Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is nagB [C]

Identifier: 187736309

GI number: 187736309

Start: 2212143

End: 2213054

Strand: Direct

Name: nagB [C]

Synonym: Amuc_1822

Alternate gene names: 187736309

Gene position: 2212143-2213054 (Clockwise)

Preceding gene: 187736306

Following gene: 187736310

Centisome position: 83.04

GC content: 55.37

Gene sequence:

>912_bases
ATGATCGGGGTGGAAAGTTCAAGGGTAATGCGGGCGGCTCCCAGAAAGGCCGTGGGAAGGGTGGAGGCCTCCGTTCCCTG
GGATTTTTCGCGCAAGTACGCCGCTGTGCATCATTCCGGGACTATTTCGGTTGAAAATGCCCGGAAACGAAGTAAAATAG
GGCGCGTTATGAAAGTAGAAACTTTTGAAACTCCCCAGGATGCTGCCAAGGCTTTGGCAGGAGAAGTTGCGGAATTGATC
CGTACGCGCGCCGCTGAAGGCAAAAACGTGGTTCTTGGCCTTGCCACGGGCGCCACTCCGCTGCCTTTTTACGCGGAGCT
GGTCCGCATGCATAAGGAGGAAGGCCTTTCCTTTGCCAACGTGATTTCCTTCAATCTGGACGAATACAGCGGCTTGGATC
GCGACCATCCGGAATCCTACTGGTACTTCATGCACACGAATCTTTTCAACCACATCGACATCAAGCCGGAAAACATCAAC
CTGCCCTCCGGCACGGTGAAGGATGATGAAATTGCCGCCCACTGCGCCGCCTATGAACAAAAGATCAAGGATTGCGGCGG
TATCGACCTCCAGATTCTCGGCATTGGCCGAACTGGCCATATCGGCTTTAACGAACCCGGCTCCGATGATACCACCGTCA
CCCGGCAGGTTCATCTGGACGAACTGACCCGTTCCGATGCTGCTCCCGCTTTCGGCGGTATTGAAAATGTTCCCACCACC
GCCATTACCATGGGCGTGGCTACCATCATGGGCGCCCGTGAAGTGGCTTTGATGGCCTGGGGAGAAAAGAAGGCGTCCAT
CGTGAAAAAGGCTGTTCAGGGGCCTGTGACGGTGGATGTGGCCGCCTCCTACCTTCAGAAGCATCCGAACGCCAAGTTTC
TTCTGGACAAGGGGGCTGCTTCCCTCCTTTAA

Upstream 100 bases:

>100_bases
AAAATTTTGCGCACTTCCGTGCCGTAAACCCAGTCGTGCCCTTGAAAAATGCGTGCTCTTGGAGAAATAATCAAACCTGC
CATGTCAGGAAAGGCAATAC

Downstream 100 bases:

>100_bases
TTTTACGTTTTAGTAACGGAAATGCCGTCTTTCCCGGTTTCGTGGAAAGGCGGCGTTTTTTATGGGGTGAAGGAAGGCGG
AAGCTTCTTCTTTCCATGGA

Product: glucosamine-6-phosphate isomerase

Products: D-fructose 6-phosphate; NH3

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MIGVESSRVMRAAPRKAVGRVEASVPWDFSRKYAAVHHSGTISVENARKRSKIGRVMKVETFETPQDAAKALAGEVAELI
RTRAAEGKNVVLGLATGATPLPFYAELVRMHKEEGLSFANVISFNLDEYSGLDRDHPESYWYFMHTNLFNHIDIKPENIN
LPSGTVKDDEIAAHCAAYEQKIKDCGGIDLQILGIGRTGHIGFNEPGSDDTTVTRQVHLDELTRSDAAPAFGGIENVPTT
AITMGVATIMGAREVALMAWGEKKASIVKKAVQGPVTVDVAASYLQKHPNAKFLLDKGAASLL

Sequences:

>Translated_303_residues
MIGVESSRVMRAAPRKAVGRVEASVPWDFSRKYAAVHHSGTISVENARKRSKIGRVMKVETFETPQDAAKALAGEVAELI
RTRAAEGKNVVLGLATGATPLPFYAELVRMHKEEGLSFANVISFNLDEYSGLDRDHPESYWYFMHTNLFNHIDIKPENIN
LPSGTVKDDEIAAHCAAYEQKIKDCGGIDLQILGIGRTGHIGFNEPGSDDTTVTRQVHLDELTRSDAAPAFGGIENVPTT
AITMGVATIMGAREVALMAWGEKKASIVKKAVQGPVTVDVAASYLQKHPNAKFLLDKGAASLL
>Mature_303_residues
MIGVESSRVMRAAPRKAVGRVEASVPWDFSRKYAAVHHSGTISVENARKRSKIGRVMKVETFETPQDAAKALAGEVAELI
RTRAAEGKNVVLGLATGATPLPFYAELVRMHKEEGLSFANVISFNLDEYSGLDRDHPESYWYFMHTNLFNHIDIKPENIN
LPSGTVKDDEIAAHCAAYEQKIKDCGGIDLQILGIGRTGHIGFNEPGSDDTTVTRQVHLDELTRSDAAPAFGGIENVPTT
AITMGVATIMGAREVALMAWGEKKASIVKKAVQGPVTVDVAASYLQKHPNAKFLLDKGAASLL

Specific function: Catalyzes The Reversible Isomerization-Deamination Of Glucosamine 6-Phosphate (Glcn6p) To Form Fructose 6-Phosphate (Fru6p) And Ammonium Ion. [C]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923881, Length=247, Percent_Identity=41.2955465587045, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI13027378, Length=229, Percent_Identity=44.9781659388646, Blast_Score=175, Evalue=5e-44,
Organism=Escherichia coli, GI1786893, Length=243, Percent_Identity=40.7407407407407, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789530, Length=227, Percent_Identity=28.6343612334802, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI48994958, Length=207, Percent_Identity=30.9178743961353, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17554876, Length=244, Percent_Identity=43.4426229508197, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24581960, Length=245, Percent_Identity=40, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI19920764, Length=245, Percent_Identity=40, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR003737
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso; PF02585 PIG-L [H]

EC number: 3.5.99.6

Molecular weight: Translated: 32840; Mature: 32840

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGVESSRVMRAAPRKAVGRVEASVPWDFSRKYAAVHHSGTISVENARKRSKIGRVMKVE
CCCCCCCHHHHHCCHHHHHCCCCCCCCCCCCCEEEEECCCEEEEHHHHHHHHHCCEEEEE
TFETPQDAAKALAGEVAELIRTRAAEGKNVVLGLATGATPLPFYAELVRMHKEEGLSFAN
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEH
VISFNLDEYSGLDRDHPESYWYFMHTNLFNHIDIKPENINLPSGTVKDDEIAAHCAAYEQ
EEEECCHHHCCCCCCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
KIKDCGGIDLQILGIGRTGHIGFNEPGSDDTTVTRQVHLDELTRSDAAPAFGGIENVPTT
HHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCHH
AITMGVATIMGAREVALMAWGEKKASIVKKAVQGPVTVDVAASYLQKHPNAKFLLDKGAA
HHHHHHHHHHCHHHEEEEECCCHHHHHHHHHHCCCEEHHHHHHHHHHCCCCEEEEECCHH
SLL
HCC
>Mature Secondary Structure
MIGVESSRVMRAAPRKAVGRVEASVPWDFSRKYAAVHHSGTISVENARKRSKIGRVMKVE
CCCCCCCHHHHHCCHHHHHCCCCCCCCCCCCCEEEEECCCEEEEHHHHHHHHHCCEEEEE
TFETPQDAAKALAGEVAELIRTRAAEGKNVVLGLATGATPLPFYAELVRMHKEEGLSFAN
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEH
VISFNLDEYSGLDRDHPESYWYFMHTNLFNHIDIKPENINLPSGTVKDDEIAAHCAAYEQ
EEEECCHHHCCCCCCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
KIKDCGGIDLQILGIGRTGHIGFNEPGSDDTTVTRQVHLDELTRSDAAPAFGGIENVPTT
HHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCHH
AITMGVATIMGAREVALMAWGEKKASIVKKAVQGPVTVDVAASYLQKHPNAKFLLDKGAA
HHHHHHHHHHCHHHEEEEECCCHHHHHHHHHHCCCEEHHHHHHHHHHCCCCEEEEECCHH
SLL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glucosamine 6-phosphate; H2O

Specific reaction: D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3

General reaction: Group transfer (transmolecular Intramolecular oxidoreduction) [C]

Inhibitor: N3-(4-Methoxyfumaroyl)-L-2, 3-diaminopropanoic acid [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]