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The map label for this gene is uvrC [H]

Identifier: 187735731

GI number: 187735731

Start: 1484750

End: 1486246

Strand: Reverse

Name: uvrC [H]

Synonym: Amuc_1237

Alternate gene names: 187735731

Gene position: 1486246-1484750 (Counterclockwise)

Preceding gene: 187735738

Following gene: 187735730

Centisome position: 55.79

GC content: 54.38

Gene sequence:

>1497_bases
ATGAAAGACGCCCGGGGAAATACCATCTACGTGGGCAAAGCCAAGGACCTTCACCGCCGCCTGGGCAACTATTTTTCTCC
CACGGGAGCCACACTCTCCAATCATAAGACAAGAGCGCTCATTAACGCTATTGCGTCATTTGATTATTTTGAAACCAGAA
ATGACCAGGAGGCTTTTCTGCTGGAAAGCAAACTGATTAAACAATATCGTCCGCATTACAATATCCAGATGAAGGACGAC
AAGCGCTACCCCCTGCTGAAAATTCCGAAGGGGGAAAAACTGCCTCGTTTCCAGCTGGCGCGAGTGCGCAAAGATGACGG
AGCGCGCTACTTCGGCCCCTTTGTCCACTCCCAGGCTCTTTACGCCACGCAGGAATGGCTTAACCGGCATTTCCGGCTGC
GAACCTGCAAGACAAAAAATCCGGGAATTCATGACTTCAGGCACTGCCATGCGGATGTGATTCGCAACTGCTCCGCTCCG
TGCATTGGCCGCATTTCCATCAATGATTACAACCGGAACTTTGACCAGGCGGTGCGTCTGCTGGAAGGAACGGGAAGAAA
AAGCACTCTGGACGAACTTACCGGGGAAATGATGGAAGCCGCCGATAAACTGGACTTTGAACGTGCGGCATACCTGCGGG
ACATCCGGGACAATCTGGTCAAGGTACTGGAACCCGCCCGGCGGTTCCGAAAAAGAACTCCCGATCTTCCCGGCACCGTT
CATCCGGAAGAAGACATGAAGGAACTGGGGGTGGCCCTGGGATTAGAATCTCCCCCAACCATCATGGAATGCTTTGACAT
TTCCAATGTCTCTTCCAACCATATCGTAGCCTCCATGGTGCGCTTTACCAACGGCAGGCCGGATAACAAAGCCTACCGTC
GGTACCGTATACGTACTGTGGACGGACAAAATGACTTCGCCTCCATGTCGGAAGTCATCCGGAGGCGTTACTCCCGCATT
CTGGCGGAGAGCGACGCCGTAGCCTCACGGCAGGCGGACATGACCCTGTACCAGTGGCTTAAGAAACTCAGCGCGGAAGG
AAAAGCCCCCATCAAAGTTCCAGATCTGGTAGTCGTGGACGGAGGTAAAGGACAGCTTTCCTCCGCTCTGGCCGATTTGG
AAGCCATCGGCCTGGGAGACATGCCCATCGTAGGCCTGGCCAAGCAGAGGGAAGAAATATTTTTTCCCCACCAGTCCCAG
CCCCTTTGCCTGCCTCACAGCACGGGAGCCCTCAAACTCATGCAGCGCATCCGCGACGAAGCCCACCGTTTCGCCAACGG
CTATAACGAACTGCTCTACCGCAAACGCATGCGGGAAAGCGCCTTGGACGACGCCCCGGGCATGAGCGCCTCAAAAAAAA
GACTGTTGCTGGAAAAATTCAAATCCGTAACTGCCATTAAAAAGGCGGACCCGGCTTCTATCGCCGCCATCCGCGGCATT
TCGGAAACTTGGGCCCGCACCCTGCTGAACTACCTTAACTCATCTTCCAACTCCTGA

Upstream 100 bases:

>100_bases
TTCTTGCCTCATATGGCATAATGCCTGCGTGGCAGACCGCGAGAAACCAACCCTGAAAGAACTCTGGAGGGAAACTCCGC
ACAAACCAGGCGTTTATATC

Downstream 100 bases:

>100_bases
CTTCTCATGCAATTCCTGATTCTGGCCGCCGGAAAGCCTTCCCTAGGCTACGCCAAGGAAGGCGTGGAACTCTATCTCAA
CCGCCTCAGGCCCTTCGGCA

Product: excinuclease ABC C subunit domain protein

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MKDARGNTIYVGKAKDLHRRLGNYFSPTGATLSNHKTRALINAIASFDYFETRNDQEAFLLESKLIKQYRPHYNIQMKDD
KRYPLLKIPKGEKLPRFQLARVRKDDGARYFGPFVHSQALYATQEWLNRHFRLRTCKTKNPGIHDFRHCHADVIRNCSAP
CIGRISINDYNRNFDQAVRLLEGTGRKSTLDELTGEMMEAADKLDFERAAYLRDIRDNLVKVLEPARRFRKRTPDLPGTV
HPEEDMKELGVALGLESPPTIMECFDISNVSSNHIVASMVRFTNGRPDNKAYRRYRIRTVDGQNDFASMSEVIRRRYSRI
LAESDAVASRQADMTLYQWLKKLSAEGKAPIKVPDLVVVDGGKGQLSSALADLEAIGLGDMPIVGLAKQREEIFFPHQSQ
PLCLPHSTGALKLMQRIRDEAHRFANGYNELLYRKRMRESALDDAPGMSASKKRLLLEKFKSVTAIKKADPASIAAIRGI
SETWARTLLNYLNSSSNS

Sequences:

>Translated_498_residues
MKDARGNTIYVGKAKDLHRRLGNYFSPTGATLSNHKTRALINAIASFDYFETRNDQEAFLLESKLIKQYRPHYNIQMKDD
KRYPLLKIPKGEKLPRFQLARVRKDDGARYFGPFVHSQALYATQEWLNRHFRLRTCKTKNPGIHDFRHCHADVIRNCSAP
CIGRISINDYNRNFDQAVRLLEGTGRKSTLDELTGEMMEAADKLDFERAAYLRDIRDNLVKVLEPARRFRKRTPDLPGTV
HPEEDMKELGVALGLESPPTIMECFDISNVSSNHIVASMVRFTNGRPDNKAYRRYRIRTVDGQNDFASMSEVIRRRYSRI
LAESDAVASRQADMTLYQWLKKLSAEGKAPIKVPDLVVVDGGKGQLSSALADLEAIGLGDMPIVGLAKQREEIFFPHQSQ
PLCLPHSTGALKLMQRIRDEAHRFANGYNELLYRKRMRESALDDAPGMSASKKRLLLEKFKSVTAIKKADPASIAAIRGI
SETWARTLLNYLNSSSNS
>Mature_498_residues
MKDARGNTIYVGKAKDLHRRLGNYFSPTGATLSNHKTRALINAIASFDYFETRNDQEAFLLESKLIKQYRPHYNIQMKDD
KRYPLLKIPKGEKLPRFQLARVRKDDGARYFGPFVHSQALYATQEWLNRHFRLRTCKTKNPGIHDFRHCHADVIRNCSAP
CIGRISINDYNRNFDQAVRLLEGTGRKSTLDELTGEMMEAADKLDFERAAYLRDIRDNLVKVLEPARRFRKRTPDLPGTV
HPEEDMKELGVALGLESPPTIMECFDISNVSSNHIVASMVRFTNGRPDNKAYRRYRIRTVDGQNDFASMSEVIRRRYSRI
LAESDAVASRQADMTLYQWLKKLSAEGKAPIKVPDLVVVDGGKGQLSSALADLEAIGLGDMPIVGLAKQREEIFFPHQSQ
PLCLPHSTGALKLMQRIRDEAHRFANGYNELLYRKRMRESALDDAPGMSASKKRLLLEKFKSVTAIKKADPASIAAIRGI
SETWARTLLNYLNSSSNS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=283, Percent_Identity=32.8621908127208, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 56649; Mature: 56649

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDARGNTIYVGKAKDLHRRLGNYFSPTGATLSNHKTRALINAIASFDYFETRNDQEAFL
CCCCCCCEEEEECHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCHHHHH
LESKLIKQYRPHYNIQMKDDKRYPLLKIPKGEKLPRFQLARVRKDDGARYFGPFVHSQAL
HHHHHHHHHCCCCCEEECCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
YATQEWLNRHFRLRTCKTKNPGIHDFRHCHADVIRNCSAPCIGRISINDYNRNFDQAVRL
HHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHH
LEGTGRKSTLDELTGEMMEAADKLDFERAAYLRDIRDNLVKVLEPARRFRKRTPDLPGTV
HHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
HPEEDMKELGVALGLESPPTIMECFDISNVSSNHIVASMVRFTNGRPDNKAYRRYRIRTV
CCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHEEEEEEE
DGQNDFASMSEVIRRRYSRILAESDAVASRQADMTLYQWLKKLSAEGKAPIKVPDLVVVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
GGKGQLSSALADLEAIGLGDMPIVGLAKQREEIFFPHQSQPLCLPHSTGALKLMQRIRDE
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHH
AHRFANGYNELLYRKRMRESALDDAPGMSASKKRLLLEKFKSVTAIKKADPASIAAIRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
SETWARTLLNYLNSSSNS
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKDARGNTIYVGKAKDLHRRLGNYFSPTGATLSNHKTRALINAIASFDYFETRNDQEAFL
CCCCCCCEEEEECHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCHHHHH
LESKLIKQYRPHYNIQMKDDKRYPLLKIPKGEKLPRFQLARVRKDDGARYFGPFVHSQAL
HHHHHHHHHCCCCCEEECCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
YATQEWLNRHFRLRTCKTKNPGIHDFRHCHADVIRNCSAPCIGRISINDYNRNFDQAVRL
HHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHH
LEGTGRKSTLDELTGEMMEAADKLDFERAAYLRDIRDNLVKVLEPARRFRKRTPDLPGTV
HHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
HPEEDMKELGVALGLESPPTIMECFDISNVSSNHIVASMVRFTNGRPDNKAYRRYRIRTV
CCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHEEEEEEE
DGQNDFASMSEVIRRRYSRILAESDAVASRQADMTLYQWLKKLSAEGKAPIKVPDLVVVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
GGKGQLSSALADLEAIGLGDMPIVGLAKQREEIFFPHQSQPLCLPHSTGALKLMQRIRDE
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHH
AHRFANGYNELLYRKRMRESALDDAPGMSASKKRLLLEKFKSVTAIKKADPASIAAIRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
SETWARTLLNYLNSSSNS
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA