGATGTGGTTTATCCGGCCGGCTTCCAAACTCCGGAAGACGCGGCCAGGGCAGCTGCGGAAAGCGGCTGCGCCGTGT
GCGTCATCTGCTCCACGGATGACACTTATCCGGAAATCGTCCCCGCCTTCTGCAAGGCTCTCAGGGAGACCAGACCGGAC
ATGATGGTGGCCCTTGCCGGTTATCCGGCCGACTATGTGGAAGCATTCAAGGAAGCCGGCGTGGACATCTTCATCCACGT
CAAGGCCAACTGCTACAACACCGTTGAAGCCATTCAAAACAAAATCGGCCTTTAA

Upstream 100 bases:

>100_bases
TTTACACTTTGATTTCCTAAAATAATGTTGCGCTTTAAACTTGGCCTGGTTTGCGCATAGTTAAAAACCAACATATTAGG
CCTTACCCATTGACTTCGCC

Downstream 100 bases:

>100_bases
TAACCACCAACCTATTCCACCCAATGAGCAATATTCCTGATTTTGCATCCGCCTCCTATCCTGAAATCAAGGCTGGTGCC
CCGTCCCCGGCTTCCGAAAC

Product: Methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MQQGNKTTAPEIDFGEFAPATYAEWREAAVAALKGADFDKKLFTKLVEGITLHPIYNKWDEHSPVMPAGQFPYRRGTRAL
GYMEKPCEIAQSIPASSPEDFNAKLLHDLDRGLTAVNVQLNCKCGLKLRKQADWDAALRGVRLDGLPVYVTPGSCGLGTL
SMFLNTCKAAGVKTADLKGGVLYDPVGKAVMKGSLCGGKGICAYYDQMAVMTKWAVANAPGFQTIGVSGLPYADSGASAF
EEVGAMLSTAVAYLRAMEERGLSVDETAAHMRFTVSIGANLFLEIAKIRALRELWAIIVKECGGSEEAAKIKLHARTSFW
TLSKVDPWVNLLRGSAQAFSAIMGGVDSIDVLPFDAAVRMPDEFSRRIARNCPLILLGECNLDKVVDPAGGSWYLENLTD
EASRKIWEFFQGIEKEGGIVKALKAGSIQKKVNATAARRYELADQRRQSIVGVNQYVNLAEKKLEVPEGSCCSAHKGHGC
CKNADIQLPVVEMSVDSACKAAEEGFSTCLINKALVAGADCKCGEPLEMEALPKRRLAERFESLLAKADAWVAEKGSRPM
VFFANMGPLRQHKARADFSRDFLRAGGLDVVYPAGFQTPEDAARAAAESGCAVCVICSTDDTYPEIVPAFCKALRETRPD
MMVALAGYPADYVEAFKEAGVDIFIHVKANCYNTVEAIQNKIGL

Sequences:

>Translated_684_residues
MQQGNKTTAPEIDFGEFAPATYAEWREAAVAALKGADFDKKLFTKLVEGITLHPIYNKWDEHSPVMPAGQFPYRRGTRAL
GYMEKPCEIAQSIPASSPEDFNAKLLHDLDRGLTAVNVQLNCKCGLKLRKQADWDAALRGVRLDGLPVYVTPGSCGLGTL
SMFLNTCKAAGVKTADLKGGVLYDPVGKAVMKGSLCGGKGICAYYDQMAVMTKWAVANAPGFQTIGVSGLPYADSGASAF
EEVGAMLSTAVAYLRAMEERGLSVDETAAHMRFTVSIGANLFLEIAKIRALRELWAIIVKECGGSEEAAKIKLHARTSFW
TLSKVDPWVNLLRGSAQAFSAIMGGVDSIDVLPFDAAVRMPDEFSRRIARNCPLILLGECNLDKVVDPAGGSWYLENLTD
EASRKIWEFFQGIEKEGGIVKALKAGSIQKKVNATAARRYELADQRRQSIVGVNQYVNLAEKKLEVPEGSCCSAHKGHGC
CKNADIQLPVVEMSVDSACKAAEEGFSTCLINKALVAGADCKCGEPLEMEALPKRRLAERFESLLAKADAWVAEKGSRPM
VFFANMGPLRQHKARADFSRDFLRAGGLDVVYPAGFQTPEDAARAAAESGCAVCVICSTDDTYPEIVPAFCKALRETRPD
MMVALAGYPADYVEAFKEAGVDIFIHVKANCYNTVEAIQNKIGL
>Mature_684_residues
MQQGNKTTAPEIDFGEFAPATYAEWREAAVAALKGADFDKKLFTKLVEGITLHPIYNKWDEHSPVMPAGQFPYRRGTRAL
GYMEKPCEIAQSIPASSPEDFNAKLLHDLDRGLTAVNVQLNCKCGLKLRKQADWDAALRGVRLDGLPVYVTPGSCGLGTL
SMFLNTCKAAGVKTADLKGGVLYDPVGKAVMKGSLCGGKGICAYYDQMAVMTKWAVANAPGFQTIGVSGLPYADSGASAF
EEVGAMLSTAVAYLRAMEERGLSVDETAAHMRFTVSIGANLFLEIAKIRALRELWAIIVKECGGSEEAAKIKLHARTSFW
TLSKVDPWVNLLRGSAQAFSAIMGGVDSIDVLPFDAAVRMPDEFSRRIARNCPLILLGECNLDKVVDPAGGSWYLENLTD
EASRKIWEFFQGIEKEGGIVKALKAGSIQKKVNATAARRYELADQRRQSIVGVNQYVNLAEKKLEVPEGSCCSAHKGHGC
CKNADIQLPVVEMSVDSACKAAEEGFSTCLINKALVAGADCKCGEPLEMEALPKRRLAERFESLLAKADAWVAEKGSRPM
VFFANMGPLRQHKARADFSRDFLRAGGLDVVYPAGFQTPEDAARAAAESGCAVCVICSTDDTYPEIVPAFCKALRETRPD
MMVALAGYPADYVEAFKEAGVDIFIHVKANCYNTVEAIQNKIGL

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=699, Percent_Identity=26.3233190271817, Blast_Score=206, Evalue=9e-53,
Organism=Escherichia coli, GI1789284, Length=704, Percent_Identity=27.2727272727273, Blast_Score=235, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI25144500, Length=700, Percent_Identity=26.2857142857143, Blast_Score=219, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 74101; Mature: 74101

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQGNKTTAPEIDFGEFAPATYAEWREAAVAALKGADFDKKLFTKLVEGITLHPIYNKWD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEECCHHCCCC
EHSPVMPAGQFPYRRGTRALGYMEKPCEIAQSIPASSPEDFNAKLLHDLDRGLTAVNVQL
CCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEE
NCKCGLKLRKQADWDAALRGVRLDGLPVYVTPGSCGLGTLSMFLNTCKAAGVKTADLKGG
EEEECCEECCCCCHHHHHCCEEECCEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCC
VLYDPVGKAVMKGSLCGGKGICAYYDQMAVMTKWAVANAPGFQTIGVSGLPYADSGASAF
EEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHH
EEVGAMLSTAVAYLRAMEERGLSVDETAAHMRFTVSIGANLFLEIAKIRALRELWAIIVK
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
ECGGSEEAAKIKLHARTSFWTLSKVDPWVNLLRGSAQAFSAIMGGVDSIDVLPFDAAVRM
HCCCCCCCEEEEEEECCCEEEHHHCCHHHHHHHCCHHHHHHHHCCCCCEEEECCCHHHCC
PDEFSRRIARNCPLILLGECNLDKVVDPAGGSWYLENLTDEASRKIWEFFQGIEKEGGIV
CHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEE
KALKAGSIQKKVNATAARRYELADQRRQSIVGVNQYVNLAEKKLEVPEGSCCSAHKGHGC
EEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
CKNADIQLPVVEMSVDSACKAAEEGFSTCLINKALVAGADCKCGEPLEMEALPKRRLAER
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHH
FESLLAKADAWVAEKGSRPMVFFANMGPLRQHKARADFSRDFLRAGGLDVVYPAGFQTPE
HHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHH
DAARAAAESGCAVCVICSTDDTYPEIVPAFCKALRETRPDMMVALAGYPADYVEAFKEAG
HHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCC
VDIFIHVKANCYNTVEAIQNKIGL
CEEEEEEECCCHHHHHHHHHHCCC
>Mature Secondary Structure
MQQGNKTTAPEIDFGEFAPATYAEWREAAVAALKGADFDKKLFTKLVEGITLHPIYNKWD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEECCHHCCCC
EHSPVMPAGQFPYRRGTRALGYMEKPCEIAQSIPASSPEDFNAKLLHDLDRGLTAVNVQL
CCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEEE
NCKCGLKLRKQADWDAALRGVRLDGLPVYVTPGSCGLGTLSMFLNTCKAAGVKTADLKGG
EEEECCEECCCCCHHHHHCCEEECCEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCC
VLYDPVGKAVMKGSLCGGKGICAYYDQMAVMTKWAVANAPGFQTIGVSGLPYADSGASAF
EEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHH
EEVGAMLSTAVAYLRAMEERGLSVDETAAHMRFTVSIGANLFLEIAKIRALRELWAIIVK
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
ECGGSEEAAKIKLHARTSFWTLSKVDPWVNLLRGSAQAFSAIMGGVDSIDVLPFDAAVRM
HCCCCCCCEEEEEEECCCEEEHHHCCHHHHHHHCCHHHHHHHHCCCCCEEEECCCHHHCC
PDEFSRRIARNCPLILLGECNLDKVVDPAGGSWYLENLTDEASRKIWEFFQGIEKEGGIV
CHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEE
KALKAGSIQKKVNATAARRYELADQRRQSIVGVNQYVNLAEKKLEVPEGSCCSAHKGHGC
EEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
CKNADIQLPVVEMSVDSACKAAEEGFSTCLINKALVAGADCKCGEPLEMEALPKRRLAER
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHH
FESLLAKADAWVAEKGSRPMVFFANMGPLRQHKARADFSRDFLRAGGLDVVYPAGFQTPE
HHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHH
DAARAAAESGCAVCVICSTDDTYPEIVPAFCKALRETRPDMMVALAGYPADYVEAFKEAG
HHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCC
VDIFIHVKANCYNTVEAIQNKIGL
CEEEEEEECCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]