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The map label for this gene is glxR [H]

Identifier: 186476045

GI number: 186476045

Start: 1443941

End: 1444834

Strand: Reverse

Name: glxR [H]

Synonym: Bphy_1286

Alternate gene names: 186476045

Gene position: 1444834-1443941 (Counterclockwise)

Preceding gene: 186476047

Following gene: 186476044

Centisome position: 41.53

GC content: 67.0

Gene sequence:

>894_bases
GTGGAGATCGGTTTTTGCGGACCGGGCCTGATGGGGGCGCCGATGATTCGCCATCTGCTGGGTGCAGGCCATGCAGTGCA
GGTCTGGAACCGCACACGCGCGAAGGCTGAAGCGCTCGTGCCGGACGGCGCCACCGTCGCGTCGACACCTGCCGAGCTGG
TCAGCCGGGCTGAAGGCATTTTCCTGTGCGTGCTGGATTCGGCGGCCGTGGAAGAAGTCGTGTTCGGTGTAAATGGAATC
GTGCCAGCCGTGATGCAGCAGGAGGGCGGTAGTCCCGTACGCTGGATTGTCGATCACGGCAGCATGCCGCCGTCGGCTAC
GCGTGGTTTCGCGAGGCGCGCCGCCGAAGCGGACATCGGCTGGATAGACGCACCCGTCTCGGGCGGCGTGGCGGGCGCGA
TGGCGGGAACACTCGCGGTGATGGCGGGCGGCGAGACGGCCGATGTCGCTGCCGTGACGCCGGTGATCAAGGCCTATGCG
GCCCGCGTCACGCATATGGGCGCGGCGGGCGCGGGGCAGACCACCAAGCTATGCAATCAGGCGATCGTGACGTCGACGGT
GGCGGCCATTGCCGAGGCCGTCAGTCTTGCGCAGCGCAGCGGCATCGATGCCGCGCGCCTGACGCAGGCGCTCGCCGGCG
GGTGGGCTGACTCGGTGCTGCTGCAGACCTTCGTGCCGCGCATGACGCAGGCGGGGCAGCCTCCGATCGGCGCACTGGGC
ACGTTTCAGAAGGATGTCGATACGATTGCAGCGGCCGCCTACGAAACAGGCACTCCAATGCCGGTTTCGGGCGCAGTGCA
GCAATTGTTGCGTCTGGGTGCAGCGATGGGACTCGCGGATGCGGATCTGTCCGGTTTCATCGACGTGTTGCAGACGCCGC
GCAAAGACGGATAG

Upstream 100 bases:

>100_bases
GCTGCAACCGGATGTGGCCGGTATCATGAATGGTTCGAGGCCGTCGACGCTCAGGTCGGGGCAATCCGATGCATGCAGTG
CATCGAACCAAGGAGAAGAA

Downstream 100 bases:

>100_bases
GGGCTATCGTTGCCGCCTTGGGCGCGGCGCGCGTGACGCGATAACCTGCTAAAATAATTGGTTTTTCGCCGATCTATCAT
TCAAAGGGACGCGCCGTGCT

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MEIGFCGPGLMGAPMIRHLLGAGHAVQVWNRTRAKAEALVPDGATVASTPAELVSRAEGIFLCVLDSAAVEEVVFGVNGI
VPAVMQQEGGSPVRWIVDHGSMPPSATRGFARRAAEADIGWIDAPVSGGVAGAMAGTLAVMAGGETADVAAVTPVIKAYA
ARVTHMGAAGAGQTTKLCNQAIVTSTVAAIAEAVSLAQRSGIDAARLTQALAGGWADSVLLQTFVPRMTQAGQPPIGALG
TFQKDVDTIAAAAYETGTPMPVSGAVQQLLRLGAAMGLADADLSGFIDVLQTPRKDG

Sequences:

>Translated_297_residues
MEIGFCGPGLMGAPMIRHLLGAGHAVQVWNRTRAKAEALVPDGATVASTPAELVSRAEGIFLCVLDSAAVEEVVFGVNGI
VPAVMQQEGGSPVRWIVDHGSMPPSATRGFARRAAEADIGWIDAPVSGGVAGAMAGTLAVMAGGETADVAAVTPVIKAYA
ARVTHMGAAGAGQTTKLCNQAIVTSTVAAIAEAVSLAQRSGIDAARLTQALAGGWADSVLLQTFVPRMTQAGQPPIGALG
TFQKDVDTIAAAAYETGTPMPVSGAVQQLLRLGAAMGLADADLSGFIDVLQTPRKDG
>Mature_297_residues
MEIGFCGPGLMGAPMIRHLLGAGHAVQVWNRTRAKAEALVPDGATVASTPAELVSRAEGIFLCVLDSAAVEEVVFGVNGI
VPAVMQQEGGSPVRWIVDHGSMPPSATRGFARRAAEADIGWIDAPVSGGVAGAMAGTLAVMAGGETADVAAVTPVIKAYA
ARVTHMGAAGAGQTTKLCNQAIVTSTVAAIAEAVSLAQRSGIDAARLTQALAGGWADSVLLQTFVPRMTQAGQPPIGALG
TFQKDVDTIAAAAYETGTPMPVSGAVQQLLRLGAAMGLADADLSGFIDVLQTPRKDG

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=28.6219081272085, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI23308751, Length=296, Percent_Identity=27.7027027027027, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=35.0515463917526, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI145693186, Length=286, Percent_Identity=34.2657342657343, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=27.5261324041812, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=24.5733788395904, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17557316, Length=283, Percent_Identity=27.5618374558304, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24655230, Length=302, Percent_Identity=26.8211920529801, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI19922568, Length=302, Percent_Identity=26.8211920529801, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=25.177304964539, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30022; Mature: 30022

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIGFCGPGLMGAPMIRHLLGAGHAVQVWNRTRAKAEALVPDGATVASTPAELVSRAEGI
CCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCE
FLCVLDSAAVEEVVFGVNGIVPAVMQQEGGSPVRWIVDHGSMPPSATRGFARRAAEADIG
EEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
WIDAPVSGGVAGAMAGTLAVMAGGETADVAAVTPVIKAYAARVTHMGAAGAGQTTKLCNQ
EEECCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AIVTSTVAAIAEAVSLAQRSGIDAARLTQALAGGWADSVLLQTFVPRMTQAGQPPIGALG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHH
TFQKDVDTIAAAAYETGTPMPVSGAVQQLLRLGAAMGLADADLSGFIDVLQTPRKDG
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEIGFCGPGLMGAPMIRHLLGAGHAVQVWNRTRAKAEALVPDGATVASTPAELVSRAEGI
CCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCE
FLCVLDSAAVEEVVFGVNGIVPAVMQQEGGSPVRWIVDHGSMPPSATRGFARRAAEADIG
EEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
WIDAPVSGGVAGAMAGTLAVMAGGETADVAAVTPVIKAYAARVTHMGAAGAGQTTKLCNQ
EEECCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AIVTSTVAAIAEAVSLAQRSGIDAARLTQALAGGWADSVLLQTFVPRMTQAGQPPIGALG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHH
TFQKDVDTIAAAAYETGTPMPVSGAVQQLLRLGAAMGLADADLSGFIDVLQTPRKDG
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]