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The map label for this gene is srrA [H]

Identifier: 187736215

GI number: 187736215

Start: 2110233

End: 2110937

Strand: Reverse

Name: srrA [H]

Synonym: Amuc_1728

Alternate gene names: 187736215

Gene position: 2110937-2110233 (Counterclockwise)

Preceding gene: 187736216

Following gene: 187736214

Centisome position: 79.24

GC content: 63.26

Gene sequence:

>705_bases
ATGAGTGATTCAGCCTATACCATTCTGATTGCGGAGGACGACGACAGCATCAGGCATGCCCTGACGGACGTTCTGACCGC
ATCCGGCTACGAAGTGCTGGCTCTGGAAGAAGGCCTGGCCGCCATCCATGCCGTGCGGGAACGCAATTTCGACCTCGCCC
TGCTGGACGTGGCCATGCCGGGCGCGGACGGATTCCAGGTGCTGCAGGTCATGTCTGAGGAACGCCCCGGAACGCCTGTC
ATCATGCTCACGGCCCGTGGAGAGGAGGAAGACCGCGTGCAGGGGCTCAAGCTGGGGGCGGACGACTATATTGTCAAACC
GTTCAGCATCCGGGAACTGCTCGCCCGCATCGAGGCCGTTCTGCGCAGGTCTCCGGAACGGCCGCGCCAGCTCCGGGAAA
TCAGGATCCCCGGCGCCACCCTGGACAGCGCCAACCGCCTGATCACCTTTAAAGACGGGAGGGAAACCTCCCTGACCGCG
CGGGAATTCGAATTCCTCACCTATATGGCCACCCACCCCAACCGCGTTATCACGAGGGACGAACTGCTCCGGCGCGTATG
GGACGTGGACCCGCGCCTGACGGATACGCGCTCCGTGGAAATGACCGTCATGCGTCTCCGGGACAAGCTCGGGGCCGCCT
CCGCCTCCCCCCTGGAGACGCTTAGAAGCCAGGGCTACCGCTGGAATTCATCCTTCGTTTCCTGA

Upstream 100 bases:

>100_bases
CCCCCCCCCCGGGAAGACGGCCTGTTATGGCATTGTTACTGAAAGGGCGCAGGTTTCTCTATACAACAGGGGAAATATTG
TGGTTTTATAGAATCAAACG

Downstream 100 bases:

>100_bases
TCCGTGAACCGGCGCATACGCATCATTCTGCTGGCAATCAGCCTGCTGCTGGTCATCGGCACGCTCGGATGGCTCACCCA
TGTTCTGCTGGTGCAGGCGG

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MSDSAYTILIAEDDDSIRHALTDVLTASGYEVLALEEGLAAIHAVRERNFDLALLDVAMPGADGFQVLQVMSEERPGTPV
IMLTARGEEEDRVQGLKLGADDYIVKPFSIRELLARIEAVLRRSPERPRQLREIRIPGATLDSANRLITFKDGRETSLTA
REFEFLTYMATHPNRVITRDELLRRVWDVDPRLTDTRSVEMTVMRLRDKLGAASASPLETLRSQGYRWNSSFVS

Sequences:

>Translated_234_residues
MSDSAYTILIAEDDDSIRHALTDVLTASGYEVLALEEGLAAIHAVRERNFDLALLDVAMPGADGFQVLQVMSEERPGTPV
IMLTARGEEEDRVQGLKLGADDYIVKPFSIRELLARIEAVLRRSPERPRQLREIRIPGATLDSANRLITFKDGRETSLTA
REFEFLTYMATHPNRVITRDELLRRVWDVDPRLTDTRSVEMTVMRLRDKLGAASASPLETLRSQGYRWNSSFVS
>Mature_233_residues
SDSAYTILIAEDDDSIRHALTDVLTASGYEVLALEEGLAAIHAVRERNFDLALLDVAMPGADGFQVLQVMSEERPGTPVI
MLTARGEEEDRVQGLKLGADDYIVKPFSIRELLARIEAVLRRSPERPRQLREIRIPGATLDSANRLITFKDGRETSLTAR
EFEFLTYMATHPNRVITRDELLRRVWDVDPRLTDTRSVEMTVMRLRDKLGAASASPLETLRSQGYRWNSSFVS

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=233, Percent_Identity=39.9141630901288, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=34.0909090909091, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=36.4864864864865, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=35.0877192982456, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.5132743362832, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.920704845815, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=29.6943231441048, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.1578947368421, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=29.5454545454545, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=32.1266968325792, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=31.4159292035398, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=32.1428571428571, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=29.3103448275862, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788550, Length=128, Percent_Identity=34.375, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1790299, Length=135, Percent_Identity=32.5925925925926, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790437, Length=124, Percent_Identity=36.2903225806452, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1788713, Length=144, Percent_Identity=31.25, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788905, Length=124, Percent_Identity=30.6451612903226, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26390; Mature: 26259

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSAYTILIAEDDDSIRHALTDVLTASGYEVLALEEGLAAIHAVRERNFDLALLDVAMP
CCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEEECC
GADGFQVLQVMSEERPGTPVIMLTARGEEEDRVQGLKLGADDYIVKPFSIRELLARIEAV
CCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCEEECCCCEEECCHHHHHHHHHHHHH
LRRSPERPRQLREIRIPGATLDSANRLITFKDGRETSLTAREFEFLTYMATHPNRVITRD
HHCCCCCCHHHHEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHEEECCCCCEECHH
ELLRRVWDVDPRLTDTRSVEMTVMRLRDKLGAASASPLETLRSQGYRWNSSFVS
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SDSAYTILIAEDDDSIRHALTDVLTASGYEVLALEEGLAAIHAVRERNFDLALLDVAMP
CCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEEECC
GADGFQVLQVMSEERPGTPVIMLTARGEEEDRVQGLKLGADDYIVKPFSIRELLARIEAV
CCCHHHHHHHHHCCCCCCCEEEEEECCCCHHHHCCEEECCCCEEECCHHHHHHHHHHHHH
LRRSPERPRQLREIRIPGATLDSANRLITFKDGRETSLTAREFEFLTYMATHPNRVITRD
HHCCCCCCHHHHEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHEEECCCCCEECHH
ELLRRVWDVDPRLTDTRSVEMTVMRLRDKLGAASASPLETLRSQGYRWNSSFVS
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA