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The map label for this gene is pntA [H]

Identifier: 183222578

GI number: 183222578

Start: 3346024

End: 3347151

Strand: Direct

Name: pntA [H]

Synonym: LEPBI_I3233

Alternate gene names: 183222578

Gene position: 3346024-3347151 (Clockwise)

Preceding gene: 183222577

Following gene: 183222584

Centisome position: 92.95

GC content: 40.07

Gene sequence:

>1128_bases
ATGAAAATAGGCGTAATCAAAGAACCATCGTATGAAAACCGAGTTGCGATCACACCAGATGTGATTGATCCGTTGAAAAA
ATTAGGATTCACAATTGCTATTGAAACAACAGCAGGTGACAGTGCTTTTTTCTCAGACCAAGATTATAAAGACGCTGGTG
CATCAGTAGAATCTAGAGACTCTATTTTATCTGGATCCGATATTGTTGTATCCATCCATGCTTTGGATGAAGCGAGTGCA
AAAAAAATCGGAAAGGATAAATTGTACATCGCTACTTTATCACCTTTGGCATTTCCCAAAAAAGTAAAAGAAATTGCGAC
TTCATCATTTAAAATCTTTTCAATGGATACGATCCCTCGCATCACACGTGCTCAATCGATGGATGTTCTCAGTAGCCAAG
CAACTGTATCTGGTTACAAAGCAGTTTTACTTGCCGCATCAAATTATAGCCGATTTTTCCCGATGTTGACAACAGCAGCA
GGAACCATTACACCAGCCAGAGTATTGATTCTAGGAGCAGGTGTTGCTGGATTACAAGCGATTGCAACATCACGTAGATT
AGGTGCGGTTGTAGATGTATTTGATACACGTCCTGAAGTAAAAGAACAGTGTATGTCTCTTGGTGCTAAGTTTGTGGAAG
TGGAAGGTGCAGCGGATGCTTCCAACACTGGTGGTTATGCGGTAGAACAATCGGAAGACTACCAAAGACGCCAAAAAGAA
GCAATTGCGAAGTATGCTGAAAAAGCGGACATCATCATTACCACCGCTCTGATTCCAGGTAGAAAAGCACCAGTGCTGAT
CACAAAAGAGATGGTTGATAAAATGAGACAAGGTTCTGTGATCGTTGACCTCGCTGCTGTGAATGGTGGTAACTGTGAAT
TAACAGAAAATGATAAAACCATCGTTTACAAAGGGATCACCATCATTGGGAACTCCAATTTACAAAGTACACAACCAATG
GACGCAAGTAAAATGTATGCAAAAAACATTGTAAACTTTCTCAAATTGTTTGTGAACAAAGAAAAACAATTTAATATCAA
TTTGGAAGACGAAATCATCAATGCATGTATGATTGCAGAAAATGGTTCCATCCGCCACAAACCGACGTTAGCCCTTCTGG
GTGAATGA

Upstream 100 bases:

>100_bases
AATTTGAGTTTGGCGAAAGAAAAATTGAATTATTCTACAACCGTTCCACTTTTGGAAGGCGTAAAAAAAACCATCGAATA
TTTTAGCAAAAGAGTATAAA

Downstream 100 bases:

>100_bases
TCTCATAAAAAAAGGTCAGAATTCCTTCTGACCTTTTTTATTTTTCTCAGCTCAAAATACTTTCAAAACATCTTTCAAAA
AATTCAAATCTACTTTCGAT

Product: NAD(P) transhydrogenase subunit alpha part 1

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKIGVIKEPSYENRVAITPDVIDPLKKLGFTIAIETTAGDSAFFSDQDYKDAGASVESRDSILSGSDIVVSIHALDEASA
KKIGKDKLYIATLSPLAFPKKVKEIATSSFKIFSMDTIPRITRAQSMDVLSSQATVSGYKAVLLAASNYSRFFPMLTTAA
GTITPARVLILGAGVAGLQAIATSRRLGAVVDVFDTRPEVKEQCMSLGAKFVEVEGAADASNTGGYAVEQSEDYQRRQKE
AIAKYAEKADIIITTALIPGRKAPVLITKEMVDKMRQGSVIVDLAAVNGGNCELTENDKTIVYKGITIIGNSNLQSTQPM
DASKMYAKNIVNFLKLFVNKEKQFNINLEDEIINACMIAENGSIRHKPTLALLGE

Sequences:

>Translated_375_residues
MKIGVIKEPSYENRVAITPDVIDPLKKLGFTIAIETTAGDSAFFSDQDYKDAGASVESRDSILSGSDIVVSIHALDEASA
KKIGKDKLYIATLSPLAFPKKVKEIATSSFKIFSMDTIPRITRAQSMDVLSSQATVSGYKAVLLAASNYSRFFPMLTTAA
GTITPARVLILGAGVAGLQAIATSRRLGAVVDVFDTRPEVKEQCMSLGAKFVEVEGAADASNTGGYAVEQSEDYQRRQKE
AIAKYAEKADIIITTALIPGRKAPVLITKEMVDKMRQGSVIVDLAAVNGGNCELTENDKTIVYKGITIIGNSNLQSTQPM
DASKMYAKNIVNFLKLFVNKEKQFNINLEDEIINACMIAENGSIRHKPTLALLGE
>Mature_375_residues
MKIGVIKEPSYENRVAITPDVIDPLKKLGFTIAIETTAGDSAFFSDQDYKDAGASVESRDSILSGSDIVVSIHALDEASA
KKIGKDKLYIATLSPLAFPKKVKEIATSSFKIFSMDTIPRITRAQSMDVLSSQATVSGYKAVLLAASNYSRFFPMLTTAA
GTITPARVLILGAGVAGLQAIATSRRLGAVVDVFDTRPEVKEQCMSLGAKFVEVEGAADASNTGGYAVEQSEDYQRRQKE
AIAKYAEKADIIITTALIPGRKAPVLITKEMVDKMRQGSVIVDLAAVNGGNCELTENDKTIVYKGITIIGNSNLQSTQPM
DASKMYAKNIVNFLKLFVNKEKQFNINLEDEIINACMIAENGSIRHKPTLALLGE

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=359, Percent_Identity=39.2757660167131, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI122939153, Length=359, Percent_Identity=39.2757660167131, Blast_Score=255, Evalue=5e-68,
Organism=Escherichia coli, GI1787887, Length=368, Percent_Identity=42.3913043478261, Blast_Score=290, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17550456, Length=367, Percent_Identity=41.1444141689373, Blast_Score=274, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 40445; Mature: 40445

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGVIKEPSYENRVAITPDVIDPLKKLGFTIAIETTAGDSAFFSDQDYKDAGASVESRD
CCCCCCCCCCCCCEEEECHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHCCCCCCCHH
SILSGSDIVVSIHALDEASAKKIGKDKLYIATLSPLAFPKKVKEIATSSFKIFSMDTIPR
CCCCCCCEEEEEEECCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCH
ITRAQSMDVLSSQATVSGYKAVLLAASNYSRFFPMLTTAAGTITPARVLILGAGVAGLQA
HHHHHHHHHHHCCCHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCEEEEEEECCHHHHHH
IATSRRLGAVVDVFDTRPEVKEQCMSLGAKFVEVEGAADASNTGGYAVEQSEDYQRRQKE
HHHHHHHHHEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCCHHHHHHHHH
AIAKYAEKADIIITTALIPGRKAPVLITKEMVDKMRQGSVIVDLAAVNGGNCELTENDKT
HHHHHHCCCCEEEEEEECCCCCCCEEEEHHHHHHHHCCCEEEEEEEECCCCEEEECCCCE
IVYKGITIIGNSNLQSTQPMDASKMYAKNIVNFLKLFVNKEKQFNINLEDEIINACMIAE
EEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHEEEEEEC
NGSIRHKPTLALLGE
CCCCCCCCCEEEECC
>Mature Secondary Structure
MKIGVIKEPSYENRVAITPDVIDPLKKLGFTIAIETTAGDSAFFSDQDYKDAGASVESRD
CCCCCCCCCCCCCEEEECHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHCCCCCCCHH
SILSGSDIVVSIHALDEASAKKIGKDKLYIATLSPLAFPKKVKEIATSSFKIFSMDTIPR
CCCCCCCEEEEEEECCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCH
ITRAQSMDVLSSQATVSGYKAVLLAASNYSRFFPMLTTAAGTITPARVLILGAGVAGLQA
HHHHHHHHHHHCCCHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCEEEEEEECCHHHHHH
IATSRRLGAVVDVFDTRPEVKEQCMSLGAKFVEVEGAADASNTGGYAVEQSEDYQRRQKE
HHHHHHHHHEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCCHHHHHHHHH
AIAKYAEKADIIITTALIPGRKAPVLITKEMVDKMRQGSVIVDLAAVNGGNCELTENDKT
HHHHHHCCCCEEEEEEECCCCCCCEEEEHHHHHHHHCCCEEEEEEEECCCCEEEECCCCE
IVYKGITIIGNSNLQSTQPMDASKMYAKNIVNFLKLFVNKEKQFNINLEDEIINACMIAE
EEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHEEEEEEC
NGSIRHKPTLALLGE
CCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]