Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 187735436

GI number: 187735436

Start: 1112690

End: 1113487

Strand: Direct

Name: map [H]

Synonym: Amuc_0935

Alternate gene names: 187735436

Gene position: 1112690-1113487 (Clockwise)

Preceding gene: 187735435

Following gene: 187735437

Centisome position: 41.77

GC content: 60.65

Gene sequence:

>798_bases
ATGGCAGAACGAATCCACATCAAGTCTCCCGGCGAGGTAGCCAAGATGCAGAAAGCCGGGGCTGTAACGGCGGAAATCTT
GATGGAGATCGGGGCCGAAGTCCAGGTGGGACGCACCACGCGGGAAATAGATGATATCGCGCGTGAAATTTTTAAAAAGC
ACAAGGTAGGCAATTCCTTTTACCGGTACCGCGGGTTTCCCGGCCAGCTCTGCATTTCCATCAATGAAGAGGTGGTGCAC
GGCAGCGGCGGCCCCCGCCGCATCCAGAACGGGGACATTGTGAGCCTGGACGTGGGCGCCATTGTGGACGGCTGGCATGG
AGACAACGCCATGACCGTTCCGGTGGGCATGGTGGATCCGGAAAAACTGCGGCTGCTGGCCGTGACGGAGGAATCCCTGT
TCCGCGCCATTGAACTGGTAAGGCCGGGCGCCTTGCTGGCGGACGTCTGCGCGGCGGTGGAGGGCTTCGTGCGTCCCCGC
GGTTTTACTGTGGTTCGGGATTTTGTGGGGCACGGCATAGGCCGCCACCTGCATGAAGAACCCCAGATTCCCAATTACCG
CCCCCATTACAAGCTTCCGCGCCTGAAAAAGGGGATGGCCCTGGCCATTGAGCCGATGGTGAATGCGGGCAGGCCTTCCG
TTAAAATTCTGGATGACGGCTGGACGGTCGTCACGGCGGACGGCAAGCCTTCCGCCCACTTTGAGCACACGGTTATCGTA
ACGGACGGCGCGCCCCTGATTGTGACGGACCGCCCCCGCATCGCGTTGCCGGAGCAGCTCGGCATTGCTCCTTTGTAA

Upstream 100 bases:

>100_bases
GTCGTTAAAATGACGGTGTCCGAAGAACGGGAACCTGCCGATGTTTCCCGGGATCTGGCCCGCAAGCTGGAAGAGTACCG
GCAATAGAAAGAATAATCCC

Downstream 100 bases:

>100_bases
CTTCAGCCTCTCCAGGGAATGACGCCGCCGGAAGCCTCCGTTCCCGTGATTCTGGAGAAGACCGCCGCCCGCCGGATGGT
GTGGGTGGATGTGGCCCGCG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MAERIHIKSPGEVAKMQKAGAVTAEILMEIGAEVQVGRTTREIDDIAREIFKKHKVGNSFYRYRGFPGQLCISINEEVVH
GSGGPRRIQNGDIVSLDVGAIVDGWHGDNAMTVPVGMVDPEKLRLLAVTEESLFRAIELVRPGALLADVCAAVEGFVRPR
GFTVVRDFVGHGIGRHLHEEPQIPNYRPHYKLPRLKKGMALAIEPMVNAGRPSVKILDDGWTVVTADGKPSAHFEHTVIV
TDGAPLIVTDRPRIALPEQLGIAPL

Sequences:

>Translated_265_residues
MAERIHIKSPGEVAKMQKAGAVTAEILMEIGAEVQVGRTTREIDDIAREIFKKHKVGNSFYRYRGFPGQLCISINEEVVH
GSGGPRRIQNGDIVSLDVGAIVDGWHGDNAMTVPVGMVDPEKLRLLAVTEESLFRAIELVRPGALLADVCAAVEGFVRPR
GFTVVRDFVGHGIGRHLHEEPQIPNYRPHYKLPRLKKGMALAIEPMVNAGRPSVKILDDGWTVVTADGKPSAHFEHTVIV
TDGAPLIVTDRPRIALPEQLGIAPL
>Mature_264_residues
AERIHIKSPGEVAKMQKAGAVTAEILMEIGAEVQVGRTTREIDDIAREIFKKHKVGNSFYRYRGFPGQLCISINEEVVHG
SGGPRRIQNGDIVSLDVGAIVDGWHGDNAMTVPVGMVDPEKLRLLAVTEESLFRAIELVRPGALLADVCAAVEGFVRPRG
FTVVRDFVGHGIGRHLHEEPQIPNYRPHYKLPRLKKGMALAIEPMVNAGRPSVKILDDGWTVVTADGKPSAHFEHTVIVT
DGAPLIVTDRPRIALPEQLGIAPL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=253, Percent_Identity=34.7826086956522, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI164420681, Length=256, Percent_Identity=34.765625, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI1786364, Length=255, Percent_Identity=42.3529411764706, Blast_Score=201, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71996291, Length=248, Percent_Identity=35.8870967741936, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323273, Length=251, Percent_Identity=35.0597609561753, Blast_Score=148, Evalue=7e-37,
Organism=Drosophila melanogaster, GI21355531, Length=248, Percent_Identity=37.0967741935484, Blast_Score=167, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=35.2459016393443, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28931; Mature: 28800

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERIHIKSPGEVAKMQKAGAVTAEILMEIGAEVQVGRTTREIDDIAREIFKKHKVGNSF
CCCEEECCCCCHHHHHHHCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCCCCCH
YRYRGFPGQLCISINEEVVHGSGGPRRIQNGDIVSLDVGAIVDGWHGDNAMTVPVGMVDP
HHHCCCCCEEEEEECCEEEECCCCCCCCCCCCEEEEECCEEEECEECCCEEEEEECCCCH
EKLRLLAVTEESLFRAIELVRPGALLADVCAAVEGFVRPRGFTVVRDFVGHGIGRHLHEE
HHEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
PQIPNYRPHYKLPRLKKGMALAIEPMVNAGRPSVKILDDGWTVVTADGKPSAHFEHTVIV
CCCCCCCCCCCCCCCCCCCEEEEEEHHCCCCCCEEEEECCCEEEEECCCCCCCEEEEEEE
TDGAPLIVTDRPRIALPEQLGIAPL
ECCCCEEEECCCCEECCHHCCCCCC
>Mature Secondary Structure 
AERIHIKSPGEVAKMQKAGAVTAEILMEIGAEVQVGRTTREIDDIAREIFKKHKVGNSF
CCEEECCCCCHHHHHHHCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCCCCCH
YRYRGFPGQLCISINEEVVHGSGGPRRIQNGDIVSLDVGAIVDGWHGDNAMTVPVGMVDP
HHHCCCCCEEEEEECCEEEECCCCCCCCCCCCEEEEECCEEEECEECCCEEEEEECCCCH
EKLRLLAVTEESLFRAIELVRPGALLADVCAAVEGFVRPRGFTVVRDFVGHGIGRHLHEE
HHEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
PQIPNYRPHYKLPRLKKGMALAIEPMVNAGRPSVKILDDGWTVVTADGKPSAHFEHTVIV
CCCCCCCCCCCCCCCCCCCEEEEEEHHCCCCCCEEEEECCCEEEEECCCCCCCEEEEEEE
TDGAPLIVTDRPRIALPEQLGIAPL
ECCCCEEEECCCCEECCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]