| Definition | Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_010602 |
| Length | 3,599,677 |
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The map label for this gene is topA [H]
Identifier: 183220559
GI number: 183220559
Start: 1210111
End: 1211988
Strand: Direct
Name: topA [H]
Synonym: LEPBI_I1163
Alternate gene names: 183220559
Gene position: 1210111-1211988 (Clockwise)
Preceding gene: 183220558
Following gene: 183220560
Centisome position: 33.62
GC content: 35.57
Gene sequence:
>1878_bases TTGGTTGTTGCAACAAAAGGTCATATCAAAGACCTACCACCCAAATCTTACGGTGTGGATCTTTCTAATCAATTTGAACC TGAATACGAGTGGTTAAAAGGCAAAAAAAGTCTTTTTACAACCATAACCACCAAAGCCAAAAAATGTTCCCTTATTTACA TAGCAAGTGACCCTGACAGAGAAGGGGAAATTATCGCCAAACATTGTTTCGATGAACTTTCCAAGTTAAAAAAACCTATT TATCGTTTGCGATTGAAAGAAATCACAAAAGAGGAATTACAGTCGCAAATTCAAAAAAAAATTGGTCTTGATCAACAAGA AATTGAATCACAAATTGCAAGGCGAGTGATAGACCGAATCTTTGGATTTGAAGTATCTCCCGATTTATGGAAACATTTAA AAATTCCATCACTTTCCGCAGGACGGGTCCAATCGACCGTATTACACTGGATTTGTGAAAGGGAAAAAGAAATCCAAAAC TTTTCCAAAGAGAATTATTTCCAACTCAAATTGATTGGTACGCTCAATGAGAATCCAATCGAACTCAAATACCAATCCAA AGAAAAACTAAAACAAGAAGAAATACAAACTATCTTAAATGAGATCCAAATATTACCGGATCCGTCCCGATTGAAAAATA TAGTTTTATCCAATCTCAAAATTAAAAAAATCAAACGAAACCCTCCGAAAGCATTTTCTACTGCAAGTTTACTCGAATCA AGTTTTCGTGCCCTACAATTTGATTCTAAAAAAACAATGCGACTGGCTCAAAGTTTATTCGAAGGTAAAAAACTTCATGC AGGTGAGACAGTAGGTCTCATCACGTATATGCGTTCGGATAGCACCAGGGTATCGGAATCAAAACAAGACTTAGGTGAGA AGTATCTAAAAGAACATTATCCAAACCTGTTATGGGAAGGGAGTCGTAACCAGGGAAAACAAAAAAAGTTTTCACAGGAT GCTCACGAAGCAATCACTCCAATCAACCCAAGTCTTTCGCCAGAACAAATCAAATCGTTTTTAACATTGGATGAATGGAA ATTGTATCAATTGATTTGGGAAAGGTTTTTAACCTCACTTTTGAAACCAGAAATTGGAGAAGAGATAGTATATGAATTTC CAATCGGAAAACATATCTTTGAACATTCATTTGAAACGATATCTGATCCCGGATTCAAAAATTTTCCACGTCCCAAAGAG AAACGTGAAAAAATCTCGTTGAATGCAAAAATAGGAGATCTCTTTTTTTATGAATCATACTCAGTTGAGGAAAAAGAAAC AGAACCACCACAACGATACACTCAAGGAAAATTGATTCAAAAAATGGAAGACACCGGAGTGGGTCGACCATCGACTTATG CGACTATCCTCGAAACTTTGAAATTGCGAAAGTACATTGTGGAGTACAAAAAAAACATCGGCCCCTCCCAACTTGGTTTG AAGGTGGATTCTTATTTGTTTTTGAATTTTTTTGACTTAATCGGTGAGTCATTTACCAAAGACCTAGAATCAAAATTGGA CCAAATCACAGATGAAAAAGCATCACGAGTGAAGCTTGTGGCTAATTTTTATGATCAATTGAAACAAATTCTAAAGTCTC CACGAAAAAAAATGGTAAGTATAGGCAAAGAAAATCAATCCAAAGTCAAATATGATACGGATGAAAAACAGACACTTTCC GAAAAAGTAAAAAATGGCAAAGGGAGTGAGAAGAAAGGTAACACTAAAAATCAGAACCAGAGTCTAACTTATATTGAGAA TAAAACTTGCCCCAAATGTTTGGATGGATATGTGAAAACCAAACTAGGGAAAAATGGAAAAACCATTTATTTTTGTTCCC GTTACCCGCACTGTGACTACATCACCTATGATAACTAA
Upstream 100 bases:
>100_bases TTTAATTTTCGTTTGATGGGATTTTAAAATCACCAATCTATTAATTGTCGAATCACCTACAAAAGCGGCAACCATCACTT CTTATCTCGGTAAGGATTGG
Downstream 100 bases:
>100_bases CAAAGTAAAAACATTGATCCTTGTGAATTTAGGTGGGCCAAGAACTCCATCTGAGATTGAAGTTTTTTTAAGAGATTTAT TTTCTGATCCCTTTGTATTT
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 625; Mature: 625
Protein sequence:
>625_residues MVVATKGHIKDLPPKSYGVDLSNQFEPEYEWLKGKKSLFTTITTKAKKCSLIYIASDPDREGEIIAKHCFDELSKLKKPI YRLRLKEITKEELQSQIQKKIGLDQQEIESQIARRVIDRIFGFEVSPDLWKHLKIPSLSAGRVQSTVLHWICEREKEIQN FSKENYFQLKLIGTLNENPIELKYQSKEKLKQEEIQTILNEIQILPDPSRLKNIVLSNLKIKKIKRNPPKAFSTASLLES SFRALQFDSKKTMRLAQSLFEGKKLHAGETVGLITYMRSDSTRVSESKQDLGEKYLKEHYPNLLWEGSRNQGKQKKFSQD AHEAITPINPSLSPEQIKSFLTLDEWKLYQLIWERFLTSLLKPEIGEEIVYEFPIGKHIFEHSFETISDPGFKNFPRPKE KREKISLNAKIGDLFFYESYSVEEKETEPPQRYTQGKLIQKMEDTGVGRPSTYATILETLKLRKYIVEYKKNIGPSQLGL KVDSYLFLNFFDLIGESFTKDLESKLDQITDEKASRVKLVANFYDQLKQILKSPRKKMVSIGKENQSKVKYDTDEKQTLS EKVKNGKGSEKKGNTKNQNQSLTYIENKTCPKCLDGYVKTKLGKNGKTIYFCSRYPHCDYITYDN
Sequences:
>Translated_625_residues MVVATKGHIKDLPPKSYGVDLSNQFEPEYEWLKGKKSLFTTITTKAKKCSLIYIASDPDREGEIIAKHCFDELSKLKKPI YRLRLKEITKEELQSQIQKKIGLDQQEIESQIARRVIDRIFGFEVSPDLWKHLKIPSLSAGRVQSTVLHWICEREKEIQN FSKENYFQLKLIGTLNENPIELKYQSKEKLKQEEIQTILNEIQILPDPSRLKNIVLSNLKIKKIKRNPPKAFSTASLLES SFRALQFDSKKTMRLAQSLFEGKKLHAGETVGLITYMRSDSTRVSESKQDLGEKYLKEHYPNLLWEGSRNQGKQKKFSQD AHEAITPINPSLSPEQIKSFLTLDEWKLYQLIWERFLTSLLKPEIGEEIVYEFPIGKHIFEHSFETISDPGFKNFPRPKE KREKISLNAKIGDLFFYESYSVEEKETEPPQRYTQGKLIQKMEDTGVGRPSTYATILETLKLRKYIVEYKKNIGPSQLGL KVDSYLFLNFFDLIGESFTKDLESKLDQITDEKASRVKLVANFYDQLKQILKSPRKKMVSIGKENQSKVKYDTDEKQTLS EKVKNGKGSEKKGNTKNQNQSLTYIENKTCPKCLDGYVKTKLGKNGKTIYFCSRYPHCDYITYDN >Mature_625_residues MVVATKGHIKDLPPKSYGVDLSNQFEPEYEWLKGKKSLFTTITTKAKKCSLIYIASDPDREGEIIAKHCFDELSKLKKPI YRLRLKEITKEELQSQIQKKIGLDQQEIESQIARRVIDRIFGFEVSPDLWKHLKIPSLSAGRVQSTVLHWICEREKEIQN FSKENYFQLKLIGTLNENPIELKYQSKEKLKQEEIQTILNEIQILPDPSRLKNIVLSNLKIKKIKRNPPKAFSTASLLES SFRALQFDSKKTMRLAQSLFEGKKLHAGETVGLITYMRSDSTRVSESKQDLGEKYLKEHYPNLLWEGSRNQGKQKKFSQD AHEAITPINPSLSPEQIKSFLTLDEWKLYQLIWERFLTSLLKPEIGEEIVYEFPIGKHIFEHSFETISDPGFKNFPRPKE KREKISLNAKIGDLFFYESYSVEEKETEPPQRYTQGKLIQKMEDTGVGRPSTYATILETLKLRKYIVEYKKNIGPSQLGL KVDSYLFLNFFDLIGESFTKDLESKLDQITDEKASRVKLVANFYDQLKQILKSPRKKMVSIGKENQSKVKYDTDEKQTLS EKVKNGKGSEKKGNTKNQNQSLTYIENKTCPKCLDGYVKTKLGKNGKTIYFCSRYPHCDYITYDN
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI4507635, Length=522, Percent_Identity=23.5632183908046, Blast_Score=112, Evalue=1e-24, Organism=Homo sapiens, GI10835218, Length=607, Percent_Identity=24.5469522240527, Blast_Score=108, Evalue=2e-23, Organism=Escherichia coli, GI1787529, Length=686, Percent_Identity=28.134110787172, Blast_Score=226, Evalue=2e-60, Organism=Caenorhabditis elegans, GI17555378, Length=538, Percent_Identity=23.4200743494424, Blast_Score=111, Evalue=1e-24, Organism=Caenorhabditis elegans, GI32563869, Length=561, Percent_Identity=22.2816399286988, Blast_Score=97, Evalue=2e-20, Organism=Drosophila melanogaster, GI24585251, Length=611, Percent_Identity=23.0769230769231, Blast_Score=107, Evalue=4e-23,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 72508; Mature: 72508
Theoretical pI: Translated: 9.74; Mature: 9.74
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 0.8 %Met (Translated Protein) 1.9 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 0.8 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVVATKGHIKDLPPKSYGVDLSNQFEPEYEWLKGKKSLFTTITTKAKKCSLIYIASDPDR CEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCC EGEIIAKHCFDELSKLKKPIYRLRLKEITKEELQSQIQKKIGLDQQEIESQIARRVIDRI CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH FGFEVSPDLWKHLKIPSLSAGRVQSTVLHWICEREKEIQNFSKENYFQLKLIGTLNENPI HCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCE ELKYQSKEKLKQEEIQTILNEIQILPDPSRLKNIVLSNLKIKKIKRNPPKAFSTASLLES EEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEHHCCCCCCHHHHHHHHHH SFRALQFDSKKTMRLAQSLFEGKKLHAGETVGLITYMRSDSTRVSESKQDLGEKYLKEHY HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHC PNLLWEGSRNQGKQKKFSQDAHEAITPINPSLSPEQIKSFLTLDEWKLYQLIWERFLTSL CCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH LKPEIGEEIVYEFPIGKHIFEHSFETISDPGFKNFPRPKEKREKISLNAKIGDLFFYESY HCCCCCCHHEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHEEECCEECEEEEECCC SVEEKETEPPQRYTQGKLIQKMEDTGVGRPSTYATILETLKLRKYIVEYKKNIGPSQLGL CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC KVDSYLFLNFFDLIGESFTKDLESKLDQITDEKASRVKLVANFYDQLKQILKSPRKKMVS CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH IGKENQSKVKYDTDEKQTLSEKVKNGKGSEKKGNTKNQNQSLTYIENKTCPKCLDGYVKT CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHH KLGKNGKTIYFCSRYPHCDYITYDN HCCCCCCEEEEEECCCCCCEEEECC >Mature Secondary Structure MVVATKGHIKDLPPKSYGVDLSNQFEPEYEWLKGKKSLFTTITTKAKKCSLIYIASDPDR CEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCC EGEIIAKHCFDELSKLKKPIYRLRLKEITKEELQSQIQKKIGLDQQEIESQIARRVIDRI CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH FGFEVSPDLWKHLKIPSLSAGRVQSTVLHWICEREKEIQNFSKENYFQLKLIGTLNENPI HCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCE ELKYQSKEKLKQEEIQTILNEIQILPDPSRLKNIVLSNLKIKKIKRNPPKAFSTASLLES EEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEHHCCCCCCHHHHHHHHHH SFRALQFDSKKTMRLAQSLFEGKKLHAGETVGLITYMRSDSTRVSESKQDLGEKYLKEHY HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHC PNLLWEGSRNQGKQKKFSQDAHEAITPINPSLSPEQIKSFLTLDEWKLYQLIWERFLTSL CCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH LKPEIGEEIVYEFPIGKHIFEHSFETISDPGFKNFPRPKEKREKISLNAKIGDLFFYESY HCCCCCCHHEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHEEECCEECEEEEECCC SVEEKETEPPQRYTQGKLIQKMEDTGVGRPSTYATILETLKLRKYIVEYKKNIGPSQLGL CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC KVDSYLFLNFFDLIGESFTKDLESKLDQITDEKASRVKLVANFYDQLKQILKSPRKKMVS CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH IGKENQSKVKYDTDEKQTLSEKVKNGKGSEKKGNTKNQNQSLTYIENKTCPKCLDGYVKT CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHH KLGKNGKTIYFCSRYPHCDYITYDN HCCCCCCEEEEEECCCCCCEEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11058132 [H]