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The map label for this gene is proC [H]

Identifier: 187736470

GI number: 187736470

Start: 2417809

End: 2418615

Strand: Reverse

Name: proC [H]

Synonym: Amuc_1990

Alternate gene names: 187736470

Gene position: 2418615-2417809 (Counterclockwise)

Preceding gene: 187736471

Following gene: 187736464

Centisome position: 90.79

GC content: 60.1

Gene sequence:

>807_bases
ATGAAAACAGGTATCATCGGACTTGGAAAAATGGGAGGCGCCCTGTTGCGGGGCATGCTGAAATCCGGAGCAGCGGTTCC
GGAGGAAGTTTGGGTGTACGATCATCATCATGAAAACGTGCAGGCCCTGCAGGAGGAATACCCCGGAGTTCATGAAGCTG
CCTCGGAGGCGGATGCGGCGGACGCCGTGGAAGTCCTGATTCTGGCCGTGAAGCCGCACGGCGTCCTTCCGCTCATTTCC
TCTCTTTCCGAACGGGGGGCGGAGCTTCCCCTTCTGATTTCTATCGCAGCCGCCGTTTCCCTGGATGATATGGAAGCCTG
TGCCAGCGACGGAACGCGCATTATACGCGCCATGCCCAATACCCCGTGCATGGTGCTGGCCGGCGTCATCGCCTACAGTA
CGGGAAACGGCGTAAAAGATGAAGATGAAGAGGCTGCCCGGATGCTGCTTTCCGGCTGCGGCTCCGTTTACAAGGTGGCG
GAATCCGGGATGAATGCCGTTTCCGCCATTTCCGGTTGCGGTCCTGCCTACATGTTTACGGCTCTGGATGCGCTTGCGGA
CGCAGGGGTAGCCATGGGATTGTCCAGGAAAACCGCTTTGGGGCTGGCTGCGGAAACCATGCGGGGGGCTTCCCTGATGC
TGGAACGGACCGGGAAGCATCCCATGGCGCTCCGGGATGAGGTCACTTCCCCCGGAGGGACCACGATTGCCGCCCTGAAT
GCGCTGGATGAATGCGGCTTCCGCAATGCCTGGATTCAGGCGGTGAAAAGTGCCGTACGGCGCGCGGAGGAAATGGAGGA
GCGGTAA

Upstream 100 bases:

>100_bases
AACGCGGAAATGACGCATTCTCGTCCATAACCATGGGCCTTAATTGGCATTTCCATTTTCTATAAATCGCTTATATGTTG
ACTGTAAAAAATTATCAACC

Downstream 100 bases:

>100_bases
CGGATGCTTCTTCTGGCTTTCCCGGCAGCCGGCTTTCTCCGGAAAGGACGGCCTGGCGGAGAAGCCTTTATTTGCACCGG
AACGGCGTTTCCCTCTGCTT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MKTGIIGLGKMGGALLRGMLKSGAAVPEEVWVYDHHHENVQALQEEYPGVHEAASEADAADAVEVLILAVKPHGVLPLIS
SLSERGAELPLLISIAAAVSLDDMEACASDGTRIIRAMPNTPCMVLAGVIAYSTGNGVKDEDEEAARMLLSGCGSVYKVA
ESGMNAVSAISGCGPAYMFTALDALADAGVAMGLSRKTALGLAAETMRGASLMLERTGKHPMALRDEVTSPGGTTIAALN
ALDECGFRNAWIQAVKSAVRRAEEMEER

Sequences:

>Translated_268_residues
MKTGIIGLGKMGGALLRGMLKSGAAVPEEVWVYDHHHENVQALQEEYPGVHEAASEADAADAVEVLILAVKPHGVLPLIS
SLSERGAELPLLISIAAAVSLDDMEACASDGTRIIRAMPNTPCMVLAGVIAYSTGNGVKDEDEEAARMLLSGCGSVYKVA
ESGMNAVSAISGCGPAYMFTALDALADAGVAMGLSRKTALGLAAETMRGASLMLERTGKHPMALRDEVTSPGGTTIAALN
ALDECGFRNAWIQAVKSAVRRAEEMEER
>Mature_268_residues
MKTGIIGLGKMGGALLRGMLKSGAAVPEEVWVYDHHHENVQALQEEYPGVHEAASEADAADAVEVLILAVKPHGVLPLIS
SLSERGAELPLLISIAAAVSLDDMEACASDGTRIIRAMPNTPCMVLAGVIAYSTGNGVKDEDEEAARMLLSGCGSVYKVA
ESGMNAVSAISGCGPAYMFTALDALADAGVAMGLSRKTALGLAAETMRGASLMLERTGKHPMALRDEVTSPGGTTIAALN
ALDECGFRNAWIQAVKSAVRRAEEMEER

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=274, Percent_Identity=39.051094890511, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI24797097, Length=274, Percent_Identity=39.051094890511, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI21361454, Length=274, Percent_Identity=37.956204379562, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI198041662, Length=271, Percent_Identity=32.8413284132841, Blast_Score=145, Evalue=3e-35,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=36.8421052631579, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=35.361216730038, Blast_Score=167, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17540664, Length=276, Percent_Identity=30.0724637681159, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=289, Percent_Identity=27.681660899654, Blast_Score=106, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=35.2059925093633, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24648116, Length=278, Percent_Identity=33.4532374100719, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24647700, Length=167, Percent_Identity=40.7185628742515, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27923; Mature: 27923

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGIIGLGKMGGALLRGMLKSGAAVPEEVWVYDHHHENVQALQEEYPGVHEAASEADAA
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHEEECCCCHHHHHHHHHCCCHHHHHHHHHHH
DAVEVLILAVKPHGVLPLISSLSERGAELPLLISIAAAVSLDDMEACASDGTRIIRAMPN
HHHHHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHCCCCEEEEECCC
TPCMVLAGVIAYSTGNGVKDEDEEAARMLLSGCGSVYKVAESGMNAVSAISGCGPAYMFT
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHH
ALDALADAGVAMGLSRKTALGLAAETMRGASLMLERTGKHPMALRDEVTSPGGTTIAALN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHH
ALDECGFRNAWIQAVKSAVRRAEEMEER
HHHHCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTGIIGLGKMGGALLRGMLKSGAAVPEEVWVYDHHHENVQALQEEYPGVHEAASEADAA
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHEEECCCCHHHHHHHHHCCCHHHHHHHHHHH
DAVEVLILAVKPHGVLPLISSLSERGAELPLLISIAAAVSLDDMEACASDGTRIIRAMPN
HHHHHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHCCCCEEEEECCC
TPCMVLAGVIAYSTGNGVKDEDEEAARMLLSGCGSVYKVAESGMNAVSAISGCGPAYMFT
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHH
ALDALADAGVAMGLSRKTALGLAAETMRGASLMLERTGKHPMALRDEVTSPGGTTIAALN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHH
ALDECGFRNAWIQAVKSAVRRAEEMEER
HHHHCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]