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The map label for this gene is ndhD1 [H]

Identifier: 187736094

GI number: 187736094

Start: 1929628

End: 1931052

Strand: Reverse

Name: ndhD1 [H]

Synonym: Amuc_1605

Alternate gene names: 187736094

Gene position: 1931052-1929628 (Counterclockwise)

Preceding gene: 187736095

Following gene: 187736093

Centisome position: 72.48

GC content: 60.56

Gene sequence:

>1425_bases
ATGCTTATCTGGCTTGTTCTCATTCCTCTGATTGCCGCGGCCCTCATCGGTCTGTGCAAGGCGCCCGCACGCCCGACAGC
CCTGCTCAGCGCCTCCCTGACGCTGGCCCTCGGCATCTGGGCCCTGGTTAGCTTTGACGGCTGTTCTTCCTGCTGGTCCC
GTTTTGAAGGGATGGACCTCCAGCTCACGTTGGCTCCGGCCCTGTCCAAAGTAATGCTGCTGCTGACCATCCTGGTTACC
TTCGCCACCGTATTGGGCACCAACCCGCCCCAGGGGGGGGAAGCTTCCTGGTACAACTCCGCCCTTCTGATTTCCGCAGG
CGCCACCGGGGCGTTCCTGTCCGACAACATAATCTCCTTCTTCGCCTTCCATGAACTGGCTCTTATCCCCACCTTCGTGA
TGATCGGCCTGTATGGACGCGGCGACCGCCGCACCACGGCCTGGCGCGCCACGCTTTACCTGGGGCTTGCCTCCATGGTG
CTGCTGGCAGCCCTGCTGATGATCGGTACGCAGGCAGGCTTCACCTTCTCCGGCCTGAAAGACTTCATGGCCAGCGGGCG
CGAACTTGCCCACGCGGAACTCATCGGGGCCCTGCTCATCGCCGGGTTCGGCACGCTGATTTCCCTCTTCCCCTTCCATT
CCTGGGCAGCCCCCGCATACGCATCCGCTCCCGCTCCGGTAGCGATGATGCATGCCGGAGTGCTTAAAAAATTTGGCCTG
TACGGGCTCTTCATGTTCCAGCCGCTGATGGAAACAGGATTCCTTCCCTGGACGAATATCCTGCTGGTCCTGCTCGTCTG
CAATGTCATTTGGGTGGGGTACGTAACCGTCAACCAGAAAAGGCTGGACCTGTTGCTGGGCAACTCTTCCGTGATGCACA
TGGGCTATATCTTCCTGGCTTTCGCCGCCCTGGTAGTTTCCGGTTCTGCGGAAGCCAATCCCTGGGCGCTGAAAGGAGCT
GCCCTGCTGATGCTGGCCCATGGCCTGACAATCGCCCTTCTCTTTCTGCTCTGCGGGCAGATTGAAAAGCAAACAGGCAC
ATTGGAAATCAACTCTCTGGGCGGACTGAGCACCAGGCTGCCGCGCATGGCTTTCGTTTTCGGCCTGGCGGGCATGGCTT
CCATCGGCCTCCCCGGCCTCGCCAATTTCCCGGGGGAATTCATGGTCTTCTTCTCCGGTTTCGCCGGTTTCAGCAACGGC
TTCGGCCCCGTTCAAATCGCCACCATCCTGTGCCTCTGGGGACTGGTCATCGGCGCGGTATACATGCTGAGGGCCTACCG
CAATATTTTCCAGGGAGATTTGTCCAAAGCCTCCGCCTACGCCACGGGACTGCAGCCCTCCGAACGGGCGGCCAACTGCT
TCCTGGTCATCGCCCTGGCGGTCTTCGGCTTCTTCCCCACGCTGGTGCTCCAGTTTTTCTCCTGA

Upstream 100 bases:

>100_bases
AACATGGCCGCCTATACGGCTCTCTTCGGCATTGGCCTGCTCCTGGTCATCTACTTTACCGTCTTCTATTCCTGCTAACC
TAACCAACCAATCACATACC

Downstream 100 bases:

>100_bases
TTTCCTCCCTTCCGAATACAATCCTAGTCTAACCTGATTCTCTTTTACCCATGCAAGCGTATATTCCGGAATTCATCCTG
GCCGGCCTGGCAATGCTTTT

Product: proton-translocating NADH-quinone oxidoreductase, chain M

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MLIWLVLIPLIAAALIGLCKAPARPTALLSASLTLALGIWALVSFDGCSSCWSRFEGMDLQLTLAPALSKVMLLLTILVT
FATVLGTNPPQGGEASWYNSALLISAGATGAFLSDNIISFFAFHELALIPTFVMIGLYGRGDRRTTAWRATLYLGLASMV
LLAALLMIGTQAGFTFSGLKDFMASGRELAHAELIGALLIAGFGTLISLFPFHSWAAPAYASAPAPVAMMHAGVLKKFGL
YGLFMFQPLMETGFLPWTNILLVLLVCNVIWVGYVTVNQKRLDLLLGNSSVMHMGYIFLAFAALVVSGSAEANPWALKGA
ALLMLAHGLTIALLFLLCGQIEKQTGTLEINSLGGLSTRLPRMAFVFGLAGMASIGLPGLANFPGEFMVFFSGFAGFSNG
FGPVQIATILCLWGLVIGAVYMLRAYRNIFQGDLSKASAYATGLQPSERAANCFLVIALAVFGFFPTLVLQFFS

Sequences:

>Translated_474_residues
MLIWLVLIPLIAAALIGLCKAPARPTALLSASLTLALGIWALVSFDGCSSCWSRFEGMDLQLTLAPALSKVMLLLTILVT
FATVLGTNPPQGGEASWYNSALLISAGATGAFLSDNIISFFAFHELALIPTFVMIGLYGRGDRRTTAWRATLYLGLASMV
LLAALLMIGTQAGFTFSGLKDFMASGRELAHAELIGALLIAGFGTLISLFPFHSWAAPAYASAPAPVAMMHAGVLKKFGL
YGLFMFQPLMETGFLPWTNILLVLLVCNVIWVGYVTVNQKRLDLLLGNSSVMHMGYIFLAFAALVVSGSAEANPWALKGA
ALLMLAHGLTIALLFLLCGQIEKQTGTLEINSLGGLSTRLPRMAFVFGLAGMASIGLPGLANFPGEFMVFFSGFAGFSNG
FGPVQIATILCLWGLVIGAVYMLRAYRNIFQGDLSKASAYATGLQPSERAANCFLVIALAVFGFFPTLVLQFFS
>Mature_474_residues
MLIWLVLIPLIAAALIGLCKAPARPTALLSASLTLALGIWALVSFDGCSSCWSRFEGMDLQLTLAPALSKVMLLLTILVT
FATVLGTNPPQGGEASWYNSALLISAGATGAFLSDNIISFFAFHELALIPTFVMIGLYGRGDRRTTAWRATLYLGLASMV
LLAALLMIGTQAGFTFSGLKDFMASGRELAHAELIGALLIAGFGTLISLFPFHSWAAPAYASAPAPVAMMHAGVLKKFGL
YGLFMFQPLMETGFLPWTNILLVLLVCNVIWVGYVTVNQKRLDLLLGNSSVMHMGYIFLAFAALVVSGSAEANPWALKGA
ALLMLAHGLTIALLFLLCGQIEKQTGTLEINSLGGLSTRLPRMAFVFGLAGMASIGLPGLANFPGEFMVFFSGFAGFSNG
FGPVQIATILCLWGLVIGAVYMLRAYRNIFQGDLSKASAYATGLQPSERAANCFLVIALAVFGFFPTLVLQFFS

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=358, Percent_Identity=29.3296089385475, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1788613, Length=510, Percent_Identity=29.2156862745098, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788829, Length=390, Percent_Identity=25.1282051282051, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788831, Length=293, Percent_Identity=25.2559726962457, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788827, Length=296, Percent_Identity=28.3783783783784, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI145693160, Length=307, Percent_Identity=27.6872964169381, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 50465; Mature: 50465

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIWLVLIPLIAAALIGLCKAPARPTALLSASLTLALGIWALVSFDGCSSCWSRFEGMDL
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCE
QLTLAPALSKVMLLLTILVTFATVLGTNPPQGGEASWYNSALLISAGATGAFLSDNIISF
EEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHH
FAFHELALIPTFVMIGLYGRGDRRTTAWRATLYLGLASMVLLAALLMIGTQAGFTFSGLK
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
DFMASGRELAHAELIGALLIAGFGTLISLFPFHSWAAPAYASAPAPVAMMHAGVLKKFGL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YGLFMFQPLMETGFLPWTNILLVLLVCNVIWVGYVTVNQKRLDLLLGNSSVMHMGYIFLA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEECCHHEEEEECCCCHHHHHHHHHH
FAALVVSGSAEANPWALKGAALLMLAHGLTIALLFLLCGQIEKQTGTLEINSLGGLSTRL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEECCCCCHHHH
PRMAFVFGLAGMASIGLPGLANFPGEFMVFFSGFAGFSNGFGPVQIATILCLWGLVIGAV
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
YMLRAYRNIFQGDLSKASAYATGLQPSERAANCFLVIALAVFGFFPTLVLQFFS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLIWLVLIPLIAAALIGLCKAPARPTALLSASLTLALGIWALVSFDGCSSCWSRFEGMDL
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCE
QLTLAPALSKVMLLLTILVTFATVLGTNPPQGGEASWYNSALLISAGATGAFLSDNIISF
EEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHH
FAFHELALIPTFVMIGLYGRGDRRTTAWRATLYLGLASMVLLAALLMIGTQAGFTFSGLK
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
DFMASGRELAHAELIGALLIAGFGTLISLFPFHSWAAPAYASAPAPVAMMHAGVLKKFGL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YGLFMFQPLMETGFLPWTNILLVLLVCNVIWVGYVTVNQKRLDLLLGNSSVMHMGYIFLA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEECCHHEEEEECCCCHHHHHHHHHH
FAALVVSGSAEANPWALKGAALLMLAHGLTIALLFLLCGQIEKQTGTLEINSLGGLSTRL
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEECCCCCHHHH
PRMAFVFGLAGMASIGLPGLANFPGEFMVFFSGFAGFSNGFGPVQIATILCLWGLVIGAV
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
YMLRAYRNIFQGDLSKASAYATGLQPSERAANCFLVIALAVFGFFPTLVLQFFS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA