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The map label for this gene is phoQ [H]

Identifier: 182682289

GI number: 182682289

Start: 1962982

End: 1964430

Strand: Reverse

Name: phoQ [H]

Synonym: XfasM23_1772

Alternate gene names: 182682289

Gene position: 1964430-1962982 (Counterclockwise)

Preceding gene: 182682290

Following gene: 182682288

Centisome position: 77.47

GC content: 50.59

Gene sequence:

>1449_bases
ATGTTAATGGGGAAACAGCGCCTCTTGTCGCGTCTGTGGTGGTTAAATGGGTTCCAGCCACGTTCGCTTCAGGCGCGCCA
ATTGTTTGCTGCAAGCTTCAGTTTAGTTGCTTTCCTGGCGTTGGCTGGTTATGCGCTTGACGCGGCTTTCGCAGATACTG
CTGAAAAGAATTTACGTGAGCGGTTGAAAGCCTACGCTACAGCATATGTCAGCAGCGTTGAGTTCCTGCGCGATGGATCA
TTATATATTAGTAGTGATCGTCCGCCACCTGACCCACACTTTGATGTGCCAGGCGGTGGATTGTATTCCGAAGTGATCTG
GCCTGCCAATCGTTGGCGTTCGTTGTCATCCGAGGGGCCACTTCTTCCTCCGGTAGGTCCATTGCTTAAGGCTCGTCAGG
AGGTCTTTGAAGGGCCGTTCGAAATGACCCAGGTTGATGGCAAGCTTGGGCGAGTGTATCGCTACGGTATGGGATTGATC
TGGAACGGTACAGGTAATCCCAACGACGAGTTCCCTTATACGATTTACGTGATGGAGGATGAGGCTGCACTAGGTGCGCA
GCTGCGTGTATTTCGCACGGCTGTCTGGTTCTATCTTGGTAGTGCTGGCATCGTACTATTACTGCTACAAGCCTTTATTT
TGCAGTGGAGTTTGCGTCCAATAAGCCATGTCATTAACGAGTTGGCTAAAGTTCAACGTGGTCAAGCGCAGAGGATGAGC
GAGCAACATCCGCCTGAGCTGGAACCACTCACCCAGAGTATCAACGCGTTTATTGAGAGCGAGCGTGAGAATCTTGATCG
TCAACGTAACACTTTGGCTGATCTAGCGCATAGTTTGAAAACGCCACTTGCGGTATTACGCACCCAGTTGGATAGCGGTG
CTAGTGAGAATGAGTTGCGCGAGGAATTGGACGTACAGTTGCGACGCATGAATAATTTGGTTTCTTACCAGCTTGCGCGC
GCTGCTTCCAGTGGCCACAAACTTTTTTCTGCTCCGGTATTGATCAATTTTACAGCTGAAGAGATCGTACGTGGCCTGGA
GAAGGTTTACGCTGCTAAGGGCGTGTTGTGCGAATTTGAGATTGATCCTAAGGCTTGTTTTTATGGTGAGCCTGGGGATT
TGCAGGAACTGCTAGGAAATCTGTTGGAGAATGCTTTCAAGTGGGCCCTATCACGTGTGTTGTTAACTGCTAGCCCAGGT
GAGCAGGTTGGTACCAGACGTCCTGGGTTGGTGTTGTCGGTTGAGGATAACGGGCCTGGCATCCCGCTTGAAGAGGTTAG
CAAAATCTTACAGCGTGGTGTGCGTGGCGATGAACGTGTACACGGTCATGGTATCGGATTGTCAATCGTTCAGGACTTAG
TTAAGGGTTATCGTGGCGAATTACAGGTGACTCGTTCGGACGAACTGGGCGGGGCTTGCTTTGAGGTGGTATTGCCTCCA
GGGTTATAA

Upstream 100 bases:

>100_bases
GCTGGATGCAGATGGTGACCTGAAGCCGATTGAGACAGTGCGTGGTCGCGGGTATCGTTTCGCAATTGCCCGCAACGAAA
ATTAAGATCTGCTGTGCACC

Downstream 100 bases:

>100_bases
CAGTTTTTGTAACATGCTTTTCTGTAACGCTTTCTTATATTGTTTGTTACATGAAGATTTTTAATGTAGCAATTATCAAT
TAATTTATATGCGTATAATT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MLMGKQRLLSRLWWLNGFQPRSLQARQLFAASFSLVAFLALAGYALDAAFADTAEKNLRERLKAYATAYVSSVEFLRDGS
LYISSDRPPPDPHFDVPGGGLYSEVIWPANRWRSLSSEGPLLPPVGPLLKARQEVFEGPFEMTQVDGKLGRVYRYGMGLI
WNGTGNPNDEFPYTIYVMEDEAALGAQLRVFRTAVWFYLGSAGIVLLLLQAFILQWSLRPISHVINELAKVQRGQAQRMS
EQHPPELEPLTQSINAFIESERENLDRQRNTLADLAHSLKTPLAVLRTQLDSGASENELREELDVQLRRMNNLVSYQLAR
AASSGHKLFSAPVLINFTAEEIVRGLEKVYAAKGVLCEFEIDPKACFYGEPGDLQELLGNLLENAFKWALSRVLLTASPG
EQVGTRRPGLVLSVEDNGPGIPLEEVSKILQRGVRGDERVHGHGIGLSIVQDLVKGYRGELQVTRSDELGGACFEVVLPP
GL

Sequences:

>Translated_482_residues
MLMGKQRLLSRLWWLNGFQPRSLQARQLFAASFSLVAFLALAGYALDAAFADTAEKNLRERLKAYATAYVSSVEFLRDGS
LYISSDRPPPDPHFDVPGGGLYSEVIWPANRWRSLSSEGPLLPPVGPLLKARQEVFEGPFEMTQVDGKLGRVYRYGMGLI
WNGTGNPNDEFPYTIYVMEDEAALGAQLRVFRTAVWFYLGSAGIVLLLLQAFILQWSLRPISHVINELAKVQRGQAQRMS
EQHPPELEPLTQSINAFIESERENLDRQRNTLADLAHSLKTPLAVLRTQLDSGASENELREELDVQLRRMNNLVSYQLAR
AASSGHKLFSAPVLINFTAEEIVRGLEKVYAAKGVLCEFEIDPKACFYGEPGDLQELLGNLLENAFKWALSRVLLTASPG
EQVGTRRPGLVLSVEDNGPGIPLEEVSKILQRGVRGDERVHGHGIGLSIVQDLVKGYRGELQVTRSDELGGACFEVVLPP
GL
>Mature_482_residues
MLMGKQRLLSRLWWLNGFQPRSLQARQLFAASFSLVAFLALAGYALDAAFADTAEKNLRERLKAYATAYVSSVEFLRDGS
LYISSDRPPPDPHFDVPGGGLYSEVIWPANRWRSLSSEGPLLPPVGPLLKARQEVFEGPFEMTQVDGKLGRVYRYGMGLI
WNGTGNPNDEFPYTIYVMEDEAALGAQLRVFRTAVWFYLGSAGIVLLLLQAFILQWSLRPISHVINELAKVQRGQAQRMS
EQHPPELEPLTQSINAFIESERENLDRQRNTLADLAHSLKTPLAVLRTQLDSGASENELREELDVQLRRMNNLVSYQLAR
AASSGHKLFSAPVLINFTAEEIVRGLEKVYAAKGVLCEFEIDPKACFYGEPGDLQELLGNLLENAFKWALSRVLLTASPG
EQVGTRRPGLVLSVEDNGPGIPLEEVSKILQRGVRGDERVHGHGIGLSIVQDLVKGYRGELQVTRSDELGGACFEVVLPP
GL

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=295, Percent_Identity=35.9322033898305, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=26.0869565217391, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=330, Percent_Identity=26.969696969697, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1790551, Length=292, Percent_Identity=27.7397260273973, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790346, Length=280, Percent_Identity=25, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=32.0833333333333, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=27.9475982532751, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53499; Mature: 53499

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMGKQRLLSRLWWLNGFQPRSLQARQLFAASFSLVAFLALAGYALDAAFADTAEKNLRE
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLKAYATAYVSSVEFLRDGSLYISSDRPPPDPHFDVPGGGLYSEVIWPANRWRSLSSEGP
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCCCCCC
LLPPVGPLLKARQEVFEGPFEMTQVDGKLGRVYRYGMGLIWNGTGNPNDEFPYTIYVMED
CCCCCCHHHHHHHHHHCCCHHHHHHCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEEEC
EAALGAQLRVFRTAVWFYLGSAGIVLLLLQAFILQWSLRPISHVINELAKVQRGQAQRMS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
EQHPPELEPLTQSINAFIESERENLDRQRNTLADLAHSLKTPLAVLRTQLDSGASENELR
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EELDVQLRRMNNLVSYQLARAASSGHKLFSAPVLINFTAEEIVRGLEKVYAAKGVLCEFE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEECHHHHHHHHHHHHHHCCCEEEEE
IDPKACFYGEPGDLQELLGNLLENAFKWALSRVLLTASPGEQVGTRRPGLVLSVEDNGPG
ECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCCCC
IPLEEVSKILQRGVRGDERVHGHGIGLSIVQDLVKGYRGELQVTRSDELGGACFEVVLPP
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCC
GL
CC
>Mature Secondary Structure
MLMGKQRLLSRLWWLNGFQPRSLQARQLFAASFSLVAFLALAGYALDAAFADTAEKNLRE
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLKAYATAYVSSVEFLRDGSLYISSDRPPPDPHFDVPGGGLYSEVIWPANRWRSLSSEGP
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCCCCCC
LLPPVGPLLKARQEVFEGPFEMTQVDGKLGRVYRYGMGLIWNGTGNPNDEFPYTIYVMED
CCCCCCHHHHHHHHHHCCCHHHHHHCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEEEC
EAALGAQLRVFRTAVWFYLGSAGIVLLLLQAFILQWSLRPISHVINELAKVQRGQAQRMS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
EQHPPELEPLTQSINAFIESERENLDRQRNTLADLAHSLKTPLAVLRTQLDSGASENELR
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EELDVQLRRMNNLVSYQLARAASSGHKLFSAPVLINFTAEEIVRGLEKVYAAKGVLCEFE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEECHHHHHHHHHHHHHHCCCEEEEE
IDPKACFYGEPGDLQELLGNLLENAFKWALSRVLLTASPGEQVGTRRPGLVLSVEDNGPG
ECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCCCC
IPLEEVSKILQRGVRGDERVHGHGIGLSIVQDLVKGYRGELQVTRSDELGGACFEVVLPP
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCC
GL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]