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The map label for this gene is hemH

Identifier: 183220560

GI number: 183220560

Start: 1211978

End: 1213066

Strand: Direct

Name: hemH

Synonym: LEPBI_I1164

Alternate gene names: 183220560

Gene position: 1211978-1213066 (Clockwise)

Preceding gene: 183220559

Following gene: 183220568

Centisome position: 33.67

GC content: 39.3

Gene sequence:

>1089_bases
ATGATAACTAACAAAGTAAAAACATTGATCCTTGTGAATTTAGGTGGGCCAAGAACTCCATCTGAGATTGAAGTTTTTTT
AAGAGATTTATTTTCTGATCCCTTTGTATTTGATTTACCATTACCTGAATTCTTACGCCTTAGACTCGCACGTTTCATTG
CCAAAAAAAGAGCTCCCAAAGTGCAAAAATCCTATGAATCAATGGGATTTGGTGGTGGTTCTCCACTTGTGGAGGAGACA
GCAAAACAAGCACATGCGCTCGAGTTGGCACTCAATGAAAGAAGTTCGGAACAATGGAATGTAAAGGTAGCCATGGCATG
TGGTTATCCCAATATGCGAGATATTGAATTTGGGAAACCCAATCAAGATACCGTCTATCTTCCGTTATACCCTCAGTTTT
CTCGTTCAACTGTTCTATCTACACTAGCCATATTGGAAACAAAGTTTGGTGAGTGTCCCGTTGGAAGCGGTGGTTATGTT
CCCCATTTTGGATTAGATCCAAACTTCCATTCAATCTCTGCGAAGTTCATTTATGAGTTTTTTACAAACCAACTTCCAAA
AGACCAATACTTACATTATCCAGAAGAAAAACCCAATTGTGATTGGAGAAATTTGGATTTAGTATTTTCTGCACACGGAG
TTCCCATGCGACTCATCCATAAAGGCGATCGATATATGGAAGAAGTGGAGTTGTCGGTAAAAGGTATCGCAGACGAACTT
TCAAAATTTGGGTTCAATGGAGGTGTGCACATATCTTACCAGAGTAAGGTGGGACCAGCTAAATGGACAGAACCAAGCAC
GATCCAAATGATTTCTTCCTTAGCGAAACAAGGAAAACATATTGCCGTTTATCCCATTAGTTTTGTCAGTGATCATTTAG
AAACGTTGGAAGAAATAGGGGAACAATTTAAGGATTTAACTTGGGAAATGGGAGGGAAATCGTTTGTCCGAATTCCAGCC
TTAGGAATCTATCCAAGTTTCATTCAATTCCTTGCAGAGAAAGTGATGCATTCTGATCGGAAGATCCAACATTGTATTTG
TAGAGAAAAAGGTGGTGAATCACTCCAACATTGTCGATTCAAAGATTGA

Upstream 100 bases:

>100_bases
TGCCCCAAATGTTTGGATGGATATGTGAAAACCAAACTAGGGAAAAATGGAAAAACCATTTATTTTTGTTCCCGTTACCC
GCACTGTGACTACATCACCT

Downstream 100 bases:

>100_bases
GCGAAGGCCAATGCCTTTGCGATAGTTCCCGTAAAATTGTATGTCCAATCCTTTTGATTTCCACTCGGTTTCTAATTGAT
CCAGTGTTTGATTAAAGTCA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MITNKVKTLILVNLGGPRTPSEIEVFLRDLFSDPFVFDLPLPEFLRLRLARFIAKKRAPKVQKSYESMGFGGGSPLVEET
AKQAHALELALNERSSEQWNVKVAMACGYPNMRDIEFGKPNQDTVYLPLYPQFSRSTVLSTLAILETKFGECPVGSGGYV
PHFGLDPNFHSISAKFIYEFFTNQLPKDQYLHYPEEKPNCDWRNLDLVFSAHGVPMRLIHKGDRYMEEVELSVKGIADEL
SKFGFNGGVHISYQSKVGPAKWTEPSTIQMISSLAKQGKHIAVYPISFVSDHLETLEEIGEQFKDLTWEMGGKSFVRIPA
LGIYPSFIQFLAEKVMHSDRKIQHCICREKGGESLQHCRFKD

Sequences:

>Translated_362_residues
MITNKVKTLILVNLGGPRTPSEIEVFLRDLFSDPFVFDLPLPEFLRLRLARFIAKKRAPKVQKSYESMGFGGGSPLVEET
AKQAHALELALNERSSEQWNVKVAMACGYPNMRDIEFGKPNQDTVYLPLYPQFSRSTVLSTLAILETKFGECPVGSGGYV
PHFGLDPNFHSISAKFIYEFFTNQLPKDQYLHYPEEKPNCDWRNLDLVFSAHGVPMRLIHKGDRYMEEVELSVKGIADEL
SKFGFNGGVHISYQSKVGPAKWTEPSTIQMISSLAKQGKHIAVYPISFVSDHLETLEEIGEQFKDLTWEMGGKSFVRIPA
LGIYPSFIQFLAEKVMHSDRKIQHCICREKGGESLQHCRFKD
>Mature_362_residues
MITNKVKTLILVNLGGPRTPSEIEVFLRDLFSDPFVFDLPLPEFLRLRLARFIAKKRAPKVQKSYESMGFGGGSPLVEET
AKQAHALELALNERSSEQWNVKVAMACGYPNMRDIEFGKPNQDTVYLPLYPQFSRSTVLSTLAILETKFGECPVGSGGYV
PHFGLDPNFHSISAKFIYEFFTNQLPKDQYLHYPEEKPNCDWRNLDLVFSAHGVPMRLIHKGDRYMEEVELSVKGIADEL
SKFGFNGGVHISYQSKVGPAKWTEPSTIQMISSLAKQGKHIAVYPISFVSDHLETLEEIGEQFKDLTWEMGGKSFVRIPA
LGIYPSFIQFLAEKVMHSDRKIQHCICREKGGESLQHCRFKD

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=336, Percent_Identity=30.6547619047619, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI60499025, Length=336, Percent_Identity=30.6547619047619, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1786681, Length=337, Percent_Identity=29.9703264094956, Blast_Score=101, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324750, Length=342, Percent_Identity=29.8245614035088, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI17864156, Length=343, Percent_Identity=29.7376093294461, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24651774, Length=277, Percent_Identity=28.5198555956679, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45552018, Length=151, Percent_Identity=33.112582781457, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_LEPBA (B0SF60)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962225.1
- ProteinModelPortal:   B0SF60
- SMR:   B0SF60
- GeneID:   6389882
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1123
- HOGENOM:   HBG697135
- OMA:   HSLPMEI
- ProtClustDB:   CLSK2336520
- BioCyc:   LBIF355278:LBF_1123-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 41045; Mature: 41045

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITNKVKTLILVNLGGPRTPSEIEVFLRDLFSDPFVFDLPLPEFLRLRLARFIAKKRAPK
CCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCH
VQKSYESMGFGGGSPLVEETAKQAHALELALNERSSEQWNVKVAMACGYPNMRDIEFGKP
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCC
NQDTVYLPLYPQFSRSTVLSTLAILETKFGECPVGSGGYVPHFGLDPNFHSISAKFIYEF
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
FTNQLPKDQYLHYPEEKPNCDWRNLDLVFSAHGVPMRLIHKGDRYMEEVELSVKGIADEL
HHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
SKFGFNGGVHISYQSKVGPAKWTEPSTIQMISSLAKQGKHIAVYPISFVSDHLETLEEIG
HHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHH
EQFKDLTWEMGGKSFVRIPALGIYPSFIQFLAEKVMHSDRKIQHCICREKGGESLQHCRF
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHCCC
KD
CC
>Mature Secondary Structure
MITNKVKTLILVNLGGPRTPSEIEVFLRDLFSDPFVFDLPLPEFLRLRLARFIAKKRAPK
CCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCH
VQKSYESMGFGGGSPLVEETAKQAHALELALNERSSEQWNVKVAMACGYPNMRDIEFGKP
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCC
NQDTVYLPLYPQFSRSTVLSTLAILETKFGECPVGSGGYVPHFGLDPNFHSISAKFIYEF
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
FTNQLPKDQYLHYPEEKPNCDWRNLDLVFSAHGVPMRLIHKGDRYMEEVELSVKGIADEL
HHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
SKFGFNGGVHISYQSKVGPAKWTEPSTIQMISSLAKQGKHIAVYPISFVSDHLETLEEIG
HHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHH
EQFKDLTWEMGGKSFVRIPALGIYPSFIQFLAEKVMHSDRKIQHCICREKGGESLQHCRF
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHCCC
KD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA