Click here to switch to the map view.

The map label for this gene is mtnP

Identifier: 182681991

GI number: 182681991

Start: 1618396

End: 1619142

Strand: Reverse

Name: mtnP

Synonym: XfasM23_1466

Alternate gene names: 182681991

Gene position: 1619142-1618396 (Counterclockwise)

Preceding gene: 182681992

Following gene: 182681990

Centisome position: 63.85

GC content: 51.67

Gene sequence:

>747_bases
ATGCAAACGATTGCTCTGGCGGTGATTGGTGGTACTGGTGTTTATACGTTGTCTCAGTTCGACGATGTACAGGTGTATGA
GGTTGAGACGTTGTATGGCCGCCCTTCTGGTCCAATCCGTGTTGGTATGTTGTTTGGCCAGCGTGTGGCTTTCTTTGCCC
GTCATGGTGAGGAGCATGCGTTGCCACCACACAAAATTAATTATCGCGCCAATATTGCCGCTTTGCAGCAGCTTGGTGTC
AGTCGTGTGCTGGCGCTCAATACTGTCGGTGGAATCAATGAGGCGTTTGGCCCACGTACGTTGGTTTGTCCTGATCAGCT
GATTGACTATACATGGGGGCGTGTCTCCACGTTCTGCGAGGAAGTGGGGAGTGAGGTGCTCCATGTGGATTTTGGTCATC
CTTATTCTCCGTTGCTGCGTGGTTGTTTGTTGCGTGCAGCACGTGATGTGGATGTAAGTTTGGTCGAGTATGGTTGCTAT
GGTGTGACTCAGGGACCACGTTTGGAAACGATTGCTGAGATTGATCGGTTACGCCGCGATGGGTGTGACTTAGTTGGTAT
GACGGGTATGCCTGAGGCTGCGTTGGCGCGTGAGAAGGGGCTGGAATATGCTTGTTTGGGGATTGTCTCCAACTGGGCGG
CGGGTTGTGGTGATGGCGCTGAGATCACAATGGGAGAAATTTTGTCCAATGTTGCGACAGCCTTCAGCTGTCTTCCGGAA
CTAATTAGTAAAGTTGCGCGAGAGTGA

Upstream 100 bases:

>100_bases
TATGGCGTGGAGGTTCCGGATCGCTATGTGTTTGGTTTTGGAATGGACATAGCGGGGCAGCTGCGCGGTATCCCGGCAAT
TTATGCGATGAGGCAATAGT

Downstream 100 bases:

>100_bases
TTGTCATTTGGACACAAGCTTTGCATACTCAGTCTGTGCGCTAGGGGACGTACATTACTCATTTCAATTTGAAAAGGTCT
CGCATCACCATGCAGAGCGG

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MQTIALAVIGGTGVYTLSQFDDVQVYEVETLYGRPSGPIRVGMLFGQRVAFFARHGEEHALPPHKINYRANIAALQQLGV
SRVLALNTVGGINEAFGPRTLVCPDQLIDYTWGRVSTFCEEVGSEVLHVDFGHPYSPLLRGCLLRAARDVDVSLVEYGCY
GVTQGPRLETIAEIDRLRRDGCDLVGMTGMPEAALAREKGLEYACLGIVSNWAAGCGDGAEITMGEILSNVATAFSCLPE
LISKVARE

Sequences:

>Translated_248_residues
MQTIALAVIGGTGVYTLSQFDDVQVYEVETLYGRPSGPIRVGMLFGQRVAFFARHGEEHALPPHKINYRANIAALQQLGV
SRVLALNTVGGINEAFGPRTLVCPDQLIDYTWGRVSTFCEEVGSEVLHVDFGHPYSPLLRGCLLRAARDVDVSLVEYGCY
GVTQGPRLETIAEIDRLRRDGCDLVGMTGMPEAALAREKGLEYACLGIVSNWAAGCGDGAEITMGEILSNVATAFSCLPE
LISKVARE
>Mature_248_residues
MQTIALAVIGGTGVYTLSQFDDVQVYEVETLYGRPSGPIRVGMLFGQRVAFFARHGEEHALPPHKINYRANIAALQQLGV
SRVLALNTVGGINEAFGPRTLVCPDQLIDYTWGRVSTFCEEVGSEVLHVDFGHPYSPLLRGCLLRAARDVDVSLVEYGCY
GVTQGPRLETIAEIDRLRRDGCDLVGMTGMPEAALAREKGLEYACLGIVSNWAAGCGDGAEITMGEILSNVATAFSCLPE
LISKVARE

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA)

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family

Homologues:

Organism=Homo sapiens, GI47132622, Length=218, Percent_Identity=30.7339449541284, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71980569, Length=250, Percent_Identity=30.8, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323045, Length=246, Percent_Identity=31.3008130081301, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221459247, Length=228, Percent_Identity=35.5263157894737, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI20130079, Length=252, Percent_Identity=30.5555555555556, Blast_Score=127, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNP_XYLFT (Q87BR7)

Other databases:

- EMBL:   AE009442
- RefSeq:   NP_779579.1
- ProteinModelPortal:   Q87BR7
- SMR:   Q87BR7
- STRING:   Q87BR7
- GeneID:   1144103
- GenomeReviews:   AE009442_GR
- KEGG:   xft:PD1381
- eggNOG:   COG0005
- HOGENOM:   HBG286690
- OMA:   QIIDYTW
- ProtClustDB:   PRK09136
- BioCyc:   XFAS183190:PD_1381-MONOMER
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099
- PANTHER:   PTHR11904

Pfam domain/function: PF01048 PNP_UDP_1

EC number: =2.4.2.28

Molecular weight: Translated: 26809; Mature: 26809

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIALAVIGGTGVYTLSQFDDVQVYEVETLYGRPSGPIRVGMLFGQRVAFFARHGEEHA
CCEEEEEEECCCCEEEECCCCCEEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCCC
LPPHKINYRANIAALQQLGVSRVLALNTVGGINEAFGPRTLVCPDQLIDYTWGRVSTFCE
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEECHHHHHHHCHHHHHHHHH
EVGSEVLHVDFGHPYSPLLRGCLLRAARDVDVSLVEYGCYGVTQGPRLETIAEIDRLRRD
HHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHC
GCDLVGMTGMPEAALAREKGLEYACLGIVSNWAAGCGDGAEITMGEILSNVATAFSCLPE
CCCEECCCCCCHHHHHHHHCCCEEEHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHH
LISKVARE
HHHHHHCC
>Mature Secondary Structure
MQTIALAVIGGTGVYTLSQFDDVQVYEVETLYGRPSGPIRVGMLFGQRVAFFARHGEEHA
CCEEEEEEECCCCEEEECCCCCEEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCCC
LPPHKINYRANIAALQQLGVSRVLALNTVGGINEAFGPRTLVCPDQLIDYTWGRVSTFCE
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEECHHHHHHHCHHHHHHHHH
EVGSEVLHVDFGHPYSPLLRGCLLRAARDVDVSLVEYGCYGVTQGPRLETIAEIDRLRRD
HHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHC
GCDLVGMTGMPEAALAREKGLEYACLGIVSNWAAGCGDGAEITMGEILSNVATAFSCLPE
CCCEECCCCCCHHHHHHHHCCCEEEHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHH
LISKVARE
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12533478