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The map label for this gene is sucD [H]

Identifier: 183221439

GI number: 183221439

Start: 2145799

End: 2146689

Strand: Direct

Name: sucD [H]

Synonym: LEPBI_I2057

Alternate gene names: 183221439

Gene position: 2145799-2146689 (Clockwise)

Preceding gene: 183221438

Following gene: 183221440

Centisome position: 59.61

GC content: 47.03

Gene sequence:

>891_bases
ATGGCTGTATTAGTAGATGAAAATACAAGAGTAGTTGTACAGGGGATCACTGGAAAAGAAGGTTCCTTCCACGCAACACA
AATGTTGGAATATGGTACAAAAGTAGTCGCAGGTGTGACTCCAGGAAAGGGTGGCCAAACTTGGACATCGGAATTTGGAA
AATCGGCACCAGTTCGTAATACCATTAAAGACGCAATGAAAGAGGACGGAGCAAACGCAGCAGTGATTTTTGTTCCCCCT
CCATTCGCAGCAGATGCAATTCTCGAAGGAATCTTCGCTGAGATCCCGCTTGTGGTTTGTATCACAGAAGGAATTCCAAC
ACATGACATGTTAAAAGTGTACAGTGTCTTACGAAATTCCAAAACAAAACTCGTGGGACCAAATTGTCCAGGCGTTATTA
ACCCTCGTTACAATGTAAAAATGGGGATCATGCCAGGTTTCATCCACACTCCAGGGAACATTGGAATCGTATCTCGTTCT
GGAACGTTGACATACGAATCCGTTGCATCCCTAACTGCGGCAGGCCTCGGCCAGTCGACTTGTATTGGGATCGGAGGAGA
CCCAGTTCCAGGGATGAACCATGTGGAAGCAGTTCGCCTCCTCAATGAAGACCCAGACACTGAGGGCATTGTCATGATCG
GCGAGATCGGTGGAACTTCTGAAGAAGAAGCAGCCGCCTACATCAAAGCTCACGTGAAAAAACCAGTCGTTGGTTTTATC
GCAGGCCAAACCGCTCCTCCAGGGAAACGAATGGGACACGCAGGTGCCATCATTTCTGGTGGAATGGGAACTGCCACTTC
CAAGATTGCAGCCATGCAAGATGCTGGTGTGAGCATTTGTGCTCATATTGGAGAAGTGGGAGAAAAAATGAAGGCAGCCT
TTAAAAAATAA

Upstream 100 bases:

>100_bases
AATCCTGAACGAATCTGGGATGAACATTGTGGGAGTCGAAGGGCTCCGTGACGCGGCAGACAAAATTGTCTCCCTAATCA
AAAAATAGGAAACAGGAAAC

Downstream 100 bases:

>100_bases
GGGCTTTTTTCGAAAAAAAACAACTTTGCAAGGGAAATGAGGAGTCTGAATTAAGAATATGGAACGACGTTCATGGGTTT
CTAGTGGATTGATTCTCTTC

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MAVLVDENTRVVVQGITGKEGSFHATQMLEYGTKVVAGVTPGKGGQTWTSEFGKSAPVRNTIKDAMKEDGANAAVIFVPP
PFAADAILEGIFAEIPLVVCITEGIPTHDMLKVYSVLRNSKTKLVGPNCPGVINPRYNVKMGIMPGFIHTPGNIGIVSRS
GTLTYESVASLTAAGLGQSTCIGIGGDPVPGMNHVEAVRLLNEDPDTEGIVMIGEIGGTSEEEAAAYIKAHVKKPVVGFI
AGQTAPPGKRMGHAGAIISGGMGTATSKIAAMQDAGVSICAHIGEVGEKMKAAFKK

Sequences:

>Translated_296_residues
MAVLVDENTRVVVQGITGKEGSFHATQMLEYGTKVVAGVTPGKGGQTWTSEFGKSAPVRNTIKDAMKEDGANAAVIFVPP
PFAADAILEGIFAEIPLVVCITEGIPTHDMLKVYSVLRNSKTKLVGPNCPGVINPRYNVKMGIMPGFIHTPGNIGIVSRS
GTLTYESVASLTAAGLGQSTCIGIGGDPVPGMNHVEAVRLLNEDPDTEGIVMIGEIGGTSEEEAAAYIKAHVKKPVVGFI
AGQTAPPGKRMGHAGAIISGGMGTATSKIAAMQDAGVSICAHIGEVGEKMKAAFKK
>Mature_295_residues
AVLVDENTRVVVQGITGKEGSFHATQMLEYGTKVVAGVTPGKGGQTWTSEFGKSAPVRNTIKDAMKEDGANAAVIFVPPP
FAADAILEGIFAEIPLVVCITEGIPTHDMLKVYSVLRNSKTKLVGPNCPGVINPRYNVKMGIMPGFIHTPGNIGIVSRSG
TLTYESVASLTAAGLGQSTCIGIGGDPVPGMNHVEAVRLLNEDPDTEGIVMIGEIGGTSEEEAAAYIKAHVKKPVVGFIA
GQTAPPGKRMGHAGAIISGGMGTATSKIAAMQDAGVSICAHIGEVGEKMKAAFKK

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=299, Percent_Identity=57.8595317725752, Blast_Score=278, Evalue=3e-75,
Organism=Homo sapiens, GI38569423, Length=319, Percent_Identity=27.8996865203762, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI38569421, Length=319, Percent_Identity=27.8996865203762, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786949, Length=295, Percent_Identity=57.6271186440678, Blast_Score=340, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17550194, Length=295, Percent_Identity=56.271186440678, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17553126, Length=297, Percent_Identity=51.1784511784512, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17557344, Length=318, Percent_Identity=25.7861635220126, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17551266, Length=318, Percent_Identity=26.4150943396226, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324716, Length=302, Percent_Identity=50.9933774834437, Blast_Score=284, Evalue=1e-77,
Organism=Drosophila melanogaster, GI21356559, Length=291, Percent_Identity=51.5463917525773, Blast_Score=287, Evalue=6e-78,
Organism=Drosophila melanogaster, GI28574296, Length=297, Percent_Identity=52.5252525252525, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI281363477, Length=276, Percent_Identity=28.9855072463768, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281363475, Length=276, Percent_Identity=28.9855072463768, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281363473, Length=276, Percent_Identity=28.9855072463768, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30581; Mature: 30450

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLVDENTRVVVQGITGKEGSFHATQMLEYGTKVVAGVTPGKGGQTWTSEFGKSAPVRN
CEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCEEEEECCCCCCCCHHHHHHCCCCCCHH
TIKDAMKEDGANAAVIFVPPPFAADAILEGIFAEIPLVVCITEGIPTHDMLKVYSVLRNS
HHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHCC
KTKLVGPNCPGVINPRYNVKMGIMPGFIHTPGNIGIVSRSGTLTYESVASLTAAGLGQST
CCEEECCCCCCCCCCCCEEEEECCCCEEECCCCEEEEECCCCEEHHHHHHHHHHCCCCCE
CIGIGGDPVPGMNHVEAVRLLNEDPDTEGIVMIGEIGGTSEEEAAAYIKAHVKKPVVGFI
EEECCCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEE
AGQTAPPGKRMGHAGAIISGGMGTATSKIAAMQDAGVSICAHIGEVGEKMKAAFKK
ECCCCCCCHHCCCCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVLVDENTRVVVQGITGKEGSFHATQMLEYGTKVVAGVTPGKGGQTWTSEFGKSAPVRN
EEEEECCCEEEEEECCCCCCCHHHHHHHHHCCEEEEECCCCCCCCHHHHHHCCCCCCHH
TIKDAMKEDGANAAVIFVPPPFAADAILEGIFAEIPLVVCITEGIPTHDMLKVYSVLRNS
HHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHCC
KTKLVGPNCPGVINPRYNVKMGIMPGFIHTPGNIGIVSRSGTLTYESVASLTAAGLGQST
CCEEECCCCCCCCCCCCEEEEECCCCEEECCCCEEEEECCCCEEHHHHHHHHHHCCCCCE
CIGIGGDPVPGMNHVEAVRLLNEDPDTEGIVMIGEIGGTSEEEAAAYIKAHVKKPVVGFI
EEECCCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEE
AGQTAPPGKRMGHAGAIISGGMGTATSKIAAMQDAGVSICAHIGEVGEKMKAAFKK
ECCCCCCCHHCCCCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]