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The map label for this gene is trxA [C]

Identifier: 187735197

GI number: 187735197

Start: 816498

End: 816815

Strand: Reverse

Name: trxA [C]

Synonym: Amuc_0691

Alternate gene names: 187735197

Gene position: 816815-816498 (Counterclockwise)

Preceding gene: 187735198

Following gene: 187735196

Centisome position: 30.66

GC content: 50.94

Gene sequence:

>318_bases
ATGGCAAACGTATTTTCTGAAGCAAATTTTGAGGATGAAGTTCTGAAGTCCGACATTCCTGTGCTTGTCGATTTCTGGGC
TACATGGTGCGGTCCCTGCCGCATGATCGCCCCGATTATTGACCAGCTTTCTACGGAATTGGCCGGTAAGATCAAAGTGG
GCAAAGTGGATGTGGACGCCAACAACGGACTGGCCGCCACCTATGGCGTGCGCACTATCCCCACTCTTCTGATTATCAAG
GACGGGGAAATCATGGATACGATGGTGGGAGCTTCTTCCAAGGACGCTATCATGCAGCGTTTGCGTCCGTTCATGTAA

Upstream 100 bases:

>100_bases
AAACGGCCGATGACGTTTCTGCTGAAGAGTCTTCCGATGATGGCGCCGATGCGGAAGAATAAGTGAACGTAATGATTGTT
GAAATACTCTAAGCGGTACT

Downstream 100 bases:

>100_bases
ATCATCGGACTGGTTTATTCATTCAAACCGGCCTGCTGCGGAATTTACTGCGGCAGGCCGGTTTTTTTACCGGGCAGCAT
TATTAGAAAAGGACGGATGG

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MANVFSEANFEDEVLKSDIPVLVDFWATWCGPCRMIAPIIDQLSTELAGKIKVGKVDVDANNGLAATYGVRTIPTLLIIK
DGEIMDTMVGASSKDAIMQRLRPFM

Sequences:

>Translated_105_residues
MANVFSEANFEDEVLKSDIPVLVDFWATWCGPCRMIAPIIDQLSTELAGKIKVGKVDVDANNGLAATYGVRTIPTLLIIK
DGEIMDTMVGASSKDAIMQRLRPFM
>Mature_104_residues
ANVFSEANFEDEVLKSDIPVLVDFWATWCGPCRMIAPIIDQLSTELAGKIKVGKVDVDANNGLAATYGVRTIPTLLIIKD
GEIMDTMVGASSKDAIMQRLRPFM

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=37.8947368421053, Blast_Score=89, Evalue=9e-19,
Organism=Homo sapiens, GI21361657, Length=100, Percent_Identity=35, Blast_Score=68, Evalue=1e-12,
Organism=Homo sapiens, GI5031973, Length=74, Percent_Identity=40.5405405405405, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=97, Percent_Identity=50.5154639175258, Blast_Score=111, Evalue=1e-26,
Organism=Escherichia coli, GI1788936, Length=83, Percent_Identity=45.7831325301205, Blast_Score=97, Evalue=2e-22,
Organism=Escherichia coli, GI87081747, Length=94, Percent_Identity=31.9148936170213, Blast_Score=65, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=92, Percent_Identity=35.8695652173913, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=47.887323943662, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=78, Percent_Identity=38.4615384615385, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=98, Percent_Identity=33.6734693877551, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=82, Percent_Identity=36.5853658536585, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=81, Percent_Identity=38.2716049382716, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=68, Percent_Identity=45.5882352941176, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=68, Percent_Identity=45.5882352941176, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=99, Percent_Identity=32.3232323232323, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=96, Percent_Identity=37.5, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=68, Percent_Identity=44.1176470588235, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=85, Percent_Identity=36.4705882352941, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=74, Percent_Identity=37.8378378378378, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=92, Percent_Identity=41.304347826087, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=87, Percent_Identity=36.7816091954023, Blast_Score=66, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=79, Percent_Identity=32.9113924050633, Blast_Score=60, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=35.0515463917526, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=40, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664269, Length=72, Percent_Identity=48.6111111111111, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21358065, Length=95, Percent_Identity=41.0526315789474, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=43.2432432432432, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=43.2432432432432, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921434, Length=74, Percent_Identity=41.8918918918919, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639068, Length=88, Percent_Identity=32.9545454545455, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11491; Mature: 11359

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANVFSEANFEDEVLKSDIPVLVDFWATWCGPCRMIAPIIDQLSTELAGKIKVGKVDVDA
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEECEEEECC
NNGLAATYGVRTIPTLLIIKDGEIMDTMVGASSKDAIMQRLRPFM
CCCEEEECCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
ANVFSEANFEDEVLKSDIPVLVDFWATWCGPCRMIAPIIDQLSTELAGKIKVGKVDVDA
CCCCCCCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEECEEEECC
NNGLAATYGVRTIPTLLIIKDGEIMDTMVGASSKDAIMQRLRPFM
CCCEEEECCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]