Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is hisG [H]

Identifier: 187735602

GI number: 187735602

Start: 1322696

End: 1323571

Strand: Direct

Name: hisG [H]

Synonym: Amuc_1107

Alternate gene names: 187735602

Gene position: 1322696-1323571 (Clockwise)

Preceding gene: 187735601

Following gene: 187735603

Centisome position: 49.65

GC content: 55.82

Gene sequence:

>876_bases
ATGTCGAAGAAACTCAAAATAGCTCTTCCCAAAGGCAGTTTGCAGGATTCCACCGTGGAATTGTTCCGCAAGGCCGGCTA
CAATGTGTATGTGTCCAGCCGCGGATACCGCCCGACCTGCGACGACGACGATCTGGAGCTCTTCCTGATCCGTGCCCAGG
AAATAGGCCGTTATGTCAATGACGGTTTCATCGACTGCGGCATTACCGGGCGCGACTGGATTTATGAAAACAGGGCGGAC
GTGGAAGTGCTGACGGATCTTCAATACTCCAAGGCTACCTCCAAGCCTACCCGCTGGGTGCTGGTAGTCCCGGAAAATTC
CCCCATTACCTGTGCGGAAGACCTTCAGGGCAAGCGCATCGCCACGGAAGGCGTGGGCATCACGGAACGCTGGCTTCAGG
AAAAGGGTATTGAAGCCCACGTGGAATTCTCCTGGGGAGCTACGGAAGTGAAGGTGCCGGAACTGGTGGACGCCATTGTG
GACATCACGGAAACGGGAAGCTCCATCAAGGCCAACAAGCTCCGTATCGTGGACACCCTGATGACCTCCTATCCCCAGTT
TATCGCGAACCGGGAAACCATGCAGGACGAGTGGAAAAAACAGAAGCTGGAACGCCTGGTCATGATGCTCAAGGGCGCTC
TGGAAGCGCGCCGGAAAGTGGGTCTGAAAATGAACCTTCCTGCTGCTTCCCTGAACGGCCTGGTAGAGGCCCTTCCGTCT
CTGCGCCGTCCCACTATTTCCCATTTGGCGGAAGAAGGCTGGCTGGCCGTGGAAACGGTCATTGACGAATCCGTTGTGAG
GGATATCATTCCCCAGCTCAAGGCCCTGGGAGCGGAAGGCATCATTGAATACCCGCTTAACAAGCTGGTTTACTAG

Upstream 100 bases:

>100_bases
TGCCTGATGACATTGAACGGCTCATGGCCCGGTAAAATGGGCCGGATACGGTTCTGAACTTGACAATGGGGCCCGTGTGG
GTTTTCATTCCCGTCCCATC

Downstream 100 bases:

>100_bases
ATTTTTTTCTCACCACAGTAAAACAACAAACGAACCACAATCATGGGATCGCTCAAAAAACGCCGTAAAGCAAAAATCAA
CAAGCATAAGCGCAGCAAGC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSKKLKIALPKGSLQDSTVELFRKAGYNVYVSSRGYRPTCDDDDLELFLIRAQEIGRYVNDGFIDCGITGRDWIYENRAD
VEVLTDLQYSKATSKPTRWVLVVPENSPITCAEDLQGKRIATEGVGITERWLQEKGIEAHVEFSWGATEVKVPELVDAIV
DITETGSSIKANKLRIVDTLMTSYPQFIANRETMQDEWKKQKLERLVMMLKGALEARRKVGLKMNLPAASLNGLVEALPS
LRRPTISHLAEEGWLAVETVIDESVVRDIIPQLKALGAEGIIEYPLNKLVY

Sequences:

>Translated_291_residues
MSKKLKIALPKGSLQDSTVELFRKAGYNVYVSSRGYRPTCDDDDLELFLIRAQEIGRYVNDGFIDCGITGRDWIYENRAD
VEVLTDLQYSKATSKPTRWVLVVPENSPITCAEDLQGKRIATEGVGITERWLQEKGIEAHVEFSWGATEVKVPELVDAIV
DITETGSSIKANKLRIVDTLMTSYPQFIANRETMQDEWKKQKLERLVMMLKGALEARRKVGLKMNLPAASLNGLVEALPS
LRRPTISHLAEEGWLAVETVIDESVVRDIIPQLKALGAEGIIEYPLNKLVY
>Mature_290_residues
SKKLKIALPKGSLQDSTVELFRKAGYNVYVSSRGYRPTCDDDDLELFLIRAQEIGRYVNDGFIDCGITGRDWIYENRADV
EVLTDLQYSKATSKPTRWVLVVPENSPITCAEDLQGKRIATEGVGITERWLQEKGIEAHVEFSWGATEVKVPELVDAIVD
ITETGSSIKANKLRIVDTLMTSYPQFIANRETMQDEWKKQKLERLVMMLKGALEARRKVGLKMNLPAASLNGLVEALPSL
RRPTISHLAEEGWLAVETVIDESVVRDIIPQLKALGAEGIIEYPLNKLVY

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=297, Percent_Identity=29.2929292929293, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320896, Length=295, Percent_Identity=27.1186440677966, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32697; Mature: 32566

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKLKIALPKGSLQDSTVELFRKAGYNVYVSSRGYRPTCDDDDLELFLIRAQEIGRYVN
CCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHC
DGFIDCGITGRDWIYENRADVEVLTDLQYSKATSKPTRWVLVVPENSPITCAEDLQGKRI
CCCEECCCCCCCCEECCCCCHHHHHCCHHHHCCCCCCEEEEEEECCCCCEEHHHCCCCEE
ATEGVGITERWLQEKGIEAHVEFSWGATEVKVPELVDAIVDITETGSSIKANKLRIVDTL
EECCCCHHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
MTSYPQFIANRETMQDEWKKQKLERLVMMLKGALEARRKVGLKMNLPAASLNGLVEALPS
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHH
LRRPTISHLAEEGWLAVETVIDESVVRDIIPQLKALGAEGIIEYPLNKLVY
HCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SKKLKIALPKGSLQDSTVELFRKAGYNVYVSSRGYRPTCDDDDLELFLIRAQEIGRYVN
CCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHC
DGFIDCGITGRDWIYENRADVEVLTDLQYSKATSKPTRWVLVVPENSPITCAEDLQGKRI
CCCEECCCCCCCCEECCCCCHHHHHCCHHHHCCCCCCEEEEEEECCCCCEEHHHCCCCEE
ATEGVGITERWLQEKGIEAHVEFSWGATEVKVPELVDAIVDITETGSSIKANKLRIVDTL
EECCCCHHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
MTSYPQFIANRETMQDEWKKQKLERLVMMLKGALEARRKVGLKMNLPAASLNGLVEALPS
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHH
LRRPTISHLAEEGWLAVETVIDESVVRDIIPQLKALGAEGIIEYPLNKLVY
HCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA