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The map label for this gene is lpxK

Identifier: 183220344

GI number: 183220344

Start: 972158

End: 973282

Strand: Direct

Name: lpxK

Synonym: LEPBI_I0940

Alternate gene names: 183220344

Gene position: 972158-973282 (Clockwise)

Preceding gene: 183220343

Following gene: 183220347

Centisome position: 27.01

GC content: 35.2

Gene sequence:

>1125_bases
ATGAAATTTTTTTTCATTCTATTTTACCCACTCTCTTTGTTGTACCAGTTTCTATTTTGGGTTTCACAATTTAAGATAAA
ACCCTTTGTTTTGCCCCATGTTTTAGTCATCAGTGTGGGTAATGTCACCATGGGTGGAACGGGGAAAACTCCTTTTGTGC
AATATCTTGTTCGTTACTTTAAGGCAAAAAACAAAAAGTATGCGATCACTATTTTGTCACGTGGTTATAAAGCAAAATTG
TCGAAAGTGGGTGCAATTCTTCGGGACGGACTTTCTCCACATCTGTATGGAGATGAACCAAGTGAACACAAAGAACTTTT
TCCAGATGTGCAAGTCATCATCGGCAAAAATAGAAAAGAGAGTTTTTTAAAACACAATCAAATTCATTCTAAGTTTCATA
TTGTCATTTTGGATGATGGATTCCAACACAAACAAATCCATAGAGATTTTGATATTGTTCTATTGGATGCCAATGGGCCT
TTTGGGAATGGGCAAACGATCCCTTTGGGATTTTTACGAGAACCAATCTCACATTTAAGAAGAGCGCATACAATTGTCTT
CACAAAACTTACGGATCAAAATAAAGATAAATCGATACGTGCCATAAATATCTTAAAACAAAAACAGATTCCTGTTCCAT
CTTACACTTCGCATTTTTTGGCAAATCTTGTGCAAATCGATTTGAATACGCTCAAATCAAACCCGGTCCAATTACCAGTC
GATCAAATTCGTCAAACTAAGGTTTTGGATGAAGATGCTAACGATGGTTATTTCCTGTTTACGGGTGTTGGAAATCCAAA
ACATGTATTGGAGACTGCAGAATCAATCATCGGAAAAAAAATAAATCAGCATCGATTTTTTCCTGACCATTATGAATTTG
AAGAAAGTGTTTTAGGATCAATTATAGGAGAAGTGAAACAGGGAACAGTTCTATTGACGACAGAAAAAGACTGGGTGAAA
GTTCGTACAAAAAAAGGATTTTTGGAAGAATTAAAAAAAAGAAACATTCAAATCTTTGTGATCAAAATTGAAGTGGTTGT
GAATGAGAAAGAAAGTTTCGAATCTATGTTAGCTGGTCTCGTTTCCACATACGAAGCAAAAAACGATCTGGTTTCAATGA
ATTGA

Upstream 100 bases:

>100_bases
TTTAGAAGTGTTAATGGTCGAAAAAGGAATTAGTTTAACTACCATCGCAAAAGAATTAGAAAAAAGACATAGTTAAACAA
GTTTCCTATCGCGAAACGTC

Downstream 100 bases:

>100_bases
TGAGATTGTTTGGAATGTCCATCGTTTGATTTAAAATTGATTTCACTAAAATTTCAGCTGCAAGTAAAGAGTGTGTGAGA
CCTCTGGATCCTAAACCATT

Product: putative tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MKFFFILFYPLSLLYQFLFWVSQFKIKPFVLPHVLVISVGNVTMGGTGKTPFVQYLVRYFKAKNKKYAITILSRGYKAKL
SKVGAILRDGLSPHLYGDEPSEHKELFPDVQVIIGKNRKESFLKHNQIHSKFHIVILDDGFQHKQIHRDFDIVLLDANGP
FGNGQTIPLGFLREPISHLRRAHTIVFTKLTDQNKDKSIRAINILKQKQIPVPSYTSHFLANLVQIDLNTLKSNPVQLPV
DQIRQTKVLDEDANDGYFLFTGVGNPKHVLETAESIIGKKINQHRFFPDHYEFEESVLGSIIGEVKQGTVLLTTEKDWVK
VRTKKGFLEELKKRNIQIFVIKIEVVVNEKESFESMLAGLVSTYEAKNDLVSMN

Sequences:

>Translated_374_residues
MKFFFILFYPLSLLYQFLFWVSQFKIKPFVLPHVLVISVGNVTMGGTGKTPFVQYLVRYFKAKNKKYAITILSRGYKAKL
SKVGAILRDGLSPHLYGDEPSEHKELFPDVQVIIGKNRKESFLKHNQIHSKFHIVILDDGFQHKQIHRDFDIVLLDANGP
FGNGQTIPLGFLREPISHLRRAHTIVFTKLTDQNKDKSIRAINILKQKQIPVPSYTSHFLANLVQIDLNTLKSNPVQLPV
DQIRQTKVLDEDANDGYFLFTGVGNPKHVLETAESIIGKKINQHRFFPDHYEFEESVLGSIIGEVKQGTVLLTTEKDWVK
VRTKKGFLEELKKRNIQIFVIKIEVVVNEKESFESMLAGLVSTYEAKNDLVSMN
>Mature_374_residues
MKFFFILFYPLSLLYQFLFWVSQFKIKPFVLPHVLVISVGNVTMGGTGKTPFVQYLVRYFKAKNKKYAITILSRGYKAKL
SKVGAILRDGLSPHLYGDEPSEHKELFPDVQVIIGKNRKESFLKHNQIHSKFHIVILDDGFQHKQIHRDFDIVLLDANGP
FGNGQTIPLGFLREPISHLRRAHTIVFTKLTDQNKDKSIRAINILKQKQIPVPSYTSHFLANLVQIDLNTLKSNPVQLPV
DQIRQTKVLDEDANDGYFLFTGVGNPKHVLETAESIIGKKINQHRFFPDHYEFEESVLGSIIGEVKQGTVLLTTEKDWVK
VRTKKGFLEELKKRNIQIFVIKIEVVVNEKESFESMLAGLVSTYEAKNDLVSMN

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=332, Percent_Identity=25.6024096385542, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_LEPBA (B0SDY8)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962016.1
- GeneID:   6387392
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_0907
- HOGENOM:   HBG530586
- OMA:   VILMDDG
- ProtClustDB:   CLSK2336458
- BioCyc:   LBIF355278:LBF_0907-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 42852; Mature: 42852

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFFILFYPLSLLYQFLFWVSQFKIKPFVLPHVLVISVGNVTMGGTGKTPFVQYLVRYF
CEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHCEEEEEEECCEEECCCCCCHHHHHHHHHH
KAKNKKYAITILSRGYKAKLSKVGAILRDGLSPHLYGDEPSEHKELFPDVQVIIGKNRKE
HCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHH
SFLKHNQIHSKFHIVILDDGFQHKQIHRDFDIVLLDANGPFGNGQTIPLGFLREPISHLR
HHHHHHCCCCEEEEEEEECCCCHHHHCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHH
RAHTIVFTKLTDQNKDKSIRAINILKQKQIPVPSYTSHFLANLVQIDLNTLKSNPVQLPV
HHHEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
DQIRQTKVLDEDANDGYFLFTGVGNPKHVLETAESIIGKKINQHRFFPDHYEFEESVLGS
HHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
IIGEVKQGTVLLTTEKDWVKVRTKKGFLEELKKRNIQIFVIKIEVVVNEKESFESMLAGL
HHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHHCCEEEEEEEEEEEECCHHHHHHHHHHH
VSTYEAKNDLVSMN
HHHHHHCCCCCCCC
>Mature Secondary Structure
MKFFFILFYPLSLLYQFLFWVSQFKIKPFVLPHVLVISVGNVTMGGTGKTPFVQYLVRYF
CEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHCEEEEEEECCEEECCCCCCHHHHHHHHHH
KAKNKKYAITILSRGYKAKLSKVGAILRDGLSPHLYGDEPSEHKELFPDVQVIIGKNRKE
HCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHH
SFLKHNQIHSKFHIVILDDGFQHKQIHRDFDIVLLDANGPFGNGQTIPLGFLREPISHLR
HHHHHHCCCCEEEEEEEECCCCHHHHCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHH
RAHTIVFTKLTDQNKDKSIRAINILKQKQIPVPSYTSHFLANLVQIDLNTLKSNPVQLPV
HHHEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
DQIRQTKVLDEDANDGYFLFTGVGNPKHVLETAESIIGKKINQHRFFPDHYEFEESVLGS
HHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
IIGEVKQGTVLLTTEKDWVKVRTKKGFLEELKKRNIQIFVIKIEVVVNEKESFESMLAGL
HHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHHCCEEEEEEEEEEEECCHHHHHHHHHHH
VSTYEAKNDLVSMN
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA