Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is exoA [H]

Identifier: 187735459

GI number: 187735459

Start: 1143584

End: 1144345

Strand: Direct

Name: exoA [H]

Synonym: Amuc_0958

Alternate gene names: 187735459

Gene position: 1143584-1144345 (Clockwise)

Preceding gene: 187735455

Following gene: 187735460

Centisome position: 42.93

GC content: 62.07

Gene sequence:

>762_bases
ATGAAACTCGTCTCATGGAACGTGAACGGATTGCGGGCGGTTCTGGGCAAGGGAATGGCGGACGCCGTGGATGCCCTGGA
GCCGGACGTCCTCTGCCTTCAGGAGATCAAGGCGCGTCCGGAACAGGTGAAAGACCTGTGGATTTCCTCCTGGCCGCACC
AGCTCTGGAATCCGGCGGAGAAGGCCGGCTATTCCGGCGTGCTGATCCTCAGCCGGGTGCGGCCTCTTTCCACGTCCGTC
GGAATCGGCTGGCCGGAGCATGACCGGGAAGGGCGCGTCTGCACGATGGAATTCGAGGGGTTTTACCTGGTCAACTGCTA
TACGCCCAATTCACAGAATGAACTGGTGCGCCTTCCGTACCGGGAGCAGTGGGACGCCGCGTTCCGCGAGTATGTGGCGG
GACTGGCGGAAACCAAGCCGGTCGTTTTCTGCGGAGACTTGAACGTGGCCCATGAGGAGATTGACATTGCACGTCCCAAA
GAGAACCGTTTTTCCGCCGGGTTCAGCGACCAGGAGCGCGCCGGGTTCACGCTGCTGCTTGAGGCCGGTTTTACGGATAC
GTTCCGCGCCCTGCATCCGGAGGAGCCGGGCTGGTACAGCTGGTGGTCCTACCGCGCGGGCGCCCGCGCCCGGAATATCG
GATGGCGCATTGACTATTTCTGCGTTTCCAATCCGCTGGCTTCCAGGGTGAAGGATGCCGCCATCCATCCGGATGTGACG
GGGTCCGACCATTGCCCCGTCAGCCTGGAGATTGACTGCTGA

Upstream 100 bases:

>100_bases
ATGATTCCGGAAGAAGAATTTTCCGGAGCCCTCCGGGAGGGGGCGGGACAACGGTGTTTGAGGGCTTGACGGACCCGTGA
AAAACGGGAAGTATGCGCGC

Downstream 100 bases:

>100_bases
GCGCGGTCTTTCAGATGATTTTCAACTGTAAAAGATTGATGATTATGGAACAGGAATTGCCGCTGCTGGTGGTTGCCACG
CGCAACGCCCACAAGACCGG

Product: exodeoxyribonuclease III Xth

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MKLVSWNVNGLRAVLGKGMADAVDALEPDVLCLQEIKARPEQVKDLWISSWPHQLWNPAEKAGYSGVLILSRVRPLSTSV
GIGWPEHDREGRVCTMEFEGFYLVNCYTPNSQNELVRLPYREQWDAAFREYVAGLAETKPVVFCGDLNVAHEEIDIARPK
ENRFSAGFSDQERAGFTLLLEAGFTDTFRALHPEEPGWYSWWSYRAGARARNIGWRIDYFCVSNPLASRVKDAAIHPDVT
GSDHCPVSLEIDC

Sequences:

>Translated_253_residues
MKLVSWNVNGLRAVLGKGMADAVDALEPDVLCLQEIKARPEQVKDLWISSWPHQLWNPAEKAGYSGVLILSRVRPLSTSV
GIGWPEHDREGRVCTMEFEGFYLVNCYTPNSQNELVRLPYREQWDAAFREYVAGLAETKPVVFCGDLNVAHEEIDIARPK
ENRFSAGFSDQERAGFTLLLEAGFTDTFRALHPEEPGWYSWWSYRAGARARNIGWRIDYFCVSNPLASRVKDAAIHPDVT
GSDHCPVSLEIDC
>Mature_253_residues
MKLVSWNVNGLRAVLGKGMADAVDALEPDVLCLQEIKARPEQVKDLWISSWPHQLWNPAEKAGYSGVLILSRVRPLSTSV
GIGWPEHDREGRVCTMEFEGFYLVNCYTPNSQNELVRLPYREQWDAAFREYVAGLAETKPVVFCGDLNVAHEEIDIARPK
ENRFSAGFSDQERAGFTLLLEAGFTDTFRALHPEEPGWYSWWSYRAGARARNIGWRIDYFCVSNPLASRVKDAAIHPDVT
GSDHCPVSLEIDC

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=255, Percent_Identity=50.1960784313725, Blast_Score=251, Evalue=5e-67,
Organism=Homo sapiens, GI18375503, Length=255, Percent_Identity=50.1960784313725, Blast_Score=251, Evalue=5e-67,
Organism=Homo sapiens, GI18375501, Length=255, Percent_Identity=50.1960784313725, Blast_Score=251, Evalue=5e-67,
Organism=Escherichia coli, GI1788046, Length=264, Percent_Identity=28.030303030303, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71989536, Length=254, Percent_Identity=44.4881889763779, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71989539, Length=144, Percent_Identity=36.1111111111111, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221330655, Length=253, Percent_Identity=46.2450592885375, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17136678, Length=253, Percent_Identity=46.2450592885375, Blast_Score=221, Evalue=3e-58,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 28575; Mature: 28575

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00726 AP_NUCLEASE_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVSWNVNGLRAVLGKGMADAVDALEPDVLCLQEIKARPEQVKDLWISSWPHQLWNPAE
CEEEEECCCHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHCCHHH
KAGYSGVLILSRVRPLSTSVGIGWPEHDREGRVCTMEFEGFYLVNCYTPNSQNELVRLPY
HCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCCCEEECCC
REQWDAAFREYVAGLAETKPVVFCGDLNVAHEEIDIARPKENRFSAGFSDQERAGFTLLL
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE
EAGFTDTFRALHPEEPGWYSWWSYRAGARARNIGWRIDYFCVSNPLASRVKDAAIHPDVT
ECCCCHHHHHCCCCCCCCCCCCHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHCCCCCCC
GSDHCPVSLEIDC
CCCCCCEEEEECC
>Mature Secondary Structure
MKLVSWNVNGLRAVLGKGMADAVDALEPDVLCLQEIKARPEQVKDLWISSWPHQLWNPAE
CEEEEECCCHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHCCHHH
KAGYSGVLILSRVRPLSTSVGIGWPEHDREGRVCTMEFEGFYLVNCYTPNSQNELVRLPY
HCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCCCEEECCC
REQWDAAFREYVAGLAETKPVVFCGDLNVAHEEIDIARPKENRFSAGFSDQERAGFTLLL
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE
EAGFTDTFRALHPEEPGWYSWWSYRAGARARNIGWRIDYFCVSNPLASRVKDAAIHPDVT
ECCCCHHHHHCCCCCCCCCCCCHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHCCCCCCC
GSDHCPVSLEIDC
CCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]