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The map label for this gene is ndk

Identifier: 183219511

GI number: 183219511

Start: 83799

End: 84212

Strand: Reverse

Name: ndk

Synonym: LEPBI_I0084

Alternate gene names: 183219511

Gene position: 84212-83799 (Counterclockwise)

Preceding gene: 183219512

Following gene: 183219510

Centisome position: 2.34

GC content: 43.72

Gene sequence:

>414_bases
ATGGAAAGAACTTTTATCATGCTTAAACCCGATGCAGTGAAAAACAAACACATCGGTGACATCCTTCAAAGAATTGAAAA
AGAAGGATTTAAAATCCTAGGAATGAAATTCCTAAAACTCAGCCTAGAAGACGCAAAACAATTTTACGCAGTCCATGCGG
CTCGTCCTTTTTACAACGACCTATGCACATACATGGCATCCGGTCCTATCGTTGCTTGTGCTTTGGAGCGTGACAACGCG
GTGGCACACTGGAGAGACGTGATTGGCGCCACTGACCCGAAAGAAGCAAAAGCGGGAACTATCCGCGCTCTTTTTGCAGA
AAGTAAGGAAGCGAACGCAGTACACGGTTCTGACTCAGTCGCAAATGCATTACAAGAAATTGCATTTTTCTTCAAAGGGT
ATGAGCTTAACTAA

Upstream 100 bases:

>100_bases
TGAAAAAATGGATCTTCTCCCCACCTCTTTTCTTTTGGTCCGATTTTTAACCACCTAAAGATTCGATTGCTTTTTTCGGT
TTCTCCAAGCAACTGGAGAT

Downstream 100 bases:

>100_bases
GCTTTTGATTTACACTCAGATCGGTTCTTAATTCAGAACCGGTCTCACCCATCGTGCCAAATTCGTTCGAATCAATCCTA
CTAAAATCCAAACAAGTTTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MERTFIMLKPDAVKNKHIGDILQRIEKEGFKILGMKFLKLSLEDAKQFYAVHAARPFYNDLCTYMASGPIVACALERDNA
VAHWRDVIGATDPKEAKAGTIRALFAESKEANAVHGSDSVANALQEIAFFFKGYELN

Sequences:

>Translated_137_residues
MERTFIMLKPDAVKNKHIGDILQRIEKEGFKILGMKFLKLSLEDAKQFYAVHAARPFYNDLCTYMASGPIVACALERDNA
VAHWRDVIGATDPKEAKAGTIRALFAESKEANAVHGSDSVANALQEIAFFFKGYELN
>Mature_137_residues
MERTFIMLKPDAVKNKHIGDILQRIEKEGFKILGMKFLKLSLEDAKQFYAVHAARPFYNDLCTYMASGPIVACALERDNA
VAHWRDVIGATDPKEAKAGTIRALFAESKEANAVHGSDSVANALQEIAFFFKGYELN

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=45.5882352941176, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=45.5882352941176, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=45.5882352941176, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=45.5882352941176, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=45.5882352941176, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=44.4444444444444, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=42.962962962963, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=42.962962962963, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=42.2222222222222, Blast_Score=113, Evalue=4e-26,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=37.593984962406, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=37.593984962406, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=36.2962962962963, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=37.6811594202899, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=32.8571428571429, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=31.1111111111111, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI1788866, Length=131, Percent_Identity=51.9083969465649, Blast_Score=142, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=38.9705882352941, Blast_Score=101, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=41.4814814814815, Blast_Score=112, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=44.4444444444444, Blast_Score=119, Evalue=8e-28,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=34.0579710144928, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24645457, Length=137, Percent_Identity=30.6569343065693, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_LEPBA (B0S9J3)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001961208.1
- ProteinModelPortal:   B0S9J3
- SMR:   B0S9J3
- GeneID:   6388392
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_0084
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK14542
- BioCyc:   LBIF355278:LBF_0084-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15281; Mature: 15281

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFIMLKPDAVKNKHIGDILQRIEKEGFKILGMKFLKLSLEDAKQFYAVHAARPFYND
CCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
LCTYMASGPIVACALERDNAVAHWRDVIGATDPKEAKAGTIRALFAESKEANAVHGSDSV
HHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHH
ANALQEIAFFFKGYELN
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MERTFIMLKPDAVKNKHIGDILQRIEKEGFKILGMKFLKLSLEDAKQFYAVHAARPFYND
CCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
LCTYMASGPIVACALERDNAVAHWRDVIGATDPKEAKAGTIRALFAESKEANAVHGSDSV
HHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHH
ANALQEIAFFFKGYELN
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA