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The map label for this gene is sulI [H]

Identifier: 183222584

GI number: 183222584

Start: 3353311

End: 3354126

Strand: Direct

Name: sulI [H]

Synonym: LEPBI_I3239

Alternate gene names: 183222584

Gene position: 3353311-3354126 (Clockwise)

Preceding gene: 183222578

Following gene: 183222587

Centisome position: 93.16

GC content: 39.09

Gene sequence:

>816_bases
ATGGCTGAAATCTTCGGAATCTTAAACATCACCACTGACTCCTTTAGTGATGGAGGTAAGTACATAAACCCCGATGACGC
TATCAAAAAAGGAGTCCAACTCTTACAAGAAGGGGCTGATTGGTTGGATGTCTCAGGCCAATCTTCCAATATTGCGGCAA
ACCTCGTCACAGAGGAGGAAGAATGGAAACGTGTGGAACCTGTCATCCGTTACTTTGTTCCGAAAGGGGTTCGAATCAGT
TTGGATAGTTTCCGACCCAATGTACAAAAGAAAGCAATTGAGGCTGGGGTTCGTTGTTTGAATGACATCACTGGATTTAC
CTACGAAGGGGATCGTGAGTTTTTAAAAACTTACGGTGCAAAGCACTCTGATCTAAAATTCATCATCATGCATTCGCATA
ACAGAAATATTGCGAAAATGAAATCAACTTTGTCTCCAGAAAAAGTAATCAAAAAAATCCAGATCTTTTTTAGAGACAGA
AGAAATGATCTAACTGCGATGGGAATTTCAGAATCATCTATCTTTTTTGATCCAGGGATGGGTTTTTTCTTGAGTGATGA
CCCTATGGTTTCCTTTCGAGTGCTTCAAGATCTAGAAATCCTAAAATTGGAATTTCCACAACTGATGGTGAGTGTCTCTC
GAAAATCATTTCTCGGAAATGTTTTGGGAAATTTACCAATTGAAGATCGGGAATTTGCAACTCTCGCATGTGAATTACAT
TTATTAAAAAATAAAATCCCTTTCATTCGGACGCATAACGTCCTTAAGCTGAGACATGCCGAAAAAATTTGGAATTTATG
CCAAGAGAGTGAATGA

Upstream 100 bases:

>100_bases
TTTTCATCTGCCGTCTCTCCTATGTATCGGCCGAACGGAATTTTCTGCCAAGGGAAAAATATGGCTTTAAGAGTGAGCAT
CCCAAGGAATCCTCTAAAAC

Downstream 100 bases:

>100_bases
CATCACAGTTTTAAAAATCCATCCAACAAAAATGATTCTGGAATCTCTATTTAGAATCCATCGAAGCGTAGGCTAACTCC
TACCTGATCGAACTGCCTTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: Dihydropteroate pyrophosphorylase type I; Dihydropteroate synthase type I; DHPS [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MAEIFGILNITTDSFSDGGKYINPDDAIKKGVQLLQEGADWLDVSGQSSNIAANLVTEEEEWKRVEPVIRYFVPKGVRIS
LDSFRPNVQKKAIEAGVRCLNDITGFTYEGDREFLKTYGAKHSDLKFIIMHSHNRNIAKMKSTLSPEKVIKKIQIFFRDR
RNDLTAMGISESSIFFDPGMGFFLSDDPMVSFRVLQDLEILKLEFPQLMVSVSRKSFLGNVLGNLPIEDREFATLACELH
LLKNKIPFIRTHNVLKLRHAEKIWNLCQESE

Sequences:

>Translated_271_residues
MAEIFGILNITTDSFSDGGKYINPDDAIKKGVQLLQEGADWLDVSGQSSNIAANLVTEEEEWKRVEPVIRYFVPKGVRIS
LDSFRPNVQKKAIEAGVRCLNDITGFTYEGDREFLKTYGAKHSDLKFIIMHSHNRNIAKMKSTLSPEKVIKKIQIFFRDR
RNDLTAMGISESSIFFDPGMGFFLSDDPMVSFRVLQDLEILKLEFPQLMVSVSRKSFLGNVLGNLPIEDREFATLACELH
LLKNKIPFIRTHNVLKLRHAEKIWNLCQESE
>Mature_270_residues
AEIFGILNITTDSFSDGGKYINPDDAIKKGVQLLQEGADWLDVSGQSSNIAANLVTEEEEWKRVEPVIRYFVPKGVRISL
DSFRPNVQKKAIEAGVRCLNDITGFTYEGDREFLKTYGAKHSDLKFIIMHSHNRNIAKMKSTLSPEKVIKKIQIFFRDRR
NDLTAMGISESSIFFDPGMGFFLSDDPMVSFRVLQDLEILKLEFPQLMVSVSRKSFLGNVLGNLPIEDREFATLACELHL
LKNKIPFIRTHNVLKLRHAEKIWNLCQESE

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. The type II enzyme is stable whereas type I DHPS loses its activity rapidly. Implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=262, Percent_Identity=30.1526717557252, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324073, Length=307, Percent_Identity=24.7557003257329, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30930; Mature: 30799

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIFGILNITTDSFSDGGKYINPDDAIKKGVQLLQEGADWLDVSGQSSNIAANLVTEEE
CCCEEEEEEEECCCCCCCCCEECHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCHH
EWKRVEPVIRYFVPKGVRISLDSFRPNVQKKAIEAGVRCLNDITGFTYEGDREFLKTYGA
HHHHHHHHHHHHCCCCCEEEHHCCCCCHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHCC
KHSDLKFIIMHSHNRNIAKMKSTLSPEKVIKKIQIFFRDRRNDLTAMGISESSIFFDPGM
CCCCEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCC
GFFLSDDPMVSFRVLQDLEILKLEFPQLMVSVSRKSFLGNVLGNLPIEDREFATLACELH
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LLKNKIPFIRTHNVLKLRHAEKIWNLCQESE
HHHCCCCEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEIFGILNITTDSFSDGGKYINPDDAIKKGVQLLQEGADWLDVSGQSSNIAANLVTEEE
CCEEEEEEEECCCCCCCCCEECHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCHH
EWKRVEPVIRYFVPKGVRISLDSFRPNVQKKAIEAGVRCLNDITGFTYEGDREFLKTYGA
HHHHHHHHHHHHCCCCCEEEHHCCCCCHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHCC
KHSDLKFIIMHSHNRNIAKMKSTLSPEKVIKKIQIFFRDRRNDLTAMGISESSIFFDPGM
CCCCEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCC
GFFLSDDPMVSFRVLQDLEILKLEFPQLMVSVSRKSFLGNVLGNLPIEDREFATLACELH
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LLKNKIPFIRTHNVLKLRHAEKIWNLCQESE
HHHCCCCEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2163027 [H]