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The map label for this gene is ndk

Identifier: 182682235

GI number: 182682235

Start: 1896983

End: 1897408

Strand: Reverse

Name: ndk

Synonym: XfasM23_1717

Alternate gene names: 182682235

Gene position: 1897408-1896983 (Counterclockwise)

Preceding gene: 182682237

Following gene: 182682234

Centisome position: 74.83

GC content: 47.42

Gene sequence:

>426_bases
ATGGTGCTTGAGCGTACTCTTTCGATTATCAAGCCTGATGCCGTTGCGAAGAACGTGATTGGCGATATCTATAGCCGTTT
TGAGAAGGCTGGTCTTAAGATCGTTGCTGCTAAATATAAGCAGTTATCGCGTCGTGAGGCTGAAGGTTTTTATGCTGTGC
ATCGTGATCGCCCGTTTTTTAACGCCTTGGTTGAATTTATGATCTCAGGGCCAGTAATGATTCAGGTACTGGAGAGCGAA
AATGCTGTGGCTCGTCATCGTGAGTTGTTAGGAGCGACCAATCCGAAGGATGCCGCTCCAGGTACGATCCGCGCTGATTT
TGCTGAGTCGATTGAAGCCAATGCTGCACATGGTTCGGATTCGGTCGAGAATGCTGCGATTGAAGTGGCTTACTTTTTCG
CTGCTACCGAAATTATTTTGCGATGA

Upstream 100 bases:

>100_bases
TTCATTGCTGTAAAAATAAGCTAAGCCCGCGTTCAGACGCGGGTTTTTTTCATGTAGACTTCCGGGCTGTCAGTAGCCCG
CCCAACAGGAGATCCTGTAC

Downstream 100 bases:

>100_bases
GATTGTAGGCATGAATGGGTTTGCGGTGATTCCCAGTGTGACAACAACGACAACTAGTGGTGAGCCCATCGCTAGCGATG
TTGCTCGTAAACAGAATCTG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MVLERTLSIIKPDAVAKNVIGDIYSRFEKAGLKIVAAKYKQLSRREAEGFYAVHRDRPFFNALVEFMISGPVMIQVLESE
NAVARHRELLGATNPKDAAPGTIRADFAESIEANAAHGSDSVENAAIEVAYFFAATEIILR

Sequences:

>Translated_141_residues
MVLERTLSIIKPDAVAKNVIGDIYSRFEKAGLKIVAAKYKQLSRREAEGFYAVHRDRPFFNALVEFMISGPVMIQVLESE
NAVARHRELLGATNPKDAAPGTIRADFAESIEANAAHGSDSVENAAIEVAYFFAATEIILR
>Mature_141_residues
MVLERTLSIIKPDAVAKNVIGDIYSRFEKAGLKIVAAKYKQLSRREAEGFYAVHRDRPFFNALVEFMISGPVMIQVLESE
NAVARHRELLGATNPKDAAPGTIRADFAESIEANAAHGSDSVENAAIEVAYFFAATEIILR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=46.7153284671533, Blast_Score=129, Evalue=6e-31,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=44.5255474452555, Blast_Score=128, Evalue=1e-30,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=44.5255474452555, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=44.5255474452555, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=44.5255474452555, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=44.5255474452555, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=44.5255474452555, Blast_Score=127, Evalue=2e-30,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=44.5255474452555, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=41.1764705882353, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI37574614, Length=141, Percent_Identity=39.7163120567376, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI7019465, Length=141, Percent_Identity=39.7163120567376, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=36.2962962962963, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=32.1167883211679, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=34.5588235294118, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=31.3868613138686, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=61.7021276595745, Blast_Score=186, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=45.1851851851852, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=44.1176470588235, Blast_Score=125, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=46.3235294117647, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.8358208955224, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_XYLF2 (B2I7V6)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830395.1
- ProteinModelPortal:   B2I7V6
- SMR:   B2I7V6
- GeneID:   6202887
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1717
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15510; Mature: 15510

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLERTLSIIKPDAVAKNVIGDIYSRFEKAGLKIVAAKYKQLSRREAEGFYAVHRDRPFF
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCHHH
NALVEFMISGPVMIQVLESENAVARHRELLGATNPKDAAPGTIRADFAESIEANAAHGSD
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
SVENAAIEVAYFFAATEIILR
CHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLERTLSIIKPDAVAKNVIGDIYSRFEKAGLKIVAAKYKQLSRREAEGFYAVHRDRPFF
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCHHH
NALVEFMISGPVMIQVLESENAVARHRELLGATNPKDAAPGTIRADFAESIEANAAHGSD
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
SVENAAIEVAYFFAATEIILR
CHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA