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The map label for this gene is flhF [H]

Identifier: 183220347

GI number: 183220347

Start: 975355

End: 976710

Strand: Direct

Name: flhF [H]

Synonym: LEPBI_I0943

Alternate gene names: 183220347

Gene position: 975355-976710 (Clockwise)

Preceding gene: 183220344

Following gene: 183220348

Centisome position: 27.1

GC content: 42.26

Gene sequence:

>1356_bases
ATGGATTTTGTGAAAATCCGAGGCAAAGACTTACAAGACTGCATCATGCAGATGAAAATGAAGTATGGCCCTGAGGCTCA
TTTGTATGACCAACGAGTGATCACCGAAGGGGGACTCTTTGGAACCGGTCTTATGGCACAACGCATGTATGAAATTGATG
TGGGTGTTCCTGAAAAACAAAATTCCAAAGAAAGAATTGAACGAAAACTCAAAGACCTCAAAGAACTCATCAAACAAAAA
CAAAGGACAGAATCACATCCTGAATCTGGTCTCGTTGGAGTGGGAATCCCCTCACATTCTTCCCACTCGGTAAATCTTTC
GAACGCAAATACTTACACGGGACGTAAAAAAAACATTGAATCGGTCCGTCCTTTTTCCGAACGAAAACGAAGACAAACTT
CCGCTATTTACGAAATTGAATCCTTTGAAGAAAGGCCCGTGGGTTTATCTCTCGCCGAAGCGAAAGAATCCTTTCTTGAA
TCCATTCCCGAAAGAACAATCAGTCCCAAAGAAAAACACCCTCACATCCAAAAGCTCATCGATCGACTGTTACGTGAAGG
ATTTTCTGAATCGTATCTAGAAGAAATGGCAGTCACACTCGAACAAAGGTTATCTGCCGTGGATTTAACTCGTTATGCCA
ATGTGACCGACAAAGCGGTCACCTATTTAGAAGAACGGATCCAAGTGGACTCCGACCTTTTTAGTGGAACTCCTCGTGGA
AAACGAAAGGTAGTTTTTTTTGTCGGGCCCACAGGTTCTGGCAAAACGACATCCATTGCGAAACTGGCAGCGAAATACAG
TTTGCATATGGGGAAAAAAGTTTCTCTCTATACAACAGATAACTACCGCATTGCGGCCATTGACCAATTGAAATTTTATG
CAGATGCGATGGGACTTCCTTTCTATGCAGCCAAAGACCTTCGCAAATGGAAAGAAACGATTCTACGTGATGGATCGGAA
CTCATCCTCGTTGATACCGCTGGATACTCACATCGTAAGTCAGAAAACTTGGAAAAACTTCAGGAATTCTACGAAGTCTT
TGGGGAAAAGGATCATATTGAAACCATCTTAGTGCTTTCCTCCACGGTGGCAAAAGACAATGCCCTCGCAGTCACAAACG
CGTATGAGTCGGTAGGTTATAAAAGAATTTTATTAACTAAGCTTGATGAAGCAGAATTTTTAGGTTCTGTCGTAGAATTA
GCCGATACTATTCACAGGGAATTCGCATTCTTAAGTGTAGGGCAGGATGTTCCGTTTGATATCCTAAATGCCACCAAAAA
AATCCTTGCCGAATGTGTAATTTTTCCTGAAAAATTGAAAGGGATAGCGGGCGAAGTCTTCGAGAAGACTGTGTAA

Upstream 100 bases:

>100_bases
AATCCTGACACCCTTCTTGGCAAATTTATTATGTCTCATAAAAAAGGCTTTCCAAATAGAGGGTACCCTTCATATTTTTC
CCAGGTTTGGGGGAGATTCT

Downstream 100 bases:

>100_bases
AGGAGCCTCGTTATCCTGATACCTAGGGGTAACGATGGACCAAGCAGCAAATCTTAGAAAGTTAACAGAAACTGGCACCG
GATTGAAACTCGTCCAACCT

Product: flagellar biosynthesis regulator FlhF

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MDFVKIRGKDLQDCIMQMKMKYGPEAHLYDQRVITEGGLFGTGLMAQRMYEIDVGVPEKQNSKERIERKLKDLKELIKQK
QRTESHPESGLVGVGIPSHSSHSVNLSNANTYTGRKKNIESVRPFSERKRRQTSAIYEIESFEERPVGLSLAEAKESFLE
SIPERTISPKEKHPHIQKLIDRLLREGFSESYLEEMAVTLEQRLSAVDLTRYANVTDKAVTYLEERIQVDSDLFSGTPRG
KRKVVFFVGPTGSGKTTSIAKLAAKYSLHMGKKVSLYTTDNYRIAAIDQLKFYADAMGLPFYAAKDLRKWKETILRDGSE
LILVDTAGYSHRKSENLEKLQEFYEVFGEKDHIETILVLSSTVAKDNALAVTNAYESVGYKRILLTKLDEAEFLGSVVEL
ADTIHREFAFLSVGQDVPFDILNATKKILAECVIFPEKLKGIAGEVFEKTV

Sequences:

>Translated_451_residues
MDFVKIRGKDLQDCIMQMKMKYGPEAHLYDQRVITEGGLFGTGLMAQRMYEIDVGVPEKQNSKERIERKLKDLKELIKQK
QRTESHPESGLVGVGIPSHSSHSVNLSNANTYTGRKKNIESVRPFSERKRRQTSAIYEIESFEERPVGLSLAEAKESFLE
SIPERTISPKEKHPHIQKLIDRLLREGFSESYLEEMAVTLEQRLSAVDLTRYANVTDKAVTYLEERIQVDSDLFSGTPRG
KRKVVFFVGPTGSGKTTSIAKLAAKYSLHMGKKVSLYTTDNYRIAAIDQLKFYADAMGLPFYAAKDLRKWKETILRDGSE
LILVDTAGYSHRKSENLEKLQEFYEVFGEKDHIETILVLSSTVAKDNALAVTNAYESVGYKRILLTKLDEAEFLGSVVEL
ADTIHREFAFLSVGQDVPFDILNATKKILAECVIFPEKLKGIAGEVFEKTV
>Mature_451_residues
MDFVKIRGKDLQDCIMQMKMKYGPEAHLYDQRVITEGGLFGTGLMAQRMYEIDVGVPEKQNSKERIERKLKDLKELIKQK
QRTESHPESGLVGVGIPSHSSHSVNLSNANTYTGRKKNIESVRPFSERKRRQTSAIYEIESFEERPVGLSLAEAKESFLE
SIPERTISPKEKHPHIQKLIDRLLREGFSESYLEEMAVTLEQRLSAVDLTRYANVTDKAVTYLEERIQVDSDLFSGTPRG
KRKVVFFVGPTGSGKTTSIAKLAAKYSLHMGKKVSLYTTDNYRIAAIDQLKFYADAMGLPFYAAKDLRKWKETILRDGSE
LILVDTAGYSHRKSENLEKLQEFYEVFGEKDHIETILVLSSTVAKDNALAVTNAYESVGYKRILLTKLDEAEFLGSVVEL
ADTIHREFAFLSVGQDVPFDILNATKKILAECVIFPEKLKGIAGEVFEKTV

Specific function: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum [H]

COG id: COG1419

COG function: function code N; Flagellar GTP-binding protein

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI226371618, Length=252, Percent_Identity=26.984126984127, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4507215, Length=258, Percent_Identity=27.5193798449612, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1789874, Length=194, Percent_Identity=29.3814432989691, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788963, Length=179, Percent_Identity=28.4916201117318, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17539958, Length=229, Percent_Identity=26.6375545851528, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325345, Length=188, Percent_Identity=30.3191489361702, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17647949, Length=203, Percent_Identity=28.0788177339901, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR020006 [H]

Pfam domain/function: PF00448 SRP54 [H]

EC number: NA

Molecular weight: Translated: 51039; Mature: 51039

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFVKIRGKDLQDCIMQMKMKYGPEAHLYDQRVITEGGLFGTGLMAQRMYEIDVGVPEKQ
CCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHEECCCCCHHHHHHHHHHHCCCCCCCCC
NSKERIERKLKDLKELIKQKQRTESHPESGLVGVGIPSHSSHSVNLSNANTYTGRKKNIE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEECCCCCCCCCCCCCHH
SVRPFSERKRRQTSAIYEIESFEERPVGLSLAEAKESFLESIPERTISPKEKHPHIQKLI
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
DRLLREGFSESYLEEMAVTLEQRLSAVDLTRYANVTDKAVTYLEERIQVDSDLFSGTPRG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KRKVVFFVGPTGSGKTTSIAKLAAKYSLHMGKKVSLYTTDNYRIAAIDQLKFYADAMGLP
CEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHHHHHHCCCC
FYAAKDLRKWKETILRDGSELILVDTAGYSHRKSENLEKLQEFYEVFGEKDHIETILVLS
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHEEHH
STVAKDNALAVTNAYESVGYKRILLTKLDEAEFLGSVVELADTIHREFAFLSVGQDVPFD
HHHCCCCCEEEECHHHHCCHHEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ILNATKKILAECVIFPEKLKGIAGEVFEKTV
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFVKIRGKDLQDCIMQMKMKYGPEAHLYDQRVITEGGLFGTGLMAQRMYEIDVGVPEKQ
CCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHEECCCCCHHHHHHHHHHHCCCCCCCCC
NSKERIERKLKDLKELIKQKQRTESHPESGLVGVGIPSHSSHSVNLSNANTYTGRKKNIE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEECCCCCCCCCCCCCHH
SVRPFSERKRRQTSAIYEIESFEERPVGLSLAEAKESFLESIPERTISPKEKHPHIQKLI
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
DRLLREGFSESYLEEMAVTLEQRLSAVDLTRYANVTDKAVTYLEERIQVDSDLFSGTPRG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KRKVVFFVGPTGSGKTTSIAKLAAKYSLHMGKKVSLYTTDNYRIAAIDQLKFYADAMGLP
CEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHHHHHHCCCC
FYAAKDLRKWKETILRDGSELILVDTAGYSHRKSENLEKLQEFYEVFGEKDHIETILVLS
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHEEHH
STVAKDNALAVTNAYESVGYKRILLTKLDEAEFLGSVVELADTIHREFAFLSVGQDVPFD
HHHCCCCCEEEECHHHHCCHHEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ILNATKKILAECVIFPEKLKGIAGEVFEKTV
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9168127; 9403685 [H]