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The map label for this gene is nadC [H]

Identifier: 187735757

GI number: 187735757

Start: 1523804

End: 1524667

Strand: Reverse

Name: nadC [H]

Synonym: Amuc_1263

Alternate gene names: 187735757

Gene position: 1524667-1523804 (Counterclockwise)

Preceding gene: 187735758

Following gene: 187735756

Centisome position: 57.23

GC content: 59.03

Gene sequence:

>864_bases
ATGCCCGCAGAAACCGTATCCGACAACGTGGAAACCCTGATCAATCTGGCGCTGGCCGAAGACTTCGGCTCCGGCGACGT
GACTTCCACATACTTCGTCCCGGAACATCTGACCGCCAGAGCTATTTTGACCCCCCGGAAAAAAGGCGTTCTTTCCGGCG
TCAATGTCGCGGCGGAAGTTTTCCGCAAGGTGGATCCCACCCTGAAGGTGGAAGTTTACCTGCATGACGGGGAAGCCGTG
GCGCCCGGCGCCGTGGTGATGCTTATTGAAGGGTCCGCCCGCTCCATTCTTGGGGCGGAACGCACCGCCCTCAACTTCAT
CCAGCGTCTTTCCGGAGTAGCTACGCTCACCAGACAATATGTGAAAGCCATTTCCCACACCAGCGCCCGCATTCTGGATA
CCCGCAAAACCACTCCCGGCTACCGTCTGCTGGAAAAAGCGGCCGTGCTCCATGGCGGAGGCACCAACCACCGCATGGGC
CTTTATGACCGCGCCATGGTGAAAGACAACCACCTGATGACGGATGGAAATACGGAACACCTTCAGGAATGCATCAACAG
GCTGCGTCAGGAAAAGCCCGGCGTGGAAATCCAGCTGGAAGCGGACACCCTGGAACAGGTGGGCAACTTCCTTAAACTGG
AAGGCGTGGACCATATCCTTCTGGACAACATGACGCCGGAAATGCTGAAACAAGCCGTCGCCATGCGCGGAGGATGCACC
ACCCCCCTGCTGGAAGCCAGCGGAGGCGTTCACCTGGACACGGTAGCCGCCATTGCGGAATCCGGCGTGGACTTCGTCTC
CGTAGGCTACGTGACCCACTCGGCCCCCTCCCTGGACCTGGGGCTGGATTTCAGCGTAGAATAA

Upstream 100 bases:

>100_bases
TCTGGATGCCCTGATGATCTTCCCGGAAGAACGCCGCGCCCGCCTGGTGGAACTGGCCAACTATCTTCTTAACCGCGAAT
ATTAAGCCGCTTTTTCTTTC

Downstream 100 bases:

>100_bases
CCACTCATCGTTCAACACGCCATGGACTTGTCCAATTTCAGAGAAGAATACCTCAAAGGCCAGCTGCACAGAAAGGACCT
GGCGGAAAATCCCTTTGAAC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPAETVSDNVETLINLALAEDFGSGDVTSTYFVPEHLTARAILTPRKKGVLSGVNVAAEVFRKVDPTLKVEVYLHDGEAV
APGAVVMLIEGSARSILGAERTALNFIQRLSGVATLTRQYVKAISHTSARILDTRKTTPGYRLLEKAAVLHGGGTNHRMG
LYDRAMVKDNHLMTDGNTEHLQECINRLRQEKPGVEIQLEADTLEQVGNFLKLEGVDHILLDNMTPEMLKQAVAMRGGCT
TPLLEASGGVHLDTVAAIAESGVDFVSVGYVTHSAPSLDLGLDFSVE

Sequences:

>Translated_287_residues
MPAETVSDNVETLINLALAEDFGSGDVTSTYFVPEHLTARAILTPRKKGVLSGVNVAAEVFRKVDPTLKVEVYLHDGEAV
APGAVVMLIEGSARSILGAERTALNFIQRLSGVATLTRQYVKAISHTSARILDTRKTTPGYRLLEKAAVLHGGGTNHRMG
LYDRAMVKDNHLMTDGNTEHLQECINRLRQEKPGVEIQLEADTLEQVGNFLKLEGVDHILLDNMTPEMLKQAVAMRGGCT
TPLLEASGGVHLDTVAAIAESGVDFVSVGYVTHSAPSLDLGLDFSVE
>Mature_286_residues
PAETVSDNVETLINLALAEDFGSGDVTSTYFVPEHLTARAILTPRKKGVLSGVNVAAEVFRKVDPTLKVEVYLHDGEAVA
PGAVVMLIEGSARSILGAERTALNFIQRLSGVATLTRQYVKAISHTSARILDTRKTTPGYRLLEKAAVLHGGGTNHRMGL
YDRAMVKDNHLMTDGNTEHLQECINRLRQEKPGVEIQLEADTLEQVGNFLKLEGVDHILLDNMTPEMLKQAVAMRGGCTT
PLLEASGGVHLDTVAAIAESGVDFVSVGYVTHSAPSLDLGLDFSVE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=250, Percent_Identity=32.8, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1786299, Length=287, Percent_Identity=36.2369337979094, Blast_Score=160, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=283, Percent_Identity=33.2155477031802, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30914; Mature: 30782

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAETVSDNVETLINLALAEDFGSGDVTSTYFVPEHLTARAILTPRKKGVLSGVNVAAEV
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHEECCCHHCHHHHHHHHHHH
FRKVDPTLKVEVYLHDGEAVAPGAVVMLIEGSARSILGAERTALNFIQRLSGVATLTRQY
HHHCCCCEEEEEEEECCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKAISHTSARILDTRKTTPGYRLLEKAAVLHGGGTNHRMGLYDRAMVKDNHLMTDGNTEH
HHHHHHCHHHEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEECCCCHHH
LQECINRLRQEKPGVEIQLEADTLEQVGNFLKLEGVDHILLDNMTPEMLKQAVAMRGGCT
HHHHHHHHHHHCCCCEEEECHHHHHHHHCEEECCCCCEEECCCCCHHHHHHHHHHCCCCC
TPLLEASGGVHLDTVAAIAESGVDFVSVGYVTHSAPSLDLGLDFSVE
CCHHHCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEECC
>Mature Secondary Structure 
PAETVSDNVETLINLALAEDFGSGDVTSTYFVPEHLTARAILTPRKKGVLSGVNVAAEV
CCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHEECCCHHCHHHHHHHHHHH
FRKVDPTLKVEVYLHDGEAVAPGAVVMLIEGSARSILGAERTALNFIQRLSGVATLTRQY
HHHCCCCEEEEEEEECCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKAISHTSARILDTRKTTPGYRLLEKAAVLHGGGTNHRMGLYDRAMVKDNHLMTDGNTEH
HHHHHHCHHHEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEECCCCHHH
LQECINRLRQEKPGVEIQLEADTLEQVGNFLKLEGVDHILLDNMTPEMLKQAVAMRGGCT
HHHHHHHHHHHCCCCEEEECHHHHHHHHCEEECCCCCEEECCCCCHHHHHHHHHHCCCCC
TPLLEASGGVHLDTVAAIAESGVDFVSVGYVTHSAPSLDLGLDFSVE
CCHHHCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]