Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
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Accession | NC_010655 |
Length | 2,664,102 |
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The map label for this gene is exoA [H]
Identifier: 187735459
GI number: 187735459
Start: 1143584
End: 1144345
Strand: Direct
Name: exoA [H]
Synonym: Amuc_0958
Alternate gene names: 187735459
Gene position: 1143584-1144345 (Clockwise)
Preceding gene: 187735455
Following gene: 187735460
Centisome position: 42.93
GC content: 62.07
Gene sequence:
>762_bases ATGAAACTCGTCTCATGGAACGTGAACGGATTGCGGGCGGTTCTGGGCAAGGGAATGGCGGACGCCGTGGATGCCCTGGA GCCGGACGTCCTCTGCCTTCAGGAGATCAAGGCGCGTCCGGAACAGGTGAAAGACCTGTGGATTTCCTCCTGGCCGCACC AGCTCTGGAATCCGGCGGAGAAGGCCGGCTATTCCGGCGTGCTGATCCTCAGCCGGGTGCGGCCTCTTTCCACGTCCGTC GGAATCGGCTGGCCGGAGCATGACCGGGAAGGGCGCGTCTGCACGATGGAATTCGAGGGGTTTTACCTGGTCAACTGCTA TACGCCCAATTCACAGAATGAACTGGTGCGCCTTCCGTACCGGGAGCAGTGGGACGCCGCGTTCCGCGAGTATGTGGCGG GACTGGCGGAAACCAAGCCGGTCGTTTTCTGCGGAGACTTGAACGTGGCCCATGAGGAGATTGACATTGCACGTCCCAAA GAGAACCGTTTTTCCGCCGGGTTCAGCGACCAGGAGCGCGCCGGGTTCACGCTGCTGCTTGAGGCCGGTTTTACGGATAC GTTCCGCGCCCTGCATCCGGAGGAGCCGGGCTGGTACAGCTGGTGGTCCTACCGCGCGGGCGCCCGCGCCCGGAATATCG GATGGCGCATTGACTATTTCTGCGTTTCCAATCCGCTGGCTTCCAGGGTGAAGGATGCCGCCATCCATCCGGATGTGACG GGGTCCGACCATTGCCCCGTCAGCCTGGAGATTGACTGCTGA
Upstream 100 bases:
>100_bases ATGATTCCGGAAGAAGAATTTTCCGGAGCCCTCCGGGAGGGGGCGGGACAACGGTGTTTGAGGGCTTGACGGACCCGTGA AAAACGGGAAGTATGCGCGC
Downstream 100 bases:
>100_bases GCGCGGTCTTTCAGATGATTTTCAACTGTAAAAGATTGATGATTATGGAACAGGAATTGCCGCTGCTGGTGGTTGCCACG CGCAACGCCCACAAGACCGG
Product: exodeoxyribonuclease III Xth
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 253; Mature: 253
Protein sequence:
>253_residues MKLVSWNVNGLRAVLGKGMADAVDALEPDVLCLQEIKARPEQVKDLWISSWPHQLWNPAEKAGYSGVLILSRVRPLSTSV GIGWPEHDREGRVCTMEFEGFYLVNCYTPNSQNELVRLPYREQWDAAFREYVAGLAETKPVVFCGDLNVAHEEIDIARPK ENRFSAGFSDQERAGFTLLLEAGFTDTFRALHPEEPGWYSWWSYRAGARARNIGWRIDYFCVSNPLASRVKDAAIHPDVT GSDHCPVSLEIDC
Sequences:
>Translated_253_residues MKLVSWNVNGLRAVLGKGMADAVDALEPDVLCLQEIKARPEQVKDLWISSWPHQLWNPAEKAGYSGVLILSRVRPLSTSV GIGWPEHDREGRVCTMEFEGFYLVNCYTPNSQNELVRLPYREQWDAAFREYVAGLAETKPVVFCGDLNVAHEEIDIARPK ENRFSAGFSDQERAGFTLLLEAGFTDTFRALHPEEPGWYSWWSYRAGARARNIGWRIDYFCVSNPLASRVKDAAIHPDVT GSDHCPVSLEIDC >Mature_253_residues MKLVSWNVNGLRAVLGKGMADAVDALEPDVLCLQEIKARPEQVKDLWISSWPHQLWNPAEKAGYSGVLILSRVRPLSTSV GIGWPEHDREGRVCTMEFEGFYLVNCYTPNSQNELVRLPYREQWDAAFREYVAGLAETKPVVFCGDLNVAHEEIDIARPK ENRFSAGFSDQERAGFTLLLEAGFTDTFRALHPEEPGWYSWWSYRAGARARNIGWRIDYFCVSNPLASRVKDAAIHPDVT GSDHCPVSLEIDC
Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase
COG id: COG0708
COG function: function code L; Exonuclease III
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]
Homologues:
Organism=Homo sapiens, GI18375505, Length=255, Percent_Identity=50.1960784313725, Blast_Score=251, Evalue=5e-67, Organism=Homo sapiens, GI18375503, Length=255, Percent_Identity=50.1960784313725, Blast_Score=251, Evalue=5e-67, Organism=Homo sapiens, GI18375501, Length=255, Percent_Identity=50.1960784313725, Blast_Score=251, Evalue=5e-67, Organism=Escherichia coli, GI1788046, Length=264, Percent_Identity=28.030303030303, Blast_Score=106, Evalue=2e-24, Organism=Caenorhabditis elegans, GI71989536, Length=254, Percent_Identity=44.4881889763779, Blast_Score=222, Evalue=2e-58, Organism=Caenorhabditis elegans, GI71989539, Length=144, Percent_Identity=36.1111111111111, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI221330655, Length=253, Percent_Identity=46.2450592885375, Blast_Score=222, Evalue=2e-58, Organism=Drosophila melanogaster, GI17136678, Length=253, Percent_Identity=46.2450592885375, Blast_Score=221, Evalue=3e-58,
Paralogues:
None
Copy number: 900 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000097 - InterPro: IPR020847 - InterPro: IPR020848 - InterPro: IPR005135 - InterPro: IPR004808 [H]
Pfam domain/function: PF03372 Exo_endo_phos [H]
EC number: =3.1.11.2 [H]
Molecular weight: Translated: 28575; Mature: 28575
Theoretical pI: Translated: 5.03; Mature: 5.03
Prosite motif: PS00726 AP_NUCLEASE_F1_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.8 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 2.8 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKLVSWNVNGLRAVLGKGMADAVDALEPDVLCLQEIKARPEQVKDLWISSWPHQLWNPAE CEEEEECCCHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHCCHHH KAGYSGVLILSRVRPLSTSVGIGWPEHDREGRVCTMEFEGFYLVNCYTPNSQNELVRLPY HCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCCCEEECCC REQWDAAFREYVAGLAETKPVVFCGDLNVAHEEIDIARPKENRFSAGFSDQERAGFTLLL HHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE EAGFTDTFRALHPEEPGWYSWWSYRAGARARNIGWRIDYFCVSNPLASRVKDAAIHPDVT ECCCCHHHHHCCCCCCCCCCCCHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHCCCCCCC GSDHCPVSLEIDC CCCCCCEEEEECC >Mature Secondary Structure MKLVSWNVNGLRAVLGKGMADAVDALEPDVLCLQEIKARPEQVKDLWISSWPHQLWNPAE CEEEEECCCHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHCCHHH KAGYSGVLILSRVRPLSTSVGIGWPEHDREGRVCTMEFEGFYLVNCYTPNSQNELVRLPY HCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCCCEEECCC REQWDAAFREYVAGLAETKPVVFCGDLNVAHEEIDIARPKENRFSAGFSDQERAGFTLLL HHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE EAGFTDTFRALHPEEPGWYSWWSYRAGARARNIGWRIDYFCVSNPLASRVKDAAIHPDVT ECCCCHHHHHCCCCCCCCCCCCHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHCCCCCCC GSDHCPVSLEIDC CCCCCCEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7584024; 9384377 [H]