Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is ispA [C]

Identifier: 187735758

GI number: 187735758

Start: 1524683

End: 1525576

Strand: Reverse

Name: ispA [C]

Synonym: Amuc_1264

Alternate gene names: 187735758

Gene position: 1525576-1524683 (Counterclockwise)

Preceding gene: 187735759

Following gene: 187735757

Centisome position: 57.26

GC content: 60.18

Gene sequence:

>894_bases
ATGTGTGAACAATCACTGAACGACTACATCACAGAACAATGCGCCCTGATTGACGCAGCGCTGGACAGACTGCTGCCAGC
AGAGGACGAAAGCCCCGAAACCATCCACAAAGCCATGCGCTACAGCATATTTGCGGGTGGGAAAAGAATGCGCCCCGTCC
TTTGCCTGGCGGCGGCGGAGGCCTGCGGAGGACTGGCAGTGGACGCCCTGGTTCCCGCCTGCGCCGTGGAAATGATGCAT
ACGTATTCCCTCATCCATGACGACCTGCCAGCCATGGACAACGACGATCTGCGCCGTGGGAAACCCACCAGCCACAAGGC
TTTCGGAGAAGGCGTCGCCATCCTGGCGGGAGACGCGCTGCTGACGGAGGCTTTTGCCGTAATCGCCCAGGTGGACGATA
CGGAACGCTATACCGTCAGGGATTACGTGAGGGAGCTGGCAGCCACCGGCGGCAGCACCATGCTCATCGGAGGCCAGATT
CTGGATTTGGAGGGAGAACACAAGCAGCTCTCCGAACCGGAAGTCCGCACCGTGTACGAAGGGAAGACGGCCGCCCTGCT
AACCACGGCCCTTCGCTTCGGCGGCATGTCCGCAAACGCCACAGAGTCCCAGCTGGAAGCTCTGACGGACTTCGGTTACA
ACCTGGGGCTGGCTTTCCAGGTGATTGACGACATTCTGGACCTGACGGCTTCCACGGAAAAACTCGGCAAGACCGCCGGC
AAGGACGTCAATTCCCAGAAATCCACCTGTCCGGCCCTGATTGGCCTGGACGGCGCCCGTTCCGAAGCCAAATGCCGCAC
TCAGGCGGCTCTGGATGCCCTGATGATCTTCCCGGAAGAACGCCGCGCCCGCCTGGTGGAACTGGCCAACTATCTTCTTA
ACCGCGAATATTAA

Upstream 100 bases:

>100_bases
AGGTCCGAAAAGGGGCCGCACTCAACGCCGTACAAATCGCGGAATTGCTGGTCAACCGCTGACCTGTTTCCTCCACACCC
CGCACCTATTCCATAACGCC

Downstream 100 bases:

>100_bases
GCCGCTTTTTCTTTCATGCCCGCAGAAACCGTATCCGACAACGTGGAAACCCTGATCAATCTGGCGCTGGCCGAAGACTT
CGGCTCCGGCGACGTGACTT

Product: Polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MCEQSLNDYITEQCALIDAALDRLLPAEDESPETIHKAMRYSIFAGGKRMRPVLCLAAAEACGGLAVDALVPACAVEMMH
TYSLIHDDLPAMDNDDLRRGKPTSHKAFGEGVAILAGDALLTEAFAVIAQVDDTERYTVRDYVRELAATGGSTMLIGGQI
LDLEGEHKQLSEPEVRTVYEGKTAALLTTALRFGGMSANATESQLEALTDFGYNLGLAFQVIDDILDLTASTEKLGKTAG
KDVNSQKSTCPALIGLDGARSEAKCRTQAALDALMIFPEERRARLVELANYLLNREY

Sequences:

>Translated_297_residues
MCEQSLNDYITEQCALIDAALDRLLPAEDESPETIHKAMRYSIFAGGKRMRPVLCLAAAEACGGLAVDALVPACAVEMMH
TYSLIHDDLPAMDNDDLRRGKPTSHKAFGEGVAILAGDALLTEAFAVIAQVDDTERYTVRDYVRELAATGGSTMLIGGQI
LDLEGEHKQLSEPEVRTVYEGKTAALLTTALRFGGMSANATESQLEALTDFGYNLGLAFQVIDDILDLTASTEKLGKTAG
KDVNSQKSTCPALIGLDGARSEAKCRTQAALDALMIFPEERRARLVELANYLLNREY
>Mature_297_residues
MCEQSLNDYITEQCALIDAALDRLLPAEDESPETIHKAMRYSIFAGGKRMRPVLCLAAAEACGGLAVDALVPACAVEMMH
TYSLIHDDLPAMDNDDLRRGKPTSHKAFGEGVAILAGDALLTEAFAVIAQVDDTERYTVRDYVRELAATGGSTMLIGGQI
LDLEGEHKQLSEPEVRTVYEGKTAALLTTALRFGGMSANATESQLEALTDFGYNLGLAFQVIDDILDLTASTEKLGKTAG
KDVNSQKSTCPALIGLDGARSEAKCRTQAALDALMIFPEERRARLVELANYLLNREY

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=229, Percent_Identity=32.3144104803493, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1786623, Length=288, Percent_Identity=40.9722222222222, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789578, Length=253, Percent_Identity=32.8063241106719, Blast_Score=126, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17505681, Length=245, Percent_Identity=24.8979591836735, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24651612, Length=226, Percent_Identity=30.0884955752212, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32110; Mature: 32110

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCEQSLNDYITEQCALIDAALDRLLPAEDESPETIHKAMRYSIFAGGKRMRPVLCLAAAE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ACGGLAVDALVPACAVEMMHTYSLIHDDLPAMDNDDLRRGKPTSHKAFGEGVAILAGDAL
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCEEEEECHHH
LTEAFAVIAQVDDTERYTVRDYVRELAATGGSTMLIGGQILDLEGEHKQLSEPEVRTVYE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCEEEECCCCHHHCCCCCHHHHHC
GKTAALLTTALRFGGMSANATESQLEALTDFGYNLGLAFQVIDDILDLTASTEKLGKTAG
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
KDVNSQKSTCPALIGLDGARSEAKCRTQAALDALMIFPEERRARLVELANYLLNREY
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MCEQSLNDYITEQCALIDAALDRLLPAEDESPETIHKAMRYSIFAGGKRMRPVLCLAAAE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ACGGLAVDALVPACAVEMMHTYSLIHDDLPAMDNDDLRRGKPTSHKAFGEGVAILAGDAL
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCEEEEECHHH
LTEAFAVIAQVDDTERYTVRDYVRELAATGGSTMLIGGQILDLEGEHKQLSEPEVRTVYE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCEEEECCCCHHHCCCCCHHHHHC
GKTAALLTTALRFGGMSANATESQLEALTDFGYNLGLAFQVIDDILDLTASTEKLGKTAG
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
KDVNSQKSTCPALIGLDGARSEAKCRTQAALDALMIFPEERRARLVELANYLLNREY
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]