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The map label for this gene is rmlA1 [C]

Identifier: 187736401

GI number: 187736401

Start: 2330162

End: 2331073

Strand: Direct

Name: rmlA1 [C]

Synonym: Amuc_1919

Alternate gene names: 187736401

Gene position: 2330162-2331073 (Clockwise)

Preceding gene: 187736399

Following gene: 187736402

Centisome position: 87.47

GC content: 60.75

Gene sequence:

>912_bases
ATGCATATCACAGCAGGCCTCCGCATTTCCCGTGCGTTTATTCTCGGCGCCGGGCTGGGTACCCGCCTGCGCCCTCTCAC
CGGCATTCTGCCCAAGCCGCTGATTCCCTTTTTCCATGAGCCCCTTATTCTGCATTCCATGCGCCGATGCTACGATTGCG
GCATACGGGAGTTCATCATCAACACCCACCATCTGGCGGCAGCCTGGGACAAGGTGTTCCCTGAACATTCATGGAACGGC
TGCCCCGTTCATTTCAGCCATGAACCCGTGCTGCTGGATTCCGGCGGCGGCGTCAAAAAGATAGAGCCCCTGGCTTCCGC
GGAAGAACCGCTGCTGGTGGTGAACGGAGACATGGCGGCCACATTTGACCTGGGCCGCCTGCTGGAGGAGCATTTGAGCC
GCCGCCCTCCCGTAACGCTGGCCCTCCGCACTTCCGGAGACAAGAAGAACGTGGGATTTGATTTTTCTTCCGGCCTGGTG
ACGGATATGAGGCACGCCTTGGGCCGCGACCCCGGATCCTGCCAATTCACCGGCGCGTACTGTATGGAGCCGGAAATATT
CCGACGCATCCCTTCCGGGGAAGCCGTTTCCATTATTCCCCTGTTTCTGGATTATATCCGGGAAGGATGCCTGCGCGGCA
TTCTGGCGGACGACGGGTTGTGGATGGACATGGGAACACCGGAGGCCTATCTTCAAGCCCATCTGGATTTCCCATCCCCC
GCTCCGCGCATCCACCCCCGGGCCAGAGTGTCCCCCCGCGCCTTTGTGGACAGCCATTGCGTGATAGGCCCCGGAGCTGC
GGTAGAGGACGGTTGCCGCCTGCAAGGCTGCGTTGTCTGGCCGGGCGTATGCGTGCCTTCCGGCACTTGCGCGGAACGCC
GGATTTTCTATTGTTCCCCCACCGATTACTGA

Upstream 100 bases:

>100_bases
CTTTAAATTCGGGGAAGAGGCGGCATTCCGGCGTGTCATCCCGGAAAGAAGAGGATAAAGGGCGCTTGAAAAAAAGCCGC
TCACCCAGTAGTGATGTTCC

Downstream 100 bases:

>100_bases
CGATGCTTTTTCTGCGCCTGCTTCCCCTGATATTGTGCTTTTCCGGCCTGGTTCACGCAGAACACCGCGTCTTCACCAGG
AAGGACGGATTTTTGTCCAT

Product: Nucleotidyl transferase

Products: dTDPglucose; Diphosphate [C]

Alternate protein names: Mannose-1-Phosphate Guanyltransferase; Mannose-1-Phosphate Guanylyltransferase; Nucleotidyltransferase Family Protein; Nucleotidyl Transferase Family Protein; Nucleotide Phosphorylase; Nucleoside-Diphosphate-Sugar Pyrophosphorylase; Sugar-Phosphate Nucleotidyl Transferase; Nucleotidyl Transferase Family; Nucleotidyltransferase; Phosphoglucomutase/Phosphomannomutase Family Protein; Sugar-Phosphate Nucleotidyltransferase; Glucose-1-Phosphate Thymidylyltransferase; D-Alpha-D-Mannose-1-Phosphate Guanylyltransferase ManB; Aminoglycoside Phosphotransferase; NDP-Sugar Synthase; Nucleotidyl Transferase Superfamily; Mannose-1-Phosphate Guanyltransferase Related Protein; Sugar-Phosphate Nucleotydyl Transferase; Two-Component Fusion Protein; Phosphoglucomutase; Nucleotidyl Transferase Protein; Sugar Nucleotidyltransferase; Nucleoside-Diphosphate-Sugar Transferase; Glucose-1-Phosphate Nucleotidyltransferase; Sugar-Phosphate Nucleotydyltransferase; Phosphoglucomutase/Phosphomannomutase

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MHITAGLRISRAFILGAGLGTRLRPLTGILPKPLIPFFHEPLILHSMRRCYDCGIREFIINTHHLAAAWDKVFPEHSWNG
CPVHFSHEPVLLDSGGGVKKIEPLASAEEPLLVVNGDMAATFDLGRLLEEHLSRRPPVTLALRTSGDKKNVGFDFSSGLV
TDMRHALGRDPGSCQFTGAYCMEPEIFRRIPSGEAVSIIPLFLDYIREGCLRGILADDGLWMDMGTPEAYLQAHLDFPSP
APRIHPRARVSPRAFVDSHCVIGPGAAVEDGCRLQGCVVWPGVCVPSGTCAERRIFYCSPTDY

Sequences:

>Translated_303_residues
MHITAGLRISRAFILGAGLGTRLRPLTGILPKPLIPFFHEPLILHSMRRCYDCGIREFIINTHHLAAAWDKVFPEHSWNG
CPVHFSHEPVLLDSGGGVKKIEPLASAEEPLLVVNGDMAATFDLGRLLEEHLSRRPPVTLALRTSGDKKNVGFDFSSGLV
TDMRHALGRDPGSCQFTGAYCMEPEIFRRIPSGEAVSIIPLFLDYIREGCLRGILADDGLWMDMGTPEAYLQAHLDFPSP
APRIHPRARVSPRAFVDSHCVIGPGAAVEDGCRLQGCVVWPGVCVPSGTCAERRIFYCSPTDY
>Mature_303_residues
MHITAGLRISRAFILGAGLGTRLRPLTGILPKPLIPFFHEPLILHSMRRCYDCGIREFIINTHHLAAAWDKVFPEHSWNG
CPVHFSHEPVLLDSGGGVKKIEPLASAEEPLLVVNGDMAATFDLGRLLEEHLSRRPPVTLALRTSGDKKNVGFDFSSGLV
TDMRHALGRDPGSCQFTGAYCMEPEIFRRIPSGEAVSIIPLFLDYIREGCLRGILADDGLWMDMGTPEAYLQAHLDFPSP
APRIHPRARVSPRAFVDSHCVIGPGAAVEDGCRLQGCVVWPGVCVPSGTCAERRIFYCSPTDY

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Caenorhabditis elegans, GI133931050, Length=289, Percent_Identity=26.643598615917, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320148, Length=301, Percent_Identity=22.5913621262458, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355443, Length=293, Percent_Identity=26.2798634812287, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24644084, Length=293, Percent_Identity=26.2798634812287, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.7.24 [C]

Molecular weight: Translated: 33307; Mature: 33307

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHITAGLRISRAFILGAGLGTRLRPLTGILPKPLIPFFHEPLILHSMRRCYDCGIREFII
CEEECCCEEEEEEEEECCCCCCHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHCCHHHHHH
NTHHLAAAWDKVFPEHSWNGCPVHFSHEPVLLDSGGGVKKIEPLASAEEPLLVVNGDMAA
CCHHHHHHHHHHCCCCCCCCCEEEECCCCEEEECCCCCCEECCCCCCCCCEEEEECCCEE
TFDLGRLLEEHLSRRPPVTLALRTSGDKKNVGFDFSSGLVTDMRHALGRDPGSCQFTGAY
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECEE
CMEPEIFRRIPSGEAVSIIPLFLDYIREGCLRGILADDGLWMDMGTPEAYLQAHLDFPSP
ECCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCEECCCCEEEECCCCHHHHEEECCCCCC
APRIHPRARVSPRAFVDSHCVIGPGAAVEDGCRLQGCVVWPGVCVPSGTCAERRIFYCSP
CCCCCCCCCCCCHHHHCCCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEECC
TDY
CCC
>Mature Secondary Structure
MHITAGLRISRAFILGAGLGTRLRPLTGILPKPLIPFFHEPLILHSMRRCYDCGIREFII
CEEECCCEEEEEEEEECCCCCCHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHCCHHHHHH
NTHHLAAAWDKVFPEHSWNGCPVHFSHEPVLLDSGGGVKKIEPLASAEEPLLVVNGDMAA
CCHHHHHHHHHHCCCCCCCCCEEEECCCCEEEECCCCCCEECCCCCCCCCEEEEECCCEE
TFDLGRLLEEHLSRRPPVTLALRTSGDKKNVGFDFSSGLVTDMRHALGRDPGSCQFTGAY
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECEE
CMEPEIFRRIPSGEAVSIIPLFLDYIREGCLRGILADDGLWMDMGTPEAYLQAHLDFPSP
ECCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCEECCCCEEEECCCCHHHHEEECCCCCC
APRIHPRARVSPRAFVDSHCVIGPGAAVEDGCRLQGCVVWPGVCVPSGTCAERRIFYCSP
CCCCCCCCCCCCHHHHCCCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEECC
TDY
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dTTP; D-Glucose 1-phosphate; H+ [C]

Specific reaction: dTTP + D-Glucose 1-phosphate + H+ --> dTDPglucose + Diphosphate [C]

General reaction: Nucleotidyl group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA