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The map label for this gene is ppx [H]

Identifier: 182682583

GI number: 182682583

Start: 2327713

End: 2329248

Strand: Reverse

Name: ppx [H]

Synonym: XfasM23_2071

Alternate gene names: 182682583

Gene position: 2329248-2327713 (Counterclockwise)

Preceding gene: 182682584

Following gene: 182682582

Centisome position: 91.86

GC content: 55.34

Gene sequence:

>1536_bases
ATGCCCTCTATGCCCAATACGTTGCCATCCTATCCCCCGCTGAAGGACGGTGACCTCTTGGCCGCCATTGATCTTGGCTC
CAATAGTTTCCACATGGTGGTTGCACGTTATCTGCTCGGTCAGTTACACGTGGTCGATCGTCTCCGTGAAGCAGTGCGTA
TTGCCGATGGACTTGATGCTAAAGGGGGATTGTCGAGCAAGGCATGTGAGCGTGCACTCGAATGCTTGGCGCGCTTTGGT
CAGCGTCTGCGTAATATGCCTTCTCCCCATGTGCGTGCTTTGGCTACCAATACGGTGCGTCGACTCCGTTCGCCGCAGGC
CTTCCTGGTGTTGGCTGAGACCGCCTTGGGACATTCGATTGAGGTTGTCAGTGGCCGCGAAGAGGCGCGTCTGATTTATC
TTGGTGTTGCCCATGCGCAGCCACCCCGATTGGATCAGCATCGGTTGGTGATTGATATTGGTGGCGGCTCGACTGAATTT
ATCATCGGTAAAGGCTTCGAGCCTCTGGAGCGAGAGAGCTTACAGGTCGGGTGTATCGCCAGTACGCGGCGTTTTTTCCC
AGAGGGTAAATTGTCCAAAAAGCGGTGGAATGATGCACTGACTGAGATCGGTACTGAGTTTCAACAATTTGCGGCTCAAT
ACAATGCATTAGGTTGGCAGGAGGCACTGGGTTCCTCGGGGACGCACAAAACGATTGCCAAGATCTGCACGGAGATGAAG
CTTGCCAAGGGGGAAATCACCGCCGAAGCGTTGCCTGTATTGCGTGAGGAACTACTCAAAGCCAAGCGTATTGAAGATAT
TCATTTGCCTGGTTTGTCTGCTCATCGCCGTCCCATCATCGCTGGTGGAATATTGGTGCTGGAGGCCGTGTTTCAGACGC
TTGGCCTGGAAAAGCTGTTGGTCAGCAAGGCAGCAATGCGTGAGGGTATCCTCTACGACATGCTCGGCCGAGCTGGTGAC
AACGACCCGCGTGACACATCGGTGGCCGTGTTGATGCACCGCTATGCCATTGACGAACAGCAAGCGTTGCGTGTGGAGAC
GACTGCACAGCTCCTGTTCCAGCAGGCGTGTGGTCCCTGGGCCTTGGATGCTGACGATGCCCGTGTGCTTTGTTGGGCGG
CGCGCTTGCATGAGTTGGGGTTAGTGATTGCGCATAGTCACTACCACGTGCATGGCAGCTACGTGCTGGAGCATTCCGAT
ATTGCAGGTTTCTCTCGCCAGGAGCAGCAAGTACTAGCTGTGCTCGTGTGTACGCATCGTCGTCATGTGTCGAAGAACGC
GTTTGACGTGTTACCTGACCGCCTACGGGTGTCGGTTCGCCGCAGAGCTGCGCTGCTGCGTCTGGCGGCATTGCTGCATC
GTGCGCGCGAACCCGATTGGGTGCCTACGTTGAATCTGCATGTCGATGGCGATGTGCTGATGTTGACCGTTCCCAAGGGG
TGCTTGGCCTCACGGCCGCTGCTGCATAGTGACTTGAATGCAGAGGTTGAAGCAATGGTGGATTTAGGAATCGTGTTCAA
ACTGTCTGTCGTTTGA

Upstream 100 bases:

>100_bases
CGCCATACTCGGCCCAGGCGGCTCTACTGGAGTCTTTATAGATGTTGCTTTGCACTATGCCGGTGATGTTTACAGCGCTG
GCGGGATTTTCAGTTAGAAT

Downstream 100 bases:

>100_bases
GACAGATGCTGTGTACGGTTGAGCGTACCGTATTGTTGCGCATGCGGTTTTTGACTTATCTTCCATGCTGATATGGGCAA
GAGAGTGCGTTGTTCGTTGC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MPSMPNTLPSYPPLKDGDLLAAIDLGSNSFHMVVARYLLGQLHVVDRLREAVRIADGLDAKGGLSSKACERALECLARFG
QRLRNMPSPHVRALATNTVRRLRSPQAFLVLAETALGHSIEVVSGREEARLIYLGVAHAQPPRLDQHRLVIDIGGGSTEF
IIGKGFEPLERESLQVGCIASTRRFFPEGKLSKKRWNDALTEIGTEFQQFAAQYNALGWQEALGSSGTHKTIAKICTEMK
LAKGEITAEALPVLREELLKAKRIEDIHLPGLSAHRRPIIAGGILVLEAVFQTLGLEKLLVSKAAMREGILYDMLGRAGD
NDPRDTSVAVLMHRYAIDEQQALRVETTAQLLFQQACGPWALDADDARVLCWAARLHELGLVIAHSHYHVHGSYVLEHSD
IAGFSRQEQQVLAVLVCTHRRHVSKNAFDVLPDRLRVSVRRRAALLRLAALLHRAREPDWVPTLNLHVDGDVLMLTVPKG
CLASRPLLHSDLNAEVEAMVDLGIVFKLSVV

Sequences:

>Translated_511_residues
MPSMPNTLPSYPPLKDGDLLAAIDLGSNSFHMVVARYLLGQLHVVDRLREAVRIADGLDAKGGLSSKACERALECLARFG
QRLRNMPSPHVRALATNTVRRLRSPQAFLVLAETALGHSIEVVSGREEARLIYLGVAHAQPPRLDQHRLVIDIGGGSTEF
IIGKGFEPLERESLQVGCIASTRRFFPEGKLSKKRWNDALTEIGTEFQQFAAQYNALGWQEALGSSGTHKTIAKICTEMK
LAKGEITAEALPVLREELLKAKRIEDIHLPGLSAHRRPIIAGGILVLEAVFQTLGLEKLLVSKAAMREGILYDMLGRAGD
NDPRDTSVAVLMHRYAIDEQQALRVETTAQLLFQQACGPWALDADDARVLCWAARLHELGLVIAHSHYHVHGSYVLEHSD
IAGFSRQEQQVLAVLVCTHRRHVSKNAFDVLPDRLRVSVRRRAALLRLAALLHRAREPDWVPTLNLHVDGDVLMLTVPKG
CLASRPLLHSDLNAEVEAMVDLGIVFKLSVV
>Mature_510_residues
PSMPNTLPSYPPLKDGDLLAAIDLGSNSFHMVVARYLLGQLHVVDRLREAVRIADGLDAKGGLSSKACERALECLARFGQ
RLRNMPSPHVRALATNTVRRLRSPQAFLVLAETALGHSIEVVSGREEARLIYLGVAHAQPPRLDQHRLVIDIGGGSTEFI
IGKGFEPLERESLQVGCIASTRRFFPEGKLSKKRWNDALTEIGTEFQQFAAQYNALGWQEALGSSGTHKTIAKICTEMKL
AKGEITAEALPVLREELLKAKRIEDIHLPGLSAHRRPIIAGGILVLEAVFQTLGLEKLLVSKAAMREGILYDMLGRAGDN
DPRDTSVAVLMHRYAIDEQQALRVETTAQLLFQQACGPWALDADDARVLCWAARLHELGLVIAHSHYHVHGSYVLEHSDI
AGFSRQEQQVLAVLVCTHRRHVSKNAFDVLPDRLRVSVRRRAALLRLAALLHRAREPDWVPTLNLHVDGDVLMLTVPKGC
LASRPLLHSDLNAEVEAMVDLGIVFKLSVV

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=444, Percent_Identity=38.5135135135135, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI48994966, Length=475, Percent_Identity=34.3157894736842, Blast_Score=271, Evalue=9e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56414; Mature: 56283

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSMPNTLPSYPPLKDGDLLAAIDLGSNSFHMVVARYLLGQLHVVDRLREAVRIADGLDA
CCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KGGLSSKACERALECLARFGQRLRNMPSPHVRALATNTVRRLRSPQAFLVLAETALGHSI
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCEE
EVVSGREEARLIYLGVAHAQPPRLDQHRLVIDIGGGSTEFIIGKGFEPLERESLQVGCIA
EEECCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCCHHHCCEEEEEEH
STRRFFPEGKLSKKRWNDALTEIGTEFQQFAAQYNALGWQEALGSSGTHKTIAKICTEMK
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHH
LAKGEITAEALPVLREELLKAKRIEDIHLPGLSAHRRPIIAGGILVLEAVFQTLGLEKLL
HHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHH
VSKAAMREGILYDMLGRAGDNDPRDTSVAVLMHRYAIDEQQALRVETTAQLLFQQACGPW
HHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
ALDADDARVLCWAARLHELGLVIAHSHYHVHGSYVLEHSDIAGFSRQEQQVLAVLVCTHR
CCCCCCCHHHHHHHHHHHCCEEEEECEEEEECEEEEECCCCCCCCHHHHHHHHHHHHHHH
RHVSKNAFDVLPDRLRVSVRRRAALLRLAALLHRAREPDWVPTLNLHVDGDVLMLTVPKG
HHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCH
CLASRPLLHSDLNAEVEAMVDLGIVFKLSVV
HHHCCCCHHCCCCCHHHHHHHHCEEEEEECC
>Mature Secondary Structure 
PSMPNTLPSYPPLKDGDLLAAIDLGSNSFHMVVARYLLGQLHVVDRLREAVRIADGLDA
CCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KGGLSSKACERALECLARFGQRLRNMPSPHVRALATNTVRRLRSPQAFLVLAETALGHSI
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCEE
EVVSGREEARLIYLGVAHAQPPRLDQHRLVIDIGGGSTEFIIGKGFEPLERESLQVGCIA
EEECCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCCHHHCCEEEEEEH
STRRFFPEGKLSKKRWNDALTEIGTEFQQFAAQYNALGWQEALGSSGTHKTIAKICTEMK
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHH
LAKGEITAEALPVLREELLKAKRIEDIHLPGLSAHRRPIIAGGILVLEAVFQTLGLEKLL
HHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHH
VSKAAMREGILYDMLGRAGDNDPRDTSVAVLMHRYAIDEQQALRVETTAQLLFQQACGPW
HHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
ALDADDARVLCWAARLHELGLVIAHSHYHVHGSYVLEHSDIAGFSRQEQQVLAVLVCTHR
CCCCCCCHHHHHHHHHHHCCEEEEECEEEEECEEEEECCCCCCCCHHHHHHHHHHHHHHH
RHVSKNAFDVLPDRLRVSVRRRAALLRLAALLHRAREPDWVPTLNLHVDGDVLMLTVPKG
HHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCH
CLASRPLLHSDLNAEVEAMVDLGIVFKLSVV
HHHCCCCHHCCCCCHHHHHHHHCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]