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The map label for this gene is mtnP [H]

Identifier: 183219498

GI number: 183219498

Start: 71745

End: 72608

Strand: Direct

Name: mtnP [H]

Synonym: LEPBI_I0071

Alternate gene names: 183219498

Gene position: 71745-72608 (Clockwise)

Preceding gene: 183219494

Following gene: 183219501

Centisome position: 1.99

GC content: 41.55

Gene sequence:

>864_bases
ATGGCAAATGTAGTGAAAATCGGGGTGATTGGCGGAACAGGTTTGTATTCAATCGACGGGATGGAAATTCTAAAAGAAAT
CCACCCTGATACTCCGTGGGGAAAACCTTCTGATACCATCACCATTGGTCGATTCAAAGGAAAAGAAATTGCCTTTTTAC
CAAGGCATGGAAAGGGACATTTTTTAAATCCTAGCGAAGTCCCTGCTCGTGCGAACATTGCCGCATTAAAGCAGTTAGGT
GTAGAAGAAATCATTGCCTTTAGTTCTGTGGGAAGTCTCCGACAAGAAATTGCACCACGAGATTTTGTGATTCCGTCACA
GATCATTGATCGAACGAAATCGAGACATGCAACATTTTTTGAAAATGGTATGGTGGCCCATGCTCCGTTTGCTGATCCGT
TTTCTTCCGGTCTTGCAAAAAAAGTAGAAGAAGCCGCAAAACAAATCAACCTTCCCATCCATACCAACAAAACTTTGATT
TGTATGGAAGGACCTCTATTTTCAACAAGAGCCGAATCTCACATGTATCGTTCTTGGGGTGCTGATATCATCAACATGAC
AGTGTTGCCAGAAGCAAAACTTGCCAGAGAAGCAGAAATTCTATACCAAATGGTTTGTATGTCCACAGACTATGACTGTT
GGAAAGAAGACGAAGCCCACGTCACTTTGGAGATGGTCCTTGCGAACTTGAGCACCAATGCAGATACTGCAAAAAAACTT
TTGTCCACTCTGATTGACTTATTAGGAAAGTCGGATGATACGAGTTTGGTGGGAAGCACGAAGTTTTCTTTGGTGACGGC
TCCGGAAAAAAGAAACCCAGAACAAATCAACAAACTTAAATTTTTATTCCCAAGTTATTTTTAA

Upstream 100 bases:

>100_bases
GATTTCATGTACTCTCCCATGAGCATTCTACAGTCTGGAGACTTAAAAAACGAATGCAACCAAAATCGTTAGGGGAAAAC
TGCACTTTAAGAGGATTCAT

Downstream 100 bases:

>100_bases
GTATGTGCAATTGCTTGCTCCAGTGTTGGAAAAATCTGGAGTAGGCTTTTTAGTTTTGTGAGTTCTAAAACATAACGTAC
TTTTTCAGAAGGGGATACAA

Product: putative S-methyl-5-thioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MANVVKIGVIGGTGLYSIDGMEILKEIHPDTPWGKPSDTITIGRFKGKEIAFLPRHGKGHFLNPSEVPARANIAALKQLG
VEEIIAFSSVGSLRQEIAPRDFVIPSQIIDRTKSRHATFFENGMVAHAPFADPFSSGLAKKVEEAAKQINLPIHTNKTLI
CMEGPLFSTRAESHMYRSWGADIINMTVLPEAKLAREAEILYQMVCMSTDYDCWKEDEAHVTLEMVLANLSTNADTAKKL
LSTLIDLLGKSDDTSLVGSTKFSLVTAPEKRNPEQINKLKFLFPSYF

Sequences:

>Translated_287_residues
MANVVKIGVIGGTGLYSIDGMEILKEIHPDTPWGKPSDTITIGRFKGKEIAFLPRHGKGHFLNPSEVPARANIAALKQLG
VEEIIAFSSVGSLRQEIAPRDFVIPSQIIDRTKSRHATFFENGMVAHAPFADPFSSGLAKKVEEAAKQINLPIHTNKTLI
CMEGPLFSTRAESHMYRSWGADIINMTVLPEAKLAREAEILYQMVCMSTDYDCWKEDEAHVTLEMVLANLSTNADTAKKL
LSTLIDLLGKSDDTSLVGSTKFSLVTAPEKRNPEQINKLKFLFPSYF
>Mature_286_residues
ANVVKIGVIGGTGLYSIDGMEILKEIHPDTPWGKPSDTITIGRFKGKEIAFLPRHGKGHFLNPSEVPARANIAALKQLGV
EEIIAFSSVGSLRQEIAPRDFVIPSQIIDRTKSRHATFFENGMVAHAPFADPFSSGLAKKVEEAAKQINLPIHTNKTLIC
MEGPLFSTRAESHMYRSWGADIINMTVLPEAKLAREAEILYQMVCMSTDYDCWKEDEAHVTLEMVLANLSTNADTAKKLL
STLIDLLGKSDDTSLVGSTKFSLVTAPEKRNPEQINKLKFLFPSYF

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=253, Percent_Identity=46.2450592885375, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71980569, Length=254, Percent_Identity=38.5826771653543, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6323045, Length=305, Percent_Identity=45.9016393442623, Blast_Score=268, Evalue=7e-73,
Organism=Drosophila melanogaster, GI20130079, Length=253, Percent_Identity=41.501976284585, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221459247, Length=253, Percent_Identity=32.4110671936759, Blast_Score=160, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 31706; Mature: 31575

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANVVKIGVIGGTGLYSIDGMEILKEIHPDTPWGKPSDTITIGRFKGKEIAFLPRHGKGH
CCCEEEEEEECCCCEEECCHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCC
FLNPSEVPARANIAALKQLGVEEIIAFSSVGSLRQEIAPRDFVIPSQIIDRTKSRHATFF
CCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHH
ENGMVAHAPFADPFSSGLAKKVEEAAKQINLPIHTNKTLICMEGPLFSTRAESHMYRSWG
HCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCCCHHHHHHHHHHHC
ADIINMTVLPEAKLAREAEILYQMVCMSTDYDCWKEDEAHVTLEMVLANLSTNADTAKKL
CCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHCCCCHHHHHHH
LSTLIDLLGKSDDTSLVGSTKFSLVTAPEKRNPEQINKLKFLFPSYF
HHHHHHHHCCCCCCCEECCCEEEEEECCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ANVVKIGVIGGTGLYSIDGMEILKEIHPDTPWGKPSDTITIGRFKGKEIAFLPRHGKGH
CCEEEEEEECCCCEEECCHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCC
FLNPSEVPARANIAALKQLGVEEIIAFSSVGSLRQEIAPRDFVIPSQIIDRTKSRHATFF
CCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHH
ENGMVAHAPFADPFSSGLAKKVEEAAKQINLPIHTNKTLICMEGPLFSTRAESHMYRSWG
HCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCCCHHHHHHHHHHHC
ADIINMTVLPEAKLAREAEILYQMVCMSTDYDCWKEDEAHVTLEMVLANLSTNADTAKKL
CCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHCCCCHHHHHHH
LSTLIDLLGKSDDTSLVGSTKFSLVTAPEKRNPEQINKLKFLFPSYF
HHHHHHHHCCCCCCCEECCCEEEEEECCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA