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The map label for this gene is pepP [H]

Identifier: 187735601

GI number: 187735601

Start: 1321347

End: 1322630

Strand: Direct

Name: pepP [H]

Synonym: Amuc_1106

Alternate gene names: 187735601

Gene position: 1321347-1322630 (Clockwise)

Preceding gene: 187735599

Following gene: 187735602

Centisome position: 49.6

GC content: 55.06

Gene sequence:

>1284_bases
ATGAGATACGAGCCGCTTCCTTCTTCCTTTTTTGCCGGCAACCGTGAAGAACTTGCTTCCCGCCTGCCTGCCGGCAGTAT
GCTGATTCTGCACGCCAACGACGTATTTCCTACGAATGCGGACGGCACTTTTGCCCTGCATCAGAATGCCAACCTCTTTT
ATCTTACGGGAGTTGACCAGGAAGAAACCGTCCTGGTCATGACCATCCGGGAGGACGGCTGGGATGAGATCCTGCTGTTG
CGTGAGACAAATGAACAGATTGCCATCTGGGAAGGCGCCCGGCTCTCGCAGGAACAGGCGAGAGAGCTGAGCGGCATCCA
GGACGTGCGCTGGACCGATGAATATGATGCGCTGCTGGAGGCCCTGGTGCCGTCCGCATCCATGGTCTTTGTGGAAGCCA
ACCAGCATCCGCGATGCACATGCCCGGTGGAAACGCGCAATGCCCGCATGACCAAGGAGCTGAAGGAAAAATTCCCGGAC
GCTGTTTTGAAGAATGTCTATGAAATCTTGGCGGACATGCGGCAAATCAAAAAGCCGGAAGAAATCAAGGCTCTCAAAAA
AGCCTGCGACATCACCAATGAAGGCTTCCGGGAATTGCTCCGGTTCATCAGGCCGGGGGTGGGCGAATGGCAGATTGAGG
GATTCCTGGCCAACGAATTCATCAGCCGCGGTCCGCGCAAATTCTCCTTCCTACCCATCATCGCTTCCGGAAAGGATACC
TGTGTGCTGCATTATATCCAAAACGACAAACGGTGCGAAGACGGCGATCTGGTGCTTATGGACATAGGCACGGAATACGG
GAATTACAACTCCGACATGACCCGCACCGTTCCCGTGAACGGAAAATTCACTCCCCGCCAGCGCGCTGTGTATGAAAGCG
TGCTGAATATGATGACCTACGCCAAAAAGATTCTGAAACCCGGAATCCTGAAATCGGAGTACGAACGCCTGGTGCGCGTT
TTTGCCGCCGGGGAACTCGTCAAGCTGGGGCTGATCACACCCGCGCAGGTGGCGGAAAAACCGTCCGATCCTCCCATTGT
CCGGAAATATTACATGCACGGGTGTTCCCACTTCCTGGGGCTGGATGTGCACGATGTGGGCGAAGCCAACCCCGTTGTGT
TGCCGGGCATGGTTTTCACCGTGGAACCGGGCATCTATATTGCGGAAGAAGGCATAGGCATCCGTTTGGAAAACGACGTC
CTGATCGGGGAAACAGAAAACATCGACCTGTTGGGAGACGTGCCTTTGCTGCCTGATGACATTGAACGGCTCATGGCCCG
GTAA

Upstream 100 bases:

>100_bases
GGCACGGTCAGAAGAACTCCGGACGACAAGGAAACGCGCAAGGTTGCCCCGTGTCCGGATGCATGATTGACAAGCCGGAA
AAGCGGGGCATGCTGTTGAT

Downstream 100 bases:

>100_bases
AATGGGCCGGATACGGTTCTGAACTTGACAATGGGGCCCGTGTGGGTTTTCATTCCCGTCCCATCATGTCGAAGAAACTC
AAAATAGCTCTTCCCAAAGG

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRYEPLPSSFFAGNREELASRLPAGSMLILHANDVFPTNADGTFALHQNANLFYLTGVDQEETVLVMTIREDGWDEILLL
RETNEQIAIWEGARLSQEQARELSGIQDVRWTDEYDALLEALVPSASMVFVEANQHPRCTCPVETRNARMTKELKEKFPD
AVLKNVYEILADMRQIKKPEEIKALKKACDITNEGFRELLRFIRPGVGEWQIEGFLANEFISRGPRKFSFLPIIASGKDT
CVLHYIQNDKRCEDGDLVLMDIGTEYGNYNSDMTRTVPVNGKFTPRQRAVYESVLNMMTYAKKILKPGILKSEYERLVRV
FAAGELVKLGLITPAQVAEKPSDPPIVRKYYMHGCSHFLGLDVHDVGEANPVVLPGMVFTVEPGIYIAEEGIGIRLENDV
LIGETENIDLLGDVPLLPDDIERLMAR

Sequences:

>Translated_427_residues
MRYEPLPSSFFAGNREELASRLPAGSMLILHANDVFPTNADGTFALHQNANLFYLTGVDQEETVLVMTIREDGWDEILLL
RETNEQIAIWEGARLSQEQARELSGIQDVRWTDEYDALLEALVPSASMVFVEANQHPRCTCPVETRNARMTKELKEKFPD
AVLKNVYEILADMRQIKKPEEIKALKKACDITNEGFRELLRFIRPGVGEWQIEGFLANEFISRGPRKFSFLPIIASGKDT
CVLHYIQNDKRCEDGDLVLMDIGTEYGNYNSDMTRTVPVNGKFTPRQRAVYESVLNMMTYAKKILKPGILKSEYERLVRV
FAAGELVKLGLITPAQVAEKPSDPPIVRKYYMHGCSHFLGLDVHDVGEANPVVLPGMVFTVEPGIYIAEEGIGIRLENDV
LIGETENIDLLGDVPLLPDDIERLMAR
>Mature_427_residues
MRYEPLPSSFFAGNREELASRLPAGSMLILHANDVFPTNADGTFALHQNANLFYLTGVDQEETVLVMTIREDGWDEILLL
RETNEQIAIWEGARLSQEQARELSGIQDVRWTDEYDALLEALVPSASMVFVEANQHPRCTCPVETRNARMTKELKEKFPD
AVLKNVYEILADMRQIKKPEEIKALKKACDITNEGFRELLRFIRPGVGEWQIEGFLANEFISRGPRKFSFLPIIASGKDT
CVLHYIQNDKRCEDGDLVLMDIGTEYGNYNSDMTRTVPVNGKFTPRQRAVYESVLNMMTYAKKILKPGILKSEYERLVRV
FAAGELVKLGLITPAQVAEKPSDPPIVRKYYMHGCSHFLGLDVHDVGEANPVVLPGMVFTVEPGIYIAEEGIGIRLENDV
LIGETENIDLLGDVPLLPDDIERLMAR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=416, Percent_Identity=28.125, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI149589008, Length=475, Percent_Identity=28.2105263157895, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI260593665, Length=304, Percent_Identity=31.25, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI260593663, Length=474, Percent_Identity=26.5822784810127, Blast_Score=135, Evalue=9e-32,
Organism=Escherichia coli, GI1789275, Length=437, Percent_Identity=35.2402745995423, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1788728, Length=238, Percent_Identity=32.7731092436975, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1790282, Length=303, Percent_Identity=24.7524752475248, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=483, Percent_Identity=28.3643892339545, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71989583, Length=384, Percent_Identity=27.0833333333333, Blast_Score=124, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6320922, Length=438, Percent_Identity=27.3972602739726, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6321118, Length=439, Percent_Identity=25.2847380410023, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323273, Length=219, Percent_Identity=25.1141552511416, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920384, Length=401, Percent_Identity=30.4239401496259, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21357079, Length=485, Percent_Identity=27.0103092783505, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48195; Mature: 48195

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYEPLPSSFFAGNREELASRLPAGSMLILHANDVFPTNADGTFALHQNANLFYLTGVDQ
CCCCCCCHHHHCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEECCCC
EETVLVMTIREDGWDEILLLRETNEQIAIWEGARLSQEQARELSGIQDVRWTDEYDALLE
CCEEEEEEEECCCCCEEEEEEECCCEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHH
ALVPSASMVFVEANQHPRCTCPVETRNARMTKELKEKFPDAVLKNVYEILADMRQIKKPE
HHCCCCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCH
EIKALKKACDITNEGFRELLRFIRPGVGEWQIEGFLANEFISRGPRKFSFLPIIASGKDT
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCEEEEEEEECCCCE
CVLHYIQNDKRCEDGDLVLMDIGTEYGNYNSDMTRTVPVNGKFTPRQRAVYESVLNMMTY
EEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
AKKILKPGILKSEYERLVRVFAAGELVKLGLITPAQVAEKPSDPPIVRKYYMHGCSHFLG
HHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHC
LDVHDVGEANPVVLPGMVFTVEPGIYIAEEGIGIRLENDVLIGETENIDLLGDVPLLPDD
CCHHHCCCCCCEEECCEEEEECCCEEEECCCCEEEEECCEEECCCCCEEEEECCCCCHHH
IERLMAR
HHHHHCC
>Mature Secondary Structure
MRYEPLPSSFFAGNREELASRLPAGSMLILHANDVFPTNADGTFALHQNANLFYLTGVDQ
CCCCCCCHHHHCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEECCCC
EETVLVMTIREDGWDEILLLRETNEQIAIWEGARLSQEQARELSGIQDVRWTDEYDALLE
CCEEEEEEEECCCCCEEEEEEECCCEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHHH
ALVPSASMVFVEANQHPRCTCPVETRNARMTKELKEKFPDAVLKNVYEILADMRQIKKPE
HHCCCCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCH
EIKALKKACDITNEGFRELLRFIRPGVGEWQIEGFLANEFISRGPRKFSFLPIIASGKDT
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCEEEEEEEECCCCE
CVLHYIQNDKRCEDGDLVLMDIGTEYGNYNSDMTRTVPVNGKFTPRQRAVYESVLNMMTY
EEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
AKKILKPGILKSEYERLVRVFAAGELVKLGLITPAQVAEKPSDPPIVRKYYMHGCSHFLG
HHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHC
LDVHDVGEANPVVLPGMVFTVEPGIYIAEEGIGIRLENDVLIGETENIDLLGDVPLLPDD
CCHHHCCCCCCEEECCEEEEECCCEEEECCCCEEEEECCEEECCCCCEEEEECCCCCHHH
IERLMAR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]