Click here to switch to the map view.

The map label for this gene is pdxA [H]

Identifier: 187735968

GI number: 187735968

Start: 1768113

End: 1768982

Strand: Reverse

Name: pdxA [H]

Synonym: Amuc_1477

Alternate gene names: 187735968

Gene position: 1768982-1768113 (Counterclockwise)

Preceding gene: 187735969

Following gene: 187735967

Centisome position: 66.4

GC content: 62.18

Gene sequence:

>870_bases
ATGAAACCGGTCATTGGATACACGCTGGGCGACCAGTCGGGCATAGGCCCGGAAGTCATCTCCGCCGCGCTTGCCTCCGG
AGAACTCCCGGAAGATGCGGAATACCGCCTCATCGGCAAGAGAGTGGAGCTTCCCCCGGGAAGGCCTAATGCGGAATCCG
CCAAACACGCCTTCGACCATCTGGAACAGGCGGCCCATGCCCTGCGGGAAGGAACGGTTGACGCTGTTGTCACCGCCCCC
GTCTGCAAGGAAACCCTGCATGAGGCAGGTTTCCGCTGGCCGGGGCAGACGGAATTCTTTGCAGAACGCCTGAAAACGGA
CAATTACGCCATGTGCCTGACCGGGAAACGGTTGACGGTGGGGCTGGCAACCATTCATACTTCCCTCCAAAGCGTGCCTT
CCCTGCTGGAAACAGAGGAACTGGTCCGCATCGGAACCCTGCTGAAAGACTTCTGCATCCGCAAAGGAATCATGCGCCCG
CGTATCGCCCTGGCAGCCCTGAACCCCCACGCCGGGGAACACGGCGCTTTCGGCGATGAGGACGGGAACATCATTGCCCC
GGCCGTGGAACGGCTGAGGGCGATCCATCCGGATGCTGCATTTGACGGGCCTTCCGTCCCGGACTGCGTGTACCGGGATG
CCGTGGAAGGAAACTATGACGCCGTGCTGGCCCCTTACCATGACCAGGGGTTGATTCCGCTGAAGCTGGTGGACTTCCAT
ACCGCCGTCAACGTCACCCTGGGCCTTCCCCGCCCCCGGCTGAGCCCGGACCATGGTACCGCCTTCAACCTGGCGGGAAC
CGGAAAAGCCAATCCGTCCAGCACCATCCACGCCTTCCAGCTGGCCGTACAGATGGCGCGGAGGCGTTAA

Upstream 100 bases:

>100_bases
CCGGCAGAAAAAACTCCTGTTTCCCCCGCGGAAGAAATTCCCGCTTCCCCTGCCGGAATGCCGGAACCCGCGGAATTGTA
ATCCCTCCTGTTGCCGCACT

Downstream 100 bases:

>100_bases
CGTTTTTCTTCTTTCCGGAATTTTTCCCGCCATACCTGCACCATCCCGTTCCGGGGGTGAATCCCAGTACCGGAATATCA
CCCCATCAGGGAGAAGCCCT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKPVIGYTLGDQSGIGPEVISAALASGELPEDAEYRLIGKRVELPPGRPNAESAKHAFDHLEQAAHALREGTVDAVVTAP
VCKETLHEAGFRWPGQTEFFAERLKTDNYAMCLTGKRLTVGLATIHTSLQSVPSLLETEELVRIGTLLKDFCIRKGIMRP
RIALAALNPHAGEHGAFGDEDGNIIAPAVERLRAIHPDAAFDGPSVPDCVYRDAVEGNYDAVLAPYHDQGLIPLKLVDFH
TAVNVTLGLPRPRLSPDHGTAFNLAGTGKANPSSTIHAFQLAVQMARRR

Sequences:

>Translated_289_residues
MKPVIGYTLGDQSGIGPEVISAALASGELPEDAEYRLIGKRVELPPGRPNAESAKHAFDHLEQAAHALREGTVDAVVTAP
VCKETLHEAGFRWPGQTEFFAERLKTDNYAMCLTGKRLTVGLATIHTSLQSVPSLLETEELVRIGTLLKDFCIRKGIMRP
RIALAALNPHAGEHGAFGDEDGNIIAPAVERLRAIHPDAAFDGPSVPDCVYRDAVEGNYDAVLAPYHDQGLIPLKLVDFH
TAVNVTLGLPRPRLSPDHGTAFNLAGTGKANPSSTIHAFQLAVQMARRR
>Mature_289_residues
MKPVIGYTLGDQSGIGPEVISAALASGELPEDAEYRLIGKRVELPPGRPNAESAKHAFDHLEQAAHALREGTVDAVVTAP
VCKETLHEAGFRWPGQTEFFAERLKTDNYAMCLTGKRLTVGLATIHTSLQSVPSLLETEELVRIGTLLKDFCIRKGIMRP
RIALAALNPHAGEHGAFGDEDGNIIAPAVERLRAIHPDAAFDGPSVPDCVYRDAVEGNYDAVLAPYHDQGLIPLKLVDFH
TAVNVTLGLPRPRLSPDHGTAFNLAGTGKANPSSTIHAFQLAVQMARRR

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=253, Percent_Identity=39.5256916996047, Blast_Score=154, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 31156; Mature: 31156

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVIGYTLGDQSGIGPEVISAALASGELPEDAEYRLIGKRVELPPGRPNAESAKHAFDH
CCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEECCEEECCCCCCCHHHHHHHHHH
LEQAAHALREGTVDAVVTAPVCKETLHEAGFRWPGQTEFFAERLKTDNYAMCLTGKRLTV
HHHHHHHHHCCCHHHEEECHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCEE
GLATIHTSLQSVPSLLETEELVRIGTLLKDFCIRKGIMRPRIALAALNPHAGEHGAFGDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
DGNIIAPAVERLRAIHPDAAFDGPSVPDCVYRDAVEGNYDAVLAPYHDQGLIPLKLVDFH
CCCEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCEEEECCCCCCCCEEEEEEEE
TAVNVTLGLPRPRLSPDHGTAFNLAGTGKANPSSTIHAFQLAVQMARRR
EEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPVIGYTLGDQSGIGPEVISAALASGELPEDAEYRLIGKRVELPPGRPNAESAKHAFDH
CCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEECCEEECCCCCCCHHHHHHHHHH
LEQAAHALREGTVDAVVTAPVCKETLHEAGFRWPGQTEFFAERLKTDNYAMCLTGKRLTV
HHHHHHHHHCCCHHHEEECHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCEE
GLATIHTSLQSVPSLLETEELVRIGTLLKDFCIRKGIMRPRIALAALNPHAGEHGAFGDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
DGNIIAPAVERLRAIHPDAAFDGPSVPDCVYRDAVEGNYDAVLAPYHDQGLIPLKLVDFH
CCCEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCEEEECCCCCCCCEEEEEEEE
TAVNVTLGLPRPRLSPDHGTAFNLAGTGKANPSSTIHAFQLAVQMARRR
EEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA