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The map label for this gene is mtaD [H]

Identifier: 187736175

GI number: 187736175

Start: 2051564

End: 2052886

Strand: Direct

Name: mtaD [H]

Synonym: Amuc_1688

Alternate gene names: 187736175

Gene position: 2051564-2052886 (Clockwise)

Preceding gene: 187736173

Following gene: 187736176

Centisome position: 77.01

GC content: 60.54

Gene sequence:

>1323_bases
ATGGAACAACAAGCGTGTGATTTGCTGGTGACCGCTTCCCGCATGCTGGGCGGAGCGGAACAGTCCGTTGCTCCCGGGGA
TGCGGCCGTCGCCGTCCGGGACGGGAAAATTCTGGAAACGGGAAGCGCCGCAGAACTGGAGGCCAGGTGGAGGCCCGCCG
TCCGCAGGAATTTGGGGAATGTGCTGCTGATGCCGGGGCTTATTAATGCCCATACGCATGTCCCCATGACCTTTTTGCGC
GGTTTTGCGGATGACTTGCCGCTGATGGAATGGCTGACCGGACATATTTTCCCAGTGGAAGCCCGGCTGACGGATAAAAT
CGTCTCCCTGGGGGCCCGGCTGGGCATGTATGAAATGATGCGGACGGGCACCACGGCATTTGTAGATTCCTACCTGTTGG
AAGCCAACGTTCTCCAGGAGGCGGAACGCATGGGAATGCGCTGTGTGGGCGGAGAGGTTGTTTTTGCCTTTCCCTCTCCG
GCGTACGGCGGGTGGGACGGTGCGGAAGCCCTGTACCGGGAGCAGGCGGAGCGCTTTTCCGGCCGCGGCAGGGTACAGGT
GGCCCTGATGCCGCACAGCGTGTACACCACCAGTGACGAAGTGCTCCGGCGTTCCATGAAGCTGGCGGAGGAACTGGACC
TGATGCTGCATATCCATTTGTCCGAATCCGCCGGGGAAGTGGAGCAGTGCCGTTCCCTGCACGGGGGCAGGCGTCCCGTA
GGCTATGCCCGTGATATGGGGCTGCTGAATGAACGCTCCGTGCTGGCCCATATGGTGGACGTGACGGATGAGGAACTGGA
ACTGGTGGCCGCTTCCGGAGCGGCGGTTGTCCATAACCCGGTCAGCAACCTGAAACTGGCATCCGGCTTCGCCCGCGTGC
GGGATATGGTGCGGGCCGGCGTTCCCGTCTCTCTGGGAACGGACGGAGCGTGCAGCAACAACAGTCTGGACATGTTTGAA
ACAATGAAGCTGGCCGCTATTCTTGCCAAGGGGTACAGCGGGGACGCTACCGCGGTCCCCGCCATGCAGGCGTTGAAGAT
GGCGACGGAGGAGGGCGCCCGCATTTTCCGGACGCCGGGGCTGGGAACACTGGTTCCGGGGGCTCCCGCGGATATGATCG
CCCTGAACCTGGATGAACCGAACCTGTGCCCGATTTTCAACGAAACGTCCCATGCCGTTTATGCCTCTTCCGGCAAGGAT
TGCGTGTTCACCATGGTGGAAGGGAGAATTTTGTATGATCATGGAATTTACACGGACGGCCTGTATGCGGATACCGCCGC
GGAAATGCGGGATCTGGTAAAGTGGGTGAAGAATAGTGATTGA

Upstream 100 bases:

>100_bases
TCTCTTTTGAAGTCAAACATGAAATGTCAAATGGATGCGAAATCCCCGAGCCGAGGAGATGAAGTTGCCAGAACCCTCCC
GCTGGGGTACATTCTGCGCC

Downstream 100 bases:

>100_bases
GTATTGAGGATGAGCGAATAAAGGCAGGTTCTCAACACATGCTTTAATCTCTGGGTCCTTACCTCTGCTATCTGTCGGCC
TCCCGAACCGGCGCATGCTC

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MEQQACDLLVTASRMLGGAEQSVAPGDAAVAVRDGKILETGSAAELEARWRPAVRRNLGNVLLMPGLINAHTHVPMTFLR
GFADDLPLMEWLTGHIFPVEARLTDKIVSLGARLGMYEMMRTGTTAFVDSYLLEANVLQEAERMGMRCVGGEVVFAFPSP
AYGGWDGAEALYREQAERFSGRGRVQVALMPHSVYTTSDEVLRRSMKLAEELDLMLHIHLSESAGEVEQCRSLHGGRRPV
GYARDMGLLNERSVLAHMVDVTDEELELVAASGAAVVHNPVSNLKLASGFARVRDMVRAGVPVSLGTDGACSNNSLDMFE
TMKLAAILAKGYSGDATAVPAMQALKMATEEGARIFRTPGLGTLVPGAPADMIALNLDEPNLCPIFNETSHAVYASSGKD
CVFTMVEGRILYDHGIYTDGLYADTAAEMRDLVKWVKNSD

Sequences:

>Translated_440_residues
MEQQACDLLVTASRMLGGAEQSVAPGDAAVAVRDGKILETGSAAELEARWRPAVRRNLGNVLLMPGLINAHTHVPMTFLR
GFADDLPLMEWLTGHIFPVEARLTDKIVSLGARLGMYEMMRTGTTAFVDSYLLEANVLQEAERMGMRCVGGEVVFAFPSP
AYGGWDGAEALYREQAERFSGRGRVQVALMPHSVYTTSDEVLRRSMKLAEELDLMLHIHLSESAGEVEQCRSLHGGRRPV
GYARDMGLLNERSVLAHMVDVTDEELELVAASGAAVVHNPVSNLKLASGFARVRDMVRAGVPVSLGTDGACSNNSLDMFE
TMKLAAILAKGYSGDATAVPAMQALKMATEEGARIFRTPGLGTLVPGAPADMIALNLDEPNLCPIFNETSHAVYASSGKD
CVFTMVEGRILYDHGIYTDGLYADTAAEMRDLVKWVKNSD
>Mature_440_residues
MEQQACDLLVTASRMLGGAEQSVAPGDAAVAVRDGKILETGSAAELEARWRPAVRRNLGNVLLMPGLINAHTHVPMTFLR
GFADDLPLMEWLTGHIFPVEARLTDKIVSLGARLGMYEMMRTGTTAFVDSYLLEANVLQEAERMGMRCVGGEVVFAFPSP
AYGGWDGAEALYREQAERFSGRGRVQVALMPHSVYTTSDEVLRRSMKLAEELDLMLHIHLSESAGEVEQCRSLHGGRRPV
GYARDMGLLNERSVLAHMVDVTDEELELVAASGAAVVHNPVSNLKLASGFARVRDMVRAGVPVSLGTDGACSNNSLDMFE
TMKLAAILAKGYSGDATAVPAMQALKMATEEGARIFRTPGLGTLVPGAPADMIALNLDEPNLCPIFNETSHAVYASSGKD
CVFTMVEGRILYDHGIYTDGLYADTAAEMRDLVKWVKNSD

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=378, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1789249, Length=375, Percent_Identity=28, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540282, Length=360, Percent_Identity=25.2777777777778, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319963, Length=345, Percent_Identity=25.7971014492754, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643849, Length=417, Percent_Identity=27.8177458033573, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 47596; Mature: 47596

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQQACDLLVTASRMLGGAEQSVAPGDAAVAVRDGKILETGSAAELEARWRPAVRRNLGN
CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEECCCCCHHHHHCCHHHHHCCCC
VLLMPGLINAHTHVPMTFLRGFADDLPLMEWLTGHIFPVEARLTDKIVSLGARLGMYEMM
EEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHH
RTGTTAFVDSYLLEANVLQEAERMGMRCVGGEVVFAFPSPAYGGWDGAEALYREQAERFS
HCCCHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHC
GRGRVQVALMPHSVYTTSDEVLRRSMKLAEELDLMLHIHLSESAGEVEQCRSLHGGRRPV
CCCEEEEEEECCCEECCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHCCCCCCC
GYARDMGLLNERSVLAHMVDVTDEELELVAASGAAVVHNPVSNLKLASGFARVRDMVRAG
CHHHHCCCCCHHHHHHHHHHCCCCHHHEEEECCCEEEECCHHHHHHHHHHHHHHHHHHCC
VPVSLGTDGACSNNSLDMFETMKLAAILAKGYSGDATAVPAMQALKMATEEGARIFRTPG
CCEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCC
LGTLVPGAPADMIALNLDEPNLCPIFNETSHAVYASSGKDCVFTMVEGRILYDHGIYTDG
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCEEEEEECCEEEEECCCCCCC
LYADTAAEMRDLVKWVKNSD
CCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEQQACDLLVTASRMLGGAEQSVAPGDAAVAVRDGKILETGSAAELEARWRPAVRRNLGN
CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEECCCCCHHHHHCCHHHHHCCCC
VLLMPGLINAHTHVPMTFLRGFADDLPLMEWLTGHIFPVEARLTDKIVSLGARLGMYEMM
EEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHH
RTGTTAFVDSYLLEANVLQEAERMGMRCVGGEVVFAFPSPAYGGWDGAEALYREQAERFS
HCCCHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHC
GRGRVQVALMPHSVYTTSDEVLRRSMKLAEELDLMLHIHLSESAGEVEQCRSLHGGRRPV
CCCEEEEEEECCCEECCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHCCCCCCC
GYARDMGLLNERSVLAHMVDVTDEELELVAASGAAVVHNPVSNLKLASGFARVRDMVRAG
CHHHHCCCCCHHHHHHHHHHCCCCHHHEEEECCCEEEECCHHHHHHHHHHHHHHHHHHCC
VPVSLGTDGACSNNSLDMFETMKLAAILAKGYSGDATAVPAMQALKMATEEGARIFRTPG
CCEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCC
LGTLVPGAPADMIALNLDEPNLCPIFNETSHAVYASSGKDCVFTMVEGRILYDHGIYTDG
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCEEEEEECCEEEEECCCCCCC
LYADTAAEMRDLVKWVKNSD
CCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA