Click here to switch to the map view.

The map label for this gene is hisE

Identifier: 183220343

GI number: 183220343

Start: 971855

End: 972133

Strand: Direct

Name: hisE

Synonym: LEPBI_I0939

Alternate gene names: 183220343

Gene position: 971855-972133 (Clockwise)

Preceding gene: 183220341

Following gene: 183220344

Centisome position: 27.0

GC content: 34.77

Gene sequence:

>279_bases
ATGGAATTTTTATTAAAATTAGAAGATTTACTCCGCAAACGAAAAGAGGAATTACCCGAAAAATCCTACACAGCGGAATT
ATTCCGAGATGGGGTAGACCGAATCCTAAAAAAAATTGGGGAAGAAGCGGGGGAAGTGATCATCGCCGCAAAAAATCCAA
ATGAAAAAGAACTCATCCATGAAATTGCAGATTTGATTTTCCATTTAGAAGTGTTAATGGTCGAAAAAGGAATTAGTTTA
ACTACCATCGCAAAAGAATTAGAAAAAAGACATAGTTAA

Upstream 100 bases:

>100_bases
TTCAATCTGATTCTACCCTAATTCGAGGTGAAGCCACAACCAATTTTCGCTTTTTGAAAATAGAAAGGGCCGTTTCCATG
GTAGTTAGAAGGCAAACGAA

Downstream 100 bases:

>100_bases
ACAAGTTTCCTATCGCGAAACGTCATGAAATTTTTTTTCATTCTATTTTACCCACTCTCTTTGTTGTACCAGTTTCTATT
TTGGGTTTCACAATTTAAGA

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 92; Mature: 92

Protein sequence:

>92_residues
MEFLLKLEDLLRKRKEELPEKSYTAELFRDGVDRILKKIGEEAGEVIIAAKNPNEKELIHEIADLIFHLEVLMVEKGISL
TTIAKELEKRHS

Sequences:

>Translated_92_residues
MEFLLKLEDLLRKRKEELPEKSYTAELFRDGVDRILKKIGEEAGEVIIAAKNPNEKELIHEIADLIFHLEVLMVEKGISL
TTIAKELEKRHS
>Mature_92_residues
MEFLLKLEDLLRKRKEELPEKSYTAELFRDGVDRILKKIGEEAGEVIIAAKNPNEKELIHEIADLIFHLEVLMVEKGISL
TTIAKELEKRHS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=47.1910112359551, Blast_Score=84, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_LEPBA (B0SDY7)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962015.1
- ProteinModelPortal:   B0SDY7
- SMR:   B0SDY7
- GeneID:   6387552
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_0906
- HOGENOM:   HBG646527
- OMA:   KLGEETT
- ProtClustDB:   CLSK575308
- BioCyc:   LBIF355278:LBF_0906-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 10655; Mature: 10655

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLLKLEDLLRKRKEELPEKSYTAELFRDGVDRILKKIGEEAGEVIIAAKNPNEKELIH
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHH
EIADLIFHLEVLMVEKGISLTTIAKELEKRHS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFLLKLEDLLRKRKEELPEKSYTAELFRDGVDRILKKIGEEAGEVIIAAKNPNEKELIH
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHH
EIADLIFHLEVLMVEKGISLTTIAKELEKRHS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA