Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is lpd [H]

Identifier: 187736176

GI number: 187736176

Start: 2053033

End: 2054421

Strand: Direct

Name: lpd [H]

Synonym: Amuc_1689

Alternate gene names: 187736176

Gene position: 2053033-2054421 (Clockwise)

Preceding gene: 187736175

Following gene: 187736177

Centisome position: 77.06

GC content: 59.25

Gene sequence:

>1389_bases
ATGCAATATGATCTTATCGTCATTGGTGGAGGCCCTGCCGGCTATGTGGGCGCCATCCGCGCCGCCCAGCTGGGGAAATC
CGTGGTGTGCGTGGAACGCGACCGGGTGGGGGGCACCTGTCTGAACTGGGGATGCATCCCCACCAAGGCGCTTCTGAAAA
ATGCGGAGGCCTACCGGATCGTGACGGACCGCGCCAGGGAATTCGGCATGATGGTGGAGGGCGTCAGCGTGGATTGGAGT
GAAGTGATCGGCCGTTCCCGCAAGGTCAGCGACCGCCTGGCAGGCGGCGTGGGGTTCCTCTTCAAGAAAAACAAGGTGGA
TTCCGTTACGGGGGAAGCCTCCATCATTTCCCCCGGCAGGGTGGAAGTAAAGGCCGCCGACGGAACGGTGAATGTTCTGG
AGGGAAAGAATATCCTGATCTGTACCGGCTGCGTCACCCGCACGGTGCCCAGCCTTCCCCTGAACGGCACTACTGTCATC
GGCTCCAGGGAAGCCATGGTGCTGGAAAAGCGGCCTGAAAGCATGATCATCATCGGTTCCGGAGCTATCGGCACGGAATT
TGCCTACATTTACAATTCATTCGGCACCAGGGTGACGCTTATTGAAGCGCTTCCCCGGATGCTTCCCAATGAAGACGACG
ACTCCTGCATGACGCTGGAACGGGCATTCAAGAAGCAGGGCATCAAGGTGATGACGGGAGCTTCCGTGGAATCCGTCACG
GAAACCTGTGACGGACAGGTCAGGGCCAACGTGAAAAACAGCAGGGGACAGGAAGAGGAAATCACGGCGGACGTCTGCCT
GGTGGCCATCGGCGTGAAGCCGGTCGTTCCCGCCGCTCCCGGCCTGGAATTGACGGAAAAGGGATTCATCAAGGTGAATG
ACCGCTATGCGACTTCCATTCCCGGCGTTTATGCGGCAGGCGACGTGATCGGCGGCGTGCTGCTGGCGCATACGGCTTCT
TTTGAAGCTGTCCAGGCTGTGGAGGGCATGTTTAATCCGGACTACCAGCCCCGGCAGGTCGGCTTCTTCCCGAGCTGCAC
GTACTGCTACCCTCAGGTGGCTTCCGTAGGTAAAACGGAACGCGCCCTCAAGGAAGCGGGCGTGGAATACAAGGTGGGGA
AATTCCCCTTCCAGGCCATTGGCAAGGCTGTAGCCGCCGGAGAGCCGGACGGCTTCGTGAAAACCCTGTACGGCGCCAAA
AACGGAGAATTGCTGGGTGCCCATATCGTGGGGCCGGAAGCCACGGAACTGATTGCCGCGCTGGGCATCGGCATTCAGGC
GGAACTGACGGATGAAGATATCCACGCCACCATTTTCGCCCATCCCACGCTGTCTGAGGCCATTCATGAATCCATGCTGG
CTTCCGAGGGGATTGCCATTCACATGTAA

Upstream 100 bases:

>100_bases
ATCTCTGGGTCCTTACCTCTGCTATCTGTCGGCCTCCCGAACCGGCGCATGCTCATATTCCTTCTTTACCCGCAAGGGGG
GATGCCTTTATAGTAATTTC

Downstream 100 bases:

>100_bases
CGGTTTTCACGGGAAGAGCCCCGCAACGGGGCTCTTTTTCTCCATTAAAAAAGATGAACGATAACCTGCGCTGGAAACAA
AGGCTTCAAAACCTGAATAA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MQYDLIVIGGGPAGYVGAIRAAQLGKSVVCVERDRVGGTCLNWGCIPTKALLKNAEAYRIVTDRAREFGMMVEGVSVDWS
EVIGRSRKVSDRLAGGVGFLFKKNKVDSVTGEASIISPGRVEVKAADGTVNVLEGKNILICTGCVTRTVPSLPLNGTTVI
GSREAMVLEKRPESMIIIGSGAIGTEFAYIYNSFGTRVTLIEALPRMLPNEDDDSCMTLERAFKKQGIKVMTGASVESVT
ETCDGQVRANVKNSRGQEEEITADVCLVAIGVKPVVPAAPGLELTEKGFIKVNDRYATSIPGVYAAGDVIGGVLLAHTAS
FEAVQAVEGMFNPDYQPRQVGFFPSCTYCYPQVASVGKTERALKEAGVEYKVGKFPFQAIGKAVAAGEPDGFVKTLYGAK
NGELLGAHIVGPEATELIAALGIGIQAELTDEDIHATIFAHPTLSEAIHESMLASEGIAIHM

Sequences:

>Translated_462_residues
MQYDLIVIGGGPAGYVGAIRAAQLGKSVVCVERDRVGGTCLNWGCIPTKALLKNAEAYRIVTDRAREFGMMVEGVSVDWS
EVIGRSRKVSDRLAGGVGFLFKKNKVDSVTGEASIISPGRVEVKAADGTVNVLEGKNILICTGCVTRTVPSLPLNGTTVI
GSREAMVLEKRPESMIIIGSGAIGTEFAYIYNSFGTRVTLIEALPRMLPNEDDDSCMTLERAFKKQGIKVMTGASVESVT
ETCDGQVRANVKNSRGQEEEITADVCLVAIGVKPVVPAAPGLELTEKGFIKVNDRYATSIPGVYAAGDVIGGVLLAHTAS
FEAVQAVEGMFNPDYQPRQVGFFPSCTYCYPQVASVGKTERALKEAGVEYKVGKFPFQAIGKAVAAGEPDGFVKTLYGAK
NGELLGAHIVGPEATELIAALGIGIQAELTDEDIHATIFAHPTLSEAIHESMLASEGIAIHM
>Mature_462_residues
MQYDLIVIGGGPAGYVGAIRAAQLGKSVVCVERDRVGGTCLNWGCIPTKALLKNAEAYRIVTDRAREFGMMVEGVSVDWS
EVIGRSRKVSDRLAGGVGFLFKKNKVDSVTGEASIISPGRVEVKAADGTVNVLEGKNILICTGCVTRTVPSLPLNGTTVI
GSREAMVLEKRPESMIIIGSGAIGTEFAYIYNSFGTRVTLIEALPRMLPNEDDDSCMTLERAFKKQGIKVMTGASVESVT
ETCDGQVRANVKNSRGQEEEITADVCLVAIGVKPVVPAAPGLELTEKGFIKVNDRYATSIPGVYAAGDVIGGVLLAHTAS
FEAVQAVEGMFNPDYQPRQVGFFPSCTYCYPQVASVGKTERALKEAGVEYKVGKFPFQAIGKAVAAGEPDGFVKTLYGAK
NGELLGAHIVGPEATELIAALGIGIQAELTDEDIHATIFAHPTLSEAIHESMLASEGIAIHM

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=466, Percent_Identity=39.6995708154506, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=26.304347826087, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=26.6375545851528, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI33519430, Length=462, Percent_Identity=23.3766233766234, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI33519428, Length=462, Percent_Identity=23.3766233766234, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI33519426, Length=462, Percent_Identity=23.3766233766234, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI148277065, Length=462, Percent_Identity=23.3766233766234, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI148277071, Length=462, Percent_Identity=23.3766233766234, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI291045266, Length=486, Percent_Identity=23.2510288065844, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786307, Length=458, Percent_Identity=31.6593886462882, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=27.9735682819383, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI87081717, Length=471, Percent_Identity=28.2377919320594, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI1789915, Length=436, Percent_Identity=26.3761467889908, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=36.0691144708423, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17557007, Length=480, Percent_Identity=25.8333333333333, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71983429, Length=462, Percent_Identity=26.1904761904762, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71983419, Length=462, Percent_Identity=26.1904761904762, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=23.75, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=476, Percent_Identity=37.6050420168067, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6325240, Length=467, Percent_Identity=27.4089935760171, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=27.2532188841202, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=38.3116883116883, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24640553, Length=480, Percent_Identity=26.6666666666667, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24640549, Length=480, Percent_Identity=26.6666666666667, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24640551, Length=479, Percent_Identity=26.7223382045929, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=24.6315789473684, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48952; Mature: 48952

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYDLIVIGGGPAGYVGAIRAAQLGKSVVCVERDRVGGTCLNWGCIPTKALLKNAEAYRI
CCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHHCCCCEEEE
VTDRAREFGMMVEGVSVDWSEVIGRSRKVSDRLAGGVGFLFKKNKVDSVTGEASIISPGR
HHHHHHHCCEEEECCCCCHHHHHCCCHHHHHHHCCCEEEEEECCCCCCCCCCEEEECCCE
VEVKAADGTVNVLEGKNILICTGCVTRTVPSLPLNGTTVIGSREAMVLEKRPESMIIIGS
EEEEECCCEEEEECCCCEEEECCHHHHCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEC
GAIGTEFAYIYNSFGTRVTLIEALPRMLPNEDDDSCMTLERAFKKQGIKVMTGASVESVT
CCCCHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHH
ETCDGQVRANVKNSRGQEEEITADVCLVAIGVKPVVPAAPGLELTEKGFIKVNDRYATSI
HHCCCEEEECCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCEEECCCEECCC
PGVYAAGDVIGGVLLAHTASFEAVQAVEGMFNPDYQPRQVGFFPSCTYCYPQVASVGKTE
CCCEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEECCCCCCHHHCHHHHHCCHHH
RALKEAGVEYKVGKFPFQAIGKAVAAGEPDGFVKTLYGAKNGELLGAHIVGPEATELIAA
HHHHHCCCEEEECCCCHHHHHHHHHCCCCCCHHHHECCCCCCCEEEEEECCCCHHHHHHH
LGIGIQAELTDEDIHATIFAHPTLSEAIHESMLASEGIAIHM
HCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEC
>Mature Secondary Structure
MQYDLIVIGGGPAGYVGAIRAAQLGKSVVCVERDRVGGTCLNWGCIPTKALLKNAEAYRI
CCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHHCCCCEEEE
VTDRAREFGMMVEGVSVDWSEVIGRSRKVSDRLAGGVGFLFKKNKVDSVTGEASIISPGR
HHHHHHHCCEEEECCCCCHHHHHCCCHHHHHHHCCCEEEEEECCCCCCCCCCEEEECCCE
VEVKAADGTVNVLEGKNILICTGCVTRTVPSLPLNGTTVIGSREAMVLEKRPESMIIIGS
EEEEECCCEEEEECCCCEEEECCHHHHCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEC
GAIGTEFAYIYNSFGTRVTLIEALPRMLPNEDDDSCMTLERAFKKQGIKVMTGASVESVT
CCCCHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHH
ETCDGQVRANVKNSRGQEEEITADVCLVAIGVKPVVPAAPGLELTEKGFIKVNDRYATSI
HHCCCEEEECCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCEEECCCEECCC
PGVYAAGDVIGGVLLAHTASFEAVQAVEGMFNPDYQPRQVGFFPSCTYCYPQVASVGKTE
CCCEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEECCCCCCHHHCHHHHHCCHHH
RALKEAGVEYKVGKFPFQAIGKAVAAGEPDGFVKTLYGAKNGELLGAHIVGPEATELIAA
HHHHHCCCEEEECCCCHHHHHHHHHCCCCCCHHHHECCCCCCCEEEEEECCCCHHHHHHH
LGIGIQAELTDEDIHATIFAHPTLSEAIHESMLASEGIAIHM
HCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]