Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is comEC [H]

Identifier: 187735350

GI number: 187735350

Start: 1010391

End: 1012460

Strand: Direct

Name: comEC [H]

Synonym: Amuc_0848

Alternate gene names: 187735350

Gene position: 1010391-1012460 (Clockwise)

Preceding gene: 187735349

Following gene: 187735354

Centisome position: 37.93

GC content: 61.35

Gene sequence:

>2070_bases
ATGACGGCATCTGCTCCCTTGCTGATTCCGGCTTTGTCCCTGCTGTGCGCCTGCGCGGCAATGGATGTTTCCCTTTGGCT
CTGGATTCCATGCTTCTGCCTGGCGTCGCTGCCGTGTTTTTTACGTGCGCCCTCCATGGGGGTGCTTGCCGTTGCCCTGG
CGATGTGGGCCGCCGTATATCTTTTCGCGTATGAACGGGAATACGCAGGCGTTCCCGTGGAAGCGGGGAGAGTCATGGTT
ATGGAAGGCTCCGTTGAGGCTGTTTCCGGAAAATCCGTGTTGTTTCGCCCGGATGGTTCCCGGTGGCTGTACGCGGTTTC
CTCCCGTGACGGGGCCTGCCCTCTGGAGGCAGGGGAACGCTACCGGATCAGGGGAGAGGCGTATCCGCTTCAGGCGCCGT
GCGGTCCCGGCATCTTTGACCGGGAGCGTTGGGGGTACCTGCACGGCATCATCGCCGGAATCCGGCTGGATGAGTACTGC
CGGAACGGGCCGGGAGACTGGCGCAGCCGTTTCCGGGCTTTTTCCCTGCGGCTCCGGGAAAGGGCTGCCTCCCTGCTCAG
GGAGGGCGCCCCTCCGGATGATGAGGCCCGGCAGGTGATGGTTTCCGCCGTGCTTGGGGACAAGACGGACGCGAGGCTGG
AAACGATGGCGAAGTTTCTGGAAAGCGGCTGCATGCATGTATTCGCTGTCAGCGGCATGCATGTGGGCGTGGCCGCCATG
CTGGTTCTGGGTATGCTGAGGCTTTTGCATGTGCACCCCCGTGCGGCCCGGCTGGCCTGCATCCTTTTGCTGGCGGCGTA
CGTGTTCGTGACCGGGATGTCCGCTTCCGCCCTGCGGGCGTTCATCATGGCGACAGTCTGGCTTCTGGCGTTTGTGCTGC
GCAGAAAGGGACATCCGGCCAATATTCTGGCACTCGCTTTCATCCTCCTCTGTTTAATGAACCCGCTCCAGGTTTTCCAG
CCGGGGTTCCAGCTTTCTTTTTGCGTTTTTGCCGTCATTGTCTGCCTGGCGGAATGGCTCAGTCGGGAAAAGCCCCTGTG
GTCGCCGGACCCGTTTATTCCTCCCCGGATTTATCATGCGCGGGAAAGATTCCTGGTGCGGCTGGAAAAAGCATGCCGCG
GCGCGCTGATCGTCTCCGTGGGGGCGTGGCTGGCTTCCATTCCCCTGACGGCATGGCACTTCGGAACCTGGAACCTGTAT
GCTCCCTTGACCAATTTGTGCCTGAGCGTACTTGTCTTTCCCCTTATGGGCATTTCCCTGTCCGGGCTGATGTTCGCGTG
GTGCCCGTGGATGCTGCATGTCTGTAATACGGCCGCTTCCTGGCTGGCGTCCGCCATGCTGTCCGTAGCCGGGGGAGTGG
CTTCCCTGCCGTACAGTTATCTTTCTTCCGCACCGCCTTCCGGGGAAAATGAAGCTGTTATCGTTCCCTTGCAGAAGGAT
GCCTGGGCCACAGTCATTTCCAATCCCGCATTGGTTGTGGGAAGCGGAACGGAAGATGCGGTGCGGTACACCCTCCTTCC
CGTGCTGAAGGCGCGCAGTGTCCGGCCCTGCGGCATGCTGTCCTGGGGAAACGGCAAGGCAGAACGGGCCGGAGAGAAAG
AACTGGAGAAGGAATATCCCGGAATCCGGAACTGGGGCGCGGAGCCCGGGGAATGTCCCGTCCGGCAATGGAGGTTACGG
CCGGGCAATGCACTTGTGCTGGAAGATTTTCCTGTCCCGTTGCGCACGGGAATCCGTCAGGACCGGAGCCGGGTGTTGTC
ATGGGAATGCCGCGGGCGGCGGTTCCTGATGATAGGGAATACCGGGTTTTCTTCCCTGGCGCGCGCGGAAAAAACACCGC
GGGCGGACGTATTGCTCATCGGGCATCATCCGCGCGACCCGGTGGACAGCGCAGCGTGGATCAGGGCCACAGGCGCCCGC
GCGGTCATTTTCACGACGGAGCATGAATGCCCCGTACCGGAGGGAACAGCCGTATACCGTCTCCGGGAAACCGGAAGCCT
CTATCTGCGAATGGAAGAAAAGAGCGTGCAAATCATCCCCTGGAGGGGCATGGAACGCCGTACAGAGTAA

Upstream 100 bases:

>100_bases
TTCCGTCCTCCCGCTGGAGCCGGATGGTGCGGATGCCATGCCGTAAGGTTCACCCTGCATGGAAGAAGTTCGGCGTGTTC
TGCGTCCGTGGCCGGAACGG

Downstream 100 bases:

>100_bases
ATCCCGTGCTTTCCTCAATGCGGATGGGAAGGATCTCTCCCGCCAGGTCAGGGGCGGCATCCACCATGACGGGCTTGTTC
TGGGAGGTCCGGCCGGAGAG

Product: ComEC/Rec2-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MTASAPLLIPALSLLCACAAMDVSLWLWIPCFCLASLPCFLRAPSMGVLAVALAMWAAVYLFAYEREYAGVPVEAGRVMV
MEGSVEAVSGKSVLFRPDGSRWLYAVSSRDGACPLEAGERYRIRGEAYPLQAPCGPGIFDRERWGYLHGIIAGIRLDEYC
RNGPGDWRSRFRAFSLRLRERAASLLREGAPPDDEARQVMVSAVLGDKTDARLETMAKFLESGCMHVFAVSGMHVGVAAM
LVLGMLRLLHVHPRAARLACILLLAAYVFVTGMSASALRAFIMATVWLLAFVLRRKGHPANILALAFILLCLMNPLQVFQ
PGFQLSFCVFAVIVCLAEWLSREKPLWSPDPFIPPRIYHARERFLVRLEKACRGALIVSVGAWLASIPLTAWHFGTWNLY
APLTNLCLSVLVFPLMGISLSGLMFAWCPWMLHVCNTAASWLASAMLSVAGGVASLPYSYLSSAPPSGENEAVIVPLQKD
AWATVISNPALVVGSGTEDAVRYTLLPVLKARSVRPCGMLSWGNGKAERAGEKELEKEYPGIRNWGAEPGECPVRQWRLR
PGNALVLEDFPVPLRTGIRQDRSRVLSWECRGRRFLMIGNTGFSSLARAEKTPRADVLLIGHHPRDPVDSAAWIRATGAR
AVIFTTEHECPVPEGTAVYRLRETGSLYLRMEEKSVQIIPWRGMERRTE

Sequences:

>Translated_689_residues
MTASAPLLIPALSLLCACAAMDVSLWLWIPCFCLASLPCFLRAPSMGVLAVALAMWAAVYLFAYEREYAGVPVEAGRVMV
MEGSVEAVSGKSVLFRPDGSRWLYAVSSRDGACPLEAGERYRIRGEAYPLQAPCGPGIFDRERWGYLHGIIAGIRLDEYC
RNGPGDWRSRFRAFSLRLRERAASLLREGAPPDDEARQVMVSAVLGDKTDARLETMAKFLESGCMHVFAVSGMHVGVAAM
LVLGMLRLLHVHPRAARLACILLLAAYVFVTGMSASALRAFIMATVWLLAFVLRRKGHPANILALAFILLCLMNPLQVFQ
PGFQLSFCVFAVIVCLAEWLSREKPLWSPDPFIPPRIYHARERFLVRLEKACRGALIVSVGAWLASIPLTAWHFGTWNLY
APLTNLCLSVLVFPLMGISLSGLMFAWCPWMLHVCNTAASWLASAMLSVAGGVASLPYSYLSSAPPSGENEAVIVPLQKD
AWATVISNPALVVGSGTEDAVRYTLLPVLKARSVRPCGMLSWGNGKAERAGEKELEKEYPGIRNWGAEPGECPVRQWRLR
PGNALVLEDFPVPLRTGIRQDRSRVLSWECRGRRFLMIGNTGFSSLARAEKTPRADVLLIGHHPRDPVDSAAWIRATGAR
AVIFTTEHECPVPEGTAVYRLRETGSLYLRMEEKSVQIIPWRGMERRTE
>Mature_688_residues
TASAPLLIPALSLLCACAAMDVSLWLWIPCFCLASLPCFLRAPSMGVLAVALAMWAAVYLFAYEREYAGVPVEAGRVMVM
EGSVEAVSGKSVLFRPDGSRWLYAVSSRDGACPLEAGERYRIRGEAYPLQAPCGPGIFDRERWGYLHGIIAGIRLDEYCR
NGPGDWRSRFRAFSLRLRERAASLLREGAPPDDEARQVMVSAVLGDKTDARLETMAKFLESGCMHVFAVSGMHVGVAAML
VLGMLRLLHVHPRAARLACILLLAAYVFVTGMSASALRAFIMATVWLLAFVLRRKGHPANILALAFILLCLMNPLQVFQP
GFQLSFCVFAVIVCLAEWLSREKPLWSPDPFIPPRIYHARERFLVRLEKACRGALIVSVGAWLASIPLTAWHFGTWNLYA
PLTNLCLSVLVFPLMGISLSGLMFAWCPWMLHVCNTAASWLASAMLSVAGGVASLPYSYLSSAPPSGENEAVIVPLQKDA
WATVISNPALVVGSGTEDAVRYTLLPVLKARSVRPCGMLSWGNGKAERAGEKELEKEYPGIRNWGAEPGECPVRQWRLRP
GNALVLEDFPVPLRTGIRQDRSRVLSWECRGRRFLMIGNTGFSSLARAEKTPRADVLLIGHHPRDPVDSAAWIRATGARA
VIFTTEHECPVPEGTAVYRLRETGSLYLRMEEKSVQIIPWRGMERRTE

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 76043; Mature: 75912

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASAPLLIPALSLLCACAAMDVSLWLWIPCFCLASLPCFLRAPSMGVLAVALAMWAAVY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHH
LFAYEREYAGVPVEAGRVMVMEGSVEAVSGKSVLFRPDGSRWLYAVSSRDGACPLEAGER
HHHHHHHHCCCCCCCCEEEEEECCEEEECCCEEEECCCCCCEEEEECCCCCCCCCCCCCE
YRIRGEAYPLQAPCGPGIFDRERWGYLHGIIAGIRLDEYCRNGPGDWRSRFRAFSLRLRE
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHH
RAASLLREGAPPDDEARQVMVSAVLGDKTDARLETMAKFLESGCMHVFAVSGMHVGVAAM
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
LVLGMLRLLHVHPRAARLACILLLAAYVFVTGMSASALRAFIMATVWLLAFVLRRKGHPA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
NILALAFILLCLMNPLQVFQPGFQLSFCVFAVIVCLAEWLSREKPLWSPDPFIPPRIYHA
HHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
RERFLVRLEKACRGALIVSVGAWLASIPLTAWHFGTWNLYAPLTNLCLSVLVFPLMGISL
HHHHHHHHHHHHCCEEEEHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
SGLMFAWCPWMLHVCNTAASWLASAMLSVAGGVASLPYSYLSSAPPSGENEAVIVPLQKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHCCCCCCCCCEEEEEECCC
AWATVISNPALVVGSGTEDAVRYTLLPVLKARSVRPCGMLSWGNGKAERAGEKELEKEYP
CHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHCCHHHHHHHCC
GIRNWGAEPGECPVRQWRLRPGNALVLEDFPVPLRTGIRQDRSRVLSWECRGRRFLMIGN
CCCCCCCCCCCCCHHHEECCCCCEEEEECCCCHHHHCCHHHHHHEEEEEECCCEEEEECC
TGFSSLARAEKTPRADVLLIGHHPRDPVDSAAWIRATGARAVIFTTEHECPVPEGTAVYR
CCHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHEEECCCEEEEEEECCCCCCCCCCEEEE
LRETGSLYLRMEEKSVQIIPWRGMERRTE
EECCCEEEEEEECCCEEEEECCCCCCCCC
>Mature Secondary Structure 
TASAPLLIPALSLLCACAAMDVSLWLWIPCFCLASLPCFLRAPSMGVLAVALAMWAAVY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHH
LFAYEREYAGVPVEAGRVMVMEGSVEAVSGKSVLFRPDGSRWLYAVSSRDGACPLEAGER
HHHHHHHHCCCCCCCCEEEEEECCEEEECCCEEEECCCCCCEEEEECCCCCCCCCCCCCE
YRIRGEAYPLQAPCGPGIFDRERWGYLHGIIAGIRLDEYCRNGPGDWRSRFRAFSLRLRE
EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHH
RAASLLREGAPPDDEARQVMVSAVLGDKTDARLETMAKFLESGCMHVFAVSGMHVGVAAM
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
LVLGMLRLLHVHPRAARLACILLLAAYVFVTGMSASALRAFIMATVWLLAFVLRRKGHPA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
NILALAFILLCLMNPLQVFQPGFQLSFCVFAVIVCLAEWLSREKPLWSPDPFIPPRIYHA
HHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
RERFLVRLEKACRGALIVSVGAWLASIPLTAWHFGTWNLYAPLTNLCLSVLVFPLMGISL
HHHHHHHHHHHHCCEEEEHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
SGLMFAWCPWMLHVCNTAASWLASAMLSVAGGVASLPYSYLSSAPPSGENEAVIVPLQKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHCCCCCCCCCEEEEEECCC
AWATVISNPALVVGSGTEDAVRYTLLPVLKARSVRPCGMLSWGNGKAERAGEKELEKEYP
CHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHCCHHHHHHHCC
GIRNWGAEPGECPVRQWRLRPGNALVLEDFPVPLRTGIRQDRSRVLSWECRGRRFLMIGN
CCCCCCCCCCCCCHHHEECCCCCEEEEECCCCHHHHCCHHHHHHEEEEEECCCEEEEECC
TGFSSLARAEKTPRADVLLIGHHPRDPVDSAAWIRATGARAVIFTTEHECPVPEGTAVYR
CCHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHEEECCCEEEEEEECCCCCCCCCCEEEE
LRETGSLYLRMEEKSVQIIPWRGMERRTE
EECCCEEEEEEECCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]