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The map label for this gene is sufS [C]

Identifier: 182677103

GI number: 182677103

Start: 115208

End: 116452

Strand: Direct

Name: sufS [C]

Synonym: Bind_0101

Alternate gene names: 182677103

Gene position: 115208-116452 (Clockwise)

Preceding gene: 182677102

Following gene: 182677104

Centisome position: 2.76

GC content: 55.18

Gene sequence:

>1245_bases
ATGAACAAGCATATAGCTGCGCAAGCGCCATGGGATGTGAATCTGATCCGTCAGGATTTTCCGATTCTGTCCCTGGAAGT
CTACGGCAAGCCGCTGGTCTATCTCGACAATGCCGCCTCGGCGCAAAAGCCGAAGGAGGTCGTGGACCGTATGGTGCACG
CAACCTACCACGAATATGCCAATGTGCACCGCGGTCTGCATTATCTCGCCAATGCCGCGACGGATGCCTTCGAAGTCGCC
CGCGAAAGCGTGCGCTCGTTCCTGAATGCGGAAAGTGTCAACGAGATCATTTTCACGAAATCGGCGACGGAAGCGATCAA
TCTTGTCGCGTCCTCCTTCGGGCAAGCCTTCATCAATGAAGGCGATGAAATCGTGCTCTCGATCATGGAGCACCACGCCA
ATATCGTGCCCTGGAATTTCCTGCGCGAGCGCAAGGGTGCGGTGCTGAAATGGGTTGATGTCGATGATGACGGCAATTTC
CTGATCGAGGAATTTGAAAAGGCTCTGTCGCCGAAAACCAAGATCGTCGCCATGACGCATATGTCGAATATGCTCGGCAC
GATCACGCCGGTGAAGGAAATCATCAAAATCGCTCATGATCGCGGCATTCCGGTGCTGATCGATGGATCGCAAGGGGCCG
TGCATCTCGAGGTCGATGTTCGCGATCTCGACGCGGATTTCTATGTCGTGACCGGCCATAAGCTTTATGGGCCGACCGGC
ATTGGCGCTCTTTACGGCAAGAAGGAATGGCTTGAGAAACTGCCGCCCTTCCTTGGCGGCGGTGAAATGATCAATGAAGT
GACGCGTGACCGCGTGACCTATAACGAGCCTCCGCATCGTTTCGAGGCCGGCACACCGCCGATCATCCAGGCCATCGGCC
TCGGTGCCGCTGTTGATTATATGCAAAAGCTCGGTCGCAATCGCATTCATGCGCATGAAATGGCGCTGAGCGATTATGCC
CATGAACGGCTGTCCAAAATCAATTCGCTGAAAATTTTCGGACGCGCCAAGGGCAAGGGAGCGATCATTTCCTTTGAAAT
GAAGAATGCCCATGCGCATGATGTCGCGACGATCATCGATCGTTCGGGCGTGGCCGTGCGGGCCGGCACGCATTGTGCTC
AGCCGTTGCTTGCCCGCTTTGGCGTGACTTCGACCTGTCGTGCTTCCTTCGCTGCTTACAATACGTTCGAGGAAGTCGAC
AAACTTGCCGAGGCGTTGATCCGAGCCGAAGGCCTTTTTGCTTGA

Upstream 100 bases:

>100_bases
TCAAAAGTGCTGGCAAGATCCAAGTGATCTTGCCGGAACGAAAAATGCGATAGACCGTCTGCGATAGACTTGGCATCAGG
CGCCAAGCATGGAGTTGGGC

Downstream 100 bases:

>100_bases
GAGATGAGGAATTCGTCATGTCCGAATCGCAAACCGCCGAAGTCCAGGAAGTTCAGCCGAACGAACCTGCGTGGATTTTT
GATGCCGGTATTTCCCAGAA

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNKHIAAQAPWDVNLIRQDFPILSLEVYGKPLVYLDNAASAQKPKEVVDRMVHATYHEYANVHRGLHYLANAATDAFEVA
RESVRSFLNAESVNEIIFTKSATEAINLVASSFGQAFINEGDEIVLSIMEHHANIVPWNFLRERKGAVLKWVDVDDDGNF
LIEEFEKALSPKTKIVAMTHMSNMLGTITPVKEIIKIAHDRGIPVLIDGSQGAVHLEVDVRDLDADFYVVTGHKLYGPTG
IGALYGKKEWLEKLPPFLGGGEMINEVTRDRVTYNEPPHRFEAGTPPIIQAIGLGAAVDYMQKLGRNRIHAHEMALSDYA
HERLSKINSLKIFGRAKGKGAIISFEMKNAHAHDVATIIDRSGVAVRAGTHCAQPLLARFGVTSTCRASFAAYNTFEEVD
KLAEALIRAEGLFA

Sequences:

>Translated_414_residues
MNKHIAAQAPWDVNLIRQDFPILSLEVYGKPLVYLDNAASAQKPKEVVDRMVHATYHEYANVHRGLHYLANAATDAFEVA
RESVRSFLNAESVNEIIFTKSATEAINLVASSFGQAFINEGDEIVLSIMEHHANIVPWNFLRERKGAVLKWVDVDDDGNF
LIEEFEKALSPKTKIVAMTHMSNMLGTITPVKEIIKIAHDRGIPVLIDGSQGAVHLEVDVRDLDADFYVVTGHKLYGPTG
IGALYGKKEWLEKLPPFLGGGEMINEVTRDRVTYNEPPHRFEAGTPPIIQAIGLGAAVDYMQKLGRNRIHAHEMALSDYA
HERLSKINSLKIFGRAKGKGAIISFEMKNAHAHDVATIIDRSGVAVRAGTHCAQPLLARFGVTSTCRASFAAYNTFEEVD
KLAEALIRAEGLFA
>Mature_414_residues
MNKHIAAQAPWDVNLIRQDFPILSLEVYGKPLVYLDNAASAQKPKEVVDRMVHATYHEYANVHRGLHYLANAATDAFEVA
RESVRSFLNAESVNEIIFTKSATEAINLVASSFGQAFINEGDEIVLSIMEHHANIVPWNFLRERKGAVLKWVDVDDDGNF
LIEEFEKALSPKTKIVAMTHMSNMLGTITPVKEIIKIAHDRGIPVLIDGSQGAVHLEVDVRDLDADFYVVTGHKLYGPTG
IGALYGKKEWLEKLPPFLGGGEMINEVTRDRVTYNEPPHRFEAGTPPIIQAIGLGAAVDYMQKLGRNRIHAHEMALSDYA
HERLSKINSLKIFGRAKGKGAIISFEMKNAHAHDVATIIDRSGVAVRAGTHCAQPLLARFGVTSTCRASFAAYNTFEEVD
KLAEALIRAEGLFA

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=401, Percent_Identity=25.4364089775561, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI156713448, Length=322, Percent_Identity=28.2608695652174, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1787970, Length=405, Percent_Identity=46.9135802469136, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1789175, Length=394, Percent_Identity=40.6091370558376, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI48994898, Length=400, Percent_Identity=25, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=296, Percent_Identity=27.027027027027, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=368, Percent_Identity=25.2717391304348, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17533177, Length=338, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319831, Length=393, Percent_Identity=26.972010178117, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20129463, Length=280, Percent_Identity=28.2142857142857, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45764; Mature: 45764

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKHIAAQAPWDVNLIRQDFPILSLEVYGKPLVYLDNAASAQKPKEVVDRMVHATYHEYA
CCCCCCCCCCCCHHHHHCCCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
NVHRGLHYLANAATDAFEVARESVRSFLNAESVNEIIFTKSATEAINLVASSFGQAFINE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEECCHHHHHHHHHHHHHHHHHCC
GDEIVLSIMEHHANIVPWNFLRERKGAVLKWVDVDDDGNFLIEEFEKALSPKTKIVAMTH
CHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEHHH
MSNMLGTITPVKEIIKIAHDRGIPVLIDGSQGAVHLEVDVRDLDADFYVVTGHKLYGPTG
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEEECCCCEEEEECCEEECCCC
IGALYGKKEWLEKLPPFLGGGEMINEVTRDRVTYNEPPHRFEAGTPPIIQAIGLGAAVDY
CHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MQKLGRNRIHAHEMALSDYAHERLSKINSLKIFGRAKGKGAIISFEMKNAHAHDVATIID
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCHHHHHHHHC
RSGVAVRAGTHCAQPLLARFGVTSTCRASFAAYNTFEEVDKLAEALIRAEGLFA
CCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKHIAAQAPWDVNLIRQDFPILSLEVYGKPLVYLDNAASAQKPKEVVDRMVHATYHEYA
CCCCCCCCCCCCHHHHHCCCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
NVHRGLHYLANAATDAFEVARESVRSFLNAESVNEIIFTKSATEAINLVASSFGQAFINE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEECCHHHHHHHHHHHHHHHHHCC
GDEIVLSIMEHHANIVPWNFLRERKGAVLKWVDVDDDGNFLIEEFEKALSPKTKIVAMTH
CHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEHHH
MSNMLGTITPVKEIIKIAHDRGIPVLIDGSQGAVHLEVDVRDLDADFYVVTGHKLYGPTG
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEEEECCCCEEEEECCEEECCCC
IGALYGKKEWLEKLPPFLGGGEMINEVTRDRVTYNEPPHRFEAGTPPIIQAIGLGAAVDY
CHHHHCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MQKLGRNRIHAHEMALSDYAHERLSKINSLKIFGRAKGKGAIISFEMKNAHAHDVATIID
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCCHHHHHHHHC
RSGVAVRAGTHCAQPLLARFGVTSTCRASFAAYNTFEEVDKLAEALIRAEGLFA
CCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA