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The map label for this gene is nuoL [H]

Identifier: 187736095

GI number: 187736095

Start: 1931075

End: 1932907

Strand: Reverse

Name: nuoL [H]

Synonym: Amuc_1606

Alternate gene names: 187736095

Gene position: 1932907-1931075 (Counterclockwise)

Preceding gene: 187736096

Following gene: 187736094

Centisome position: 72.55

GC content: 58.32

Gene sequence:

>1833_bases
ATGTTCAATATTGATATTCAATACACCTGGCTTCTGCTCTTCCTGCCGCTGGTCGTAGCCGCCTTTGACTGGTTCCTGCT
GACCAAACGTCCTGACGTCGCAGCCCTCACCTCCACCTTCTCCTGCCTGGCGACCTTCGTCCTTTCCCTGGGTCTGCTGG
ACCGGACCGGATCCGATTCCTTCTCCTGGCTCCCGATTTCCGACATCTCTTCCGTGGACCTGGGTTTCGTGCTGGATCCC
CTTTCCTCCCGCATGATGCTGGTGGTCACGGGCATCGGCCTGCTGGTCCATGTTTTCTCTCTGGGTTACATGGCGGACGA
CAAGGCCAAAACACGCTACTTCGCATGCCTGAGCCTTTTCATGTTCTCCATGACGGGCATCGTCCTGGCGAACAACATCG
CCATGACCTTTATCTTCTGGGAATTGGTGGGCCTCTCCTCCTATCTGCTTATCGGCCACTGGTACACACGGGACACTGCC
GCCAACGCCGCCAAAAAAGCCTTCATCTGCAACCGCGTCGGGGACTTCGGCTTCCTGATCGGCATTCTGACTCTCTGGGC
GCTGACCAACACGCTGGATTTCAGCCTGATGGAAATACCCGCAGGAATCAGTGAAAACCTGCTGAACATTACGGTACTGT
GCCTCTTCTGCGGAGCGGTGGGCAAATCCGCCCAATTCCCGTTGCACGTCTGGCTTCCGGACGCCATGGAAGGCCCCACC
CCCGTCTCCGCCCTGATCCATGCGGCCACCATGGTAGCCGCCGGCGTTTACATGATGGTGCGCGTTCAATACTCCATCGG
CATTGAGGCCTTCCCCGCCCTGGCCTGCAATGTCATTGCCGGCATCGGAGCCATTACGGCCGTCATCGCCGCCTTCATGG
CCACCCAGCAGAATGACATCAAACGCGTCCTGGCCTATTCCACCCTCTCCCAGCTCGGCTATATGGTCATGGCCCTGGGA
CTTCTGGCCGGGGAGGCAGCCATGTTCCACCTCTTCACCCACGCATGGTTCAAGGCTCTGCTCTTCCTGGGCGCCGGTGC
CATCATCTTCGCCTGCCACCATGAACAGGACATCTGGAAAATGGGCGGCATCATGAAGCGCATGAAGCTGACTTCCCTCA
CCTTCATCATTGCCACCATGGCGCTGATTGCCATTCCGTTCACGTCCGGCTTCTTCTCCAAGGAAGCCATTCTGGAAGCA
GCCCTTCGCAAAAACCCGGTCTTCTTCTGGATCGGCGCGGGCGTAGCCCTGCTGACAACCTTCTATATGATGCGTGTCAT
CTTTGTGGTCTTCTTCGGCAAGAGCCGCAGCCACAGTTCGGAACACGCCTCGGAAGTTGGCGGCCTCATGCTGGTGCCCC
TGCTGATTCTGGCTGTCCTGGCTCTCATCTCCGGCTACGGGTTCATCGCAGACAGGCTGGTTCCTTTCAACGGATTCGTT
TCCGAAAGCTTCCACATGGGCATGCCCTTCTACGTCTCCATGGGGGCGCTGGTGCTCGGAATCCTGCTGGCGGCTGCCTT
CTACGCAGGCTCCCCGGCTTCTGACAAACTCTCCGGCAATGCCGTTTCCCGGGCTCTCGCCAACCGCCTTTATATTGATC
TGTTCTATGATAAAGTGCTGGTCAGGGGAGTCCAGGGCGTTCTGGCCGCCATCATCGACTTTATGGACCAGTTCATCATC
TCCGGCCTCATCGTTGGCGGACTGGCGCGGTTGACCGCCGCCATAGGCTCCCTGCTGCGCCGCCTGCAGTCCGGCAACAT
GGCCGCCTATACGGCTCTCTTCGGCATTGGCCTGCTCCTGGTCATCTACTTTACCGTCTTCTATTCCTGCTAA

Upstream 100 bases:

>100_bases
GCCTAGCCCTCATCGTCTCCCTGTACAGGGCCAGGCGCACGGCCAGCACGCAAGATCTCAACACGCTGAAAGATTAAGAG
CAACACACTACTCCACGAAC

Downstream 100 bases:

>100_bases
CCTAACCAACCAATCACATACCATGCTTATCTGGCTTGTTCTCATTCCTCTGATTGCCGCGGCCCTCATCGGTCTGTGCA
AGGCGCCCGCACGCCCGACA

Product: proton-translocating NADH-quinone oxidoreductase, chain L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MFNIDIQYTWLLLFLPLVVAAFDWFLLTKRPDVAALTSTFSCLATFVLSLGLLDRTGSDSFSWLPISDISSVDLGFVLDP
LSSRMMLVVTGIGLLVHVFSLGYMADDKAKTRYFACLSLFMFSMTGIVLANNIAMTFIFWELVGLSSYLLIGHWYTRDTA
ANAAKKAFICNRVGDFGFLIGILTLWALTNTLDFSLMEIPAGISENLLNITVLCLFCGAVGKSAQFPLHVWLPDAMEGPT
PVSALIHAATMVAAGVYMMVRVQYSIGIEAFPALACNVIAGIGAITAVIAAFMATQQNDIKRVLAYSTLSQLGYMVMALG
LLAGEAAMFHLFTHAWFKALLFLGAGAIIFACHHEQDIWKMGGIMKRMKLTSLTFIIATMALIAIPFTSGFFSKEAILEA
ALRKNPVFFWIGAGVALLTTFYMMRVIFVVFFGKSRSHSSEHASEVGGLMLVPLLILAVLALISGYGFIADRLVPFNGFV
SESFHMGMPFYVSMGALVLGILLAAAFYAGSPASDKLSGNAVSRALANRLYIDLFYDKVLVRGVQGVLAAIIDFMDQFII
SGLIVGGLARLTAAIGSLLRRLQSGNMAAYTALFGIGLLLVIYFTVFYSC

Sequences:

>Translated_610_residues
MFNIDIQYTWLLLFLPLVVAAFDWFLLTKRPDVAALTSTFSCLATFVLSLGLLDRTGSDSFSWLPISDISSVDLGFVLDP
LSSRMMLVVTGIGLLVHVFSLGYMADDKAKTRYFACLSLFMFSMTGIVLANNIAMTFIFWELVGLSSYLLIGHWYTRDTA
ANAAKKAFICNRVGDFGFLIGILTLWALTNTLDFSLMEIPAGISENLLNITVLCLFCGAVGKSAQFPLHVWLPDAMEGPT
PVSALIHAATMVAAGVYMMVRVQYSIGIEAFPALACNVIAGIGAITAVIAAFMATQQNDIKRVLAYSTLSQLGYMVMALG
LLAGEAAMFHLFTHAWFKALLFLGAGAIIFACHHEQDIWKMGGIMKRMKLTSLTFIIATMALIAIPFTSGFFSKEAILEA
ALRKNPVFFWIGAGVALLTTFYMMRVIFVVFFGKSRSHSSEHASEVGGLMLVPLLILAVLALISGYGFIADRLVPFNGFV
SESFHMGMPFYVSMGALVLGILLAAAFYAGSPASDKLSGNAVSRALANRLYIDLFYDKVLVRGVQGVLAAIIDFMDQFII
SGLIVGGLARLTAAIGSLLRRLQSGNMAAYTALFGIGLLLVIYFTVFYSC
>Mature_610_residues
MFNIDIQYTWLLLFLPLVVAAFDWFLLTKRPDVAALTSTFSCLATFVLSLGLLDRTGSDSFSWLPISDISSVDLGFVLDP
LSSRMMLVVTGIGLLVHVFSLGYMADDKAKTRYFACLSLFMFSMTGIVLANNIAMTFIFWELVGLSSYLLIGHWYTRDTA
ANAAKKAFICNRVGDFGFLIGILTLWALTNTLDFSLMEIPAGISENLLNITVLCLFCGAVGKSAQFPLHVWLPDAMEGPT
PVSALIHAATMVAAGVYMMVRVQYSIGIEAFPALACNVIAGIGAITAVIAAFMATQQNDIKRVLAYSTLSQLGYMVMALG
LLAGEAAMFHLFTHAWFKALLFLGAGAIIFACHHEQDIWKMGGIMKRMKLTSLTFIIATMALIAIPFTSGFFSKEAILEA
ALRKNPVFFWIGAGVALLTTFYMMRVIFVVFFGKSRSHSSEHASEVGGLMLVPLLILAVLALISGYGFIADRLVPFNGFV
SESFHMGMPFYVSMGALVLGILLAAAFYAGSPASDKLSGNAVSRALANRLYIDLFYDKVLVRGVQGVLAAIIDFMDQFII
SGLIVGGLARLTAAIGSLLRRLQSGNMAAYTALFGIGLLLVIYFTVFYSC

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=443, Percent_Identity=37.4717832957111, Blast_Score=251, Evalue=1e-66,
Organism=Escherichia coli, GI1788614, Length=503, Percent_Identity=41.948310139165, Blast_Score=336, Evalue=3e-93,
Organism=Escherichia coli, GI1788829, Length=412, Percent_Identity=33.7378640776699, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1788827, Length=460, Percent_Identity=29.7826086956522, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1788831, Length=363, Percent_Identity=29.2011019283747, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI2367154, Length=430, Percent_Identity=25.5813953488372, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788613, Length=428, Percent_Identity=26.1682242990654, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693160, Length=384, Percent_Identity=25, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66228; Mature: 66228

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNIDIQYTWLLLFLPLVVAAFDWFLLTKRPDVAALTSTFSCLATFVLSLGLLDRTGSDS
CEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FSWLPISDISSVDLGFVLDPLSSRMMLVVTGIGLLVHVFSLGYMADDKAKTRYFACLSLF
CCEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
MFSMTGIVLANNIAMTFIFWELVGLSSYLLIGHWYTRDTAANAAKKAFICNRVGDFGFLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHCCHHHHHH
GILTLWALTNTLDFSLMEIPAGISENLLNITVLCLFCGAVGKSAQFPLHVWLPDAMEGPT
HHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
PVSALIHAATMVAAGVYMMVRVQYSIGIEAFPALACNVIAGIGAITAVIAAFMATQQNDI
HHHHHHHHHHHHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRVLAYSTLSQLGYMVMALGLLAGEAAMFHLFTHAWFKALLFLGAGAIIFACHHEQDIWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHH
MGGIMKRMKLTSLTFIIATMALIAIPFTSGFFSKEAILEAALRKNPVFFWIGAGVALLTT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHH
FYMMRVIFVVFFGKSRSHSSEHASEVGGLMLVPLLILAVLALISGYGFIADRLVPFNGFV
HHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
SESFHMGMPFYVSMGALVLGILLAAAFYAGSPASDKLSGNAVSRALANRLYIDLFYDKVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VRGVQGVLAAIIDFMDQFIISGLIVGGLARLTAAIGSLLRRLQSGNMAAYTALFGIGLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VIYFTVFYSC
HHHHHHHHCC
>Mature Secondary Structure
MFNIDIQYTWLLLFLPLVVAAFDWFLLTKRPDVAALTSTFSCLATFVLSLGLLDRTGSDS
CEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FSWLPISDISSVDLGFVLDPLSSRMMLVVTGIGLLVHVFSLGYMADDKAKTRYFACLSLF
CCEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
MFSMTGIVLANNIAMTFIFWELVGLSSYLLIGHWYTRDTAANAAKKAFICNRVGDFGFLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHCCHHHHHH
GILTLWALTNTLDFSLMEIPAGISENLLNITVLCLFCGAVGKSAQFPLHVWLPDAMEGPT
HHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
PVSALIHAATMVAAGVYMMVRVQYSIGIEAFPALACNVIAGIGAITAVIAAFMATQQNDI
HHHHHHHHHHHHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRVLAYSTLSQLGYMVMALGLLAGEAAMFHLFTHAWFKALLFLGAGAIIFACHHEQDIWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHH
MGGIMKRMKLTSLTFIIATMALIAIPFTSGFFSKEAILEAALRKNPVFFWIGAGVALLTT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHH
FYMMRVIFVVFFGKSRSHSSEHASEVGGLMLVPLLILAVLALISGYGFIADRLVPFNGFV
HHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
SESFHMGMPFYVSMGALVLGILLAAAFYAGSPASDKLSGNAVSRALANRLYIDLFYDKVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VRGVQGVLAAIIDFMDQFIISGLIVGGLARLTAAIGSLLRRLQSGNMAAYTALFGIGLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VIYFTVFYSC
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]