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The map label for this gene is adk [H]

Identifier: 187735435

GI number: 187735435

Start: 1112026

End: 1112676

Strand: Direct

Name: adk [H]

Synonym: Amuc_0934

Alternate gene names: 187735435

Gene position: 1112026-1112676 (Clockwise)

Preceding gene: 187735434

Following gene: 187735436

Centisome position: 41.74

GC content: 58.83

Gene sequence:

>651_bases
ATGAAGGAACTCAAGCATTTCATTCTGGTTGGGGCTCCCGCATCCGGCAAAGGGACCCAGGGCCGGTTTTTGGCTGATAC
CTTCGGCCTTCACTCCCTGAGCACCGGCTCCCTGTTGCGGAGGGAAGTGGAATCCTGCACGGAACTGGGCCGGAAAGCCT
TGAGCTATATGGACAGGGCCATGCTGGTTCCGGACGAAATTGTCAATGACATGGTGCGCGGCTGGCTGTCGGAGATGGAC
CATGGCGCGTGGCTGCTGGACGGCTATCCCCGCACGGTTGCGCAGGCGGAAGCGCTGGACCATTTTCTAAACCAGCGGGG
AACCTCCGTGGATGTAGTCGTCTGGATGGATGTGTCCAGGGAACTCATTGAACAGCGCATCATGCGCCGCCGGGAATGTT
CCACATGCGGTTACGTGGTGCAGACGCCGGAAGAGGAATGTTCCAAGTGCGGAGGGAAAATGGTTTCCCGCAAGGATGAC
AACATGGAAGCTTTCGCCCGCCGCTGGAAGGATTTTGAAGCCATGACGCTGCCCGTAGCCAGGTACTACGAGGCCCGCGG
CCTGGTCGTTAAAATGACGGTGTCCGAAGAACGGGAACCTGCCGATGTTTCCCGGGATCTGGCCCGCAAGCTGGAAGAGT
ACCGGCAATAG

Upstream 100 bases:

>100_bases
CGTTACCGTCATGTGGATTGTTATCGCTCTGCTTGTGCTGGCCGGAGCCATCGCCTACAACGCCATGCAGTAAGCCCCCT
TTTTTACTGAAAGTAAAGAT

Downstream 100 bases:

>100_bases
AAAGAATAATCCCATGGCAGAACGAATCCACATCAAGTCTCCCGGCGAGGTAGCCAAGATGCAGAAAGCCGGGGCTGTAA
CGGCGGAAATCTTGATGGAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MKELKHFILVGAPASGKGTQGRFLADTFGLHSLSTGSLLRREVESCTELGRKALSYMDRAMLVPDEIVNDMVRGWLSEMD
HGAWLLDGYPRTVAQAEALDHFLNQRGTSVDVVVWMDVSRELIEQRIMRRRECSTCGYVVQTPEEECSKCGGKMVSRKDD
NMEAFARRWKDFEAMTLPVARYYEARGLVVKMTVSEEREPADVSRDLARKLEEYRQ

Sequences:

>Translated_216_residues
MKELKHFILVGAPASGKGTQGRFLADTFGLHSLSTGSLLRREVESCTELGRKALSYMDRAMLVPDEIVNDMVRGWLSEMD
HGAWLLDGYPRTVAQAEALDHFLNQRGTSVDVVVWMDVSRELIEQRIMRRRECSTCGYVVQTPEEECSKCGGKMVSRKDD
NMEAFARRWKDFEAMTLPVARYYEARGLVVKMTVSEEREPADVSRDLARKLEEYRQ
>Mature_216_residues
MKELKHFILVGAPASGKGTQGRFLADTFGLHSLSTGSLLRREVESCTELGRKALSYMDRAMLVPDEIVNDMVRGWLSEMD
HGAWLLDGYPRTVAQAEALDHFLNQRGTSVDVVVWMDVSRELIEQRIMRRRECSTCGYVVQTPEEECSKCGGKMVSRKDD
NMEAFARRWKDFEAMTLPVARYYEARGLVVKMTVSEEREPADVSRDLARKLEEYRQ

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI19923437, Length=195, Percent_Identity=33.8461538461538, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI310110345, Length=195, Percent_Identity=32.8205128205128, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI53832003, Length=195, Percent_Identity=32.8205128205128, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI8051579, Length=195, Percent_Identity=32.8205128205128, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI53832001, Length=195, Percent_Identity=32.8205128205128, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI7524346, Length=196, Percent_Identity=34.6938775510204, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=35.6382978723404, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4502011, Length=195, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI28144897, Length=205, Percent_Identity=29.7560975609756, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI28144899, Length=205, Percent_Identity=29.7560975609756, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI7706497, Length=205, Percent_Identity=27.3170731707317, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786680, Length=215, Percent_Identity=37.2093023255814, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17552384, Length=217, Percent_Identity=33.6405529953917, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17567503, Length=190, Percent_Identity=32.6315789473684, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=197, Percent_Identity=26.9035532994924, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=32.8638497652582, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321018, Length=191, Percent_Identity=36.1256544502618, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322828, Length=204, Percent_Identity=25.4901960784314, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI22026816, Length=197, Percent_Identity=36.0406091370558, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17737899, Length=198, Percent_Identity=31.8181818181818, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645822, Length=198, Percent_Identity=31.8181818181818, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17647141, Length=214, Percent_Identity=25.7009345794392, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI221459597, Length=198, Percent_Identity=24.7474747474747, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356893, Length=198, Percent_Identity=24.7474747474747, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24663208, Length=206, Percent_Identity=26.2135922330097, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24690; Mature: 24690

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELKHFILVGAPASGKGTQGRFLADTFGLHSLSTGSLLRREVESCTELGRKALSYMDRA
CCCCCEEEEECCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVPDEIVNDMVRGWLSEMDHGAWLLDGYPRTVAQAEALDHFLNQRGTSVDVVVWMDVSR
HCCCHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEEHHHH
ELIEQRIMRRRECSTCGYVVQTPEEECSKCGGKMVSRKDDNMEAFARRWKDFEAMTLPVA
HHHHHHHHHHHHCCCCCCEEECCHHHHHHHCCHHHCCCCCCHHHHHHHHHCHHHHHHHHH
RYYEARGLVVKMTVSEEREPADVSRDLARKLEEYRQ
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKELKHFILVGAPASGKGTQGRFLADTFGLHSLSTGSLLRREVESCTELGRKALSYMDRA
CCCCCEEEEECCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVPDEIVNDMVRGWLSEMDHGAWLLDGYPRTVAQAEALDHFLNQRGTSVDVVVWMDVSR
HCCCHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEEHHHH
ELIEQRIMRRRECSTCGYVVQTPEEECSKCGGKMVSRKDDNMEAFARRWKDFEAMTLPVA
HHHHHHHHHHHHCCCCCCEEECCHHHHHHHCCHHHCCCCCCHHHHHHHHHCHHHHHHHHH
RYYEARGLVVKMTVSEEREPADVSRDLARKLEEYRQ
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA