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The map label for this gene is phoP [H]

Identifier: 182682290

GI number: 182682290

Start: 1964446

End: 1965129

Strand: Reverse

Name: phoP [H]

Synonym: XfasM23_1773

Alternate gene names: 182682290

Gene position: 1965129-1964446 (Counterclockwise)

Preceding gene: 182682291

Following gene: 182682289

Centisome position: 77.5

GC content: 48.98

Gene sequence:

>684_bases
ATGCGTATCCTTTTGGTCGAAGATGAGGCCCCATTGCGTGAGACGCTGGCTGCGCGTTTGAAGCGTGAAGGTTTCGCGGT
TGATGCCGCTCAGGATGGTGAAGAAGGTATTTACATGGGGCGTGAGGTGCCGTTCGATGTTGGTATTATTGATTTGGGCT
TACCTAAGATGTCTGGTATGGATCTTGTCAAAGCTTTACGTGACGAAGGTAAGAAGTTTCCAGTCTTAATATTGACGGCG
CGCTCTAGTTGGCAGAGTAAGGTTGAGGGGCTGAAGCAAGGAGCTGATGACTACTTGGTTAAGCCTTTCCATGTGGAGGA
GTTGTTAGCACGCGTCAATGCTTTGCTGCGTAGGGCTGCTGGTTGGAGTAAGCCAACTCTTGAATGCGGTTCTGTAGCGC
TTGACCTTGCTGCGCAGACGGTGAGCGTTAATGGGACCAATGTCGATCTTACCAGTTATGAGTACAAGGTGCTTGAATAC
TTGATGGTGCATGCTGGTGAATTGGTTTCTAAGGCTGATTTGACCGAGCATATTTATCAGCAGGATTTCGATCGTGATTC
AAATGTGCTTGAGGTGTTTATCGGTCGCTTGCGTAAGAAGCTGGATGCAGATGGTGACCTGAAGCCGATTGAGACAGTGC
GTGGTCGCGGGTATCGTTTCGCAATTGCCCGCAACGAAAATTAA

Upstream 100 bases:

>100_bases
TAACCTTTAGATACGATAGATTTTGTGGCTTGCATTATATTTTTTAGTGTATTTACATTCCCACGGCCTCCCAGGCCACT
AACGAAACTAGGGAGAGTTC

Downstream 100 bases:

>100_bases
GATCTGCTGTGCACCATGTTAATGGGGAAACAGCGCCTCTTGTCGCGTCTGTGGTGGTTAAATGGGTTCCAGCCACGTTC
GCTTCAGGCGCGCCAATTGT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MRILLVEDEAPLRETLAARLKREGFAVDAAQDGEEGIYMGREVPFDVGIIDLGLPKMSGMDLVKALRDEGKKFPVLILTA
RSSWQSKVEGLKQGADDYLVKPFHVEELLARVNALLRRAAGWSKPTLECGSVALDLAAQTVSVNGTNVDLTSYEYKVLEY
LMVHAGELVSKADLTEHIYQQDFDRDSNVLEVFIGRLRKKLDADGDLKPIETVRGRGYRFAIARNEN

Sequences:

>Translated_227_residues
MRILLVEDEAPLRETLAARLKREGFAVDAAQDGEEGIYMGREVPFDVGIIDLGLPKMSGMDLVKALRDEGKKFPVLILTA
RSSWQSKVEGLKQGADDYLVKPFHVEELLARVNALLRRAAGWSKPTLECGSVALDLAAQTVSVNGTNVDLTSYEYKVLEY
LMVHAGELVSKADLTEHIYQQDFDRDSNVLEVFIGRLRKKLDADGDLKPIETVRGRGYRFAIARNEN
>Mature_227_residues
MRILLVEDEAPLRETLAARLKREGFAVDAAQDGEEGIYMGREVPFDVGIIDLGLPKMSGMDLVKALRDEGKKFPVLILTA
RSSWQSKVEGLKQGADDYLVKPFHVEELLARVNALLRRAAGWSKPTLECGSVALDLAAQTVSVNGTNVDLTSYEYKVLEY
LMVHAGELVSKADLTEHIYQQDFDRDSNVLEVFIGRLRKKLDADGDLKPIETVRGRGYRFAIARNEN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=41.7040358744395, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=40.3587443946188, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=39.0909090909091, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=40.3669724770642, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=34.9775784753363, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=39.1304347826087, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=38.3561643835616, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.8854625550661, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=33.6322869955157, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=30.8370044052863, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=30.5676855895196, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=30.9734513274336, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=30.8370044052863, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=33.0508474576271, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=29.6610169491525, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=37.037037037037, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=32.4324324324324, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25323; Mature: 25323

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLVEDEAPLRETLAARLKREGFAVDAAQDGEEGIYMGREVPFDVGIIDLGLPKMSGM
CEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCEEECCCCCCCCCEEECCCCCCCCH
DLVKALRDEGKKFPVLILTARSSWQSKVEGLKQGADDYLVKPFHVEELLARVNALLRRAA
HHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHC
GWSKPTLECGSVALDLAAQTVSVNGTNVDLTSYEYKVLEYLMVHAGELVSKADLTEHIYQ
CCCCCCCHHHHHHHHHHHEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNVLEVFIGRLRKKLDADGDLKPIETVRGRGYRFAIARNEN
HHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MRILLVEDEAPLRETLAARLKREGFAVDAAQDGEEGIYMGREVPFDVGIIDLGLPKMSGM
CEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCEEECCCCCCCCCEEECCCCCCCCH
DLVKALRDEGKKFPVLILTARSSWQSKVEGLKQGADDYLVKPFHVEELLARVNALLRRAA
HHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHC
GWSKPTLECGSVALDLAAQTVSVNGTNVDLTSYEYKVLEYLMVHAGELVSKADLTEHIYQ
CCCCCCCHHHHHHHHHHHEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNVLEVFIGRLRKKLDADGDLKPIETVRGRGYRFAIARNEN
HHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA