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The map label for this gene is thrB [H]

Identifier: 183220537

GI number: 183220537

Start: 1189167

End: 1190120

Strand: Direct

Name: thrB [H]

Synonym: LEPBI_I1140

Alternate gene names: 183220537

Gene position: 1189167-1190120 (Clockwise)

Preceding gene: 183220536

Following gene: 183220540

Centisome position: 33.04

GC content: 40.15

Gene sequence:

>954_bases
ATGGTTCGCTTACCAAAGATTCATATCAAAGTCCCAGGGACTTCTGCCAATTTGGGCCCTGGATTTGACCTCATGGGCCT
TGCCCTTGACATACATAATGAATTCGAGTTCCAGTTTTCCAAAGAAATCACGGAAACAAAAACCGAATTAAAAAATGGAA
AATCATTACCTTTTACCAAAAAGGAAGATTTGGTAGAACAATCGTATTTGTCATATTTTTCTAAATTTGCTCCAAAACTC
TCTCCTCCACCTTATCATTGTAAAATGACACTTGCCTTACCCTTAAAAGGCGGGCTTGGTTCGAGTGCTTCTGCAATTGT
CGCTGGGCTTTCTTTGGCAAAGGAAGTTCACAAACGGATGGATGGGACCTCTGTTCCAACAGAAGCGATGTTCACTCAAT
TTTTAGCAGAGTTTGAAGGACACCCAGACAATACCTTACCTGCCTATCTGGGAGGGTTTGTTTTCGCCTATTCTACGTTT
GGTGAAAAACTCAGATACTTTCGGAAAAAATTTCCATCTTCCGTGGCAATTTTTGTCCTCACTCCTGAATTTTTTGTTTC
AACAGAAGAATCGAGAAAATCACTTCCTAAACAGTATGTGACCTCCGATGTCATTTTTAATTTATCTAGGATTGGGGCTT
GGATGCATTTTTTAGACAAACGTAGGTTTGGTGACTTACTTGTAGGTCTCGAAGATAAAATGCACACACCTTACCGAATT
CCGAATACTTCTCCACTTTTTCCATTGGCTGATACGTTAAAACAAGATGGAATTGGGTATTGTTTATCAGGTTCCGGTCC
GAGTTTACTGATATTTTTAGAACGAAAGTCTTTAAATTCCAAACTCAAAGAATTGGAGGATACGGTAACAAAGATTATGG
GAGATGCAGGGATTCGTTTTTCCTTTCGTCGTGTCAAACCCGATGGGGTCGGCGTACGCATCCAAATCAAATGA

Upstream 100 bases:

>100_bases
ATCCCTGCTGTGGTACTTGGTGGGCTCAATGCTGTGGAACAATTCTACGGAAGAAAGAGAGGTTGATTTTGAAGCCGAAT
CGTAGAGCCTGGGCGAAACG

Downstream 100 bases:

>100_bases
TTTTGGTTTAGTCTTCTTCGGCTCCTTCCTCTTTTCCAAATCCATACACATCACCGCGAAACCTTACTTTTCGGTTGATC
CCCGGTTGGATTTTTCCCAC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MVRLPKIHIKVPGTSANLGPGFDLMGLALDIHNEFEFQFSKEITETKTELKNGKSLPFTKKEDLVEQSYLSYFSKFAPKL
SPPPYHCKMTLALPLKGGLGSSASAIVAGLSLAKEVHKRMDGTSVPTEAMFTQFLAEFEGHPDNTLPAYLGGFVFAYSTF
GEKLRYFRKKFPSSVAIFVLTPEFFVSTEESRKSLPKQYVTSDVIFNLSRIGAWMHFLDKRRFGDLLVGLEDKMHTPYRI
PNTSPLFPLADTLKQDGIGYCLSGSGPSLLIFLERKSLNSKLKELEDTVTKIMGDAGIRFSFRRVKPDGVGVRIQIK

Sequences:

>Translated_317_residues
MVRLPKIHIKVPGTSANLGPGFDLMGLALDIHNEFEFQFSKEITETKTELKNGKSLPFTKKEDLVEQSYLSYFSKFAPKL
SPPPYHCKMTLALPLKGGLGSSASAIVAGLSLAKEVHKRMDGTSVPTEAMFTQFLAEFEGHPDNTLPAYLGGFVFAYSTF
GEKLRYFRKKFPSSVAIFVLTPEFFVSTEESRKSLPKQYVTSDVIFNLSRIGAWMHFLDKRRFGDLLVGLEDKMHTPYRI
PNTSPLFPLADTLKQDGIGYCLSGSGPSLLIFLERKSLNSKLKELEDTVTKIMGDAGIRFSFRRVKPDGVGVRIQIK
>Mature_317_residues
MVRLPKIHIKVPGTSANLGPGFDLMGLALDIHNEFEFQFSKEITETKTELKNGKSLPFTKKEDLVEQSYLSYFSKFAPKL
SPPPYHCKMTLALPLKGGLGSSASAIVAGLSLAKEVHKRMDGTSVPTEAMFTQFLAEFEGHPDNTLPAYLGGFVFAYSTF
GEKLRYFRKKFPSSVAIFVLTPEFFVSTEESRKSLPKQYVTSDVIFNLSRIGAWMHFLDKRRFGDLLVGLEDKMHTPYRI
PNTSPLFPLADTLKQDGIGYCLSGSGPSLLIFLERKSLNSKLKELEDTVTKIMGDAGIRFSFRRVKPDGVGVRIQIK

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321814, Length=369, Percent_Identity=26.5582655826558, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 35421; Mature: 35421

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRLPKIHIKVPGTSANLGPGFDLMGLALDIHNEFEFQFSKEITETKTELKNGKSLPFTK
CCCCCEEEEEECCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCC
KEDLVEQSYLSYFSKFAPKLSPPPYHCKMTLALPLKGGLGSSASAIVAGLSLAKEVHKRM
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
DGTSVPTEAMFTQFLAEFEGHPDNTLPAYLGGFVFAYSTFGEKLRYFRKKFPSSVAIFVL
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
TPEFFVSTEESRKSLPKQYVTSDVIFNLSRIGAWMHFLDKRRFGDLLVGLEDKMHTPYRI
CCHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHCCCCCEEC
PNTSPLFPLADTLKQDGIGYCLSGSGPSLLIFLERKSLNSKLKELEDTVTKIMGDAGIRF
CCCCCCCHHHHHHHHCCCCEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEE
SFRRVKPDGVGVRIQIK
EEEEECCCCCCEEEEEC
>Mature Secondary Structure
MVRLPKIHIKVPGTSANLGPGFDLMGLALDIHNEFEFQFSKEITETKTELKNGKSLPFTK
CCCCCEEEEEECCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCC
KEDLVEQSYLSYFSKFAPKLSPPPYHCKMTLALPLKGGLGSSASAIVAGLSLAKEVHKRM
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
DGTSVPTEAMFTQFLAEFEGHPDNTLPAYLGGFVFAYSTFGEKLRYFRKKFPSSVAIFVL
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
TPEFFVSTEESRKSLPKQYVTSDVIFNLSRIGAWMHFLDKRRFGDLLVGLEDKMHTPYRI
CCHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHCCCCCEEC
PNTSPLFPLADTLKQDGIGYCLSGSGPSLLIFLERKSLNSKLKELEDTVTKIMGDAGIRF
CCCCCCCHHHHHHHHCCCCEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEE
SFRRVKPDGVGVRIQIK
EEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA